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Protein

Tripartite terminase subunit 2

Gene

TRM2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.UniRule annotation2 Publications

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite terminase subunit 2UniRule annotation
Gene namesi
Name:TRM2UniRule annotation
Ordered Locus Names:UL33
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001160231 – 130Tripartite terminase subunit 2Add BLAST130

Proteomic databases

PRIDEiP10217

Interactioni

Subunit structurei

Associates with TRM1 and TRM3 to form the tripartite terminase complex.UniRule annotation1 Publication

Binary interactionsi

Protein-protein interaction databases

IntActiP10217, 2 interactors
MINTiP10217

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRM2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000Y6

Family and domain databases

HAMAPiMF_04015 HSV_TRM2, 1 hit
InterProiView protein in InterPro
IPR005208 Herpes_TT2
PfamiView protein in Pfam
PF03581 Herpes_UL33, 1 hit

Sequencei

Sequence statusi: Complete.

P10217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGREGRTRQ RTLRDTIPDC ALRSQTLESL DARYVSRDGA HDAAVWFEDM
60 70 80 90 100
TPAELEVVFP TTDAKLNYLS RTQRLASLLT YAGPIKAPDD AAAPQTPDTA
110 120 130
CVHGELLAAK RERFAAVINR FLDLHQILRG
Length:130
Mass (Da):14,437
Last modified:July 1, 1989 - v1
Checksum:iD04CFDA7A3C585D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32308.1
M62932 Genomic DNA Translation: AAA45829.1
PIRiF30085 WMBEH3

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32308.1
M62932 Genomic DNA Translation: AAA45829.1
PIRiF30085 WMBEH3

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10217, 2 interactors
MINTiP10217

Proteomic databases

PRIDEiP10217

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000Y6

Family and domain databases

HAMAPiMF_04015 HSV_TRM2, 1 hit
InterProiView protein in InterPro
IPR005208 Herpes_TT2
PfamiView protein in Pfam
PF03581 Herpes_UL33, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRM2_HHV11
AccessioniPrimary (citable) accession number: P10217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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