UniProtKB - P10212 (TRM1_HHV11)
Protein
Tripartite terminase subunit 1
Gene
TRM1
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.UniRule annotation2 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 197 – 225 | C3H1-typeUniRule annotationAdd BLAST | 29 | |
Nucleotide bindingi | 696 – 703 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- protein processing Source: UniProtKB-UniRule
- viral capsid assembly Source: UniProtKB-UniRule
- viral DNA genome packaging Source: InterPro
- viral release from host cell Source: UniProtKB-UniRule
Keywordsi
Biological process | Viral genome packaging, Viral release from host cell |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite terminase subunit 1UniRule annotation |
Gene namesi | Name:TRM1UniRule annotation Ordered Locus Names:UL28 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host nucleus UniRule annotation1 Publication Note: Found associated with the external surface of the viral capsid during assembly and DNA packaging, but seems absent in extracellular mature virions.UniRule annotation
GO - Cellular componenti
- host cell nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115874 | 1 – 785 | Tripartite terminase subunit 1Add BLAST | 785 |
Proteomic databases
PRIDEi | P10212 |
Interactioni
Subunit structurei
Associates with TRM2 and TRM3 to form the tripartite terminase complex.
Interacts with portal protein.
UniRule annotation3 PublicationsBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 971470, 1 interactor |
IntActi | P10212, 3 interactors |
MINTi | P10212 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 465 – 468 | Poly-Gly | 4 |
Sequence similaritiesi
Belongs to the herpesviridae TRM1 protein family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 197 – 225 | C3H1-typeUniRule annotationAdd BLAST | 29 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
HAMAPi | MF_04014, HSV_TRM1, 1 hit |
InterProi | View protein in InterPro IPR000501, UL28/UL56 |
Pfami | View protein in Pfam PF01366, PRTP, 1 hit |
i Sequence
Sequence statusi: Complete.
P10212-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAPVSEPTV ARQKLLALLG QVQTYVFQIE LLRRCDPHIG RGKLPQLKLN
60 70 80 90 100
ALQVRALRRR LRPGLEAQAG AFLTPLSVTL ELLLEYAWRE GERLLGSLET
110 120 130 140 150
FATAGDVAAF FTETMGLARP CPYHQRVRLD TYGGTVHMEL CFLHDVENFL
160 170 180 190 200
KQLNYCHLIT PSRGATAALE RVREFMVGAV GSGLIVPPEL SDPSHPCAVC
210 220 230 240 250
FEELCVTANQ GATIARRLAD RICNHVTQQA QVRLDANELR RYLPHAAGLS
260 270 280 290 300
DADRARALSV LDHALARTAG GDGQPHPSPE NDSVRKEADA LLEAHDVFQA
310 320 330 340 350
TTPGLYAISE LRFWLASGDR AGQTTMDAFA SNLTALARRE LQQETAAVAV
360 370 380 390 400
ELALFGRRAE HFDRAFGSHL AALDMVDALI IGGQATSPDD QIEALIRACY
410 420 430 440 450
DHHLTTPLLR RLVSPEQCDE EALRRVLARM GAGGAADAPK GGAGPDDDGD
460 470 480 490 500
RVAVEEGARG LGAPGGGGED EDRRRGPGGQ GPETWGDIAT QAAADVRERR
510 520 530 540 550
RLYADRLTKR SLASLGRCVR EQRGELEKML RVSVHGEVLP ATFAAVANGF
560 570 580 590 600
AARARFCALT AGAGTVIDNR SAPGVFDAHR FMRASLLRHQ VDPALLPSIT
610 620 630 640 650
HRFFELVNGP LFDHSTHSFA QPPNTALYYS VENVGLLPHL KEELARFIMG
660 670 680 690 700
AGGSGADWAV SEFQRFYCFD GISGITPTQR AAWRYIRELI IATTLFASVY
710 720 730 740 750
RCGELELRRP DCSRPTSEGR YRYPPGVYLT YDSDCPLVAI VESAPDGCIG
760 770 780
PRSVVVYDRD VFSILYSVLQ HLAPRLPDGG HDGPP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32321.1 |
PIRi | A30085, WMBEW8 |
RefSeqi | YP_009137103.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703457 |
KEGGi | vg:2703457 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32321.1 |
PIRi | A30085, WMBEW8 |
RefSeqi | YP_009137103.1, NC_001806.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6M5R | electron microscopy | 3.50 | B | 2-775 | [»] | |
6M5S | electron microscopy | 3.90 | B | 2-775 | [»] | |
6M5U | electron microscopy | 3.80 | B | 2-775 | [»] | |
6M5V | electron microscopy | 4.50 | B | 2-772 | [»] | |
SMRi | P10212 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 971470, 1 interactor |
IntActi | P10212, 3 interactors |
MINTi | P10212 |
Proteomic databases
PRIDEi | P10212 |
Genome annotation databases
GeneIDi | 2703457 |
KEGGi | vg:2703457 |
Family and domain databases
HAMAPi | MF_04014, HSV_TRM1, 1 hit |
InterProi | View protein in InterPro IPR000501, UL28/UL56 |
Pfami | View protein in Pfam PF01366, PRTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRM1_HHV11 | |
Accessioni | P10212Primary (citable) accession number: P10212 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families