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Protein

Capsid vertex component 2

Gene

CVC2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes. Participates in the interaction between the capsid and the tegument through interaction with the large tegument protein/LTP. May mediate the capsid docking to the nuclear pore allowing entry of the viral genome into the host nucleus through binding to host nucleoporins NUP214.UniRule annotation2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral genome packaging, Viral penetration into host nucleus, Viral release from host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid vertex component 2UniRule annotation
Gene namesi
Name:CVC2UniRule annotation
Ordered Locus Names:UL25
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159931 – 580Capsid vertex component 2Add BLAST580

Proteomic databases

PRIDEiP10209

Interactioni

Subunit structurei

Heterodimerizes with CVC1. Interacts with major capsid protein/MCP and triplex capsid protein 1/TRX1 at the pentamer vertices. Interacts with the large tegument protein/LTP. Interacts with host NUP214; this interaction might be essential to the capsid docking to the host nuclear pore. Interacts with host TMEM250.UniRule annotation5 Publications

Protein-protein interaction databases

BioGridi971417, 1 interactor
DIPiDIP-60387N
IntActiP10209, 9 interactors

Structurei

Secondary structure

1580
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10209
SMRiP10209
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10209

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Interaction with major capsid protein/MCPAdd BLAST50
Regioni1 – 49Interaction with major capsid protein/MCPUniRule annotationAdd BLAST49

Sequence similaritiesi

Belongs to the herpesviridae CVC2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900005N

Family and domain databases

HAMAPiMF_04025 HSV_CVC2, 1 hit
InterProiView protein in InterPro
IPR002493 Herpes_UL25
PfamiView protein in Pfam
PF01499 Herpes_UL25, 1 hit

Sequencei

Sequence statusi: Complete.

P10209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPYCPFDAL DVWEHRRFIV ADSRNFITPE FPRDFWMSPV FNLPRETAAE
60 70 80 90 100
QVVVLQAQRT AAAAALENAA MQAAELPVDI ERRLRPIERN VHEIAGALEA
110 120 130 140 150
LETAAAAAEE ADAARGDEPA GGGDGGAPPG LAVAEMEVQI VRNDPPLRYD
160 170 180 190 200
TNLPVDLLHM VYAGRGATGS SGVVFGTWYR TIQDRTITDF PLTTRSADFR
210 220 230 240 250
DGRMSKTFMT ALVLSLQACG RLYVGQRHYS AFECAVLCLY LLYRNTHGAA
260 270 280 290 300
DDSDRAPVTF GDLLGRLPRY LACLAAVIGT EGGRPQYRYR DDKLPKTQFA
310 320 330 340 350
AGGGRYEHGA LASHIVIATL MHHGVLPAAP GDVPRDASTH VNPDGVAHHD
360 370 380 390 400
DINRAAAAFL SRGHNLFLWE DQTLLRATAN TITALGVIQR LLANGNVYAD
410 420 430 440 450
RLNNRLQLGM LIPGAVPSEA IARGASGSDS GAIKSGDNNL EALCANYVLP
460 470 480 490 500
LYRADPAVEL TQLFPGLAAL CLDAQAGRPV GSTRRVVDMS SGARQAALVR
510 520 530 540 550
LTALELINRT RTNPTPVGEV IHAHDALAIQ YEQGLGLLAQ QARIGLGSNT
560 570 580
KRFSAFNVSS DYDMLYFLCL GFIPQYLSAV
Length:580
Mass (Da):62,670
Last modified:July 1, 1989 - v1
Checksum:i3F8F0B7C122B2E36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32317.1
PIRiG30084 WMBEW5
RefSeqiYP_009137099.1, NC_001806.2

Genome annotation databases

GeneIDi2703377
KEGGivg:2703377

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32317.1
PIRiG30084 WMBEW5
RefSeqiYP_009137099.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F5UX-ray2.10A134-580[»]
ProteinModelPortaliP10209
SMRiP10209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971417, 1 interactor
DIPiDIP-60387N
IntActiP10209, 9 interactors

Proteomic databases

PRIDEiP10209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703377
KEGGivg:2703377

Phylogenomic databases

OrthoDBiVOG0900005N

Miscellaneous databases

EvolutionaryTraceiP10209

Family and domain databases

HAMAPiMF_04025 HSV_CVC2, 1 hit
InterProiView protein in InterPro
IPR002493 Herpes_UL25
PfamiView protein in Pfam
PF01499 Herpes_UL25, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCVC2_HHV11
AccessioniPrimary (citable) accession number: P10209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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