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Protein

Tegument protein UL21

Gene

UL21

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) (By similarity).By similarity1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL21
Gene namesi
ORF Names:UL21
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159711 – 535Tegument protein UL21Add BLAST535

Proteomic databases

PRIDEiP10205

Interactioni

Subunit structurei

Interacts (via C-terminus) with UL16.1 Publication

Protein-protein interaction databases

BioGridi971413, 1 interactor

Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP10205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG0900005L

Family and domain databases

InterProiView protein in InterPro
IPR004936 Herpes_UL21
PfamiView protein in Pfam
PF03252 Herpes_UL21, 1 hit

Sequencei

Sequence statusi: Complete.

P10205-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF
60 70 80 90 100
GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV
110 120 130 140 150
SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE
160 170 180 190 200
HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ
210 220 230 240 250
PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR
260 270 280 290 300
VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
310 320 330 340 350
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV
360 370 380 390 400
YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD
410 420 430 440 450
ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV
460 470 480 490 500
ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA
510 520 530
FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
Length:535
Mass (Da):57,642
Last modified:July 1, 1989 - v1
Checksum:i9D0621FF490DA745
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti40C → Y in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32334.1
DQ889502 Genomic DNA Translation: ABI63483.1
FJ593289 Genomic DNA Translation: ACM62243.1
PIRiC30084 WMBEW1
RefSeqiYP_009137095.1, NC_001806.2

Genome annotation databases

GeneIDi2703372
KEGGivg:2703372

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32334.1
DQ889502 Genomic DNA Translation: ABI63483.1
FJ593289 Genomic DNA Translation: ACM62243.1
PIRiC30084 WMBEW1
RefSeqiYP_009137095.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U4HX-ray2.05A1-198[»]
5ED7X-ray2.72A279-530[»]
SMRiP10205
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971413, 1 interactor

Proteomic databases

PRIDEiP10205

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703372
KEGGivg:2703372

Phylogenomic databases

OrthoDBiVOG0900005L

Family and domain databases

InterProiView protein in InterPro
IPR004936 Herpes_UL21
PfamiView protein in Pfam
PF03252 Herpes_UL21, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEG4_HHV11
AccessioniPrimary (citable) accession number: P10205
Secondary accession number(s): B9VQE8, Q09IB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: March 15, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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