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UniProtKB - P10205 (TEG4_HHV11)
Protein
Tegument protein UL21
Gene
UL21
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
May participate in DNA packaging/capsid maturation events. Promotes efficient incorporation of tegument proteins UL46, UL49, and US3 into virions. May also play a role in capsid transport to the trans-Golgi network (TGN) (By similarity).
By similarity1 PublicationNames & Taxonomyi
Protein namesi | Recommended name: Tegument protein UL21 |
Gene namesi | ORF Names:UL21 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
Other locations
- Virion tegument 1 Publication
- Host cytoplasm 1 Publication
- Host nucleus 1 Publication
Other locations
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB-SubCell
- viral tegument Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cytoplasm, Host nucleus, Virion, Virion tegumentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115971 | 1 – 535 | Tegument protein UL21Add BLAST | 535 |
Proteomic databases
PRIDEi | P10205 |
Interactioni
Subunit structurei
Interacts (via C-terminus) with UL16.
1 PublicationProtein-protein interaction databases
BioGRIDi | 971413, 1 interactor |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P10205 |
SMRi | P10205 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 251 – 279 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the alphaherpesvirinae UL21 protein family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR004936, Herpes_UL21 |
Pfami | View protein in Pfam PF03252, Herpes_UL21, 1 hit |
i Sequence
Sequence statusi: Complete.
P10205-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELSYATTMH YRDVVFYVTT DRNRAYFVCG GCVYSVGRPC ASQPGEIAKF
60 70 80 90 100
GLVVRGTGPD DRVVANYVRS ELRQRGLQDV RPIGEDEVFL DSVCLLNPNV
110 120 130 140 150
SSELDVINTN DVEVLDECLA EYCTSLRTSP GVLISGLRVR AQDRIIELFE
160 170 180 190 200
HPTIVNVSSH FVYTPSPYVF ALAQAHLPRL PSSLEALVSG LFDGIPAPRQ
210 220 230 240 250
PLDAHNPRTD VVITGRRAPR PIAGSGAGSG GAGAKRATVS EFVQVKHIDR
260 270 280 290 300
VGPAGVSPAP PPNNTDSSSL VPGAQDSAPP GPTLRELWWV FYAADRALEE
310 320 330 340 350
PRADSGLTRE EVRAVRGFRE QAWKLFGSAG APRAFIGAAL GLSPLQKLAV
360 370 380 390 400
YYYIIHRERR LSPFPALVRL VGRYTQRHGL YVPRPDDPVL ADAINGLFRD
410 420 430 440 450
ALAAGTTAEQ LLMFDLLPPK DVPVGSDVQA DSTALLRFIE SQRLAVPGGV
460 470 480 490 500
ISPEHVAYLG AFLSVLYAGR GRMSAATHTA RLTGVTSLVL AVGDVDRLSA
510 520 530
FDRGAAGAAS RTRAAGYLDV LLTVRLARSQ HGQSV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 40 | C → Y in strain: Nonneuroinvasive mutant HF10. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32334.1 DQ889502 Genomic DNA Translation: ABI63483.1 FJ593289 Genomic DNA Translation: ACM62243.1 |
PIRi | C30084, WMBEW1 |
RefSeqi | YP_009137095.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703372 |
KEGGi | vg:2703372 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32334.1 DQ889502 Genomic DNA Translation: ABI63483.1 FJ593289 Genomic DNA Translation: ACM62243.1 |
PIRi | C30084, WMBEW1 |
RefSeqi | YP_009137095.1, NC_001806.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4U4H | X-ray | 2.05 | A | 1-198 | [»] | |
5ED7 | X-ray | 2.72 | A | 279-530 | [»] | |
SASBDBi | P10205 | |||||
SMRi | P10205 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 971413, 1 interactor |
Proteomic databases
PRIDEi | P10205 |
Protocols and materials databases
DNASUi | 2703372 |
Genome annotation databases
GeneIDi | 2703372 |
KEGGi | vg:2703372 |
Family and domain databases
InterProi | View protein in InterPro IPR004936, Herpes_UL21 |
Pfami | View protein in Pfam PF03252, Herpes_UL21, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TEG4_HHV11 | |
Accessioni | P10205Primary (citable) accession number: P10205 Secondary accession number(s): B9VQE8, Q09IB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families