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Protein

Protein UL20

Gene

UL20

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.2 Publications

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL20
Gene namesi
Name:UL20
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host Golgi apparatus, Host membrane, Host nucleus, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159661 – 222Protein UL20Add BLAST222

Proteomic databases

PRIDEiP10204

Interactioni

Subunit structurei

Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression. Interacts with gB.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
gKP683315EBI-7906325,EBI-7906305

Protein-protein interaction databases

IntActiP10204, 2 interactors
MINTiP10204

Family & Domainsi

Sequence similaritiesi

Belongs to the alphaherpesvirinae UL20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000LM

Family and domain databases

InterProiView protein in InterPro
IPR007629 Herpes_UL20
PfamiView protein in Pfam
PF04544 Herpes_UL20, 1 hit

Sequencei

Sequence statusi: Complete.

P10204-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS
60 70 80 90 100
RLPPHTQPVF SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA
110 120 130 140 150
AIVGYYVTWA VRALLLYVNI KRDRLPLSAP VFWGMSVFLG GTALCALFAA
160 170 180 190 200
AHETFSPDGL FHFIATNQML PPTDPLRTRA LGIACAAGAS MWVAAADSFA
210 220
ASANFFLARF WTRAILNAPV AF
Length:222
Mass (Da):24,231
Last modified:July 1, 1989 - v1
Checksum:iD10C373183E96218
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32333.1
PIRiB30084 WMBEWN
RefSeqiYP_009137094.1, NC_001806.2

Genome annotation databases

GeneIDi2703371
KEGGivg:2703371

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32333.1
PIRiB30084 WMBEWN
RefSeqiYP_009137094.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10204, 2 interactors
MINTiP10204

Proteomic databases

PRIDEiP10204

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703371
KEGGivg:2703371

Phylogenomic databases

OrthoDBiVOG090000LM

Family and domain databases

InterProiView protein in InterPro
IPR007629 Herpes_UL20
PfamiView protein in Pfam
PF04544 Herpes_UL20, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUL20_HHV11
AccessioniPrimary (citable) accession number: P10204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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