UniProtKB - P10204 (UL20_HHV11)
Protein
Protein UL20
Gene
UL20
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
Plays an essential role in egress of virus particles from the nucleus, cytoplasmic envelopment and virus-induced cell fusion. Forms a functional protein complex with gK and this interaction is absolutely essential for their coordinate intracellular transport, gK glycosylation, expression on host cell surface, and function. Together, they modulate gB-mediated virus-induced cell fusion and virion egress and therefore actively participate in these processes.2 Publications
GO - Biological processi
- viral life cycle Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Protein UL20 |
Gene namesi | Name:UL20 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion 2 Publications
- Host Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Host nucleus membrane 1 Publication; Multi-pass membrane protein Sequence analysis Note: During virion morphogenesis, this protein probably accumulates in the trans-Golgi where secondary envelopment occurs. It is probably transported with gK to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 64 – 84 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 131 – 151 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- host cell nuclear membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- virion Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, Host nucleus, Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000115966 | 1 – 222 | Protein UL20Add BLAST | 222 |
Proteomic databases
PRIDEi | P10204 |
Interactioni
Subunit structurei
Interacts with gK (via N-terminus); this interaction plays a role in the coordinate transport of UL20 and gK to the trans-Golgi network (TGN), and is required for their cell surface expression.
Interacts with gB.
2 PublicationsBinary interactionsi
P10204
With | #Exp. | IntAct |
---|---|---|
gK [P68331] | 5 | EBI-7906325,EBI-7906305 |
Protein-protein interaction databases
IntActi | P10204, 2 interactors |
MINTi | P10204 |
Family & Domainsi
Sequence similaritiesi
Belongs to the alphaherpesvirinae UL20 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR007629, Herpes_UL20 |
Pfami | View protein in Pfam PF04544, Herpes_UL20, 1 hit |
i Sequence
Sequence statusi: Complete.
P10204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMRDDLPLV DRDLVDEAAF GGEEGELPLE EQFSLSSYGT SDFFVSSAYS
60 70 80 90 100
RLPPHTQPVF SKRVILFLWS FLVLKPLEMV AAGMYYGLTG RVVAPACILA
110 120 130 140 150
AIVGYYVTWA VRALLLYVNI KRDRLPLSAP VFWGMSVFLG GTALCALFAA
160 170 180 190 200
AHETFSPDGL FHFIATNQML PPTDPLRTRA LGIACAAGAS MWVAAADSFA
210 220
ASANFFLARF WTRAILNAPV AF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32333.1 |
PIRi | B30084, WMBEWN |
RefSeqi | YP_009137094.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703371 |
KEGGi | vg:2703371 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32333.1 |
PIRi | B30084, WMBEWN |
RefSeqi | YP_009137094.1, NC_001806.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P10204, 2 interactors |
MINTi | P10204 |
Proteomic databases
PRIDEi | P10204 |
Genome annotation databases
GeneIDi | 2703371 |
KEGGi | vg:2703371 |
Family and domain databases
InterProi | View protein in InterPro IPR007629, Herpes_UL20 |
Pfami | View protein in Pfam PF04544, Herpes_UL20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UL20_HHV11 | |
Accessioni | P10204Primary (citable) accession number: P10204 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families