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Protein

Cytoplasmic envelopment protein 2

Gene

UL16

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.UniRule annotation1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 2UniRule annotation
Gene namesi
Name:UL16
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221C → S: No effect on the interaction with UL11. 1 Publication1
Mutagenesisi244C → S: No effect on the interaction with UL11. 1 Publication1
Mutagenesisi247C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi269C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi271C → S: Complete loss of interaction with UL11. 1 Publication1
Mutagenesisi275C → S: Complete loss of interaction with UL11. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159491 – 373Cytoplasmic envelopment protein 2Add BLAST373

Proteomic databases

PRIDEiP10200

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 3 and with the capsid.UniRule annotation3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL11P042893EBI-7044955,EBI-7044930

Protein-protein interaction databases

IntActiP10200, 2 interactors
MINTiP10200

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000ON

Family and domain databases

HAMAPiMF_04039 HSV_CEP2, 1 hit
InterProiView protein in InterPro
IPR004286 Herpes_UL16/UL94
PfamiView protein in Pfam
PF03044 Herpes_UL16, 1 hit

Sequencei

Sequence statusi: Complete.

P10200-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLGPRRPL APPGPPGTLP RPDSRAGARG TRDRVDDLGT DVDSIARIVN
60 70 80 90 100
SVFVWRVVRA DERLKIFRCL TVLTEPLCQV ALPNPDPGRA LFCEIFLYLT
110 120 130 140 150
RPKALRLPPN TFFALFFFNR ERRYCAIVHL RSVTHPLTPL LCTLTFARIR
160 170 180 190 200
AATPPEETPD PTTEQLAEEP VVGELDGAYL VPAKTPPEPG ACCALGPGAW
210 220 230 240 250
WHLPSGQIYC WAMDSDLGSL CPPGSRARHL GWLLARITNH PGGCESCAPP
260 270 280 290 300
PHIDSANALW LSSVVTESCP CVAPCLWAKM AQCTLAVQGD ASLCPLLFGH
310 320 330 340 350
PVDTVTLLQA PRRPCITDRL QEVVGGRCGA DNIPPTSAGW RLCVFSSYIS
360 370
RLFATSCPTV ARAVARASSS DPE
Length:373
Mass (Da):40,443
Last modified:July 1, 1989 - v1
Checksum:i85D9914C533FE34B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32328.1
PIRiG30083 WMBET6
RefSeqiYP_009137090.1, NC_001806.2

Genome annotation databases

GeneIDi24271465
KEGGivg:24271465

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32328.1
PIRiG30083 WMBET6
RefSeqiYP_009137090.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP10200, 2 interactors
MINTiP10200

Proteomic databases

PRIDEiP10200

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24271465
KEGGivg:24271465

Phylogenomic databases

OrthoDBiVOG090000ON

Family and domain databases

HAMAPiMF_04039 HSV_CEP2, 1 hit
InterProiView protein in InterPro
IPR004286 Herpes_UL16/UL94
PfamiView protein in Pfam
PF03044 Herpes_UL16, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEP2_HHV11
AccessioniPrimary (citable) accession number: P10200
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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