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Protein

Replication origin-binding protein

Gene

UL9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a docking protein to recruit essential components of the viral replication machinery to viral DNA origins. In the presence of the major DNA-binding protein, opens dsDNA leading to a conformational change in the origin that facilitates DNA unwinding and subsequent replication.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 88ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA replication origin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Replication origin-binding protein
Short name:
OBP
Alternative name(s):
OriBP
Gene namesi
ORF Names:UL9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001158661 – 851Replication origin-binding proteinAdd BLAST851

Proteomic databases

PRIDEiP10193

Interactioni

Subunit structurei

Homodimer. Interacts with the major DNA-binding protein ICP8. Interacts with the helicase/primase component UL8 and the polymerase accessory protein UL42.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi971457, 1 interactor
DIPiDIP-1095N
IntActiP10193, 2 interactors
MINTiP10193

Structurei

3D structure databases

ProteinModelPortaliP10193
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 233Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166

Sequence similaritiesi

Belongs to the herpesviridae OriBP family.Curated

Phylogenomic databases

OrthoDBiVOG0900001O

Family and domain databases

InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR003450 Replication_origin-bd
PfamiView protein in Pfam
PF02399 Herpes_ori_bp, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit

Sequencei

Sequence statusi: Complete.

P10193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFVGGAESG DPLGAGRPIG DDECEQYTSS VSLARMLYGG DLAEWVPRVH
60 70 80 90 100
PKTTIERQQH GPVTFPNASA PTARCVTVVR APMGSGKTTA LIRWLREAIH
110 120 130 140 150
SPDTSVLVVS CRRSFTQTLA TRFAESGLVD FVTYFSSTNY IMNDRPFHRL
160 170 180 190 200
IVQVESLHRV GPNLLNNYDV LVLDEVMSTL GQLYSPTMQQ LGRVDALMLR
210 220 230 240 250
LLRICPRIIA MDATANAQLV DFLCGLRGEK NVHVVVGEYA MPGFSARRCL
260 270 280 290 300
FLPRLGTELL QAALRPPGPP SGPSPDASPE ARGATFFGEL EARLGGGDNI
310 320 330 340 350
CIFSSTVSFA EIVARFCRQF TDRVLLLHSL TPLGDVTTWG QYRVVIYTTV
360 370 380 390 400
VTVGLSFDPL HFDGMFAYVK PMNYGPDMVS VYQSLGRVRT LRKGELLIYM
410 420 430 440 450
DGSGARSEPV FTPMLLNHVV SSCGQWPAQF SQVTNLLCRR FKGRCDASAC
460 470 480 490 500
DTSLGRGSRI YNKFRYKHYF ERCTLACLSD SLNILHMLLT LNCIRVRFWG
510 520 530 540 550
HDDTLTPKDF CLFLRGVHFD ALRAQRDLRE LRCRDPEASL PAQAAETEEV
560 570 580 590 600
GLFVEKYLRS DVAPAEIVAL MRNLNSLMGR TRFIYLALLE ACLRVPMATR
610 620 630 640 650
SSAIFRRIYD HYATGVIPTI NVTGELELVA LPPTLNVTPV WELLCLCSTM
660 670 680 690 700
AARLHWDSAA GGSGRTFGPD DVLDLLTPHY DRYMQLVFEL GHCNVTDGLL
710 720 730 740 750
LSEEAVKRVA DALSGCPPRG SVSETDHAVA LFKIIWGELF GVQMAKSTQT
760 770 780 790 800
FPGAGRVKNL TKQTIVGLLD AHHIDHSACR THRQLYALLM AHKREFAGAR
810 820 830 840 850
FKLRVPAWGR CLRTHSSSAN PNADIILEAA LSELPTEAWP MMQGAVNFST

L
Length:851
Mass (Da):94,262
Last modified:July 1, 1989 - v1
Checksum:i961A133FE7A30CA7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti149R → Q in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti204I → T in strain: Nonneuroinvasive mutant HF10 and 17 syn+. 1
Natural varianti280E → D in strain: Nonneuroinvasive mutant HF10 and 17 syn+. 1
Natural varianti668 – 669GP → SH in strain: Nonneuroinvasive mutant HF10. 2
Natural varianti745A → T in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti797A → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti818S → N in strain: 17 syn+. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32345.1
M19120 Genomic DNA Translation: AAA45822.1
DQ889502 Genomic DNA Translation: ABI63471.1
FJ593289 Genomic DNA Translation: ACM62231.1
PIRiB29890 WMBEU9

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32345.1
M19120 Genomic DNA Translation: AAA45822.1
DQ889502 Genomic DNA Translation: ABI63471.1
FJ593289 Genomic DNA Translation: ACM62231.1
PIRiB29890 WMBEU9

3D structure databases

ProteinModelPortaliP10193
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971457, 1 interactor
DIPiDIP-1095N
IntActiP10193, 2 interactors
MINTiP10193

Proteomic databases

PRIDEiP10193

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900001O

Family and domain databases

InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR003450 Replication_origin-bd
PfamiView protein in Pfam
PF02399 Herpes_ori_bp, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOBP_HHV11
AccessioniPrimary (citable) accession number: P10193
Secondary accession number(s): B9VQD6, Q09IC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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