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Protein

Portal protein

Gene

UL6

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.UniRule annotation1 Publication

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal proteinUniRule annotation
Gene namesi
Name:UL6
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi145C → A: Complete loss of nuclear localization. 1 Publication1
Mutagenesisi166C → A: Complete loss of portal ring formation. 1 Publication1
Mutagenesisi254C → A: Complete loss of portal ring formation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001159031 – 676Portal proteinAdd BLAST676

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi166InterchainUniRule annotation1 Publication
Disulfide bondi254InterchainUniRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP10190

Interactioni

Subunit structurei

Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.UniRule annotation2 Publications

Protein-protein interaction databases

BioGridi971454, 1 interactor
IntActiP10190, 2 interactors
MINTiP10190

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni422 – 443Putative leucine zipper motifUniRule annotation1 PublicationAdd BLAST22

Sequence similaritiesi

Belongs to the herpesviridae portal protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900002I

Family and domain databases

HAMAPiMF_04012 HSV_PORTL, 1 hit
InterProiView protein in InterPro
IPR002660 Herpes_Portal
PfamiView protein in Pfam
PF01763 Herpes_UL6, 1 hit

Sequencei

Sequence statusi: Complete.

P10190-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAPRSRAPT TRARGDTEAL CSPEDGWVKV HPSPGTMLFR EILHGQLGYT
60 70 80 90 100
EGQGVYNVVR SSEATTRQLQ AAIFHALLNA TTYRDLEADW LGHVAARGLQ
110 120 130 140 150
PQRLVRRYRN AREADIAGVA ERVFDTWRNT LRTTLLDFAH GLVACFAPGG
160 170 180 190 200
PSGPSSFPKY IDWLTCLGLV PILRKRQEGG VTQGLRAFLK QHPLTRQLAT
210 220 230 240 250
VAEAAERAGP GFFELALAFD STRVADYDRV YIYYNHRRGD WLVRDPISGQ
260 270 280 290 300
RGECLVLWPP LWTGDRLVFD SPVQRLFPEI VACHSLREHA HVCRLRNTAS
310 320 330 340 350
VKVLLGRKSD SERGVAGAAR VVNKVLGEDD ETKAGSAASR LVRLIINMKG
360 370 380 390 400
MRHVGDINDT VRSYLDEAGG HLIDAPAVDG TLPGFGKGGN SRGSAGQDQG
410 420 430 440 450
GRAPQLRQAF RTAVVNNING VLEGYINNLF GTIERLRETN AGLATQLQER
460 470 480 490 500
DRELRRATAG ALERQQRAAD LAAESVTGGC GSRPAGADLL RADYDIIDVS
510 520 530 540 550
KSMDDDTYVA NSFQHPYIPS YAQDLERLSR LWEHELVRCF KILCHRNNQG
560 570 580 590 600
QETSISYSSG AIAAFVAPYF ESVLRAPRVG APITGSDVIL GEEELWDAVF
610 620 630 640 650
KKTRLQTYLT DIAALFVADV QHAALPPPPS PVGADFRPGA SPRGRSRSRS
660 670
PGRTARGAPD QGGGIGHRDG RRDGRR
Length:676
Mass (Da):74,092
Last modified:July 1, 1989 - v1
Checksum:i8CF9D73C6313FAE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32342.1
M19119 Genomic DNA Translation: AAA45818.2
PIRiF28133 WMBEX6

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32342.1
M19119 Genomic DNA Translation: AAA45818.2
PIRiF28133 WMBEX6

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971454, 1 interactor
IntActiP10190, 2 interactors
MINTiP10190

Proteomic databases

PRIDEiP10190

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900002I

Family and domain databases

HAMAPiMF_04012 HSV_PORTL, 1 hit
InterProiView protein in InterPro
IPR002660 Herpes_Portal
PfamiView protein in Pfam
PF01763 Herpes_UL6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPORTL_HHV11
AccessioniPrimary (citable) accession number: P10190
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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