Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uracil-DNA glycosylase

Gene

UL2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.UniRule annotation3 Publications

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei178Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.27 2647
SABIO-RKiP10186

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Alternative name(s):
UNGUniRule annotation
Gene namesi
ORF Names:UL2
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Chemistry databases

DrugBankiDB03419 Uracil

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761851 – 334Uracil-DNA glycosylaseAdd BLAST334

Proteomic databases

PRIDEiP10186

Interactioni

Protein-protein interaction databases

MINTiP10186

Structurei

Secondary structure

1334
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10186
SMRiP10186
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10186

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi198 – 201Poly-Pro4

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000E7

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P10186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRACSRSPS PRRRPSSPRR TPPRDGTPPQ KADADDPTPG ASNDASTETR
60 70 80 90 100
PGSGGEPAAC RSSGPAALLA ALEAGPAGVT FSSSAPPDPP MDLTNGGVSP
110 120 130 140 150
AATSAPLDWT TFRRVFLIDD AWRPLMEPEL ANPLTAHLLA EYNRRCQTEE
160 170 180 190 200
VLPPREDVFS WTRYCTPDEV RVVIIGQDPY HHPGQAHGLA FSVRANVPPP
210 220 230 240 250
PSLRNVLAAV KNCYPEARMS GHGCLEKWAR DGVLLLNTTL TVKRGAAASH
260 270 280 290 300
SRIGWDRFVG GVIRRLAARR PGLVFMLWGT HAQNAIRPDP RVHCVLKFSH
310 320 330
PSPLSKVPFG TCQHFLVANR YLETRSISPI DWSV
Length:334
Mass (Da):36,328
Last modified:July 1, 1989 - v1
Checksum:i7CD3B74FB43F00CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti38T → I in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti49T → N in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti53S → L in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti67 – 75ALLAALEAG → GAPRRPRGC in strain: Nonneuroinvasive mutant HF10 and 17 syn+. 9
Natural varianti126M → L in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti280T → A in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32338.1
DQ889502 Genomic DNA Translation: ABI63464.1
FJ593289 Genomic DNA Translation: ACM62224.1
PIRiB28133 DGBEX2
RefSeqiYP_009137076.1, NC_001806.2

Genome annotation databases

GeneIDi2703370
KEGGivg:2703370

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32338.1
DQ889502 Genomic DNA Translation: ABI63464.1
FJ593289 Genomic DNA Translation: ACM62224.1
PIRiB28133 DGBEX2
RefSeqiYP_009137076.1, NC_001806.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LAUX-ray1.80E91-334[»]
1UDGX-ray1.75A91-334[»]
1UDHX-ray1.75A91-334[»]
1UDIX-ray2.70E91-334[»]
2C53X-ray1.80A91-334[»]
2C56X-ray2.10A91-334[»]
4L5NX-ray2.16A/B96-334[»]
5AYSX-ray2.09A/B91-334[»]
ProteinModelPortaliP10186
SMRiP10186
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP10186

Chemistry databases

DrugBankiDB03419 Uracil

Proteomic databases

PRIDEiP10186

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703370
KEGGivg:2703370

Phylogenomic databases

OrthoDBiVOG090000E7

Enzyme and pathway databases

BRENDAi3.2.2.27 2647
SABIO-RKiP10186

Miscellaneous databases

EvolutionaryTraceiP10186

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_HHV11
AccessioniPrimary (citable) accession number: P10186
Secondary accession number(s): B9VQC9, Q09ID1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again