UniProtKB - P10185 (GL_HHV11)
Protein
Envelope glycoprotein L
Gene
gL
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.UniRule annotation2 Publications
GO - Biological processi
- fusion of virus membrane with host plasma membrane Source: UniProtKB-UniRule
Keywordsi
Biological process | Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell |
Protein family/group databases
TCDBi | 1.G.10.1.1, the herpes simplex virus membrane fusion complex (hsv-mfc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope glycoprotein LUniRule annotationShort name: gLUniRule annotation |
Gene namesi | Name:gLUniRule annotation ORF Names:UL1 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
- Host cell membrane UniRule annotation1 Publication; Peripheral membrane protein UniRule annotation; Extracellular side UniRule annotation
- host trans-Golgi network UniRule annotation Note: gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation
GO - Cellular componenti
- host cell Golgi apparatus Source: UniProtKB-SubCell
- host cell plasma membrane Source: UniProtKB-SubCell
- viral envelope Source: UniProtKB-UniRule
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | UniRule annotationAdd BLAST | 19 | |
ChainiPRO_0000038264 | 20 – 224 | Envelope glycoprotein LUniRule annotationAdd BLAST | 205 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | P10185 |
Interactioni
Subunit structurei
Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.
UniRule annotation1 PublicationProtein-protein interaction databases
BioGRIDi | 971430, 1 interactor |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 20 – 161 | Interaction with gHUniRule annotationAdd BLAST | 142 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 215 – 218 | Poly-Arg | 4 |
Sequence similaritiesi
Belongs to the herpesviridae glycoprotein L family.UniRule annotation
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 1.20.120.1540, 1 hit |
HAMAPi | MF_04034, HSV_GL_alphagamma, 1 hit |
InterProi | View protein in InterPro IPR022200, Herpes_gL_C IPR007923, Herpes_gL_N IPR038311, Herpes_gL_N_sf IPR034708, HSV_GL_alphagamma |
Pfami | View protein in Pfam PF12524, GlyL_C, 1 hit PF05259, Herpes_UL1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10185-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGILGWVGLI AVGVLCVRGG LPSTEYVIRS RVAREVGDIL KVPCVPLPSD
60 70 80 90 100
DLDWRYETPS AINYALIDGI FLRYHCPGLD TVLWDRHAQK AYWVNPFLFV
110 120 130 140 150
AGFLEDLSYP AFPANTQETE TRLALYKEIR QALDSRKQAA SHTPVKAGCV
160 170 180 190 200
NFDYSRTRRC VGRQDLGPTN GTSGRTPVLP PDDEAGLQPK PLTTPPPIIA
210 220
TSDPTPRRDA ATKSRRRRPH SRRL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 90 | K → R in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 100 | V → G in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 109 | Y → H in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 115 | N → D in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 168 | P → L in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 171 | G → R in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 181 | P → S in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 196 | P → S in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 224 | L → I in strain: Nonneuroinvasive mutant HF10. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32337.1 D00373 Genomic DNA Translation: BAA00272.1 DQ889502 Genomic DNA Translation: ABI63463.1 FJ593289 Genomic DNA Translation: ACM62223.1 |
PIRi | A28133, WMBEX1 |
RefSeqi | YP_009137075.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 2703393 |
KEGGi | vg:2703393 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14112 Genomic DNA Translation: CAA32337.1 D00373 Genomic DNA Translation: BAA00272.1 DQ889502 Genomic DNA Translation: ABI63463.1 FJ593289 Genomic DNA Translation: ACM62223.1 |
PIRi | A28133, WMBEX1 |
RefSeqi | YP_009137075.1, NC_001806.2 |
3D structure databases
SMRi | P10185 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 971430, 1 interactor |
Chemistry databases
ChEMBLi | CHEMBL2364696 |
DrugCentrali | P10185 |
Protein family/group databases
TCDBi | 1.G.10.1.1, the herpes simplex virus membrane fusion complex (hsv-mfc) family |
Proteomic databases
PRIDEi | P10185 |
Genome annotation databases
GeneIDi | 2703393 |
KEGGi | vg:2703393 |
Miscellaneous databases
PROi | PR:P10185 |
Family and domain databases
Gene3Di | 1.20.120.1540, 1 hit |
HAMAPi | MF_04034, HSV_GL_alphagamma, 1 hit |
InterProi | View protein in InterPro IPR022200, Herpes_gL_C IPR007923, Herpes_gL_N IPR038311, Herpes_gL_N_sf IPR034708, HSV_GL_alphagamma |
Pfami | View protein in Pfam PF12524, GlyL_C, 1 hit PF05259, Herpes_UL1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GL_HHV11 | |
Accessioni | P10185Primary (citable) accession number: P10185 Secondary accession number(s): Q09ID2, Q76WT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families