gL - Envelope glycoprotein L precursor - Human herpesvirus 1 (strain 17) (HHV-1)

Functionⁱ

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH.UniRule annotation2 Publications

GO - Biological processⁱ

fusion of virus membrane with host plasma membrane Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Biological process

Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell

Protein family/group databases

TCDBⁱ	1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

TCDBⁱ

1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Envelope glycoprotein LUniRule annotation Short name: gLUniRule annotation
Gene namesⁱ	Name:gLUniRule annotation ORF Names:UL1
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome UP000180652 Componentⁱ: Genome

Subcellular locationⁱ

Virion membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
1 Publication
Manual assertion based on experiment inⁱ
- Ref.6
  "Comprehensive characterization of extracellular herpes simplex virus type 1 virions."
  Loret S., Guay G., Lippe R.
  J. Virol. 82:8605-8618(2008) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
; Extracellular side
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
Host cell membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
1 Publication
Manual assertion based on experiment inⁱ
- Ref.9
  "HSV-1 gM and the gK/pUL20 complex are important for the localization of gD and gH/L to viral assembly sites."
  Lau S.Y., Crump C.M.
  Viruses 7:915-938(2015) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION.
; Peripheral membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
; Extracellular side
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034
host trans-Golgi network
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04034

Note:

gL associates with the extravirion surface through its binding to gH. During virion morphogenesis, this protein probably accumulates in the host trans-Golgi where secondary envelopment occurs.UniRule annotation

GO - Cellular componentⁱ

host cell Golgi apparatus Source: UniProtKB-SubCell
host cell plasma membrane Source: UniProtKB-SubCell
viral envelope Source: UniProtKB-UniRule
virion membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	UniRule annotationAdd BLAST		19
ChainⁱPRO_0000038264	20 – 224	Envelope glycoprotein LUniRule annotationAdd BLAST		205

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PRIDEⁱ	P10185

PRIDEⁱ

P10185

Interactionⁱ

Subunit structureⁱ

Interacts with glycoprotein H (gH); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridⁱ	971430, 1 interactor

BioGridⁱ

971430, 1 interactor

Structureⁱ

3D structure databases

SMRⁱ	P10185
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	20 – 161	Interaction with gHUniRule annotationAdd BLAST		142

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	215 – 218	Poly-Arg		4

Sequence similaritiesⁱ

Belongs to the herpesviridae glycoprotein L family.UniRule annotation

Keywords - Domainⁱ

Signal

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K19435
Database of Orthologous Groups More...OrthoDBⁱ	VOG090000O7

Family and domain databases

Gene3Dⁱ	1.20.120.1540, 1 hit
HAMAPⁱ	MF_04034 HSV_GL_alphagamma, 1 hit
InterProⁱ	View protein in InterPro IPR022200 Herpes_gL_C IPR007923 Herpes_gL_N IPR038311 Herpes_gL_N_sf IPR034708 HSV_GL_alphagamma
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12524 GlyL_C, 1 hit PF05259 Herpes_UL1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10185-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGILGWVGLI AVGVLCVRGG LPSTEYVIRS RVAREVGDIL KVPCVPLPSD 
        60         70         80         90        100
DLDWRYETPS AINYALIDGI FLRYHCPGLD TVLWDRHAQK AYWVNPFLFV 
       110        120        130        140        150
AGFLEDLSYP AFPANTQETE TRLALYKEIR QALDSRKQAA SHTPVKAGCV 
       160        170        180        190        200
NFDYSRTRRC VGRQDLGPTN GTSGRTPVLP PDDEAGLQPK PLTTPPPIIA 
       210        220 
TSDPTPRRDA ATKSRRRRPH SRRL

Length:224

Mass (Da):24,934

Last modified:July 1, 1989 - v1

Checksum:ⁱCED51D2FC1D7777F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	90	K → R in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	100	V → G in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	109	Y → H in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	115	N → D in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	168	P → L in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	171	G → R in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	181	P → S in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	196	P → S in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	224	L → I in strain: Nonneuroinvasive mutant HF10.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32337.1 D00373 Genomic DNA Translation: BAA00272.1 DQ889502 Genomic DNA Translation: ABI63463.1 FJ593289 Genomic DNA Translation: ACM62223.1
PIRⁱ	A28133 WMBEX1
NCBI Reference Sequences More...RefSeqⁱ	YP_009137075.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	2703393
KEGGⁱ	vg:2703393

Protein	Similar proteins		Species	Score	Length	Source
P10185	Envelope glycoprotein L		HHV1		224	UniRef100_P10185

Protein	Similar proteins		Species	Score	Length	Source
P10185	Envelope glycoprotein L		HHV1K		224	UniRef90_P10185
Envelope glycoprotein L		HHV1		224
Envelope glycoprotein L		HHV11		224
Envelope glycoprotein L		Human alphaherpesvirus 1 strain RH2		224
Envelope glycoprotein L		HHV1		224
+51

Protein	Similar proteins		Species	Score	Length	Source
P10185	Envelope glycoprotein L		HHV1K		224	UniRef50_P10185
Envelope glycoprotein L	)	HHV2H		224
Envelope glycoprotein L		HHV1		224
Envelope glycoprotein L		HHV11		224
Envelope glycoprotein L		Human alphaherpesvirus 1 strain RH2		224
+84

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14112 Genomic DNA Translation: CAA32337.1 D00373 Genomic DNA Translation: BAA00272.1 DQ889502 Genomic DNA Translation: ABI63463.1 FJ593289 Genomic DNA Translation: ACM62223.1
PIRⁱ	A28133 WMBEX1
RefSeqⁱ	YP_009137075.1, NC_001806.2

3D structure databases

SMRⁱ	P10185
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	971430, 1 interactor

BioGridⁱ

971430, 1 interactor

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

Protein family/group databases

TCDBⁱ	1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

TCDBⁱ

1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

Proteomic databases

PRIDEⁱ	P10185

PRIDEⁱ

P10185

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2703393
KEGGⁱ	vg:2703393

Phylogenomic databases

KOⁱ	K19435
OrthoDBⁱ	VOG090000O7

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10185

PROⁱ

PR:P10185

Family and domain databases

Gene3Dⁱ	1.20.120.1540, 1 hit
HAMAPⁱ	MF_04034 HSV_GL_alphagamma, 1 hit
InterProⁱ	View protein in InterPro IPR022200 Herpes_gL_C IPR007923 Herpes_gL_N IPR038311 Herpes_gL_N_sf IPR034708 HSV_GL_alphagamma
Pfamⁱ	View protein in Pfam PF12524 GlyL_C, 1 hit PF05259 Herpes_UL1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GL_HHV11
Accessionⁱ	P10185Primary (citable) accession number: P10185 Secondary accession number(s): Q09ID2, Q76WT7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	October 10, 2018
	This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10185 (GL_HHV11)

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Envelope glycoprotein L

gL

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ