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Protein

Cytochrome c oxidase subunit 8A, mitochondrial

Gene

COX8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-liver/heart
Cytochrome c oxidase subunit 8-2
Gene namesi
Name:COX8A
Synonyms:COX8, COX8L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176340.3
HGNCiHGNC:2294 COX8A
MIMi123870 gene
neXtProtiNX_P10176

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 36Mitochondrial matrixBy similarityAdd BLAST11
Transmembranei37 – 60HelicalBy similarityAdd BLAST24
Topological domaini61 – 69Mitochondrial intermembraneBy similarity9

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1351
MalaCardsiCOX8A
OpenTargetsiENSG00000176340
Orphaneti254905 Isolated cytochrome C oxidase deficiency
PharmGKBiPA26814

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaiCOX8A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25Mitochondrion1 PublicationAdd BLAST25
ChainiPRO_000000618626 – 69Cytochrome c oxidase subunit 8A, mitochondrialAdd BLAST44

Proteomic databases

EPDiP10176
PaxDbiP10176
PeptideAtlasiP10176
PRIDEiP10176
ProteomicsDBi52577
TopDownProteomicsiP10176

PTM databases

PhosphoSitePlusiP10176

Expressioni

Gene expression databases

BgeeiENSG00000176340 Expressed in 237 organ(s), highest expression level in apex of heart
CleanExiHS_COX8A
ExpressionAtlasiP10176 baseline and differential
GenevisibleiP10176 HS

Organism-specific databases

HPAiHPA055942

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NPM1P067483EBI-3904738,EBI-78579

Protein-protein interaction databases

BioGridi107744, 5 interactors
IntActiP10176, 8 interactors
STRINGi9606.ENSP00000321260

Structurei

3D structure databases

ProteinModelPortaliP10176
SMRiP10176
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4WR Eukaryota
ENOG410ZEYR LUCA
GeneTreeiENSGT00390000006255
HOGENOMiHOG000230478
InParanoidiP10176
KOiK02273
OMAiTMDIAIG
OrthoDBiEOG091G11UL
PhylomeDBiP10176
TreeFamiTF105070

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10176-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT
60
FLLPAGWILS HLETYRRPE
Length:69
Mass (Da):7,579
Last modified:February 1, 1991 - v2
Checksum:iE1736E52AD0F76E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04823 mRNA Translation: AAA99313.1
BC063025 mRNA Translation: AAH63025.1
CCDSiCCDS8054.1
PIRiA34103 OSHU8
RefSeqiNP_004065.1, NM_004074.2
UniGeneiHs.743989

Genome annotation databases

EnsembliENST00000314133; ENSP00000321260; ENSG00000176340
GeneIDi1351
KEGGihsa:1351

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04823 mRNA Translation: AAA99313.1
BC063025 mRNA Translation: AAH63025.1
CCDSiCCDS8054.1
PIRiA34103 OSHU8
RefSeqiNP_004065.1, NM_004074.2
UniGeneiHs.743989

3D structure databases

ProteinModelPortaliP10176
SMRiP10176
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107744, 5 interactors
IntActiP10176, 8 interactors
STRINGi9606.ENSP00000321260

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

PTM databases

PhosphoSitePlusiP10176

Polymorphism and mutation databases

BioMutaiCOX8A

Proteomic databases

EPDiP10176
PaxDbiP10176
PeptideAtlasiP10176
PRIDEiP10176
ProteomicsDBi52577
TopDownProteomicsiP10176

Protocols and materials databases

DNASUi1351
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314133; ENSP00000321260; ENSG00000176340
GeneIDi1351
KEGGihsa:1351

Organism-specific databases

CTDi1351
DisGeNETi1351
EuPathDBiHostDB:ENSG00000176340.3
GeneCardsiCOX8A
HGNCiHGNC:2294 COX8A
HPAiHPA055942
MalaCardsiCOX8A
MIMi123870 gene
neXtProtiNX_P10176
OpenTargetsiENSG00000176340
Orphaneti254905 Isolated cytochrome C oxidase deficiency
PharmGKBiPA26814
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4WR Eukaryota
ENOG410ZEYR LUCA
GeneTreeiENSGT00390000006255
HOGENOMiHOG000230478
InParanoidiP10176
KOiK02273
OMAiTMDIAIG
OrthoDBiEOG091G11UL
PhylomeDBiP10176
TreeFamiTF105070

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRSiCOX8A human
GenomeRNAii1351
PROiPR:P10176
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176340 Expressed in 237 organ(s), highest expression level in apex of heart
CleanExiHS_COX8A
ExpressionAtlasiP10176 baseline and differential
GenevisibleiP10176 HS

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8A_HUMAN
AccessioniPrimary (citable) accession number: P10176
Secondary accession number(s): P15955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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