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Protein

Cytochrome c oxidase subunit 8B, mitochondrial

Gene

COX8B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 8B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIII-heart
Cytochrome c oxidase subunit 8-1
Cytochrome c oxidase subunit 8H
IX
VIIIb
Gene namesi
Name:COX8B
Synonyms:COX8H
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 35Mitochondrial matrixAdd BLAST11
Transmembranei36 – 59HelicalAdd BLAST24
Topological domaini60 – 70Mitochondrial intermembraneAdd BLAST11

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion2 PublicationsAdd BLAST24
ChainiPRO_000000617625 – 70Cytochrome c oxidase subunit 8B, mitochondrialAdd BLAST46

Proteomic databases

PaxDbiP10175

Interactioni

Protein-protein interaction databases

CORUMiP10175
DIPiDIP-60941N
IntActiP10175, 1 interactor
STRINGi9913.ENSBTAP00000002651

Structurei

Secondary structure

170
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00780
ProteinModelPortaliP10175
SMRiP10175
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10175

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIII family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J43Z Eukaryota
ENOG4111DTJ LUCA
HOGENOMiHOG000230478
InParanoidiP10175
KOiK02273
TreeFamiTF105070

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF
60 70
LLPAGWVLYH LDNYKKSSAA
Length:70
Mass (Da):7,639
Last modified:November 1, 1995 - v3
Checksum:i17BE70ADEC45FDD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19A → V in AAA30466 (PubMed:1689292).Curated1
Sequence conflicti31K → R in AAA30466 (PubMed:1689292).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05202 mRNA Translation: AAA30466.1
U15540 Genomic DNA Translation: AAA80279.1
BC112717 mRNA Translation: AAI12718.1
PIRiA35537 OSBO8
RefSeqiNP_001107989.1, NM_001114517.2
UniGeneiBt.62953

Genome annotation databases

GeneIDi615757
KEGGibta:615757

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05202 mRNA Translation: AAA30466.1
U15540 Genomic DNA Translation: AAA80279.1
BC112717 mRNA Translation: AAI12718.1
PIRiA35537 OSBO8
RefSeqiNP_001107989.1, NM_001114517.2
UniGeneiBt.62953

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80M/Z25-70[»]
1OCOX-ray2.80M/Z25-70[»]
1OCRX-ray2.35M/Z25-70[»]
1OCZX-ray2.90M/Z25-70[»]
1V54X-ray1.80M/Z25-70[»]
1V55X-ray1.90M/Z25-70[»]
2DYRX-ray1.80M/Z25-70[»]
2DYSX-ray2.20M/Z25-70[»]
2EIJX-ray1.90M/Z25-70[»]
2EIKX-ray2.10M/Z25-70[»]
2EILX-ray2.10M/Z25-70[»]
2EIMX-ray2.60M/Z25-70[»]
2EINX-ray2.70M/Z25-70[»]
2OCCX-ray2.30M/Z25-70[»]
2Y69X-ray1.95M/Z1-70[»]
2YBBelectron microscopy19.00X25-70[»]
2ZXWX-ray2.50M/Z25-70[»]
3ABKX-ray2.00M/Z25-70[»]
3ABLX-ray2.10M/Z25-70[»]
3ABMX-ray1.95M/Z25-70[»]
3AG1X-ray2.20M/Z25-70[»]
3AG2X-ray1.80M/Z25-70[»]
3AG3X-ray1.80M/Z25-70[»]
3AG4X-ray2.05M/Z25-70[»]
3ASNX-ray3.00M/Z25-70[»]
3ASOX-ray2.30M/Z25-70[»]
3WG7X-ray1.90M/Z25-70[»]
3X2QX-ray2.00M/Z25-70[»]
5B1AX-ray1.50M/Z25-70[»]
5B1BX-ray1.60M/Z25-70[»]
5B3SX-ray1.68M/Z25-70[»]
5GPNelectron microscopy5.40s25-70[»]
5IY5X-ray2.00M/Z25-67[»]
5LUFelectron microscopy9.10025-70[»]
5W97X-ray2.30M/m25-70[»]
5WAUX-ray1.95M/m25-70[»]
5X19X-ray2.20M/Z25-70[»]
5X1BX-ray2.40M/Z25-70[»]
5X1FX-ray2.20M/Z25-70[»]
5XDQX-ray1.77M/Z25-70[»]
5XDXX-ray1.99M/Z25-70[»]
5XTHelectron microscopy3.90925-67[»]
5XTIelectron microscopy17.409/B925-67[»]
5Z84X-ray1.85M/Z25-70[»]
5Z85X-ray1.85M/Z25-70[»]
5Z86X-ray1.85M/Z25-70[»]
5ZCOX-ray1.90M/Z25-70[»]
5ZCPX-ray1.65M/Z25-70[»]
5ZCQX-ray1.65M/Z25-70[»]
DisProtiDP00780
ProteinModelPortaliP10175
SMRiP10175
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP10175
DIPiDIP-60941N
IntActiP10175, 1 interactor
STRINGi9913.ENSBTAP00000002651

Proteomic databases

PaxDbiP10175

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi615757
KEGGibta:615757

Organism-specific databases

CTDi12869

Phylogenomic databases

eggNOGiENOG410J43Z Eukaryota
ENOG4111DTJ LUCA
HOGENOMiHOG000230478
InParanoidiP10175
KOiK02273
TreeFamiTF105070

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP10175

Family and domain databases

Gene3Di4.10.81.10, 1 hit
InterProiView protein in InterPro
IPR003205 Cyt_c_oxidase_su8
IPR036548 Cyt_c_oxidase_su8_sf
PANTHERiPTHR16717 PTHR16717, 1 hit
PfamiView protein in Pfam
PF02285 COX8, 1 hit
SUPFAMiSSF81431 SSF81431, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX8B_BOVIN
AccessioniPrimary (citable) accession number: P10175
Secondary accession number(s): Q2KI98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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