UniProtKB - P10175 (COX8B_BOVIN)
Cytochrome c oxidase subunit 8B, mitochondrial
COX8B
Functioni
: oxidative phosphorylation Pathwayi
This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.1 PublicationView all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.
GO - Molecular functioni
- cytochrome-c oxidase activity Source: InterPro
GO - Biological processi
- oxidative phosphorylation Source: UniProtKB-UniPathway
Enzyme and pathway databases
BRENDAi | 1.9.3.1, 908 |
UniPathwayi | UPA00705 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 8B, mitochondrialAlternative name(s): Cytochrome c oxidase polypeptide VIII-heart Cytochrome c oxidase subunit 8-1 Cytochrome c oxidase subunit 8H IX VIIIb |
Gene namesi | Name:COX8B Synonyms:COX8H |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 2 Publications; Single-pass membrane protein 2 Publications
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respiratory chain complex IV Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 35 | Mitochondrial matrix1 PublicationAdd BLAST | 11 | |
Transmembranei | 36 – 59 | Helical1 PublicationAdd BLAST | 24 | |
Topological domaini | 60 – 70 | Mitochondrial intermembrane1 PublicationAdd BLAST | 11 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 24 | Mitochondrion2 PublicationsAdd BLAST | 24 | |
ChainiPRO_0000006176 | 25 – 70 | Cytochrome c oxidase subunit 8B, mitochondrialAdd BLAST | 46 |
Proteomic databases
PaxDbi | P10175 |
Interactioni
Subunit structurei
Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or COX4I2), COX5A, COX5B, COX6A2 (or COX6A1), COX6B1 (or COX6B2), COX6C, COX7A1 (or COX7A2), COX7B, COX7C, COX8B and NDUFA4, which are encoded in the nuclear genome (PubMed:8638158). The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI1III2IV1 and megacomplex MCI2III2IV2) (PubMed:26698328, PubMed:27830641).
3 PublicationsProtein-protein interaction databases
CORUMi | P10175 |
DIPi | DIP-60941N |
IntActi | P10175, 1 interactor |
STRINGi | 9913.ENSBTAP00000002651 |
Structurei
Secondary structure
3D structure databases
SMRi | P10175 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10175 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SB3F, Eukaryota |
HOGENOMi | CLU_203368_0_0_1 |
InParanoidi | P10175 |
OrthoDBi | 1632471at2759 |
TreeFami | TF105070 |
Family and domain databases
DisProti | DP00780 |
Gene3Di | 4.10.81.10, 1 hit |
InterProi | View protein in InterPro IPR003205, Cyt_c_oxidase_su8 IPR036548, Cyt_c_oxidase_su8_sf |
PANTHERi | PTHR16717, PTHR16717, 1 hit |
Pfami | View protein in Pfam PF02285, COX8, 1 hit |
SUPFAMi | SSF81431, SSF81431, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MLRLAPTVRL LQAPLRGWAV PKAHITAKPA KTPTSPKEQA IGLSVTFLSF
60 70
LLPAGWVLYH LDNYKKSSAA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | A → V in AAA30466 (PubMed:1689292).Curated | 1 | |
Sequence conflicti | 31 | K → R in AAA30466 (PubMed:1689292).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05202 mRNA Translation: AAA30466.1 U15540 Genomic DNA Translation: AAA80279.1 BC112717 mRNA Translation: AAI12718.1 |
PIRi | A35537, OSBO8 |
RefSeqi | NP_001107989.1, NM_001114517.2 |
Genome annotation databases
GeneIDi | 615757 |
KEGGi | bta:615757 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05202 mRNA Translation: AAA30466.1 U15540 Genomic DNA Translation: AAA80279.1 BC112717 mRNA Translation: AAI12718.1 |
PIRi | A35537, OSBO8 |
RefSeqi | NP_001107989.1, NM_001114517.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1OCC | X-ray | 2.80 | M/Z | 25-70 | [»] | |
1OCO | X-ray | 2.80 | M/Z | 25-70 | [»] | |
1OCR | X-ray | 2.35 | M/Z | 25-70 | [»] | |
1OCZ | X-ray | 2.90 | M/Z | 25-70 | [»] | |
1V54 | X-ray | 1.80 | M/Z | 25-70 | [»] | |
1V55 | X-ray | 1.90 | M/Z | 25-70 | [»] | |
2DYR | X-ray | 1.80 | M/Z | 25-70 | [»] | |
2DYS | X-ray | 2.20 | M/Z | 25-70 | [»] | |
2EIJ | X-ray | 1.90 | M/Z | 25-70 | [»] | |
2EIK | X-ray | 2.10 | M/Z | 25-70 | [»] | |
2EIL | X-ray | 2.10 | M/Z | 25-70 | [»] | |
2EIM | X-ray | 2.60 | M/Z | 25-70 | [»] | |
2EIN | X-ray | 2.70 | M/Z | 25-70 | [»] | |
2OCC | X-ray | 2.30 | M/Z | 25-70 | [»] | |
2Y69 | X-ray | 1.95 | M/Z | 1-70 | [»] | |
2YBB | electron microscopy | 19.00 | X | 25-70 | [»] | |
2ZXW | X-ray | 2.50 | M/Z | 25-70 | [»] | |
3ABK | X-ray | 2.00 | M/Z | 25-70 | [»] | |
3ABL | X-ray | 2.10 | M/Z | 25-70 | [»] | |
3ABM | X-ray | 1.95 | M/Z | 25-70 | [»] | |
3AG1 | X-ray | 2.20 | M/Z | 25-70 | [»] | |
3AG2 | X-ray | 1.80 | M/Z | 25-70 | [»] | |
3AG3 | X-ray | 1.80 | M/Z | 25-70 | [»] | |
3AG4 | X-ray | 2.05 | M/Z | 25-70 | [»] | |
3ASN | X-ray | 3.00 | M/Z | 25-70 | [»] | |
3ASO | X-ray | 2.30 | M/Z | 25-70 | [»] | |
3WG7 | X-ray | 1.90 | M/Z | 25-70 | [»] | |
3X2Q | X-ray | 2.00 | M/Z | 25-70 | [»] | |
5B1A | X-ray | 1.50 | M/Z | 25-70 | [»] | |
5B1B | X-ray | 1.60 | M/Z | 25-70 | [»] | |
5B3S | X-ray | 1.68 | M/Z | 25-70 | [»] | |
5GPN | electron microscopy | 5.40 | s | 25-70 | [»] | |
5IY5 | X-ray | 2.00 | M/Z | 25-67 | [»] | |
5LUF | electron microscopy | 9.10 | 0 | 25-70 | [»] | |
5W97 | X-ray | 2.30 | M/m | 25-70 | [»] | |
5WAU | X-ray | 1.95 | M/m | 25-70 | [»] | |
5X19 | X-ray | 2.20 | M/Z | 25-70 | [»] | |
5X1B | X-ray | 2.40 | M/Z | 25-70 | [»] | |
5X1F | X-ray | 2.20 | M/Z | 25-70 | [»] | |
5XDQ | X-ray | 1.77 | M/Z | 25-70 | [»] | |
5XDX | X-ray | 1.99 | M/Z | 25-70 | [»] | |
5XTH | electron microscopy | 3.90 | 9 | 25-67 | [»] | |
5XTI | electron microscopy | 17.40 | 9/B9 | 25-67 | [»] | |
5Z84 | X-ray | 1.85 | M/Z | 25-70 | [»] | |
5Z85 | X-ray | 1.85 | M/Z | 25-70 | [»] | |
5Z86 | X-ray | 1.85 | M/Z | 25-70 | [»] | |
5ZCO | X-ray | 1.90 | M/Z | 25-70 | [»] | |
5ZCP | X-ray | 1.65 | M/Z | 25-70 | [»] | |
5ZCQ | X-ray | 1.65 | M/Z | 25-70 | [»] | |
6J8M | X-ray | 1.90 | M/Z | 25-70 | [»] | |
6JUW | X-ray | 1.80 | M/Z | 25-67 | [»] | |
6JY3 | X-ray | 1.85 | M | 25-70 | [»] | |
6JY4 | X-ray | 1.95 | M | 25-70 | [»] | |
6NKN | X-ray | 2.50 | M/Z | 25-70 | [»] | |
6NMF | X-ray | 2.80 | M/Z | 25-70 | [»] | |
6NMP | X-ray | 2.90 | M/Z | 25-70 | [»] | |
SMRi | P10175 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
CORUMi | P10175 |
DIPi | DIP-60941N |
IntActi | P10175, 1 interactor |
STRINGi | 9913.ENSBTAP00000002651 |
Proteomic databases
PaxDbi | P10175 |
Genome annotation databases
GeneIDi | 615757 |
KEGGi | bta:615757 |
Organism-specific databases
CTDi | 12869 |
Phylogenomic databases
eggNOGi | ENOG502SB3F, Eukaryota |
HOGENOMi | CLU_203368_0_0_1 |
InParanoidi | P10175 |
OrthoDBi | 1632471at2759 |
TreeFami | TF105070 |
Enzyme and pathway databases
UniPathwayi | UPA00705 |
BRENDAi | 1.9.3.1, 908 |
Miscellaneous databases
EvolutionaryTracei | P10175 |
Family and domain databases
DisProti | DP00780 |
Gene3Di | 4.10.81.10, 1 hit |
InterProi | View protein in InterPro IPR003205, Cyt_c_oxidase_su8 IPR036548, Cyt_c_oxidase_su8_sf |
PANTHERi | PTHR16717, PTHR16717, 1 hit |
Pfami | View protein in Pfam PF02285, COX8, 1 hit |
SUPFAMi | SSF81431, SSF81431, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COX8B_BOVIN | |
Accessioni | P10175Primary (citable) accession number: P10175 Secondary accession number(s): Q2KI98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families