UniProtKB - P10172 (ASPQ_ACIGL)
Protein
Glutaminase-asparaginase
Gene
ansB
Organism
Acinetobacter glutaminasificans
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 12 | Acyl-ester intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 59 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- asparaginase activity Source: InterPro
- glutamin-(asparagin-)ase activity Source: UniProtKB-EC
- glutaminase activity Source: RHEA
GO - Biological processi
- asparagine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
SABIO-RKi | P10172 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutaminase-asparaginase (EC:3.5.1.38)Alternative name(s): L-ASNase/L-GLNase L-asparagine/L-glutamine amidohydrolase |
Gene namesi | Name:ansB |
Organismi | Acinetobacter glutaminasificans |
Taxonomic identifieri | 474 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter |
Subcellular locationi
Other locations
- Periplasm By similarity
Other locations
- periplasmic space Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeriplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000171087 | 1 – 331 | Glutaminase-asparaginaseAdd BLAST | 331 |
Interactioni
Subunit structurei
Homotetramer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10172 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10172 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 331 | Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST | 330 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 92 – 93 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the asparaginase 1 family.Curated
Family and domain databases
CDDi | cd08964, L-asparaginase_II, 1 hit |
Gene3Di | 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR004550, AsnASE_II IPR036152, Asp/glu_Ase-like_sf IPR006034, Asparaginase/glutaminase-like IPR020827, Asparaginase/glutaminase_AS1 IPR027475, Asparaginase/glutaminase_AS2 IPR040919, Asparaginase_C IPR027473, L-asparaginase_C IPR027474, L-asparaginase_N IPR037152, L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710, Asparaginase, 1 hit PF17763, Asparaginase_C, 1 hit |
PIRSFi | PIRSF001220, L-ASNase_gatD, 1 hit |
PRINTSi | PR00139, ASNGLNASE |
SMARTi | View protein in SMART SM00870, Asparaginase, 1 hit |
SUPFAMi | SSF53774, SSF53774, 1 hit |
TIGRFAMsi | TIGR00520, asnASE_II, 1 hit |
PROSITEi | View protein in PROSITE PS00144, ASN_GLN_ASE_1, 1 hit PS00917, ASN_GLN_ASE_2, 1 hit PS51732, ASN_GLN_ASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
P10172-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KNNVVIVATG GTIAGAGASS TNSATYSAAK VPVDALIKAV PQVNDLANIT
60 70 80 90 100
GIQALQVASE SITDKELLSL ARQVNDLVKK PSVNGVVITH GTDTMEETAF
110 120 130 140 150
FLNLVVHTDK PIVLVGSMRP STALSADGPL NLYSAVALAS SNEAKNKGVM
160 170 180 190 200
VLMNDSIFAA RDVTKGINIH THAFVSQWGA LGTLVEGKPY WFRSSVKKHT
210 220 230 240 250
NNSEFNIEKI QGDALPGVQI VYGSDNMMPD AYQAFAKAGV KAIIHAGTGN
260 270 280 290 300
GSMANYLVPE VRKLHDEQGL QIVRSSRVAQ GFVLRNAEQP DDKYGWIAAH
310 320 330
DLNPQKARLL MALALTKTND AKEIQNMFWN Y
Sequence databases
PIRi | A28063 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A28063 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AGX | X-ray | 2.90 | A | 1-331 | [»] | |
SMRi | P10172 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Enzyme and pathway databases
SABIO-RKi | P10172 |
Miscellaneous databases
EvolutionaryTracei | P10172 |
Family and domain databases
CDDi | cd08964, L-asparaginase_II, 1 hit |
Gene3Di | 3.40.50.1170, 1 hit 3.40.50.40, 1 hit |
InterProi | View protein in InterPro IPR004550, AsnASE_II IPR036152, Asp/glu_Ase-like_sf IPR006034, Asparaginase/glutaminase-like IPR020827, Asparaginase/glutaminase_AS1 IPR027475, Asparaginase/glutaminase_AS2 IPR040919, Asparaginase_C IPR027473, L-asparaginase_C IPR027474, L-asparaginase_N IPR037152, L-asparaginase_N_sf |
Pfami | View protein in Pfam PF00710, Asparaginase, 1 hit PF17763, Asparaginase_C, 1 hit |
PIRSFi | PIRSF001220, L-ASNase_gatD, 1 hit |
PRINTSi | PR00139, ASNGLNASE |
SMARTi | View protein in SMART SM00870, Asparaginase, 1 hit |
SUPFAMi | SSF53774, SSF53774, 1 hit |
TIGRFAMsi | TIGR00520, asnASE_II, 1 hit |
PROSITEi | View protein in PROSITE PS00144, ASN_GLN_ASE_1, 1 hit PS00917, ASN_GLN_ASE_2, 1 hit PS51732, ASN_GLN_ASE_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ASPQ_ACIGL | |
Accessioni | P10172Primary (citable) accession number: P10172 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families