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Protein

Protein L-Myc

Gene

Mycl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • regulation of inner ear auditory receptor cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein L-Myc
Gene namesi
Name:Mycl
Synonyms:Lmyc1, Mycl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:96799 Mycl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273341 – 368Protein L-MycAdd BLAST368

Proteomic databases

PaxDbiP10166
PeptideAtlasiP10166
PRIDEiP10166

PTM databases

iPTMnetiP10166
PhosphoSitePlusiP10166

Expressioni

Gene expression databases

BgeeiENSMUSG00000028654 Expressed in 250 organ(s), highest expression level in urinary bladder urothelium
ExpressionAtlasiP10166 baseline and differential
GenevisibleiP10166 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201184, 1 interactor
STRINGi10090.ENSMUSP00000030407

Structurei

3D structure databases

ProteinModelPortaliP10166
SMRiP10166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 337bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni337 – 365Leucine-zipperAdd BLAST29

Phylogenomic databases

eggNOGiENOG410IFII Eukaryota
ENOG410Y7JV LUCA
GeneTreeiENSGT00510000046414
HOGENOMiHOG000043075
HOVERGENiHBG000472
InParanoidiP10166
KOiK09110
OMAiAWGRNYA
OrthoDBiEOG091G0ZJQ
PhylomeDBiP10166
TreeFamiTF106001

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 2 hits
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P10166-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG
60 70 80 90 100
AVDPASGINP GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS
110 120 130 140 150
ARERLERVVS DRLAPGAPRG NPPKAPATPD GTPSLEASNP APATQCQLGE
160 170 180 190 200
PKTQACSGSE SPSDSEGEEI DVVTVEKRRS LDIRKPVTIT VRADPLDPCM
210 220 230 240 250
KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI EAPKEKEEEE
260 270 280 290 300
EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND
310 320 330 340 350
LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ
360
LRCRQQQLQK RIAYLSGY
Length:368
Mass (Da):40,848
Last modified:July 1, 1989 - v1
Checksum:i9174F6FD7C03321E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ARS4B1ARS4_MOUSE
Protein L-Myc
Mycl Mycl1
72Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13945 Genomic DNA Translation: CAA32128.1
BC053059 mRNA Translation: AAH53059.1
BC089346 mRNA Translation: AAH89346.1
CCDSiCCDS18606.1
PIRiS03017 TVMSML
RefSeqiNP_001290050.1, NM_001303121.1
NP_032532.1, NM_008506.3
XP_006502884.1, XM_006502821.3
UniGeneiMm.1055
Mm.479066

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654
GeneIDi16918
KEGGimmu:16918
UCSCiuc008uop.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13945 Genomic DNA Translation: CAA32128.1
BC053059 mRNA Translation: AAH53059.1
BC089346 mRNA Translation: AAH89346.1
CCDSiCCDS18606.1
PIRiS03017 TVMSML
RefSeqiNP_001290050.1, NM_001303121.1
NP_032532.1, NM_008506.3
XP_006502884.1, XM_006502821.3
UniGeneiMm.1055
Mm.479066

3D structure databases

ProteinModelPortaliP10166
SMRiP10166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201184, 1 interactor
STRINGi10090.ENSMUSP00000030407

PTM databases

iPTMnetiP10166
PhosphoSitePlusiP10166

Proteomic databases

PaxDbiP10166
PeptideAtlasiP10166
PRIDEiP10166

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654
ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654
GeneIDi16918
KEGGimmu:16918
UCSCiuc008uop.2 mouse

Organism-specific databases

CTDi4610
MGIiMGI:96799 Mycl

Phylogenomic databases

eggNOGiENOG410IFII Eukaryota
ENOG410Y7JV LUCA
GeneTreeiENSGT00510000046414
HOGENOMiHOG000043075
HOVERGENiHBG000472
InParanoidiP10166
KOiK09110
OMAiAWGRNYA
OrthoDBiEOG091G0ZJQ
PhylomeDBiP10166
TreeFamiTF106001

Miscellaneous databases

PROiPR:P10166
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028654 Expressed in 250 organ(s), highest expression level in urinary bladder urothelium
ExpressionAtlasiP10166 baseline and differential
GenevisibleiP10166 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 2 hits
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYCL_MOUSE
AccessioniPrimary (citable) accession number: P10166
Secondary accession number(s): Q5FWI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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