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UniProtKB - P10158 (FOSL1_RAT)
Protein
Fos-related antigen 1
Gene
Fosl1
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- cellular response to extracellular stimulus Source: RGD
- female pregnancy Source: RGD
- in utero embryonic development Source: RGD
- learning Source: RGD
- negative regulation of cell population proliferation Source: RGD
- placenta blood vessel development Source: RGD
- positive regulation of apoptotic process Source: RGD
- positive regulation of cell cycle Source: RGD
- positive regulation of DNA-binding transcription factor activity Source: RGD
- positive regulation of DNA-templated transcription, initiation Source: RGD
- positive regulation of miRNA transcription Source: RGD
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cAMP Source: RGD
- response to corticosterone Source: RGD
- response to cytokine Source: RGD
- response to gravity Source: RGD
- response to hydrogen peroxide Source: RGD
- response to mechanical stimulus Source: RGD
- response to organic cyclic compound Source: RGD
- response to progesterone Source: RGD
- response to xenobiotic stimulus Source: RGD
- vitellogenesis Source: RGD
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Fos-related antigen 1Short name: FRA-1 |
Gene namesi | Name:Fosl1 Synonyms:Fra1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2627, Fosl1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: RGD
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: RGD
- RNA polymerase II transcription regulator complex Source: RGD
Plasma Membrane
- presynaptic membrane Source: RGD
Other locations
- intracellular membrane-bounded organelle Source: RGD
- neuron projection Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076481 | 1 – 275 | Fos-related antigen 1Add BLAST | 275 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 269 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P10158 |
PTM databases
iPTMneti | P10158 |
PhosphoSitePlusi | P10158 |
Expressioni
Inductioni
By serum.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000020552, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | P10158, RN |
Interactioni
Subunit structurei
Heterodimer (By similarity).
Interacts with the BAF multiprotein chromatin-remodeling complex subunits SMARCB1 and SMARCD1 (By similarity).
Interacts with ARID1A and JUN (By similarity).
By similarityProtein-protein interaction databases
CORUMi | P10158 |
DIPi | DIP-1071N |
STRINGi | 10116.ENSRNOP00000027891 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 107 – 170 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 71 – 115 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 109 – 129 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 135 – 163 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 | |
Regioni | 171 – 275 | DisorderedSequence analysisAdd BLAST | 105 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 33 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 71 – 87 | Pro residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 99 – 115 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 171 – 185 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 222 – 266 | Polar residuesSequence analysisAdd BLAST | 45 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160034 |
HOGENOMi | CLU_049742_2_1_1 |
InParanoidi | P10158 |
OMAi | LEPADSC |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P10158 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029815, Fra1 |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF6, PTHR23351:SF6, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
P10158-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ
60 70 80 90 100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE
110 120 130 140 150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ
160 170 180 190 200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC
210 220 230 240 250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS
260 270
AHRKSSSSSG DPSSDPLGSP TLLAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19651 mRNA Translation: AAA41171.1 BC097342 mRNA Translation: AAH97342.1 U24154 Genomic DNA Translation: AAA82045.1 |
PIRi | A27722, TVRTFR |
RefSeqi | NP_037085.1, NM_012953.1 |
Genome annotation databases
Ensembli | ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552 |
GeneIDi | 25445 |
KEGGi | rno:25445 |
UCSCi | RGD:2627, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19651 mRNA Translation: AAA41171.1 BC097342 mRNA Translation: AAH97342.1 U24154 Genomic DNA Translation: AAA82045.1 |
PIRi | A27722, TVRTFR |
RefSeqi | NP_037085.1, NM_012953.1 |
3D structure databases
AlphaFoldDBi | P10158 |
SMRi | P10158 |
ModBasei | Search... |
Protein-protein interaction databases
CORUMi | P10158 |
DIPi | DIP-1071N |
STRINGi | 10116.ENSRNOP00000027891 |
PTM databases
iPTMneti | P10158 |
PhosphoSitePlusi | P10158 |
Proteomic databases
PaxDbi | P10158 |
Genome annotation databases
Ensembli | ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552 |
GeneIDi | 25445 |
KEGGi | rno:25445 |
UCSCi | RGD:2627, rat |
Organism-specific databases
CTDi | 8061 |
RGDi | 2627, Fosl1 |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160034 |
HOGENOMi | CLU_049742_2_1_1 |
InParanoidi | P10158 |
OMAi | LEPADSC |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P10158 |
TreeFami | TF326301 |
Miscellaneous databases
PROi | PR:P10158 |
Gene expression databases
Bgeei | ENSRNOG00000020552, Expressed in skeletal muscle tissue and 20 other tissues |
Genevisiblei | P10158, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR046347, bZIP_sf IPR029815, Fra1 |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF6, PTHR23351:SF6, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSL1_RAT | |
Accessioni | P10158Primary (citable) accession number: P10158 Secondary accession number(s): Q4V8K7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families