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Protein

Fos-related antigen 1

Gene

Fosl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fos-related antigen 1
Short name:
FRA-1
Gene namesi
Name:Fosl1
Synonyms:Fra1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2627 Fosl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764811 – 275Fos-related antigen 1Add BLAST275

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10158

PTM databases

PhosphoSitePlusiP10158

Expressioni

Inductioni

By serum.

Gene expression databases

BgeeiENSRNOG00000020552 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiP10158 RN

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

CORUMiP10158
DIPiDIP-1071N
STRINGi10116.ENSRNOP00000027891

Structurei

3D structure databases

ProteinModelPortaliP10158
SMRiP10158
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 170bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 129Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni135 – 163Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 108Poly-Glu4
Compositional biasi255 – 259Poly-Ser5

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP10158
KOiK04502
OMAiPCEQISP
OrthoDBiEOG091G0GGW
PhylomeDBiP10158
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029815 Fra1
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF6 PTHR23351:SF6, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P10158-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ
60 70 80 90 100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE
110 120 130 140 150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ
160 170 180 190 200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC
210 220 230 240 250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS
260 270
AHRKSSSSSG DPSSDPLGSP TLLAL
Length:275
Mass (Da):30,115
Last modified:July 1, 1989 - v1
Checksum:i103726AD5D1FAB2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19651 mRNA Translation: AAA41171.1
BC097342 mRNA Translation: AAH97342.1
U24154 Genomic DNA Translation: AAA82045.1
PIRiA27722 TVRTFR
RefSeqiNP_037085.1, NM_012953.1
UniGeneiRn.11306

Genome annotation databases

EnsembliENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552
GeneIDi25445
KEGGirno:25445
UCSCiRGD:2627 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19651 mRNA Translation: AAA41171.1
BC097342 mRNA Translation: AAH97342.1
U24154 Genomic DNA Translation: AAA82045.1
PIRiA27722 TVRTFR
RefSeqiNP_037085.1, NM_012953.1
UniGeneiRn.11306

3D structure databases

ProteinModelPortaliP10158
SMRiP10158
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP10158
DIPiDIP-1071N
STRINGi10116.ENSRNOP00000027891

PTM databases

PhosphoSitePlusiP10158

Proteomic databases

PaxDbiP10158

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552
GeneIDi25445
KEGGirno:25445
UCSCiRGD:2627 rat

Organism-specific databases

CTDi8061
RGDi2627 Fosl1

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110541
HOGENOMiHOG000234334
HOVERGENiHBG005743
InParanoidiP10158
KOiK04502
OMAiPCEQISP
OrthoDBiEOG091G0GGW
PhylomeDBiP10158
TreeFamiTF326301

Miscellaneous databases

PROiPR:P10158

Gene expression databases

BgeeiENSRNOG00000020552 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiP10158 RN

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR004827 bZIP
IPR029815 Fra1
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF6 PTHR23351:SF6, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOSL1_RAT
AccessioniPrimary (citable) accession number: P10158
Secondary accession number(s): Q4V8K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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