Fosl1

Functionⁱ

GO - Molecular functionⁱ

DNA binding
Source: RGD
Inferred from direct assayⁱ
- 12371906
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12371906
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12371906

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to extracellular stimulus Source: Ensembl
female pregnancy
Source: RGD
Inferred from expression patternⁱ
- 12080023
in utero embryonic development Source: Ensembl
learning
Source: RGD
Inferred from expression patternⁱ
- 16377429
negative regulation of cell proliferation
Source: RGD
Inferred from mutant phenotypeⁱ
- 14597411
placenta blood vessel development Source: Ensembl
positive regulation of apoptotic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 14597411
positive regulation of cell cycle
Source: RGD
Inferred from mutant phenotypeⁱ
- 17347653
positive regulation of DNA-binding transcription factor activity
Source: RGD
Inferred from direct assayⁱ
- 12371906
positive regulation of DNA-templated transcription, initiation Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12371906
pri-miRNA transcription by RNA polymerase II Source: Ensembl
response to cAMP
Source: RGD
Inferred from expression patternⁱ
- 10934195
response to corticosterone
Source: RGD
Inferred from expression patternⁱ
- 18485334
response to cytokine
Source: RGD
Inferred from expression patternⁱ
- 12770614
response to drug
Source: RGD
Inferred from expression patternⁱ
- 11488404
response to gravity
Source: RGD
Inferred from expression patternⁱ
- 17274184
response to hydrogen peroxide
Source: RGD
Inferred from expression patternⁱ
- 11053775
response to mechanical stimulus
Source: RGD
Inferred from expression patternⁱ
- 16373449
response to organic cyclic compound
Source: RGD
Inferred from expression patternⁱ
- 11113530
response to progesterone
Source: RGD
Inferred from expression patternⁱ
- 12080023
vitellogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fos-related antigen 1 Short name: FRA-1
Gene namesⁱ	Name:Fosl1 Synonyms:Fra1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	2627 Fosl1

RGDⁱ

2627 Fosl1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076481	1 – 275	Fos-related antigen 1Add BLAST		275

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	269	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P10158

PaxDbⁱ

P10158

PTM databases

PhosphoSitePlusⁱ	P10158

PhosphoSitePlusⁱ

P10158

Expressionⁱ

Inductionⁱ

By serum.

Gene expression databases

Bgeeⁱ	ENSRNOG00000020552 Expressed in 9 organ(s), highest expression level in heart
Genevisibleⁱ	P10158 RN

Interactionⁱ

Subunit structureⁱ

Heterodimer.By similarity

Protein-protein interaction databases

CORUMⁱ	P10158
Database of interacting proteins More...DIPⁱ	DIP-1071N
STRINGⁱ	10116.ENSRNOP00000027891

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10158
SMRⁱ	P10158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	107 – 170	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	109 – 129	Basic motifPROSITE-ProRule annotationAdd BLAST		21
Regionⁱ	135 – 163	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	105 – 108	Poly-Glu		4
Compositional biasⁱ	255 – 259	Poly-Ser		5

Sequence similaritiesⁱ

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P10158
KEGG Orthology (KO) More...KOⁱ	K04502
OMAⁱ	PCEQISP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GGW
PhylomeDBⁱ	P10158
TreeFamⁱ	TF326301

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029815 Fra1
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF6 PTHR23351:SF6, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P10158-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ 
        60         70         80         90        100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE 
       110        120        130        140        150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ 
       160        170        180        190        200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC 
       210        220        230        240        250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS 
       260        270 
AHRKSSSSSG DPSSDPLGSP TLLAL

Length:275

Mass (Da):30,115

Last modified:July 1, 1989 - v1

Checksum:ⁱ103726AD5D1FAB2F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19651 mRNA Translation: AAA41171.1 BC097342 mRNA Translation: AAH97342.1 U24154 Genomic DNA Translation: AAA82045.1
PIRⁱ	A27722 TVRTFR
NCBI Reference Sequences More...RefSeqⁱ	NP_037085.1, NM_012953.1
UniGeneⁱ	Rn.11306

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552
GeneIDⁱ	25445
KEGGⁱ	rno:25445
UCSC genome browser More...UCSCⁱ	RGD:2627 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10158	Fos-related antigen 1		HETGA		343	UniRef90_P10158
Fos-related antigen 1		CRIGR		279
fos-related antigen 1 isoform X1		DIPOR		278
FOS like 1, AP-1 transcription factor subunit		HORSE		276
Fos-related antigen 1		CASFI		275
+15

Protein	Similar proteins		Species	Score	Length	Source
P10158	Fos-related antigen 1		HUMAN		271	UniRef50_P15407
FOS like 1, AP-1 transcription factor subunit		PANTR		271
Uncharacterized protein		PANPA		271
FOS like 1, AP-1 transcription factor subunit		GORGO		271
Uncharacterized protein		SHEEP		286
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19651 mRNA Translation: AAA41171.1 BC097342 mRNA Translation: AAH97342.1 U24154 Genomic DNA Translation: AAA82045.1
PIRⁱ	A27722 TVRTFR
RefSeqⁱ	NP_037085.1, NM_012953.1
UniGeneⁱ	Rn.11306

3D structure databases

ProteinModelPortalⁱ	P10158
SMRⁱ	P10158
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P10158
DIPⁱ	DIP-1071N
STRINGⁱ	10116.ENSRNOP00000027891

PTM databases

PhosphoSitePlusⁱ	P10158

PhosphoSitePlusⁱ

P10158

Proteomic databases

PaxDbⁱ	P10158

PaxDbⁱ

P10158

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000027891; ENSRNOP00000027891; ENSRNOG00000020552
GeneIDⁱ	25445
KEGGⁱ	rno:25445
UCSCⁱ	RGD:2627 rat

Organism-specific databases

CTDⁱ	8061
RGDⁱ	2627 Fosl1

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P10158
KOⁱ	K04502
OMAⁱ	PCEQISP
OrthoDBⁱ	EOG091G0GGW
PhylomeDBⁱ	P10158
TreeFamⁱ	TF326301

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10158

PROⁱ

PR:P10158

Gene expression databases

Bgeeⁱ	ENSRNOG00000020552 Expressed in 9 organ(s), highest expression level in heart
Genevisibleⁱ	P10158 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029815 Fra1
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF6 PTHR23351:SF6, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOSL1_RAT
Accessionⁱ	P10158Primary (citable) accession number: P10158 Secondary accession number(s): Q4V8K7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	September 12, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10158 (FOSL1_RAT)

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Fos-related antigen 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ