Fos-related antigen 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem. J. 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem. J. 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem. J. 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase."
    Abell A.N., Granger D.A., Johnson N.L., Vincent-Jordan N., Dibble C.F., Johnson G.L.
    Mol. Cell. Biol. 29:2748-2761(2009) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to extracellular stimulus Source: RGDInferred from sequence orthologyⁱ
  • "Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis)."
    Schreiber M., Poirier C., Franchi A., Kurzbauer R., Guenet J.-L., Carle G.F., Wagner E.F.
    Oncogene 15:1171-1178(1997) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol. Reprod. 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Placental vascularisation requires the AP-1 component fra1."
    Schreiber M., Wang Z.Q., Jochum W., Fetka I., Elliott C., Wagner E.F.
    Development 127:4937-4948(2000) [PubMed] [Europe PMC] [Abstract]
• learning Source: RGDInferred from expression patternⁱ
  • "Learning-dependent activation of Fra-1: involvement of ventral hippocampus and SNc/VTA complex in learning and habit formation."
    Faure A., Conde F., Cheruel F., el Massioui N.
    Brain Res. Bull. 68:233-248(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells."
    Shirsat N.V., Shaikh S.A.
    Exp. Cell Res. 291:91-100(2003) [PubMed] [Europe PMC] [Abstract]
• placenta blood vessel development Source: RGDInferred from sequence orthologyⁱ
  • "Placental vascularisation requires the AP-1 component fra1."
    Schreiber M., Wang Z.Q., Jochum W., Fetka I., Elliott C., Wagner E.F.
    Development 127:4937-4948(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells."
    Shirsat N.V., Shaikh S.A.
    Exp. Cell Res. 291:91-100(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell cycle Source: RGDInferred from mutant phenotypeⁱ
  • "Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription."
    Casalino L., Bakiri L., Talotta F., Weitzman J.B., Fusco A., Yaniv M., Verde P.
    EMBO J. 26:1878-1890(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: RGDInferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem. J. 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-templated transcription, initiation Source: RGDInferred from sequence orthologyⁱ
  • "Transcriptional regulation of the interleukin-11 gene by oncogenic Ras."
    Shin S.Y., Choi C., Lee H.G., Lim Y., Lee Y.H.
    Carcinogenesis 33:2467-2476(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers."
    Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., Lovett D.H.
    Biochem. J. 369:485-496(2003) [PubMed] [Europe PMC] [Abstract]
• pri-miRNA transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer."
    Stinson S., Lackner M.R., Adai A.T., Yu N., Kim H.J., O'Brien C., Spoerke J., Jhunjhunwala S., Boyd Z., Januario T., Newman R.J., Yue P., Bourgon R., Modrusan Z., Stern H.M., Warming S., de Sauvage F.J., Amler L., Yeh R.F., Dornan D.
    Sci Signal 4:ra41-ra41(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to cAMP Source: RGDInferred from expression patternⁱ
  • "Regulation of AP1 (Jun/Fos) factor expression and activation in ovarian granulosa cells. Relation of JunD and Fra2 to terminal differentiation."
    Sharma S.C., Richards J.S.
    J. Biol. Chem. 275:33718-33728(2000) [PubMed] [Europe PMC] [Abstract]
• response to corticosterone Source: RGDInferred from expression patternⁱ
  • "Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge."
    Hansson A.C., Fuxe K.
    Brain Res. 1215:1-10(2008) [PubMed] [Europe PMC] [Abstract]
• response to cytokine Source: RGDInferred from expression patternⁱ
  • "The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: involvement of AP-1 and NFkappaB."
    Lee J.K., Choi S.S., Won J.S., Suh H.W.
    Life Sci. 73:595-609(2003) [PubMed] [Europe PMC] [Abstract]
• response to drug Source: RGDInferred from expression patternⁱ
  • "Carbetapentane attenuates kainate-induced seizures via sigma-1 receptor modulation."
    Kim H.C., Jhoo W.K., Kim W.K., Shin E.J., Cheon M.A., Shin C.Y., Ko K.H.
    Life Sci. 69:915-922(2001) [PubMed] [Europe PMC] [Abstract]
• response to gravity Source: RGDInferred from expression patternⁱ
  • "Contribution of REM sleep to Fos and FRA expression in the vestibular nuclei of rat leading to vestibular adaptation during the STS-90 Neurolab Mission."
    Pompeiano O.
    Arch Ital Biol 145:55-85(2007) [PubMed] [Europe PMC] [Abstract]
• response to hydrogen peroxide Source: RGDInferred from expression patternⁱ
  • "H(2)O(2)-induced egr-1, fra-1, and c-jun gene expression is mediated by tyrosine kinase in aortic smooth muscle cells."
    Jin N., Hatton N.D., Harrington M.A., Xia X., Larsen S.H., Rhoades R.A.
    Free Radic. Biol. Med. 29:736-746(2000) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes."
    Papachristou D., Pirttiniemi P., Kantomaa T., Agnantis N., Basdra E.K.
    Eur J Orthod 28:20-26(2006) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "The differential molecular mechanisms underlying proenkephalin mRNA expression induced by forskolin and phorbol-12-myristic-13-acetate in primary cultured astrocytes."
    Won J.S., Suh H.W.
    Brain Res. Mol. Brain Res. 84:41-51(2000) [PubMed] [Europe PMC] [Abstract]
• response to progesterone Source: RGDInferred from expression patternⁱ
  • "Differential expression of activator protein-1 transcription factors in pregnant rat myometrium."
    Mitchell J.A., Lye S.J.
    Biol. Reprod. 67:240-246(2002) [PubMed] [Europe PMC] [Abstract]
• vitellogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Placental vascularisation requires the AP-1 component fra1."
    Schreiber M., Wang Z.Q., Jochum W., Fetka I., Elliott C., Wagner E.F.
    Development 127:4937-4948(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MYRDFGEPGP SSGAGSAYGR PAQPQQAQTQ TVQQQKFHLV PSINAVSGSQ 
        60         70         80         90        100
ELQWMVQPHF LGPSGYPRPL TYPQYSPPQP RPGVIRALGP PPGVRRRPCE 
       110        120        130        140        150
QISPEEEERR RVRRERNKLA AAKCRNRRKE LTDFLQAETD KLEDEKSGLQ 
       160        170        180        190        200
REIEELQKQK ERLELVLEAH RPICKIPEED KKDTGGTSST SGAGSPPGPC 
       210        220        230        240        250
RPVPCISLSP GPVLEPEALH TPTLMTTPSL TPFTPSLVFT YPSTPEPCSS 
       260        270 
AHRKSSSSSG DPSSDPLGSP TLLAL                            

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families