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Entry version 191 (16 Oct 2019)
Sequence version 2 (27 Sep 2004)
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Protein

60 kDa SS-A/Ro ribonucleoprotein

Gene

RO60

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).2 Publications
May play roles in cilia formation and/or maintenance.By similarity

Miscellaneous

Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi378Divalent metal cationBy similarity1
Metal bindingi380Divalent metal cationBy similarity1
Metal bindingi445Divalent metal cationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processCilium biogenesis/degradation
LigandMetal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60 kDa SS-A/Ro ribonucleoproteinCurated
Short name:
60 kDa Ro protein
Short name:
60 kDa ribonucleoprotein Ro
Short name:
Ro60Curated
Short name:
RoRNP
Alternative name(s):
Ro 60 kDa autoantigen
Short name:
Ro60 autoantigen1 Publication
Sjoegren syndrome antigen A2
Sjoegren syndrome type A antigen
Short name:
SS-A
TROVE domain family member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RO60Imported
Synonyms:SSA2, TROVE2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11313 RO60

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600063 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10155

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6738

Open Targets

More...
OpenTargetsi
ENSG00000116747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36137

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P10155

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TROVE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52788235

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001741691 – 53860 kDa SS-A/Ro ribonucleoproteinAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei4PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei224N6-acetyllysineCombined sources1
Modified residuei359N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P10155

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P10155

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P10155

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10155

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P10155

PeptideAtlas

More...
PeptideAtlasi
P10155

PRoteomics IDEntifications database

More...
PRIDEi
P10155

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52574 [P10155-1]
52575 [P10155-2]
63552
63553
63554

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P10155

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P10155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000116747 Expressed in 251 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10155 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10155 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA002835
HPA005142

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.

Found in a complex with PUF60 and Y5 RNA.

Interacts with RIP11.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112616, 45 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10155

Protein interaction database and analysis system

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IntActi
P10155, 11 interactors

Molecular INTeraction database

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MINTi
P10155

STRING: functional protein association networks

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STRINGi
9606.ENSP00000356416

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10155

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 369TROVEPROSITE-ProRule annotationAdd BLAST354

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni120 – 284RNA-bindingBy similarityAdd BLAST165
Regioni361 – 538VWFA-like domainBy similarityAdd BLAST178

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).By similarity
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ro 60 kDa family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4465 Eukaryota
ENOG410YCBF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000006200

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000075167

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P10155

KEGG Orthology (KO)

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KOi
K11089

Identification of Orthologs from Complete Genome Data

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OMAi
LMAMNQI

Database of Orthologous Groups

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OrthoDBi
1520058at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10155

TreeFam database of animal gene trees

More...
TreeFami
TF105990

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.410, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR040322 TROVE2
IPR008858 TROVE_dom
IPR037214 TROVE_dom_sf
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14202 PTHR14202, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05731 TROVE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140864 SSF140864, 1 hit
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50988 TROVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P10155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEESVNQMQP LNEKQIANSQ DGYVWQVTDM NRLHRFLCFG SEGGTYYIKE
60 70 80 90 100
QKLGLENAEA LIRLIEDGRG CEVIQEIKSF SQEGRTTKQE PMLFALAICS
110 120 130 140 150
QCSDISTKQA AFKAVSEVCR IPTHLFTFIQ FKKDLKESMK CGMWGRALRK
160 170 180 190 200
AIADWYNEKG GMALALAVTK YKQRNGWSHK DLLRLSHLKP SSEGLAIVTK
210 220 230 240 250
YITKGWKEVH ELYKEKALSV ETEKLLKYLE AVEKVKRTRD ELEVIHLIEE
260 270 280 290 300
HRLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE
310 320 330 340 350
VSLVCEKLCN EKLLKKARIH PFHILIALET YKTGHGLRGK LKWRPDEEIL
360 370 380 390 400
KALDAAFYKT FKTVEPTGKR FLLAVDVSAS MNQRVLGSIL NASTVAAAMC
410 420 430 440 450
MVVTRTEKDS YVVAFSDEMV PCPVTTDMTL QQVLMAMSQI PAGGTDCSLP
460 470 480 490 500
MIWAQKTNTP ADVFIVFTDN ETFAGGVHPA IALREYRKKM DIPAKLIVCG
510 520 530
MTSNGFTIAD PDDRGMLDMC GFDTGALDVI RNFTLDMI
Length:538
Mass (Da):60,671
Last modified:September 27, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD735B1DF2B13098
GO
Isoform Short (identifier: P10155-2) [UniParc]FASTAAdd to basket
Also known as: 60E2

The sequence of this isoform differs from the canonical sequence as follows:
     195-205: LAIVTKYITKG → KHKIFIGKKGG
     206-538: Missing.

Show »
Length:205
Mass (Da):23,299
Checksum:i31CF4F9732BEB16E
GO
Isoform 3 (identifier: P10155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-538: GMLDMCGFDTGALDVIRNFTLDMI → DTVK

Show »
Length:518
Mass (Da):58,483
Checksum:iD3CE550ADBB2761B
GO
Isoform 4 (identifier: P10155-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-538: VIRNFTLDMI → PCKIPY

Show »
Length:534
Mass (Da):60,169
Checksum:i785F949FED553344
GO
Isoform 5 (identifier: P10155-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-538: GMLDMCGFDTGALDVIRNFTLDMI → ALQNTLLNKSF

Show »
Length:525
Mass (Da):59,270
Checksum:i9240B125E1038544
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9R9G5E9R9_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
RO60 TROVE2, hCG_41054
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE09D6RE09_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
RO60
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9N5H0Y9N5_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
RO60
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDN1D6RDN1_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
RO60
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136K → R in AAO47001 (Ref. 4) Curated1
Sequence conflicti136K → R in AAO47002 (Ref. 4) Curated1
Sequence conflicti239R → K in AAA35493 (PubMed:3200833).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005911195 – 205LAIVTKYITKG → KHKIFIGKKGG in isoform Short. CuratedAdd BLAST11
Alternative sequenceiVSP_005912206 – 538Missing in isoform Short. CuratedAdd BLAST333
Alternative sequenceiVSP_045262515 – 538GMLDM…TLDMI → DTVK in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_054041515 – 538GMLDM…TLDMI → ALQNTLLNKSF in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_045797529 – 538VIRNFTLDMI → PCKIPY in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J04137 mRNA Translation: AAA35493.1
M25077 mRNA Translation: AAA35532.1
U44388 Genomic DNA Translation: AAB81552.1 Different termination.
U44388 Genomic DNA Translation: AAB81553.1
AY205314 mRNA Translation: AAO47001.1
AY205315 mRNA Translation: AAO47002.1
AK314594 mRNA Translation: BAG37166.1
AL136370 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91240.1
CH471067 Genomic DNA Translation: EAW91243.1
CH471067 Genomic DNA Translation: EAW91245.1
CH471067 Genomic DNA Translation: EAW91247.1
BC036658 mRNA Translation: AAH36658.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1379.1 [P10155-1]
CCDS41449.1 [P10155-5]
CCDS41450.2 [P10155-4]
CCDS53451.1 [P10155-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31760

NCBI Reference Sequences

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RefSeqi
NP_001035828.1, NM_001042369.2 [P10155-5]
NP_001035829.2, NM_001042370.2 [P10155-4]
NP_001166995.1, NM_001173524.1 [P10155-1]
NP_001166996.1, NM_001173525.1 [P10155-3]
NP_004591.2, NM_004600.5 [P10155-1]
XP_006711560.1, XM_006711497.3 [P10155-1]
XP_016857670.1, XM_017002181.1 [P10155-1]
XP_016857671.1, XM_017002182.1 [P10155-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367441; ENSP00000356411; ENSG00000116747 [P10155-1]
ENST00000367443; ENSP00000356413; ENSG00000116747 [P10155-3]
ENST00000367444; ENSP00000356414; ENSG00000116747 [P10155-5]
ENST00000367445; ENSP00000356415; ENSG00000116747 [P10155-4]
ENST00000367446; ENSP00000356416; ENSG00000116747 [P10155-1]
ENST00000400968; ENSP00000383752; ENSG00000116747 [P10155-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6738

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6738

UCSC genome browser

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UCSCi
uc001gss.4 human [P10155-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04137 mRNA Translation: AAA35493.1
M25077 mRNA Translation: AAA35532.1
U44388 Genomic DNA Translation: AAB81552.1 Different termination.
U44388 Genomic DNA Translation: AAB81553.1
AY205314 mRNA Translation: AAO47001.1
AY205315 mRNA Translation: AAO47002.1
AK314594 mRNA Translation: BAG37166.1
AL136370 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91240.1
CH471067 Genomic DNA Translation: EAW91243.1
CH471067 Genomic DNA Translation: EAW91245.1
CH471067 Genomic DNA Translation: EAW91247.1
BC036658 mRNA Translation: AAH36658.1
CCDSiCCDS1379.1 [P10155-1]
CCDS41449.1 [P10155-5]
CCDS41450.2 [P10155-4]
CCDS53451.1 [P10155-3]
PIRiA31760
RefSeqiNP_001035828.1, NM_001042369.2 [P10155-5]
NP_001035829.2, NM_001042370.2 [P10155-4]
NP_001166995.1, NM_001173524.1 [P10155-1]
NP_001166996.1, NM_001173525.1 [P10155-3]
NP_004591.2, NM_004600.5 [P10155-1]
XP_006711560.1, XM_006711497.3 [P10155-1]
XP_016857670.1, XM_017002181.1 [P10155-1]
XP_016857671.1, XM_017002182.1 [P10155-1]

3D structure databases

SMRiP10155
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112616, 45 interactors
CORUMiP10155
IntActiP10155, 11 interactors
MINTiP10155
STRINGi9606.ENSP00000356416

PTM databases

iPTMnetiP10155
PhosphoSitePlusiP10155
SwissPalmiP10155

Polymorphism and mutation databases

BioMutaiTROVE2
DMDMi52788235

Proteomic databases

EPDiP10155
jPOSTiP10155
MassIVEiP10155
MaxQBiP10155
PaxDbiP10155
PeptideAtlasiP10155
PRIDEiP10155
ProteomicsDBi52574 [P10155-1]
52575 [P10155-2]
63552
63553
63554

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6738

Genome annotation databases

EnsembliENST00000367441; ENSP00000356411; ENSG00000116747 [P10155-1]
ENST00000367443; ENSP00000356413; ENSG00000116747 [P10155-3]
ENST00000367444; ENSP00000356414; ENSG00000116747 [P10155-5]
ENST00000367445; ENSP00000356415; ENSG00000116747 [P10155-4]
ENST00000367446; ENSP00000356416; ENSG00000116747 [P10155-1]
ENST00000400968; ENSP00000383752; ENSG00000116747 [P10155-1]
GeneIDi6738
KEGGihsa:6738
UCSCiuc001gss.4 human [P10155-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6738
DisGeNETi6738

GeneCards: human genes, protein and diseases

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GeneCardsi
RO60
HGNCiHGNC:11313 RO60
HPAiHPA002835
HPA005142
MIMi600063 gene
neXtProtiNX_P10155
OpenTargetsiENSG00000116747
PharmGKBiPA36137

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4465 Eukaryota
ENOG410YCBF LUCA
GeneTreeiENSGT00390000006200
HOGENOMiHOG000075167
InParanoidiP10155
KOiK11089
OMAiLMAMNQI
OrthoDBi1520058at2759
PhylomeDBiP10155
TreeFamiTF105990

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TROVE2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TROVE2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6738
PharosiP10155

Protein Ontology

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PROi
PR:P10155

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000116747 Expressed in 251 organ(s), highest expression level in substantia nigra
ExpressionAtlasiP10155 baseline and differential
GenevisibleiP10155 HS

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR040322 TROVE2
IPR008858 TROVE_dom
IPR037214 TROVE_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR14202 PTHR14202, 1 hit
PfamiView protein in Pfam
PF05731 TROVE, 1 hit
SUPFAMiSSF140864 SSF140864, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50988 TROVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRO60_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10155
Secondary accession number(s): B2RBB9
, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 27, 2004
Last modified: October 16, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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