Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60 kDa SS-A/Ro ribonucleoprotein

Gene

TROVE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.1 Publication
May play roles in cilia formation and/or maintenance.By similarity

Miscellaneous

Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi378Divalent metal cationBy similarity1
Metal bindingi380Divalent metal cationBy similarity1
Metal bindingi445Divalent metal cationBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: ProtInc
  • U2 snRNA binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processCilium biogenesis/degradation
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa SS-A/Ro ribonucleoprotein
Short name:
60 kDa Ro protein
Short name:
60 kDa ribonucleoprotein Ro
Short name:
RoRNP
Alternative name(s):
Ro 60 kDa autoantigen
Sjoegren syndrome antigen A2
Sjoegren syndrome type A antigen
Short name:
SS-A
TROVE domain family member 2
Gene namesi
Name:TROVE2
Synonyms:RO60, SSA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116747.12
HGNCiHGNC:11313 TROVE2
MIMi600063 gene
neXtProtiNX_P10155

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6738
OpenTargetsiENSG00000116747
PharmGKBiPA36137

Polymorphism and mutation databases

BioMutaiTROVE2
DMDMi52788235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741691 – 53860 kDa SS-A/Ro ribonucleoproteinAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei4PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei224N6-acetyllysineCombined sources1
Modified residuei359N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP10155
MaxQBiP10155
PaxDbiP10155
PeptideAtlasiP10155
PRIDEiP10155
ProteomicsDBi52574
52575 [P10155-2]

PTM databases

iPTMnetiP10155
PhosphoSitePlusiP10155
SwissPalmiP10155

Expressioni

Gene expression databases

BgeeiENSG00000116747 Expressed in 251 organ(s), highest expression level in substantia nigra
CleanExiHS_TROVE2
ExpressionAtlasiP10155 baseline and differential
GenevisibleiP10155 HS

Organism-specific databases

HPAiHPA002835
HPA005142

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.3 Publications

Protein-protein interaction databases

BioGridi112616, 38 interactors
CORUMiP10155
IntActiP10155, 8 interactors
MINTiP10155
STRINGi9606.ENSP00000356411

Structurei

3D structure databases

ProteinModelPortaliP10155
SMRiP10155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 369TROVEPROSITE-ProRule annotationAdd BLAST354

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 284RNA-bindingBy similarityAdd BLAST165
Regioni361 – 538VWFA-like domainBy similarityAdd BLAST178

Domaini

The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).By similarity
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.By similarity

Sequence similaritiesi

Belongs to the Ro 60 kDa family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4465 Eukaryota
ENOG410YCBF LUCA
GeneTreeiENSGT00390000006200
HOGENOMiHOG000075167
HOVERGENiHBG013234
InParanoidiP10155
KOiK11089
OMAiAKQEPML
OrthoDBiEOG091G04MA
PhylomeDBiP10155
TreeFamiTF105990

Family and domain databases

Gene3Di3.40.50.410, 3 hits
InterProiView protein in InterPro
IPR008858 TROVE_dom
IPR037214 TROVE_dom_sf
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF05731 TROVE, 1 hit
SUPFAMiSSF140864 SSF140864, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50988 TROVE, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform Long (identifier: P10155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEESVNQMQP LNEKQIANSQ DGYVWQVTDM NRLHRFLCFG SEGGTYYIKE
60 70 80 90 100
QKLGLENAEA LIRLIEDGRG CEVIQEIKSF SQEGRTTKQE PMLFALAICS
110 120 130 140 150
QCSDISTKQA AFKAVSEVCR IPTHLFTFIQ FKKDLKESMK CGMWGRALRK
160 170 180 190 200
AIADWYNEKG GMALALAVTK YKQRNGWSHK DLLRLSHLKP SSEGLAIVTK
210 220 230 240 250
YITKGWKEVH ELYKEKALSV ETEKLLKYLE AVEKVKRTRD ELEVIHLIEE
260 270 280 290 300
HRLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE
310 320 330 340 350
VSLVCEKLCN EKLLKKARIH PFHILIALET YKTGHGLRGK LKWRPDEEIL
360 370 380 390 400
KALDAAFYKT FKTVEPTGKR FLLAVDVSAS MNQRVLGSIL NASTVAAAMC
410 420 430 440 450
MVVTRTEKDS YVVAFSDEMV PCPVTTDMTL QQVLMAMSQI PAGGTDCSLP
460 470 480 490 500
MIWAQKTNTP ADVFIVFTDN ETFAGGVHPA IALREYRKKM DIPAKLIVCG
510 520 530
MTSNGFTIAD PDDRGMLDMC GFDTGALDVI RNFTLDMI
Length:538
Mass (Da):60,671
Last modified:September 27, 2004 - v2
Checksum:iCD735B1DF2B13098
GO
Isoform Short (identifier: P10155-2) [UniParc]FASTAAdd to basket
Also known as: 60E2

The sequence of this isoform differs from the canonical sequence as follows:
     195-205: LAIVTKYITKG → KHKIFIGKKGG
     206-538: Missing.

Show »
Length:205
Mass (Da):23,299
Checksum:i31CF4F9732BEB16E
GO
Isoform 3 (identifier: P10155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-538: GMLDMCGFDTGALDVIRNFTLDMI → DTVK

Show »
Length:518
Mass (Da):58,483
Checksum:iD3CE550ADBB2761B
GO
Isoform 4 (identifier: P10155-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-538: VIRNFTLDMI → PCKIPY

Show »
Length:534
Mass (Da):60,169
Checksum:i785F949FED553344
GO
Isoform 5 (identifier: P10155-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-538: GMLDMCGFDTGALDVIRNFTLDMI → ALQNTLLNKSF

Show »
Length:525
Mass (Da):59,270
Checksum:i9240B125E1038544
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9R9G5E9R9_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
TROVE2 hCG_41054
263Annotation score:
H0Y9N5H0Y9N5_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
TROVE2
193Annotation score:
D6RE09D6RE09_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
TROVE2
66Annotation score:
D6RDN1D6RDN1_HUMAN
60 kDa SS-A/Ro ribonucleoprotein
TROVE2
41Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136K → R in AAO47001 (Ref. 4) Curated1
Sequence conflicti136K → R in AAO47002 (Ref. 4) Curated1
Sequence conflicti239R → K in AAA35493 (PubMed:3200833).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005911195 – 205LAIVTKYITKG → KHKIFIGKKGG in isoform Short. CuratedAdd BLAST11
Alternative sequenceiVSP_005912206 – 538Missing in isoform Short. CuratedAdd BLAST333
Alternative sequenceiVSP_045262515 – 538GMLDM…TLDMI → DTVK in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_054041515 – 538GMLDM…TLDMI → ALQNTLLNKSF in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_045797529 – 538VIRNFTLDMI → PCKIPY in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04137 mRNA Translation: AAA35493.1
M25077 mRNA Translation: AAA35532.1
U44388 Genomic DNA Translation: AAB81552.1 Different termination.
U44388 Genomic DNA Translation: AAB81553.1
AY205314 mRNA Translation: AAO47001.1
AY205315 mRNA Translation: AAO47002.1
AK314594 mRNA Translation: BAG37166.1
AL136370 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91240.1
CH471067 Genomic DNA Translation: EAW91243.1
CH471067 Genomic DNA Translation: EAW91245.1
CH471067 Genomic DNA Translation: EAW91247.1
BC036658 mRNA Translation: AAH36658.1
CCDSiCCDS1379.1 [P10155-1]
CCDS41449.1 [P10155-5]
CCDS41450.2 [P10155-4]
CCDS53451.1 [P10155-3]
PIRiA31760
RefSeqiNP_001035828.1, NM_001042369.2 [P10155-5]
NP_001035829.2, NM_001042370.2 [P10155-4]
NP_001166995.1, NM_001173524.1 [P10155-1]
NP_001166996.1, NM_001173525.1 [P10155-3]
NP_004591.2, NM_004600.5 [P10155-1]
XP_006711560.1, XM_006711497.3 [P10155-1]
XP_016857670.1, XM_017002181.1 [P10155-1]
XP_016857671.1, XM_017002182.1 [P10155-1]
UniGeneiHs.288178

Genome annotation databases

EnsembliENST00000367441; ENSP00000356411; ENSG00000116747 [P10155-1]
ENST00000367443; ENSP00000356413; ENSG00000116747 [P10155-3]
ENST00000367444; ENSP00000356414; ENSG00000116747 [P10155-5]
ENST00000367445; ENSP00000356415; ENSG00000116747 [P10155-4]
ENST00000367446; ENSP00000356416; ENSG00000116747 [P10155-1]
ENST00000400968; ENSP00000383752; ENSG00000116747 [P10155-1]
GeneIDi6738
KEGGihsa:6738
UCSCiuc001gss.4 human [P10155-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRO60_HUMAN
AccessioniPrimary (citable) accession number: P10155
Secondary accession number(s): B2RBB9
, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: September 27, 2004
Last modified: September 12, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again