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Protein

Lymphotoxin-alpha

Gene

LTA

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
Gene namesi
Name:LTA
Synonyms:TNFB, TNFSF1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000003447027 – 197Lymphotoxin-alphaAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000005782

Structurei

3D structure databases

ProteinModelPortaliP10154
SMRiP10154
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00530000062992
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiP10154
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG
TreeFamiTF332169

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPGRLYLP LLLGLLLAPP PPGAQGLPGA EFPPSAARNA QQRLQKHFGH
60 70 80 90 100
STLKPAAHLV GDPSAQDSLR WRANTDRAFL RHGFSLSNNS LLVPSSGLYF
110 120 130 140 150
VYSQVVFSGE GCSPKAVPTP LYLAHEVQLF SSQYSFHVPL LSAQKSVCPG
160 170 180 190
PQGPWVRSVY QGAVFLLTQG DQLSTHTDGI AHLLLSPSSV FFGAFAL
Length:197
Mass (Da):21,126
Last modified:August 1, 1991 - v2
Checksum:i0CF18CC90B5E2345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55745 Genomic DNA Translation: CAA39275.1 Sequence problems.
M60340 Genomic DNA Translation: AAA31483.1
M60341 Genomic DNA Translation: AAA31485.1
PIRiJH0309
RefSeqiNP_001164590.1, NM_001171119.1
UniGeneiOcu.7553

Genome annotation databases

EnsembliENSOCUT00000006691; ENSOCUP00000005782; ENSOCUG00000006694
GeneIDi100328931
KEGGiocu:100328931

Similar proteinsi

Entry informationi

Entry nameiTNFB_RABIT
AccessioniPrimary (citable) accession number: P10154
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 1, 1991
Last modified: June 7, 2017
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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