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Protein

Non-secretory ribonuclease

Gene

RNASE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates. EC:3.1.27.5

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei42Proton acceptor1
Active sitei156Proton donor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • ribonuclease A activity Source: UniProtKB-EC
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processChemotaxis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Non-secretory ribonuclease (EC:3.1.27.5)
Alternative name(s):
Eosinophil-derived neurotoxin
RNase UpI-2
Ribonuclease 2
Short name:
RNase 2
Ribonuclease US
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASE2
Synonyms:EDN, RNS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169385.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10045 RNASE2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10153

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6036

Open Targets

More...
OpenTargetsi
ENSG00000169385

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34413

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5120

Drug and drug target database

More...
DrugBanki
DB02098 Adenosine-2'-5'-Diphosphate
DB01812 Adenosine-3'-5'-Diphosphate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNASE2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
133168

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 275 PublicationsAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003087428 – 161Non-secretory ribonucleaseAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00000434C-linked (Man) tryptophan2 Publications1
Glycosylationi44N-linked (GlcNAc...) asparagine1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 110
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60Nitrated tyrosine1 Publication1
Disulfide bondi64 ↔ 123
Disulfide bondi82 ↔ 138
Glycosylationi86N-linked (GlcNAc...) asparagine1
Disulfide bondi89 ↔ 98
Glycosylationi92N-linked (GlcNAc...) asparagine1
Glycosylationi111N-linked (GlcNAc...) asparagine1
Glycosylationi119N-linked (GlcNAc...) asparagine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P10153

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P10153

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10153

PeptideAtlas

More...
PeptideAtlasi
P10153

PRoteomics IDEntifications database

More...
PRIDEi
P10153

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52573

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
436
539

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10153

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10153

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P10153

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver, lung, spleen, leukocytes and body fluids.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169385 Expressed in 137 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_RNASE2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10153 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10153 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044983

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111965, 2 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P10153

Protein interaction database and analysis system

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IntActi
P10153, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000303276

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10153

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQVX-ray0.98A28-161[»]
1HI2X-ray1.60A28-161[»]
1HI3X-ray1.80A28-161[»]
1HI4X-ray1.80A28-161[»]
1HI5X-ray1.80A28-161[»]
1K2AX-ray1.00A26-160[»]
2BEXX-ray1.99C/D28-161[»]
2BZZX-ray0.98A28-161[»]
2C01X-ray1.24X28-161[»]
2C02X-ray2.00A28-161[»]
2C05X-ray1.86A28-161[»]
5E13X-ray1.34A1-161[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P10153

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10153

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10153

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 69Substrate binding5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region is necessary for mediating chemotactic activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JDT3 Eukaryota
ENOG411136R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276882

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008396

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10153

KEGG Orthology (KO)

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KOi
K01168

Identification of Orthologs from Complete Genome Data

More...
OMAi
MFYIVAC

Database of Orthologous Groups

More...
OrthoDBi
1178688at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10153

TreeFam database of animal gene trees

More...
TreeFami
TF333393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11437 PTHR11437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00074 RnaseA, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00794 RIBONUCLEASE

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00092 RNAse_Pc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54076 SSF54076, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10153-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPKLFTSQI CLLLLLGLLA VEGSLHVKPP QFTWAQWFET QHINMTSQQC
60 70 80 90 100
TNAMQVINNY QRRCKNQNTF LLTTFANVVN VCGNPNMTCP SNKTRKNCHH
110 120 130 140 150
SGSQVPLIHC NLTTPSPQNI SNCRYAQTPA NMFYIVACDN RDQRRDPPQY
160
PVVPVHLDRI I
Length:161
Mass (Da):18,354
Last modified:January 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9406C4596CA69038
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37W → R AA sequence (PubMed:3926759).Curated1
Sequence conflicti39 – 40ET → QE AA sequence (PubMed:3926759).Curated2
Sequence conflicti46T → V AA sequence (PubMed:3926759).Curated1
Sequence conflicti47S → T AA sequence (PubMed:3182786).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059820100H → Q. Corresponds to variant dbSNP:rs8012891Ensembl.1
Natural variantiVAR_013150156H → N1 PublicationCorresponds to variant dbSNP:rs146887874Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M30510 mRNA Translation: AAC82505.1
M28129 mRNA Translation: AAA50284.1
M24157 mRNA Translation: AAA52337.1
X16546 Genomic DNA Translation: CAA34546.1
AF294007 Genomic DNA Translation: AAG31577.1
AF294008 Genomic DNA Translation: AAG31578.1
AF294009 Genomic DNA Translation: AAG31579.1
AF294010 Genomic DNA Translation: AAG31580.1
AF294011 Genomic DNA Translation: AAG31581.1
AF294012 Genomic DNA Translation: AAG31582.1
AF294013 Genomic DNA Translation: AAG31583.1
AF294014 Genomic DNA Translation: AAG31584.1
AF294015 Genomic DNA Translation: AAG31585.1
X55987 Genomic DNA Translation: CAA39459.1
X55988 mRNA Translation: CAA39460.1
BC093678 mRNA Translation: AAH93678.1
BC093680 mRNA Translation: AAH93680.1
BC096059 mRNA Translation: AAH96059.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9561.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A35328 A33922

NCBI Reference Sequences

More...
RefSeqi
NP_002925.1, NM_002934.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.728

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304625; ENSP00000303276; ENSG00000169385

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6036

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30510 mRNA Translation: AAC82505.1
M28129 mRNA Translation: AAA50284.1
M24157 mRNA Translation: AAA52337.1
X16546 Genomic DNA Translation: CAA34546.1
AF294007 Genomic DNA Translation: AAG31577.1
AF294008 Genomic DNA Translation: AAG31578.1
AF294009 Genomic DNA Translation: AAG31579.1
AF294010 Genomic DNA Translation: AAG31580.1
AF294011 Genomic DNA Translation: AAG31581.1
AF294012 Genomic DNA Translation: AAG31582.1
AF294013 Genomic DNA Translation: AAG31583.1
AF294014 Genomic DNA Translation: AAG31584.1
AF294015 Genomic DNA Translation: AAG31585.1
X55987 Genomic DNA Translation: CAA39459.1
X55988 mRNA Translation: CAA39460.1
BC093678 mRNA Translation: AAH93678.1
BC093680 mRNA Translation: AAH93680.1
BC096059 mRNA Translation: AAH96059.1
CCDSiCCDS9561.1
PIRiA35328 A33922
RefSeqiNP_002925.1, NM_002934.2
UniGeneiHs.728

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GQVX-ray0.98A28-161[»]
1HI2X-ray1.60A28-161[»]
1HI3X-ray1.80A28-161[»]
1HI4X-ray1.80A28-161[»]
1HI5X-ray1.80A28-161[»]
1K2AX-ray1.00A26-160[»]
2BEXX-ray1.99C/D28-161[»]
2BZZX-ray0.98A28-161[»]
2C01X-ray1.24X28-161[»]
2C02X-ray2.00A28-161[»]
2C05X-ray1.86A28-161[»]
5E13X-ray1.34A1-161[»]
ProteinModelPortaliP10153
SMRiP10153
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111965, 2 interactors
ELMiP10153
IntActiP10153, 1 interactor
STRINGi9606.ENSP00000303276

Chemistry databases

BindingDBiP10153
ChEMBLiCHEMBL5120
DrugBankiDB02098 Adenosine-2'-5'-Diphosphate
DB01812 Adenosine-3'-5'-Diphosphate

PTM databases

GlyConnecti436
539
iPTMnetiP10153
PhosphoSitePlusiP10153
UniCarbKBiP10153

Polymorphism and mutation databases

BioMutaiRNASE2
DMDMi133168

Proteomic databases

EPDiP10153
jPOSTiP10153
PaxDbiP10153
PeptideAtlasiP10153
PRIDEiP10153
ProteomicsDBi52573

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304625; ENSP00000303276; ENSG00000169385
GeneIDi6036
KEGGihsa:6036

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6036
DisGeNETi6036
EuPathDBiHostDB:ENSG00000169385.2

GeneCards: human genes, protein and diseases

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GeneCardsi
RNASE2
HGNCiHGNC:10045 RNASE2
HPAiHPA044983
MIMi131410 gene
neXtProtiNX_P10153
OpenTargetsiENSG00000169385
PharmGKBiPA34413

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JDT3 Eukaryota
ENOG411136R LUCA
GeneTreeiENSGT00940000162253
HOGENOMiHOG000276882
HOVERGENiHBG008396
InParanoidiP10153
KOiK01168
OMAiMFYIVAC
OrthoDBi1178688at2759
PhylomeDBiP10153
TreeFamiTF333393

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RNASE2 human
EvolutionaryTraceiP10153

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Eosinophil-derived_neurotoxin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6036

Protein Ontology

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PROi
PR:P10153

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169385 Expressed in 137 organ(s), highest expression level in bone marrow
CleanExiHS_RNASE2
ExpressionAtlasiP10153 baseline and differential
GenevisibleiP10153 HS

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
PRINTSiPR00794 RIBONUCLEASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNAS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10153
Secondary accession number(s): Q52M39, Q9H2B7, Q9UCG7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 1, 1990
Last modified: January 16, 2019
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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