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Protein

C-C motif chemokine 1

Gene

Ccl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that is chemotactic for neutrophils.

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI
  • cytokine activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 1
Alternative name(s):
P500
SIS-epsilon
Small-inducible cytokine A1
T-cell activation protein 3
Short name:
TCA-3
Short name:
TCA3
Gene namesi
Name:Ccl1
Synonyms:Scya1, Tca3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98258 Ccl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000514224 – 92C-C motif chemokine 1Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57By similarity
Disulfide bondi34 ↔ 74By similarity
Disulfide bondi49 ↔ 92By similarity
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10146
PRIDEiP10146

Expressioni

Inductioni

Produced by T-cell after stimulation by antigen or induction by concanavalin a (Con-A).

Gene expression databases

BgeeiENSMUSG00000020702
CleanExiMM_CCL1
ExpressionAtlasiP10146 baseline and differential
GenevisibleiP10146 MM

Interactioni

GO - Molecular functioni

  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: MGI
  • cytokine activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103824

Structurei

3D structure databases

ProteinModelPortaliP10146
SMRiP10146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J85U Eukaryota
ENOG4111AVY LUCA
GeneTreeiENSGT00530000064270
HOGENOMiHOG000036686
HOVERGENiHBG098128
InParanoidiP10146
KOiK05514
OMAiMHVSSSN
OrthoDBiEOG091G15E8
PhylomeDBiP10146
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P10146-1) [UniParc]FASTAAdd to basket
Also known as: TCA3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKPTAMALMC LLLAAVWIQD VDSKSMLTVS NSCCLNTLKK ELPLKFIQCY
60 70 80 90
RKMGSSCPDP PAVVFRLNKG RESCASTNKT WVQNHLKKVN PC
Length:92
Mass (Da):10,276
Last modified:July 1, 1989 - v1
Checksum:iBF057DEAA1771096
GO
Isoform 2 (identifier: P10146-2) [UniParc]FASTAAdd to basket
Also known as: P500, SIS-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     65-86: FRLNKGRESCASTNKTWVQNHL → VRSSGVPGLTEAEKTVTDSSE

Show »
Length:91
Mass (Da):9,836
Checksum:iB28B9AC360F94DBE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26M → V in CAB57869 (Ref. 3) Curated1

Polymorphismi

The polymorphisms in strains DBA/2J and SJL/J may be associated with severity of clinical symptoms of experimental allergic encephalomyelitis, an animal model of multiple sclerosis, and susceptibility to the monophasic remitting/nonrelapsing form of the disease.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti36N → T in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti64V → I in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti68N → K in strain: DBA/2J and SJL/J. 1 Publication1
Natural varianti70G → D in strain: DBA/2J and SJL/J. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00105965 – 86FRLNK…VQNHL → VRSSGVPGLTEAEKTVTDSS E in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17957 mRNA Translation: AAB39499.1
M23501 mRNA Translation: AAA40147.1
X52401 Genomic DNA Translation: CAB57869.1
AK019040 mRNA Translation: BAB31521.1
AF065924 mRNA Translation: AAF15374.1
AF065925 mRNA Translation: AAF15375.1
AF065926 mRNA Translation: AAF15376.1
AF065927 mRNA Translation: AAF15377.1
AF065928 mRNA Translation: AAF15378.1
CCDSiCCDS36249.1 [P10146-1]
PIRiS24236
RefSeqiNP_035459.1, NM_011329.3 [P10146-1]
UniGeneiMm.1283

Genome annotation databases

EnsembliENSMUST00000108189; ENSMUSP00000103824; ENSMUSG00000020702 [P10146-1]
GeneIDi20290
KEGGimmu:20290
UCSCiuc007kmu.1 mouse [P10146-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL1_MOUSE
AccessioniPrimary (citable) accession number: P10146
Secondary accession number(s): P14098, Q9QUR9, Q9QUS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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