Interleukin-8

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chemokine activity Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
• CXCR chemokine receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-8 receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Structure and functional expression of a human interleukin-8 receptor."
    Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.
    Science 253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy."
    Lane B.R., Lore K., Bock P.J., Andersson J., Coffey M.J., Strieter R.M., Markovitz D.M.
    J Virol 75:8195-8202(2001) [PubMed] [Europe PMC] [Abstract]
• antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKBInferred from direct assayⁱ
  • "Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections."
    Maerki C., Meuter S., Liebi M., Muhlemann K., Frederick M.J., Yawalkar N., Moser B., Wolf M.
    J Immunol 182:507-514(2009) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling Source: UniProtKBTraceable author statementⁱ
  • "Ca(2+) signalling by recombinant human CXCR2 chemokine receptors is potentiated by P2Y nucleotide receptors in HEK cells."
    Werry T.D., Christie M.I., Dainty I.A., Wilkinson G.F., Willars G.B.
    Br J Pharmacol 135:1199-1208(2002) [PubMed] [Europe PMC] [Abstract]
• cell cycle arrest Source: UniProtKBInferred from direct assayⁱ
  • "Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1."
    DiVietro J.A., Smith M.J., Smith B.R., Petruzzelli L., Larson R.S., Lawrence M.B.
    J Immunol 167:4017-4025(2001) [PubMed] [Europe PMC] [Abstract]
• cellular response to fibroblast growth factor stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells."
    Schwarz M., Radeke H.H., Resch K., Uciechowski P.
    Kidney Int 52:1521-1531(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: UniProtKBInferred from expression patternⁱ
  • "Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells."
    Schwarz M., Radeke H.H., Resch K., Uciechowski P.
    Kidney Int 52:1521-1531(1997) [PubMed] [Europe PMC] [Abstract]
• cellular response to lipopolysaccharide Source: BHF-UCLInferred from direct assayⁱ
  • "A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation."
    Oshima N., Ishihara S., Rumi M.A., Aziz M.M., Mishima Y., Kadota C., Moriyama I., Ishimura N., Amano Y., Kinoshita Y.
    Clin Exp Immunol 159:185-198(2010) [PubMed] [Europe PMC] [Abstract]
• cellular response to tumor necrosis factor Source: UniProtKBInferred from expression patternⁱ
  • "Lymphocyte-derived cytokines induce sequential expression of monocyte- and T cell-specific chemokines in human mesangial cells."
    Schwarz M., Radeke H.H., Resch K., Uciechowski P.
    Kidney Int 52:1521-1531(1997) [PubMed] [Europe PMC] [Abstract]
• chemokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemotaxis Source: UniProtKBTraceable author statementⁱ
  • "An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4."
    Lasagni L., Francalanci M., Annunziato F., Lazzeri E., Giannini S., Cosmi L., Sagrinati C., Mazzinghi B., Orlando C., Maggi E., Marra F., Romagnani S., Serio M., Romagnani P.
    J. Exp. Med. 197:1537-1549(2003) [PubMed] [Europe PMC] [Abstract]
• cytokine-mediated signaling pathway Source: Reactome
• embryonic digestive tract development Source: DFLATInferred from expression patternⁱ
  • "TGF-beta2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine."
    Maheshwari A., Kelly D.R., Nicola T., Ambalavanan N., Jain S.K., Murphy-Ullrich J., Athar M., Shimamura M., Bhandari V., Aprahamian C., Dimmitt R.A., Serra R., Ohls R.K.
    Gastroenterology 140:242-253(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: Reactome
• immune response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• induction of positive chemotaxis Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Immobilized IL-8 triggers progressive activation of neutrophils rolling in vitro on P-selectin and intercellular adhesion molecule-1."
    DiVietro J.A., Smith M.J., Smith B.R., Petruzzelli L., Larson R.S., Lawrence M.B.
    J Immunol 167:4017-4025(2001) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: UniProtKBInferred from direct assayⁱ
  • "Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2."
    Richardson R.M., Pridgen B.C., Haribabu B., Snyderman R.
    J Biol Chem 275:9201-9208(2000) [PubMed] [Europe PMC] [Abstract]
• killing of cells of other organism Source: UniProtKBInferred from direct assayⁱ
  • "Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections."
    Maerki C., Meuter S., Liebi M., Muhlemann K., Frederick M.J., Yawalkar N., Moser B., Wolf M.
    J Immunol 182:507-514(2009) [PubMed] [Europe PMC] [Abstract]
• leukocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell adhesion molecule production Source: ARUK-UCLInferred from direct assayⁱ
  • "MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer."
    Tang C.P., Zhou H.J., Qin J., Luo Y., Zhang T.
    Oncol Rep 38:3144-3152(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: ProtIncTraceable author statementⁱ
  • "CXC chemokines suppress proliferation of myeloid progenitor cells by activation of the CXC chemokine receptor 2."
    Sanchez X., Suetomi K., Cousins-Hodges B., Horton J.K., Navarro J.
    J Immunol 160:906-910(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: ARUK-UCLInferred from direct assayⁱ
  • "MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer."
    Tang C.P., Zhou H.J., Qin J., Luo Y., Zhang T.
    Oncol Rep 38:3144-3152(2017) [PubMed] [Europe PMC] [Abstract]
• negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2."
    Richardson R.M., Pridgen B.C., Haribabu B., Snyderman R.
    J Biol Chem 275:9201-9208(2000) [PubMed] [Europe PMC] [Abstract]
• neutrophil activation Source: UniProtKBInferred from direct assayⁱ
  • "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
• neutrophil chemotaxis Source: UniProtKBInferred from direct assayⁱ
  • "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
• PERK-mediated unfolded protein response Source: Reactome
• positive regulation of angiogenesis Source: CACAOInferred from direct assayⁱ
  • "CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer."
    Matsuo Y., Ochi N., Sawai H., Yasuda A., Takahashi H., Funahashi H., Takeyama H., Tong Z., Guha S.
    Int J Cancer 124:853-861(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cellular biosynthetic process Source: ARUK-UCLInferred from direct assayⁱ
  • "MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer."
    Tang C.P., Zhou H.J., Qin J., Luo Y., Zhang T.
    Oncol Rep 38:3144-3152(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: ARUK-UCLInferred from direct assayⁱ
  • "MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer."
    Tang C.P., Zhou H.J., Qin J., Luo Y., Zhang T.
    Oncol Rep 38:3144-3152(2017) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: BHF-UCLTraceable author statementⁱ
  • "Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES."
    Schall T.J., Bacon K., Toy K.J., Goeddel D.V.
    Nature 347:669-671(1990) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: UniProtKBInferred from direct assayⁱ
  • "Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2."
    Richardson R.M., Pridgen B.C., Haribabu B., Snyderman R.
    J Biol Chem 275:9201-9208(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of cell adhesion Source: UniProtKBInferred from direct assayⁱ
  • Ref.25

    "Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide."
    Clark-Lewis I., Mose B., Walz A., Baggiolini M., Scott G.J., Aebersold R.
    Biochemistry 30:3128-3135(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: SYNTHESIS OF 28-99.
• regulation of entry of bacterium into host cell Source: AgBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to Pathogen Entry into Human Neutrophils."
    Dziadek B., Brzostek A., Grzybowski M., Fol M., Krupa A., Kryczka J., Plocinski P., Kurdowska A., Dziadek J.
    PLoS One 11:e0148030-e0148030(2016) [PubMed] [Europe PMC] [Abstract]
• regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: UniProtKBInferred from direct assayⁱ
  • "Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy."
    Lane B.R., Lore K., Bock P.J., Andersson J., Coffey M.J., Strieter R.M., Markovitz D.M.
    J Virol 75:8195-8202(2001) [PubMed] [Europe PMC] [Abstract]
• response to endoplasmic reticulum stress Source: UniProtKBInferred from direct assayⁱ
  • Ref.32

    "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."
    Park S.H., Choi H.J., Yang H., Do K.H., Kim J., Lee D.W., Moon Y.
    J. Biol. Chem. 285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: INDUCTION.
• response to molecule of bacterial origin Source: BHF-UCLInferred from direct assayⁱ
  • "A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation."
    Oshima N., Ishihara S., Rumi M.A., Aziz M.M., Mishima Y., Kadota C., Moriyama I., Ishimura N., Amano Y., Kinoshita Y.
    Clin Exp Immunol 159:185-198(2010) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: ProtIncTraceable author statementⁱ
  • "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils."
    Luu N.T., Rainger G.E., Nash G.B.
    J Immunol 164:5961-5969(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Sites

Keywords - PTMⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• chemokine activity Source: UniProtKBInferred from direct assayⁱ
  • "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."
    Proost P., Wuyts A., Conings R., Lenaerts J.-P., Billiau A., Opdenakker G., van Damme J.
    Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
• CXCR chemokine receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-8 receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "Structure and functional expression of a human interleukin-8 receptor."
    Holmes W.E., Lee J., Kuang W.-J., Rice G.C., Wood W.I.
    Science 253:1278-1280(1991) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK 
        60         70         80         90 
ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS  

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 4
   Human chromosome 4: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families