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Protein

Interleukin-8

Gene

CXCL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chemokine activity Source: UniProtKB
  • interleukin-8 receptor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-380994 ATF4 activates genes
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10145

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-8
Short name:
IL-8
Alternative name(s):
C-X-C motif chemokine 8
Chemokine (C-X-C motif) ligand 8
Emoctakin
Granulocyte chemotactic protein 1
Short name:
GCP-1
Monocyte-derived neutrophil chemotactic factor
Short name:
MDNCF
Monocyte-derived neutrophil-activating peptide
Short name:
MONAP
Neutrophil-activating protein 1
Short name:
NAP-1
Protein 3-10C
T-cell chemotactic factor
Cleaved into the following 7 chains:
Alternative name(s):
GCP/IL-8 protein IV
IL8/NAP1 form I
Alternative name(s):
(Ala-IL-8)77
GCP/IL-8 protein II
IL-8(1-77)
IL8/NAP1 form II
MDNCF-b
Alternative name(s):
(Ser-IL-8)72
GCP/IL-8 protein I
IL8/NAP1 form III
Lymphocyte-derived neutrophil-activating factor
Short name:
LYNAP
MDNCF-c
Neutrophil-activating factor
Short name:
NAF
Alternative name(s):
GCP/IL-8 protein V
IL8/NAP1 form IV
Alternative name(s):
GCP/IL-8 protein VI
IL8/NAP1 form V
Alternative name(s):
GCP/IL-8 protein III
IL8/NAP1 form VI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXCL8
Synonyms:IL8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169429.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6025 CXCL8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
146930 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10145

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3576

Open Targets

More...
OpenTargetsi
ENSG00000169429

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29841

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2157

Drug and drug target database

More...
DrugBanki
DB05434 ABT-510
DB05484 MDX-018
DB05855 Rivanicline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXCL8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124359

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 203 PublicationsAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000512621 – 99MDNCF-aAdd BLAST79
ChainiPRO_000000512723 – 99Interleukin-8Add BLAST77
ChainiPRO_000004194827 – 99IL-8(5-77)Add BLAST73
ChainiPRO_000000512828 – 99IL-8(6-77)Add BLAST72
ChainiPRO_000000512929 – 99IL-8(7-77)Add BLAST71
ChainiPRO_000000513030 – 99IL-8(8-77)Add BLAST70
ChainiPRO_000000513131 – 99IL-8(9-77)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27Citrulline2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 61
Disulfide bondi36 ↔ 77

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.6 Publications
Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei27 – 28Cleavage; by thrombinCurated2
Sitei28 – 29Cleavage; by MMP92

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P10145

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10145

PeptideAtlas

More...
PeptideAtlasi
P10145

PRoteomics IDEntifications database

More...
PRIDEi
P10145

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52570

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P10145

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By ER stress in a DDIT3/CHOP-dependent manner.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169429 Expressed in 176 organ(s), highest expression level in periodontal ligament

CleanEx database of gene expression profiles

More...
CleanExi
HS_IL8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10145 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10145 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057179

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109790, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-3778N

Protein interaction database and analysis system

More...
IntActi
P10145, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000306512

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10145

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ICWX-ray2.01A/B28-99[»]
1IKLNMR-A28-99[»]
1IKMNMR-A28-99[»]
1IL8NMR-A/B28-99[»]
1ILPNMR-A/B28-99[»]
1ILQNMR-A/B28-99[»]
1QE6X-ray2.35A/B/C/D28-99[»]
1RODNMR-A/B28-80[»]
2IL8NMR-A/B28-99[»]
3IL8X-ray2.00A28-99[»]
4XDXX-ray0.95A30-99[»]
5D14X-ray1.00A30-99[»]
5WDZNMR-A28-93[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P10145

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10145

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10145

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J24U Eukaryota
ENOG410Z1BP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160757

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107789

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10145

KEGG Orthology (KO)

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KOi
K10030

Identification of Orthologs from Complete Genome Data

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OMAi
PTAPWVQ

Database of Orthologous Groups

More...
OrthoDBi
1471901at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10145

TreeFam database of animal gene trees

More...
TreeFami
TF333433

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00273 Chemokine_CXC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10179 PTHR10179, 1 hit
PTHR10179:SF70 PTHR10179:SF70, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00048 IL8, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00437 SMALLCYTKCXC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00199 SCY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54117 SSF54117, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P10145-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK
60 70 80 90
ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Length:99
Mass (Da):11,098
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15C649996E89319F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4T6C9J4T6_HUMAN
Multifunctional fusion protein
CXCL8
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK00048 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53R → L AA sequence (PubMed:2659722).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17017 mRNA Translation: AAA35611.1
Y00787 mRNA Translation: CAA68742.1
M28130 Genomic DNA Translation: AAA59158.1
M26383 mRNA Translation: AAA36323.1
D14283 Genomic DNA Translation: BAA03245.1
BT007067 mRNA Translation: AAP35730.1
AK311874 mRNA Translation: BAG34815.1
CR542151 mRNA Translation: CAG46948.1
AF385628 Genomic DNA Translation: AAK60276.1 Sequence problems.
CH471057 Genomic DNA Translation: EAX05688.1
BC013615 mRNA Translation: AAH13615.1
Z11686 mRNA Translation: CAA77745.1
AF043337 mRNA Translation: AAK00048.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34005.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A37034

NCBI Reference Sequences

More...
RefSeqi
NP_000575.1, NM_000584.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.624

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307407; ENSP00000306512; ENSG00000169429

Database of genes from NCBI RefSeq genomes

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GeneIDi
3576

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3576

UCSC genome browser

More...
UCSCi
uc003hhe.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-8 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17017 mRNA Translation: AAA35611.1
Y00787 mRNA Translation: CAA68742.1
M28130 Genomic DNA Translation: AAA59158.1
M26383 mRNA Translation: AAA36323.1
D14283 Genomic DNA Translation: BAA03245.1
BT007067 mRNA Translation: AAP35730.1
AK311874 mRNA Translation: BAG34815.1
CR542151 mRNA Translation: CAG46948.1
AF385628 Genomic DNA Translation: AAK60276.1 Sequence problems.
CH471057 Genomic DNA Translation: EAX05688.1
BC013615 mRNA Translation: AAH13615.1
Z11686 mRNA Translation: CAA77745.1
AF043337 mRNA Translation: AAK00048.1 Sequence problems.
CCDSiCCDS34005.1
PIRiA37034
RefSeqiNP_000575.1, NM_000584.3
UniGeneiHs.624

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ICWX-ray2.01A/B28-99[»]
1IKLNMR-A28-99[»]
1IKMNMR-A28-99[»]
1IL8NMR-A/B28-99[»]
1ILPNMR-A/B28-99[»]
1ILQNMR-A/B28-99[»]
1QE6X-ray2.35A/B/C/D28-99[»]
1RODNMR-A/B28-80[»]
2IL8NMR-A/B28-99[»]
3IL8X-ray2.00A28-99[»]
4XDXX-ray0.95A30-99[»]
5D14X-ray1.00A30-99[»]
5WDZNMR-A28-93[»]
ProteinModelPortaliP10145
SMRiP10145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109790, 13 interactors
DIPiDIP-3778N
IntActiP10145, 13 interactors
STRINGi9606.ENSP00000306512

Chemistry databases

BindingDBiP10145
ChEMBLiCHEMBL2157
DrugBankiDB05434 ABT-510
DB05484 MDX-018
DB05855 Rivanicline

Polymorphism and mutation databases

BioMutaiCXCL8
DMDMi124359

Proteomic databases

EPDiP10145
PaxDbiP10145
PeptideAtlasiP10145
PRIDEiP10145
ProteomicsDBi52570

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307407; ENSP00000306512; ENSG00000169429
GeneIDi3576
KEGGihsa:3576
UCSCiuc003hhe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3576
DisGeNETi3576
EuPathDBiHostDB:ENSG00000169429.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CXCL8
HGNCiHGNC:6025 CXCL8
HPAiHPA057179
MIMi146930 gene
neXtProtiNX_P10145
OpenTargetsiENSG00000169429
PharmGKBiPA29841

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J24U Eukaryota
ENOG410Z1BP LUCA
GeneTreeiENSGT00940000160757
HOVERGENiHBG107789
InParanoidiP10145
KOiK10030
OMAiPTAPWVQ
OrthoDBi1471901at2759
PhylomeDBiP10145
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-380994 ATF4 activates genes
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiP10145

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CXCL8 human
EvolutionaryTraceiP10145

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Interleukin_8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3576
PMAP-CutDBiP10145

Protein Ontology

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PROi
PR:P10145

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169429 Expressed in 176 organ(s), highest expression level in periodontal ligament
CleanExiHS_IL8
ExpressionAtlasiP10145 baseline and differential
GenevisibleiP10145 HS

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR028469 Interleukin-8
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PTHR10179:SF70 PTHR10179:SF70, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10145
Secondary accession number(s): B2R4L8
, Q6FGF6, Q6LAE6, Q96RG6, Q9C077, Q9UCE1, Q9UCR8, Q9UCR9, Q9UCS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 216 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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