UniProtKB - P10126 (EF1A1_MOUSE)

BLAST

>sp|P10126|EF1A1_MOUSE Elongation factor 1-alpha 1 OS=Mus musculus OX=10090 GN=Eef1a1 PE=1 SV=3
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK
IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGSASGTTLLEALDCILPPTR
PTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALS
EALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPV
LDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP
LGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK

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History
Entry version 201 (07 Nov 2018)
Sequence version 3 (25 Oct 2004)
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Protein

Elongation factor 1-alpha 1

Gene

Eef1a1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	14 – 21	GTPBy similarity	8
Nucleotide bindingⁱ	91 – 95	GTPBy similarity	5
Nucleotide bindingⁱ	153 – 156	GTPBy similarity	4

GO - Molecular functionⁱ

calmodulin binding
Source: CAFA
Inferred from direct assayⁱ
- 12646217
drug binding Source: MGI
GTPase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding Source: UniProtKB-KW
mRNA binding Source: MGI
protein kinase binding Source: MGI
translation elongation factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tRNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to epidermal growth factor stimulus Source: UniProtKB
negative regulation of reactive oxygen species biosynthetic process Source: MGI
positive regulation of cell death Source: MGI
positive regulation of neuron projection development Source: MGI
protein homooligomerization Source: MGI
translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
translational elongation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Elongation factor
Biological process	Protein biosynthesis
Ligand	GTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371511 HSF1 activation R-MMU-6798695 Neutrophil degranulation R-MMU-8876725 Protein methylation

Reactomeⁱ

R-MMU-3371511 HSF1 activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8876725 Protein methylation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongation factor 1-alpha 1 Short name: EF-1-alpha-1 Alternative name(s): Elongation factor Tu Short name: EF-Tu Eukaryotic elongation factor 1 A-1 Short name: eEF1A-1
Gene namesⁱ	Name:Eef1a1 Synonyms:Eef1a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1096881 Eef1a1

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000090886	2 – 462	Elongation factor 1-alpha 1Add BLAST		461

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N,N,N-trimethylglycineBy similarity	1
Modified residueⁱ	36	N6,N6,N6-trimethyllysine; alternateBy similarity	1
Modified residueⁱ	36	N6,N6-dimethyllysine; alternateBy similarity	1
Modified residueⁱ	36	N6-methyllysine; alternateBy similarity	1
Modified residueⁱ	55	N6,N6-dimethyllysineBy similarity	1
Modified residueⁱ	79	N6,N6,N6-trimethyllysine; by EEF1AKMT1By similarity	1
Modified residueⁱ	165	N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT31 Publication	1
Modified residueⁱ	165	N6,N6-dimethyllysine; alternate; by EEF1AKMT3By similarity	1
Modified residueⁱ	165	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	165	N6-methyllysine; alternate; by EEF1AKMT3By similarity	1
Modified residueⁱ	172	N6-acetyllysineCombined sources	1
Modified residueⁱ	273	N6-acetyllysineCombined sources	1
Modified residueⁱ	300	Phosphoserine; by TGFBR1By similarity	1
Modified residueⁱ	301	5-glutamyl glycerylphosphorylethanolamine1 Publication	1
Modified residueⁱ	318	N6,N6,N6-trimethyllysine; by EEF1AKMT2By similarity	1
Modified residueⁱ	374	5-glutamyl glycerylphosphorylethanolamine1 Publication	1
Modified residueⁱ	392	N6-acetyllysine; alternateCombined sources	1
Modified residueⁱ	392	N6-succinyllysine; alternateCombined sources	1
Modified residueⁱ	432	Phosphothreonine; by PASKBy similarity	1
Modified residueⁱ	439	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

ISGylated.1 Publication

Phosphorylated by TXK. Phosphorylation by PASK increases translation efficiency. Phosphorylated by ROCK2.By similarity

Trimethylated at Lys-79 by EEF1AKMT1 (By similarity). Methylated at Lys-165 by EEF1AKMT3, methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation (PubMed:28108655). Trimethylated at Lys-318 by EEF1AKMT2 (By similarity). Mono-, di-, and trimethylated at Lys-36 by EEF1AKMT4; trimethylated form is predominant. Methylation by EEF1AKMT4 contributes to the fine-tuning of translation rates for a subset of tRNAs (By similarity).By similarity1 Publication

Keywords - PTMⁱ

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P10126
PaxDbⁱ	P10126
PeptideAtlas More...PeptideAtlasⁱ	P10126
PRIDEⁱ	P10126
TopDownProteomicsⁱ	P10126

2D gel databases

SWISS-2DPAGEⁱ	P10126

SWISS-2DPAGEⁱ

P10126

PTM databases

iPTMnetⁱ	P10126
PhosphoSitePlusⁱ	P10126
SwissPalmⁱ	P10126

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037742 Expressed in 63 organ(s), highest expression level in female gonad
ExpressionAtlasⁱ	P10126 baseline and differential
Genevisibleⁱ	P10126 MM

Interactionⁱ

Subunit structureⁱ

Found in a nuclear export complex with XPO5, EEF1A1, Ran and aminoacylated tRNA. Interacts with PARP1, TXK, XPO5 and KARS. May interact with ERGIC2 (By similarity). Interacts with IFIT1 (via TPR repeats 4-7) (PubMed:19856081). Interacts with DLC1, facilitating distribution to the membrane periphery and ruffles upon growth factor stimulation. Interacts with ZPR1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner (By similarity). Interacts with PPP1R16B (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TSPY1	Q01534	5	EBI-773865,EBI-1973142	From Homo sapiens.

With

Entry

#Exp.

IntAct

Notes

TSPY1

Q01534

EBI-773865,EBI-1973142

From Homo sapiens.

GO - Molecular functionⁱ

calmodulin binding
Source: CAFA
Inferred from direct assayⁱ
- 12646217
protein kinase binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	199385, 57 interactors
Database of interacting proteins More...DIPⁱ	DIP-46609N
IntActⁱ	P10126, 66 interactors
Molecular INTeraction database More...MINTⁱ	P10126
STRINGⁱ	10090.ENSMUSP00000042457

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10126
SMRⁱ	P10126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	5 – 242	tr-type GAdd BLAST		238

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	14 – 21	G1By similarity	8
Regionⁱ	70 – 74	G2By similarity	5
Regionⁱ	91 – 94	G3By similarity	4
Regionⁱ	153 – 156	G4By similarity	4
Regionⁱ	194 – 196	G5By similarity	3

Sequence similaritiesⁱ

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0052 Eukaryota COG5256 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144046
HOGENOMⁱ	HOG000229291
HOVERGENⁱ	HBG000179
InParanoidⁱ	P10126
KEGG Orthology (KO) More...KOⁱ	K03231
OMAⁱ	PAKETKM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05LW
PhylomeDBⁱ	P10126
TreeFamⁱ	TF300304

Family and domain databases

HAMAPⁱ	MF_00118_A EF_Tu_A, 1 hit
InterProⁱ	View protein in InterPro IPR004161 EFTu-like_2 IPR031157 G_TR_CS IPR027417 P-loop_NTPase IPR000795 TF_GTP-bd_dom IPR009000 Transl_B-barrel_sf IPR009001 Transl_elong_EF1A/Init_IF2_C IPR004539 Transl_elong_EF1A_euk/arc IPR004160 Transl_elong_EFTu/EF1A_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00009 GTP_EFTU, 1 hit PF03144 GTP_EFTU_D2, 1 hit PF03143 GTP_EFTU_D3, 1 hit
PRINTSⁱ	PR00315 ELONGATNFCT
SUPFAMⁱ	SSF50447 SSF50447, 1 hit SSF50465 SSF50465, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00483 EF-1_alpha, 1 hit
PROSITEⁱ	View protein in PROSITE PS00301 G_TR_1, 1 hit PS51722 G_TR_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P10126-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG 
        60         70         80         90        100
KGSFKYAWVL DKLKAERERG ITIDISLWKF ETSKYYVTII DAPGHRDFIK 
       110        120        130        140        150
NMITGTSQAD CAVLIVAAGV GEFEAGISKN GQTREHALLA YTLGVKQLIV 
       160        170        180        190        200
GVNKMDSTEP PYSQKRYEEI VKEVSTYIKK IGYNPDTVAF VPISGWNGDN 
       210        220        230        240        250
MLEPSANMPW FKGWKVTRKD GSASGTTLLE ALDCILPPTR PTDKPLRLPL 
       260        270        280        290        300
QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS 
       310        320        330        340        350
EALPGDNVGF NVKNVSVKDV RRGNVAGDSK NDPPMEAAGF TAQVIILNHP 
       360        370        380        390        400
GQISAGYAPV LDCHTAHIAC KFAELKEKID RRSGKKLEDG PKFLKSGDAA 
       410        420        430        440        450
IVDMVPGKPM CVESFSDYPP LGRFAVRDMR QTVAVGVIKA VDKKAAGAGK 
       460 
VTKSAQKAQK AK

Length:462

Mass (Da):50,114

Last modified:October 25, 2004 - v3

Checksum:ⁱ71072871DE7405DC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YZ68	D3YZ68_MOUSE	Elongation factor 1-alpha 1 Elongation factor 1-alpha 1	Eef1a1	249	Annotation score:
D3Z3I8	D3Z3I8_MOUSE	Elongation factor 1-alpha 1 Elongation factor 1-alpha 1	Eef1a1	186	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	7	H → R in AAA37538 (PubMed:3481036).Curated	1
Sequence conflictⁱ	15	H → L in AAA37538 (PubMed:3481036).Curated	1
Sequence conflictⁱ	23	T → S in AAA37538 (PubMed:3481036).Curated	1
Sequence conflictⁱ	77 – 78	LW → QR in CAA31957 (PubMed:2911475).Curated	2
Sequence conflictⁱ	83	S → A in CAA27324 (PubMed:3960725).Curated	1
Sequence conflictⁱ	91 – 92	DA → ES in CAA31957 (PubMed:2911475).Curated	2
Sequence conflictⁱ	108	Q → R in AAA37538 (PubMed:3481036).Curated	1
Sequence conflictⁱ	156	D → G in BAC28085 (PubMed:16141072).Curated	1
Sequence conflictⁱ	222	S → H in AAA50406 (PubMed:3215517).Curated	1
Sequence conflictⁱ	224 – 226	SGT → VAP in CAA31957 (PubMed:2911475).Curated	3
Sequence conflictⁱ	225	G → D in AAH04005 (PubMed:15489334).Curated	1
Sequence conflictⁱ	239	Missing in CAA31957 (PubMed:2911475).Curated	1
Sequence conflictⁱ	350	P → T in BAC36446 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22432 mRNA Translation: AAA50406.1 X13661 mRNA Translation: CAA31957.1 AK032914 mRNA Translation: BAC28085.1 AK076696 mRNA Translation: BAC36446.1 AK081725 mRNA Translation: BAC38311.1 AK083361 mRNA Translation: BAC38884.1 BC004005 mRNA Translation: AAH04005.1 BC004067 mRNA Translation: AAH04067.1 BC005660 mRNA Translation: AAH05660.1 BC018223 mRNA Translation: AAH18223.1 BC018485 mRNA Translation: AAH18485.1 BC083069 mRNA Translation: AAH83069.1 M17878 Genomic DNA Translation: AAA37538.1 X03688 mRNA Translation: CAA27324.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40703.1
PIRⁱ	S02114 EFMS1
NCBI Reference Sequences More...RefSeqⁱ	NP_034236.2, NM_010106.2
UniGeneⁱ	Mm.138471 Mm.335315 Mm.360075 Mm.391071 Mm.485669 Mm.491424

Genome annotation databases

Ensemblⁱ	ENSMUST00000042235; ENSMUSP00000042457; ENSMUSG00000037742
GeneIDⁱ	13627
KEGGⁱ	mmu:13627
UCSC genome browser More...UCSCⁱ	uc009qun.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10126	Elongation factor 1-alpha 1		CRIGR		462	UniRef100_P10126
Elongation factor 1-alpha 1		RAT		462
Elongation factor 1-alpha		SORAR		462
Elongation factor 1-alpha		RHIFE		462
Elongation factor 1-alpha		MOUSE		462
+5

Protein	Similar proteins		Species	Score	Length	Source
P10126	Elongation factor 1-alpha 1		CRIGR		462	UniRef90_P10126
Elongation factor 1-alpha 1		RAT		462
Elongation factor 1-alpha 2		MOUSE		463
Elongation factor 1-alpha, somatic form		XENLA		462
Elongation factor 1-alpha		DANRE		462
+521

Protein	Similar proteins		Species	Score	Length	Source
P10126	Elongation factor 1-alpha 1	)	HUMAN		462	UniRef50_P68104
Elongation factor 1-alpha 1		BOVIN		462
Elongation factor 1-alpha 1		FELCA		462
Elongation factor 1-alpha 1		PANTR		462
Elongation factor 1-alpha 1		PONAB		462
+8282

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22432 mRNA Translation: AAA50406.1 X13661 mRNA Translation: CAA31957.1 AK032914 mRNA Translation: BAC28085.1 AK076696 mRNA Translation: BAC36446.1 AK081725 mRNA Translation: BAC38311.1 AK083361 mRNA Translation: BAC38884.1 BC004005 mRNA Translation: AAH04005.1 BC004067 mRNA Translation: AAH04067.1 BC005660 mRNA Translation: AAH05660.1 BC018223 mRNA Translation: AAH18223.1 BC018485 mRNA Translation: AAH18485.1 BC083069 mRNA Translation: AAH83069.1 M17878 Genomic DNA Translation: AAA37538.1 X03688 mRNA Translation: CAA27324.1
CCDSⁱ	CCDS40703.1
PIRⁱ	S02114 EFMS1
RefSeqⁱ	NP_034236.2, NM_010106.2
UniGeneⁱ	Mm.138471 Mm.335315 Mm.360075 Mm.391071 Mm.485669 Mm.491424

3D structure databases

ProteinModelPortalⁱ	P10126
SMRⁱ	P10126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199385, 57 interactors
DIPⁱ	DIP-46609N
IntActⁱ	P10126, 66 interactors
MINTⁱ	P10126
STRINGⁱ	10090.ENSMUSP00000042457

PTM databases

iPTMnetⁱ	P10126
PhosphoSitePlusⁱ	P10126
SwissPalmⁱ	P10126

2D gel databases

SWISS-2DPAGEⁱ	P10126

SWISS-2DPAGEⁱ

P10126

Proteomic databases

EPDⁱ	P10126
PaxDbⁱ	P10126
PeptideAtlasⁱ	P10126
PRIDEⁱ	P10126
TopDownProteomicsⁱ	P10126

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042235; ENSMUSP00000042457; ENSMUSG00000037742
GeneIDⁱ	13627
KEGGⁱ	mmu:13627
UCSCⁱ	uc009qun.1 mouse

Organism-specific databases

CTDⁱ	1915
MGIⁱ	MGI:1096881 Eef1a1

Phylogenomic databases

eggNOGⁱ	KOG0052 Eukaryota COG5256 LUCA
GeneTreeⁱ	ENSGT00910000144046
HOGENOMⁱ	HOG000229291
HOVERGENⁱ	HBG000179
InParanoidⁱ	P10126
KOⁱ	K03231
OMAⁱ	PAKETKM
OrthoDBⁱ	EOG091G05LW
PhylomeDBⁱ	P10126
TreeFamⁱ	TF300304

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3371511 HSF1 activation R-MMU-6798695 Neutrophil degranulation R-MMU-8876725 Protein methylation

Reactomeⁱ

R-MMU-3371511 HSF1 activation
R-MMU-6798695 Neutrophil degranulation
R-MMU-8876725 Protein methylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10126
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037742 Expressed in 63 organ(s), highest expression level in female gonad
ExpressionAtlasⁱ	P10126 baseline and differential
Genevisibleⁱ	P10126 MM

Family and domain databases

HAMAPⁱ	MF_00118_A EF_Tu_A, 1 hit
InterProⁱ	View protein in InterPro IPR004161 EFTu-like_2 IPR031157 G_TR_CS IPR027417 P-loop_NTPase IPR000795 TF_GTP-bd_dom IPR009000 Transl_B-barrel_sf IPR009001 Transl_elong_EF1A/Init_IF2_C IPR004539 Transl_elong_EF1A_euk/arc IPR004160 Transl_elong_EFTu/EF1A_C
Pfamⁱ	View protein in Pfam PF00009 GTP_EFTU, 1 hit PF03144 GTP_EFTU_D2, 1 hit PF03143 GTP_EFTU_D3, 1 hit
PRINTSⁱ	PR00315 ELONGATNFCT
SUPFAMⁱ	SSF50447 SSF50447, 1 hit SSF50465 SSF50465, 1 hit SSF52540 SSF52540, 1 hit
TIGRFAMsⁱ	TIGR00483 EF-1_alpha, 1 hit
PROSITEⁱ	View protein in PROSITE PS00301 G_TR_1, 1 hit PS51722 G_TR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EF1A1_MOUSE
Accessionⁱ	P10126Primary (citable) accession number: P10126 Secondary accession number(s): Q61511 , Q6ZWN2, Q8BMB8, Q8BVS8, Q99KU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	October 25, 2004
	Last modified:	November 7, 2018
	This is version 201 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniParc

Help

UniRef

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Supporting data

UniProtKB - P10126 (EF1A1_MOUSE)

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Elongation factor 1-alpha 1

Eef1a1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ