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Protein

Serglycin

Gene

SRGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Biomineralization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serglycin
Alternative name(s):
Hematopoietic proteoglycan core protein
Platelet proteoglycan core protein
Short name:
P.PG
Secretory granule proteoglycan core protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SRGN
Synonyms:PRG, PRG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122862.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9361 SRGN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
177040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10124

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5552

Open Targets

More...
OpenTargetsi
ENSG00000122862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33733

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SRGN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
269849659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 272 PublicationsAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002667928 – 158SerglycinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 49Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94O-linked (Xyl...) (glycosaminoglycan) serine1 Publication1
Glycosylationi96O-linked (Xyl...) (glycosaminoglycan) serine1 Publication1
Glycosylationi100O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi102O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi104O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi106O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi108O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi110O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains chondroitin sulfate and heparan sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P10124

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P10124

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10124

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10124

PeptideAtlas

More...
PeptideAtlasi
P10124

PRoteomics IDEntifications database

More...
PRIDEi
P10124

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52568

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10124

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122862 Expressed in 233 organ(s), highest expression level in bone marrow cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_SRGN

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10124 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000759

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to activated CD44 and to GZMB.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111543, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P10124, 22 interactors

Molecular INTeraction database

More...
MINTi
P10124

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000242465

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P10124

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati94 – 9512
Repeati96 – 9722
Repeati98 – 9932
Repeati100 – 10142
Repeati102 – 10352
Repeati104 – 10562
Repeati106 – 10772
Repeati108 – 10982
Repeati110 – 11192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni94 – 1119 X 2 AA tandem repeats of [SF]-GAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serglycin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J42T Eukaryota
ENOG4111DTK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000885

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154415

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008180

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10124

KEGG Orthology (KO)

More...
KOi
K06849

Identification of Orthologs from Complete Genome Data

More...
OMAi
QWVRCSP

Database of Orthologous Groups

More...
OrthoDBi
1340705at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10124

TreeFam database of animal gene trees

More...
TreeFami
TF336310

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007455 Serglycin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04360 Serglycin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10124-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMQKLLKCSR LVLALALILV LESSVQGYPT RRARYQWVRC NPDSNSANCL
60 70 80 90 100
EEKGPMFELL PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS
110 120 130 140 150
GSGSGSGSGS GFLTEMEQDY QLVDESDAFH DNLRSLDRNL PSDSQDLGQH

GLEEDFML
Length:158
Mass (Da):17,652
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD7767F39FFBC477
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139N → S in CAA31255 (PubMed:3402609).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03276131R → Q6 PublicationsCorresponds to variant dbSNP:rs2229498Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03223 mRNA Translation: AAA60179.1
X17042 mRNA Translation: CAA34900.1
M33651, M33649, M33650 Genomic DNA Translation: AAA60322.1
M90058 Genomic DNA No translation available.
AK311873 mRNA Translation: BAG34814.1
AL442635 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54309.1
BC015516 mRNA Translation: AAH15516.1
X12765 mRNA Translation: CAA31255.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7285.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A35183 A28058

NCBI Reference Sequences

More...
RefSeqi
NP_001307982.1, NM_001321053.1
NP_001307983.1, NM_001321054.1
NP_002718.2, NM_002727.3
XP_016871881.1, XM_017016392.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.1908

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242465; ENSP00000242465; ENSG00000122862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5552

UCSC genome browser

More...
UCSCi
uc001joz.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03223 mRNA Translation: AAA60179.1
X17042 mRNA Translation: CAA34900.1
M33651, M33649, M33650 Genomic DNA Translation: AAA60322.1
M90058 Genomic DNA No translation available.
AK311873 mRNA Translation: BAG34814.1
AL442635 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54309.1
BC015516 mRNA Translation: AAH15516.1
X12765 mRNA Translation: CAA31255.1
CCDSiCCDS7285.1
PIRiA35183 A28058
RefSeqiNP_001307982.1, NM_001321053.1
NP_001307983.1, NM_001321054.1
NP_002718.2, NM_002727.3
XP_016871881.1, XM_017016392.1
UniGeneiHs.1908

3D structure databases

ProteinModelPortaliP10124
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111543, 10 interactors
IntActiP10124, 22 interactors
MINTiP10124
STRINGi9606.ENSP00000242465

PTM databases

iPTMnetiP10124

Polymorphism and mutation databases

BioMutaiSRGN
DMDMi269849659

Proteomic databases

EPDiP10124
jPOSTiP10124
MaxQBiP10124
PaxDbiP10124
PeptideAtlasiP10124
PRIDEiP10124
ProteomicsDBi52568

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5552
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242465; ENSP00000242465; ENSG00000122862
GeneIDi5552
KEGGihsa:5552
UCSCiuc001joz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5552
DisGeNETi5552
EuPathDBiHostDB:ENSG00000122862.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SRGN
HGNCiHGNC:9361 SRGN
HPAiHPA000759
MIMi177040 gene
neXtProtiNX_P10124
OpenTargetsiENSG00000122862
PharmGKBiPA33733

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J42T Eukaryota
ENOG4111DTK LUCA
GeneTreeiENSGT00390000000885
HOGENOMiHOG000154415
HOVERGENiHBG008180
InParanoidiP10124
KOiK06849
OMAiQWVRCSP
OrthoDBi1340705at2759
PhylomeDBiP10124
TreeFamiTF336310

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SRGN human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SRGN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5552

Protein Ontology

More...
PROi
PR:P10124

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122862 Expressed in 233 organ(s), highest expression level in bone marrow cell
CleanExiHS_SRGN
GenevisibleiP10124 HS

Family and domain databases

InterProiView protein in InterPro
IPR007455 Serglycin
PfamiView protein in Pfam
PF04360 Serglycin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRGN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10124
Secondary accession number(s): B2R4L7, Q5VW06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 24, 2009
Last modified: January 16, 2019
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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