UniProtKB - P10107 (ANXA1_MOUSE)
Annexin A1
Anxa1
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 59 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 60 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 62 | Calcium 1By similarity | 1 | |
Metal bindingi | 97 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 100 | Calcium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 105 | Calcium 2By similarity | 1 | |
Metal bindingi | 127 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 129 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 131 | Calcium 3; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 132 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 134 | Calcium 4By similarity | 1 | |
Metal bindingi | 171 | Calcium 3By similarity | 1 | |
Metal bindingi | 210 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 213 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 215 | Calcium 5; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 253 | Calcium 6By similarity | 1 | |
Metal bindingi | 255 | Calcium 5By similarity | 1 | |
Metal bindingi | 256 | Calcium 6; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 261 | Calcium 6By similarity | 1 | |
Metal bindingi | 286 | Calcium 7; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 288 | Calcium 7; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 290 | Calcium 7; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 328 | Calcium 8; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 330 | Calcium 7By similarity | 1 | |
Metal bindingi | 331 | Calcium 8; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 336 | Calcium 8By similarity | 1 |
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium-dependent protein binding Source: MGI
- calcium ion binding Source: UniProtKB
- DNA/DNA annealing activity Source: MGI
- double-stranded DNA helicase activity Source: MGI
- identical protein binding Source: MGI
- phospholipase A2 inhibitor activity Source: MGI
- phospholipid binding Source: MGI
- single-stranded DNA binding Source: MGI
- single-stranded RNA binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- adaptive immune response Source: UniProtKB-KW
- alpha-beta T cell differentiation Source: BHF-UCL
- arachidonic acid secretion Source: MGI
- cell surface receptor signaling pathway Source: MGI
- cellular response to glucocorticoid stimulus Source: UniProtKB
- cellular response to hydrogen peroxide Source: MGI
- cellular response to vascular endothelial growth factor stimulus Source: MGI
- DNA duplex unwinding Source: MGI
- endocrine pancreas development Source: GO_Central
- estrous cycle Source: GO_Central
- gliogenesis Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: UniProtKB
- granulocyte chemotaxis Source: UniProtKB
- hepatocyte differentiation Source: GO_Central
- inflammatory response Source: UniProtKB
- innate immune response Source: UniProtKB-KW
- insulin secretion Source: MGI
- keratinocyte differentiation Source: MGI
- monocyte chemotaxis Source: UniProtKB
- myoblast migration involved in skeletal muscle regeneration Source: CACAO
- negative regulation of exocytosis Source: UniProtKB
- negative regulation of interleukin-8 production Source: MGI
- negative regulation of phospholipase A2 activity Source: MGI
- negative regulation of protein secretion Source: MGI
- negative regulation of T-helper 2 cell differentiation Source: UniProtKB
- neutrophil clearance Source: MGI
- neutrophil homeostasis Source: BHF-UCL
- peptide cross-linking Source: MGI
- phagocytosis Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell migration involved in sprouting angiogenesis Source: MGI
- positive regulation of G1/S transition of mitotic cell cycle Source: MGI
- positive regulation of interleukin-2 production Source: UniProtKB
- positive regulation of neutrophil apoptotic process Source: BHF-UCL
- positive regulation of prostaglandin biosynthetic process Source: MGI
- positive regulation of T cell proliferation Source: UniProtKB
- positive regulation of T-helper 1 cell differentiation Source: UniProtKB
- positive regulation of vesicle fusion Source: MGI
- positive regulation of wound healing Source: UniProtKB
- prolactin secretion Source: MGI
- prostate gland development Source: GO_Central
- regulation of cell population proliferation Source: MGI
- regulation of cell shape Source: UniProtKB
- regulation of hormone secretion Source: UniProtKB
- regulation of inflammatory response Source: UniProtKB
- regulation of interleukin-1 production Source: UniProtKB
- regulation of leukocyte migration Source: UniProtKB
- response to drug Source: GO_Central
- response to estradiol Source: GO_Central
- response to interleukin-1 Source: GO_Central
- response to peptide hormone Source: GO_Central
- response to X-ray Source: GO_Central
- signal transduction Source: MGI
Keywordsi
Molecular function | Phospholipase A2 inhibitor |
Biological process | Adaptive immunity, Immunity, Inflammatory response, Innate immunity |
Ligand | Calcium, Calcium/phospholipid-binding, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A1Alternative name(s): Annexin I Annexin-1 Calpactin II Calpactin-2 Chromobindin-9 Lipocortin I1 Publication Phospholipase A2 inhibitory protein p35 |
Gene namesi | Name:Anxa1 Synonyms:Anx1, Lpc-1, Lpc1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96819, Anxa1 |
Subcellular locationi
Plasma membrane
- Basolateral cell membrane By similarity
- Lateral cell membrane 1 Publication
- Cell membrane 2 Publications; Peripheral membrane protein Curated
- Apical cell membrane 2 Publications
- Cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity
Extracellular region or secreted
- Secreted 1 Publication
- extracellular space By similarity
- extracellular exosome 1 Publication
Nucleus
- Nucleus By similarity
Endosome
- Early endosome By similarity
- Endosome membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Cytoplasm 2 Publications
- cilium 1 Publication
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
- Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity
- secretory vesicle lumen 1 Publication
- phagocytic cup 1 Publication
Note: Colocalizes with actin fibers at phagocytic cups (PubMed:21245195). Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Detected in gelatinase granules in resting neutrophils. Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect. Displays calcium-dependent binding to phospholipid membranes (By similarity).By similarity1 Publication
Cytoskeleton
- actin filament Source: Ensembl
Cytosol
- cytosol Source: MGI
Endosome
- early endosome membrane Source: UniProtKB
- endosome Source: MGI
- extrinsic component of endosome membrane Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Lysosome
- mast cell granule Source: MGI
Mitochondrion
- mitochondrial membrane Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB-SubCell
- cornified envelope Source: MGI
- extrinsic component of external side of plasma membrane Source: UniProtKB
- lateral plasma membrane Source: UniProtKB
- phagocytic cup Source: UniProtKB-SubCell
- plasma membrane Source: CACAO
- sarcolemma Source: MGI
- synaptic membrane Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- extrinsic component of membrane Source: MGI
- motile cilium Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, SecretedPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 257 | K → R: Strongly decreased sumoylation. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000067461 | 2 – 346 | Annexin A1Add BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 5 | Phosphoserine; by TRPM7By similarity | 1 | |
Cross-linki | 19 | Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)By similarity | ||
Modified residuei | 21 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 27 | Phosphoserine; by PKCBy similarity | 1 | |
Modified residuei | 34 | PhosphoserineBy similarity | 1 | |
Modified residuei | 37 | PhosphoserineBy similarity | 1 | |
Modified residuei | 58 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 136 | PhosphothreonineBy similarity | 1 | |
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 214 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 257 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication | ||
Modified residuei | 312 | N6-acetyllysineCombined sources | 1 | |
Disulfide bondi | 324 ↔ 343 | By similarity | ||
Cross-linki | 332 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P10107 |
jPOSTi | P10107 |
PaxDbi | P10107 |
PRIDEi | P10107 |
2D gel databases
COMPLUYEAST-2DPAGEi | P10107 |
PTM databases
iPTMneti | P10107 |
PhosphoSitePlusi | P10107 |
SwissPalmi | P10107 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000024659, Expressed in bone marrow and 285 other tissues |
ExpressionAtlasi | P10107, baseline and differential |
Genevisiblei | P10107, MM |
Interactioni
Subunit structurei
Homodimer; non-covalently linked (By similarity). Homodimer; linked by transglutamylation. Homodimers linked by transglutamylation are observed in placenta, but not in other tissues.
Interacts with S100A11. Heterotetramer, formed by two molecules each of S100A11 and ANXA1 (By similarity).
Interacts with DYSF (PubMed:14506282).
Interacts with EGFR (By similarity).
By similarity1 PublicationGO - Molecular functioni
- calcium-dependent protein binding Source: MGI
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201194, 16 interactors |
IntActi | P10107, 7 interactors |
MINTi | P10107 |
STRINGi | 10090.ENSMUSP00000025561 |
Miscellaneous databases
RNActi | P10107, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 42 – 113 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 114 – 185 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 197 – 269 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 273 – 344 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | P10107 |
OMAi | VYLGMPD |
OrthoDBi | 856254at2759 |
PhylomeDBi | P10107 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAMVSEFLKQ ARFLENQEQE YVQAVKSYKG GPGSAVSPYP SFNVSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRTNAQRQQI KAAYLQENGK PLDEVLRKAL
110 120 130 140 150
TGHLEEVVLA MLKTPAQFDA DELRGAMKGL GTDEDTLIEI LTTRSNEQIR
160 170 180 190 200
EINRVYREEL KRDLAKDITS DTSGDFRKAL LALAKGDRCQ DLSVNQDLAD
210 220 230 240 250
TDARALYEAG ERRKGTDVNV FTTILTSRSF PHLRRVFQNY GKYSQHDMNK
260 270 280 290 300
ALDLELKGDI EKCLTTIVKC ATSTPAFFAE KLYEAMKGAG TRHKALIRIM
310 320 330 340
VSRSEIDMNE IKVFYQKKYG ISLCQAILDE TKGDYEKILV ALCGGN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A494BBD8 | A0A494BBD8_MOUSE | Annexin | Anxa1 | 302 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 78 – 79 | QQ → PR in AAA39420 (PubMed:2522299).Curated | 2 | |
Sequence conflicti | 212 | R → I in AAA39437 (PubMed:1676980).Curated | 1 | |
Sequence conflicti | 222 | T → H in AAA39420 (PubMed:2522299).Curated | 1 | |
Sequence conflicti | 274 | T → H in AAA39420 (PubMed:2522299).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07486 mRNA Translation: CAA30371.1 M69260 , M69250, M69251, M69252, M69253, M69254, M69255, M69256, M69257, M69258, M69259 Genomic DNA Translation: AAA39437.1 BC002289 mRNA Translation: AAH02289.1 BC004594 mRNA Translation: AAH04594.1 M24554 mRNA Translation: AAA39420.1 |
CCDSi | CCDS29692.1 |
PIRi | S02181, LUMS1 |
RefSeqi | NP_034860.2, NM_010730.2 |
Genome annotation databases
Ensembli | ENSMUST00000025561; ENSMUSP00000025561; ENSMUSG00000024659 ENSMUST00000235280; ENSMUSP00000158305; ENSMUSG00000024659 |
GeneIDi | 16952 |
KEGGi | mmu:16952 |
UCSCi | uc008gyi.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07486 mRNA Translation: CAA30371.1 M69260 , M69250, M69251, M69252, M69253, M69254, M69255, M69256, M69257, M69258, M69259 Genomic DNA Translation: AAA39437.1 BC002289 mRNA Translation: AAH02289.1 BC004594 mRNA Translation: AAH04594.1 M24554 mRNA Translation: AAA39420.1 |
CCDSi | CCDS29692.1 |
PIRi | S02181, LUMS1 |
RefSeqi | NP_034860.2, NM_010730.2 |
3D structure databases
SMRi | P10107 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201194, 16 interactors |
IntActi | P10107, 7 interactors |
MINTi | P10107 |
STRINGi | 10090.ENSMUSP00000025561 |
PTM databases
iPTMneti | P10107 |
PhosphoSitePlusi | P10107 |
SwissPalmi | P10107 |
2D gel databases
COMPLUYEAST-2DPAGEi | P10107 |
Proteomic databases
EPDi | P10107 |
jPOSTi | P10107 |
PaxDbi | P10107 |
PRIDEi | P10107 |
Protocols and materials databases
Antibodypediai | 2190, 1133 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025561; ENSMUSP00000025561; ENSMUSG00000024659 ENSMUST00000235280; ENSMUSP00000158305; ENSMUSG00000024659 |
GeneIDi | 16952 |
KEGGi | mmu:16952 |
UCSCi | uc008gyi.1, mouse |
Organism-specific databases
CTDi | 301 |
MGIi | MGI:96819, Anxa1 |
Phylogenomic databases
eggNOGi | KOG0819, Eukaryota |
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_0_0_1 |
InParanoidi | P10107 |
OMAi | VYLGMPD |
OrthoDBi | 856254at2759 |
PhylomeDBi | P10107 |
TreeFami | TF105452 |
Enzyme and pathway databases
Reactomei | R-MMU-416476, G alpha (q) signalling events R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands |
Miscellaneous databases
BioGRID-ORCSi | 16952, 0 hits in 18 CRISPR screens |
ChiTaRSi | Anxa1, mouse |
PROi | PR:P10107 |
RNActi | P10107, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024659, Expressed in bone marrow and 285 other tissues |
ExpressionAtlasi | P10107, baseline and differential |
Genevisiblei | P10107, MM |
Family and domain databases
Gene3Di | 1.10.220.10, 4 hits |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 4 hits |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 4 hits |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 4 hits PS51897, ANNEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA1_MOUSE | |
Accessioni | P10107Primary (citable) accession number: P10107 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families