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Protein

Endolytic peptidoglycan transglycosylase RlpA

Gene

rlpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciEcoCyc:EG10854-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endolytic peptidoglycan transglycosylase RlpAUniRule annotation (EC:4.2.2.-UniRule annotation)
Alternative name(s):
Rare lipoprotein A1 Publication
Gene namesi
Name:rlpA1 PublicationUniRule annotation
Ordered Locus Names:b0633, JW0628
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10854 rlpA

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deletion does not result in any obvious growth or division defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotation1 PublicationAdd BLAST17
ChainiPRO_000003079618 – 362Endolytic peptidoglycan transglycosylase RlpAUniRule annotationAdd BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi18N-palmitoyl cysteineUniRule annotation1 Publication1
Lipidationi18S-diacylglycerol cysteineUniRule annotation1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP10100
PRIDEiP10100

Interactioni

Protein-protein interaction databases

BioGridi4260680, 171 interactors
IntActiP10100, 1 interactor
STRINGi316385.ECDH10B_0702

Structurei

3D structure databases

ProteinModelPortaliP10100
SMRiP10100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 361SPORUniRule annotationAdd BLAST77

Domaini

The SPOR domain binds septal peptidoglycans and is required to target RlpA to the septal ring.1 Publication

Sequence similaritiesi

Belongs to the RlpA family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105K6T Bacteria
COG0797 LUCA
HOGENOMiHOG000117956
InParanoidiP10100
KOiK03642
OMAiPFYSDRI

Family and domain databases

Gene3Di2.40.40.10, 1 hit
3.30.70.1070, 1 hit
HAMAPiMF_02071 RlpA, 1 hit
InterProiView protein in InterPro
IPR034718 RlpA
IPR009009 RlpA-like_DPBB
IPR036908 RlpA-like_sf
IPR012997 RplA
IPR007730 SPOR-like_dom
IPR036680 SPOR-like_sf
PfamiView protein in Pfam
PF03330 DPBB_1, 1 hit
PF05036 SPOR, 1 hit
SUPFAMiSSF110997 SSF110997, 1 hit
SSF50685 SSF50685, 1 hit
TIGRFAMsiTIGR00413 rlpA, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS51724 SPOR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKQWLGICI AAGMLAACTS DDGQQQTVSV PQPAVCNGPI VEISGADPRF
60 70 80 90 100
EPLNATANQD YQRDGKSYKI VQDPSRFSQA GLAAIYDAEP GSNLTASGEA
110 120 130 140 150
FDPTQLTAAH PTLPIPSYAR ITNLANGRMI VVRINDRGPY GNDRVISLSR
160 170 180 190 200
AAADRLNTSN NTKVRIDPII VAQDGSLSGP GMACTTVAKQ TYALPAPPDL
210 220 230 240 250
SGGAGTSSVS GPQGDILPVS NSTLKSEDPT GAPVTSSGFL GAPTTLAPGV
260 270 280 290 300
LEGSEPTPAP QPVVTAPSTT PATSPAMVTP QAVSQSASGN FMVQVGAVSD
310 320 330 340 350
QARAQQYQQQ LGQKFGVPGR VTQNGAVWRI QLGPFASKAE ASTLQQRLQT
360
EAQLQSFITT AQ
Length:362
Mass (Da):37,528
Last modified:July 1, 1989 - v1
Checksum:iE28B57023CF15686
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18276 Genomic DNA Translation: AAA24552.1
U82598 Genomic DNA Translation: AAB40833.1
U00096 Genomic DNA Translation: AAC73734.1
AP009048 Genomic DNA Translation: BAA35276.1
M22857 Genomic DNA Translation: AAA24572.1
PIRiA28387 LPECRA
RefSeqiNP_415166.1, NC_000913.3
WP_001231430.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73734; AAC73734; b0633
BAA35276; BAA35276; BAA35276
GeneIDi945241
KEGGiecj:JW0628
eco:b0633
PATRICifig|1411691.4.peg.1635

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18276 Genomic DNA Translation: AAA24552.1
U82598 Genomic DNA Translation: AAB40833.1
U00096 Genomic DNA Translation: AAC73734.1
AP009048 Genomic DNA Translation: BAA35276.1
M22857 Genomic DNA Translation: AAA24572.1
PIRiA28387 LPECRA
RefSeqiNP_415166.1, NC_000913.3
WP_001231430.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP10100
SMRiP10100
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260680, 171 interactors
IntActiP10100, 1 interactor
STRINGi316385.ECDH10B_0702

Proteomic databases

PaxDbiP10100
PRIDEiP10100

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73734; AAC73734; b0633
BAA35276; BAA35276; BAA35276
GeneIDi945241
KEGGiecj:JW0628
eco:b0633
PATRICifig|1411691.4.peg.1635

Organism-specific databases

EchoBASEiEB0847
EcoGeneiEG10854 rlpA

Phylogenomic databases

eggNOGiENOG4105K6T Bacteria
COG0797 LUCA
HOGENOMiHOG000117956
InParanoidiP10100
KOiK03642
OMAiPFYSDRI

Enzyme and pathway databases

BioCyciEcoCyc:EG10854-MONOMER

Miscellaneous databases

PROiPR:P10100

Family and domain databases

Gene3Di2.40.40.10, 1 hit
3.30.70.1070, 1 hit
HAMAPiMF_02071 RlpA, 1 hit
InterProiView protein in InterPro
IPR034718 RlpA
IPR009009 RlpA-like_DPBB
IPR036908 RlpA-like_sf
IPR012997 RplA
IPR007730 SPOR-like_dom
IPR036680 SPOR-like_sf
PfamiView protein in Pfam
PF03330 DPBB_1, 1 hit
PF05036 SPOR, 1 hit
SUPFAMiSSF110997 SSF110997, 1 hit
SSF50685 SSF50685, 1 hit
TIGRFAMsiTIGR00413 rlpA, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit
PS51724 SPOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRLPA_ECOLI
AccessioniPrimary (citable) accession number: P10100
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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