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Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP10082

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
PYY-IBy similarity
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)1 Publication
Alternative name(s):
PYY-IIBy similarity
Gene namesi
Name:PYY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000131096.10
HGNCiHGNC:9748 PYY
MIMi600781 gene
neXtProtiNX_P10082

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5697
OpenTargetsiENSG00000131096
PharmGKBiPA34090

Polymorphism and mutation databases

BioMutaiPYY
DMDMi317373516

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
PeptideiPRO_000002538429 – 64Peptide YYAdd BLAST36
PeptideiPRO_000002538531 – 64Peptide YY(3-36)Add BLAST34
PropeptideiPRO_000002538668 – 97Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41PhosphoserineBy similarity1
Modified residuei64Tyrosine amide2 Publications1

Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP10082
PeptideAtlasiP10082
PRIDEiP10082
ProteomicsDBi52563
52564 [P10082-2]

Expressioni

Gene expression databases

BgeeiENSG00000131096 Expressed in 50 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_PYY
GenevisibleiP10082 HS

Organism-specific databases

HPAiCAB016734
HPA010973

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111670, 6 interactors
IntActiP10082, 4 interactors
MINTiP10082
STRINGi9606.ENSP00000353198

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10082
SMRiP10082
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10082

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0E4 Eukaryota
ENOG4111U8V LUCA
GeneTreeiENSGT00390000010775
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiP10082
KOiK05233
OMAiYTALRHY
OrthoDBiEOG091G0ZRE
PhylomeDBiP10082
TreeFamiTF332778

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Length:97
Mass (Da):11,145
Last modified:January 11, 2011 - v3
Checksum:iC166B73412E356B1
GO
Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Show »
Length:90
Mass (Da):10,360
Checksum:iA1C48F08021136B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04740737R → G6 PublicationsCorresponds to variant dbSNP:rs229969Ensembl.1
Natural variantiVAR_00638272T → R3 PublicationsCorresponds to variant dbSNP:rs1058046Ensembl.1
Natural variantiVAR_04740895D → H. Corresponds to variant dbSNP:rs465407Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00508191 – 97Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA Translation: BAA02997.1
D13897 Genomic DNA Translation: BAA02998.1
D13899 mRNA Translation: BAA03000.1
D13902 mRNA Translation: BAA03002.1
L25648 Genomic DNA Translation: AAA36433.1
CR542129 mRNA Translation: CAG46926.1
AC007993 Genomic DNA No translation available.
BC041057 mRNA Translation: AAH41057.1
CCDSiCCDS32662.1 [P10082-1]
PIRiA31358
S33795
S34568
S34569
RefSeqiNP_004151.3, NM_004160.5
XP_011523337.1, XM_011525035.1 [P10082-1]
UniGeneiHs.169249

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2]
GeneIDi5697
KEGGihsa:5697
UCSCiuc002ieq.4 human [P10082-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA Translation: BAA02997.1
D13897 Genomic DNA Translation: BAA02998.1
D13899 mRNA Translation: BAA03000.1
D13902 mRNA Translation: BAA03002.1
L25648 Genomic DNA Translation: AAA36433.1
CR542129 mRNA Translation: CAG46926.1
AC007993 Genomic DNA No translation available.
BC041057 mRNA Translation: AAH41057.1
CCDSiCCDS32662.1 [P10082-1]
PIRiA31358
S33795
S34568
S34569
RefSeqiNP_004151.3, NM_004160.5
XP_011523337.1, XM_011525035.1 [P10082-1]
UniGeneiHs.169249

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
2NA5NMR-A31-63[»]
ProteinModelPortaliP10082
SMRiP10082
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111670, 6 interactors
IntActiP10082, 4 interactors
MINTiP10082
STRINGi9606.ENSP00000353198

Polymorphism and mutation databases

BioMutaiPYY
DMDMi317373516

Proteomic databases

PaxDbiP10082
PeptideAtlasiP10082
PRIDEiP10082
ProteomicsDBi52563
52564 [P10082-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1]
ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2]
GeneIDi5697
KEGGihsa:5697
UCSCiuc002ieq.4 human [P10082-1]

Organism-specific databases

CTDi5697
DisGeNETi5697
EuPathDBiHostDB:ENSG00000131096.10
GeneCardsiPYY
HGNCiHGNC:9748 PYY
HPAiCAB016734
HPA010973
MIMi600781 gene
neXtProtiNX_P10082
OpenTargetsiENSG00000131096
PharmGKBiPA34090
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0E4 Eukaryota
ENOG4111U8V LUCA
GeneTreeiENSGT00390000010775
HOGENOMiHOG000252942
HOVERGENiHBG006485
InParanoidiP10082
KOiK05233
OMAiYTALRHY
OrthoDBiEOG091G0ZRE
PhylomeDBiP10082
TreeFamiTF332778

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP10082

Miscellaneous databases

EvolutionaryTraceiP10082
GeneWikiiPeptide_YY
GenomeRNAii5697
PROiPR:P10082
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131096 Expressed in 50 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_PYY
GenevisibleiP10082 HS

Family and domain databases

CDDicd00126 PAH, 1 hit
InterProiView protein in InterPro
IPR001955 Pancreatic_hormone-like
IPR020392 Pancreatic_hormone-like_CS
PANTHERiPTHR10533 PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159 Hormone_3, 1 hit
PRINTSiPR00278 PANCHORMONE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267 Pancreatic_hormone-like, 1 hit
SMARTiView protein in SMART
SM00309 PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265 PANCREATIC_HORMONE_1, 1 hit
PS50276 PANCREATIC_HORMONE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYY_HUMAN
AccessioniPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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