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UniProtKB - P10082 (PYY_HUMAN)

Entry version 191 (25 May 2022)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Peptide YY

Gene

PYY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P10082

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P10082

SIGNOR Signaling Network Open Resource

More...SIGNORi		P10082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptide YY1 Publication
Short name:
PYY1 Publication
Alternative name(s):
PYY-IBy similarity
Peptide tyrosine tyrosine
Cleaved into the following chain:
Peptide YY(3-36)1 Publication
Alternative name(s):
PYY-IIBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PYY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9748, PYY

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600781, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10082

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131096

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		5697

Open Targets

More...OpenTargetsi		ENSG00000131096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34090

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10082, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PYY

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373516

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 282 PublicationsAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002538429 – 64Peptide YYAdd BLAST36
PeptideiPRO_000002538531 – 64Peptide YY(3-36)Add BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002538668 – 97Add BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei41PhosphoserineBy similarity1
Modified residuei64Tyrosine amide2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10082

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10082

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10082

PeptideAtlas

More...PeptideAtlasi		P10082

PRoteomics IDEntifications database

More...PRIDEi		P10082

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52563 [P10082-1]
52564 [P10082-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131096, Expressed in mucosa of transverse colon and 79 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10082, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131096, Tissue enriched (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111670, 31 interactors

Protein interaction database and analysis system

More...IntActi		P10082, 4 interactors

Molecular INTeraction database

More...MINTi		P10082

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000353198

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10082, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P10082

Biological Magnetic Resonance Data Bank

More...BMRBi		P10082

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10082

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P10082

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni65 – 97DisorderedSequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 97Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S267, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_162379_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10082

Identification of Orthologs from Complete Genome Data

More...OMAi		HAYPAKP

Database of Orthologous Groups

More...OrthoDBi		1542445at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10082

TreeFam database of animal gene trees

More...TreeFami		TF332778

Family and domain databases

Conserved Domains Database

More...CDDi		cd00126, PAH, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001955, Pancreatic_hormone-like
IPR020392, Pancreatic_hormone-like_CS

The PANTHER Classification System

More...PANTHERi		PTHR10533, PTHR10533, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00159, Hormone_3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00278, PANCHORMONE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00309, PAH, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00265, PANCREATIC_HORMONE_1, 1 hit
PS50276, PANCREATIC_HORMONE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA 
        60         70         80         90 
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Length:97
Mass (Da):11,145
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC166B73412E356B1
GO
Isoform 2 (identifier: P10082-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-97: Missing.

Show »
Length:90
Mass (Da):10,360
Checksum:iA1C48F08021136B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04740737R → G6 PublicationsCorresponds to variant dbSNP:rs229969EnsemblClinVar.1
Natural variantiVAR_00638272T → R3 PublicationsCorresponds to variant dbSNP:rs1058046Ensembl.1
Natural variantiVAR_04740895D → H. Corresponds to variant dbSNP:rs465407Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00508191 – 97Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D13897 Genomic DNA Translation: BAA02997.1
D13897 Genomic DNA Translation: BAA02998.1
D13899 mRNA Translation: BAA03000.1
D13902 mRNA Translation: BAA03002.1
L25648 Genomic DNA Translation: AAA36433.1
CR542129 mRNA Translation: CAG46926.1
AC007993 Genomic DNA No translation available.
BC041057 mRNA Translation: AAH41057.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32662.1 [P10082-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A31358
S33795
S34568
S34569

NCBI Reference Sequences

More...RefSeqi		NP_004151.3, NM_004160.5 [P10082-1]
XP_011523337.1, XM_011525035.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360085.6; ENSP00000353198.1; ENSG00000131096.11
ENST00000592796.2; ENSP00000467310.1; ENSG00000131096.11 [P10082-2]
ENST00000692052.1; ENSP00000509262.1; ENSG00000131096.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5697

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5697

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000692052.1; ENSP00000509262.1; NM_001394028.1; NP_001380957.1

UCSC genome browser

More...UCSCi		uc002ieq.4, human [P10082-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13897 Genomic DNA Translation: BAA02997.1
D13897 Genomic DNA Translation: BAA02998.1
D13899 mRNA Translation: BAA03000.1
D13902 mRNA Translation: BAA03002.1
L25648 Genomic DNA Translation: AAA36433.1
CR542129 mRNA Translation: CAG46926.1
AC007993 Genomic DNA No translation available.
BC041057 mRNA Translation: AAH41057.1
CCDSiCCDS32662.1 [P10082-1]
PIRiA31358
S33795
S34568
S34569
RefSeqiNP_004151.3, NM_004160.5 [P10082-1]
XP_011523337.1, XM_011525035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DEZNMR-A29-64[»]
2DF0NMR-A31-64[»]
2L60NMR-A41-64[»]
2NA5NMR-A31-63[»]
AlphaFoldDBiP10082
BMRBiP10082
SMRiP10082
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111670, 31 interactors
IntActiP10082, 4 interactors
MINTiP10082
STRINGi9606.ENSP00000353198

Genetic variation databases

BioMutaiPYY
DMDMi317373516

Proteomic databases

jPOSTiP10082
MassIVEiP10082
PaxDbiP10082
PeptideAtlasiP10082
PRIDEiP10082
ProteomicsDBi52563 [P10082-1]
52564 [P10082-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3390, 467 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		5697

Genome annotation databases

EnsembliENST00000360085.6; ENSP00000353198.1; ENSG00000131096.11
ENST00000592796.2; ENSP00000467310.1; ENSG00000131096.11 [P10082-2]
ENST00000692052.1; ENSP00000509262.1; ENSG00000131096.11
GeneIDi5697
KEGGihsa:5697
MANE-SelectiENST00000692052.1; ENSP00000509262.1; NM_001394028.1; NP_001380957.1
UCSCiuc002ieq.4, human [P10082-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5697
DisGeNETi5697

GeneCards: human genes, protein and diseases

More...GeneCardsi		PYY
HGNCiHGNC:9748, PYY
HPAiENSG00000131096, Tissue enriched (intestine)
MIMi600781, gene
neXtProtiNX_P10082
OpenTargetsiENSG00000131096
PharmGKBiPA34090
VEuPathDBiHostDB:ENSG00000131096

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S267, Eukaryota
GeneTreeiENSGT00940000160643
HOGENOMiCLU_162379_1_0_1
InParanoidiP10082
OMAiHAYPAKP
OrthoDBi1542445at2759
PhylomeDBiP10082
TreeFamiTF332778

Enzyme and pathway databases

PathwayCommonsiP10082
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events
SignaLinkiP10082
SIGNORiP10082

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5697, 6 hits in 1062 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PYY, human
EvolutionaryTraceiP10082

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Peptide_YY

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5697
PharosiP10082, Tbio

Protein Ontology

More...PROi		PR:P10082
RNActiP10082, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000131096, Expressed in mucosa of transverse colon and 79 other tissues
GenevisibleiP10082, HS

Family and domain databases

CDDicd00126, PAH, 1 hit
InterProiView protein in InterPro
IPR001955, Pancreatic_hormone-like
IPR020392, Pancreatic_hormone-like_CS
PANTHERiPTHR10533, PTHR10533, 1 hit
PfamiView protein in Pfam
PF00159, Hormone_3, 1 hit
PRINTSiPR00278, PANCHORMONE
SMARTiView protein in SMART
SM00309, PAH, 1 hit
PROSITEiView protein in PROSITE
PS00265, PANCREATIC_HORMONE_1, 1 hit
PS50276, PANCREATIC_HORMONE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYY_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10082
Secondary accession number(s): Q5U5Q6, Q6FGH8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 11, 2011
Last modified: May 25, 2022
This is version 191 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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