UniProtKB - P10082 (PYY_HUMAN)
Protein
Peptide YY
Gene
PYY
Organism
Homo sapiens (Human)
Status
Functioni
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
GO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
- neuropeptide Y receptor binding Source: GO_Central
GO - Biological processi
- feeding behavior Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- intestinal epithelial cell differentiation Source: GO_Central
- neuropeptide signaling pathway Source: GO_Central
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P10082 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P10082 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptide YY1 PublicationShort name: PYY1 Publication Alternative name(s): PYY-IBy similarity Peptide tyrosine tyrosine Cleaved into the following chain: Peptide YY(3-36)1 Publication Alternative name(s): PYY-IIBy similarity |
Gene namesi | Name:PYY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9748, PYY |
MIMi | 600781, gene |
neXtProti | NX_P10082 |
VEuPathDBi | HostDB:ENSG00000131096.10 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 5697 |
OpenTargetsi | ENSG00000131096 |
PharmGKBi | PA34090 |
Miscellaneous databases
Pharosi | P10082, Tbio |
Genetic variation databases
BioMutai | PYY |
DMDMi | 317373516 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 2 PublicationsAdd BLAST | 28 | |
PeptideiPRO_0000025384 | 29 – 64 | Peptide YYAdd BLAST | 36 | |
PeptideiPRO_0000025385 | 31 – 64 | Peptide YY(3-36)Add BLAST | 34 | |
PropeptideiPRO_0000025386 | 68 – 97 | Add BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 41 | PhosphoserineBy similarity | 1 | |
Modified residuei | 64 | Tyrosine amide2 Publications | 1 |
Post-translational modificationi
The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 30 – 31 | Cleavage; by FAP1 Publication | 2 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, PhosphoproteinProteomic databases
jPOSTi | P10082 |
MassIVEi | P10082 |
PaxDbi | P10082 |
PeptideAtlasi | P10082 |
PRIDEi | P10082 |
ProteomicsDBi | 52563 [P10082-1] 52564 [P10082-2] |
Expressioni
Gene expression databases
Bgeei | ENSG00000131096, Expressed in mucosa of transverse colon and 78 other tissues |
Genevisiblei | P10082, HS |
Organism-specific databases
HPAi | ENSG00000131096, Tissue enriched (intestine) |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- G protein-coupled receptor binding Source: GO_Central
- hormone activity Source: GO_Central
- neuropeptide hormone activity Source: GO_Central
- neuropeptide Y receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 111670, 7 interactors |
IntActi | P10082, 4 interactors |
MINTi | P10082 |
STRINGi | 9606.ENSP00000353198 |
Miscellaneous databases
RNActi | P10082, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P10082 |
SMRi | P10082 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10082 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NPY family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S267, Eukaryota |
GeneTreei | ENSGT00940000160643 |
HOGENOMi | CLU_162379_1_0_1 |
InParanoidi | P10082 |
OMAi | RDQRSRY |
OrthoDBi | 1542445at2759 |
PhylomeDBi | P10082 |
TreeFami | TF332778 |
Family and domain databases
CDDi | cd00126, PAH, 1 hit |
InterProi | View protein in InterPro IPR001955, Pancreatic_hormone-like IPR020392, Pancreatic_hormone-like_CS |
PANTHERi | PTHR10533, PTHR10533, 1 hit |
Pfami | View protein in Pfam PF00159, Hormone_3, 1 hit |
PRINTSi | PR00278, PANCHORMONE |
SMARTi | View protein in SMART SM00309, PAH, 1 hit |
PROSITEi | View protein in PROSITE PS00265, PANCREATIC_HORMONE_1, 1 hit PS50276, PANCREATIC_HORMONE_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P10082-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA
60 70 80 90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047407 | 37 | R → G6 PublicationsCorresponds to variant dbSNP:rs229969Ensembl. | 1 | |
Natural variantiVAR_006382 | 72 | T → R3 PublicationsCorresponds to variant dbSNP:rs1058046Ensembl. | 1 | |
Natural variantiVAR_047408 | 95 | D → H. Corresponds to variant dbSNP:rs465407Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005081 | 91 – 97 | Missing in isoform 2. 2 Publications | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13897 Genomic DNA Translation: BAA02997.1 D13897 Genomic DNA Translation: BAA02998.1 D13899 mRNA Translation: BAA03000.1 D13902 mRNA Translation: BAA03002.1 L25648 Genomic DNA Translation: AAA36433.1 CR542129 mRNA Translation: CAG46926.1 AC007993 Genomic DNA No translation available. BC041057 mRNA Translation: AAH41057.1 |
CCDSi | CCDS32662.1 [P10082-1] |
PIRi | A31358 S33795 S34568 S34569 |
RefSeqi | NP_004151.3, NM_004160.5 [P10082-1] XP_011523337.1, XM_011525035.1 |
Genome annotation databases
Ensembli | ENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1] ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2] |
GeneIDi | 5697 |
KEGGi | hsa:5697 |
UCSCi | uc002ieq.4, human [P10082-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13897 Genomic DNA Translation: BAA02997.1 D13897 Genomic DNA Translation: BAA02998.1 D13899 mRNA Translation: BAA03000.1 D13902 mRNA Translation: BAA03002.1 L25648 Genomic DNA Translation: AAA36433.1 CR542129 mRNA Translation: CAG46926.1 AC007993 Genomic DNA No translation available. BC041057 mRNA Translation: AAH41057.1 |
CCDSi | CCDS32662.1 [P10082-1] |
PIRi | A31358 S33795 S34568 S34569 |
RefSeqi | NP_004151.3, NM_004160.5 [P10082-1] XP_011523337.1, XM_011525035.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DEZ | NMR | - | A | 29-64 | [»] | |
2DF0 | NMR | - | A | 31-64 | [»] | |
2L60 | NMR | - | A | 41-64 | [»] | |
2NA5 | NMR | - | A | 31-63 | [»] | |
BMRBi | P10082 | |||||
SMRi | P10082 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111670, 7 interactors |
IntActi | P10082, 4 interactors |
MINTi | P10082 |
STRINGi | 9606.ENSP00000353198 |
Genetic variation databases
BioMutai | PYY |
DMDMi | 317373516 |
Proteomic databases
jPOSTi | P10082 |
MassIVEi | P10082 |
PaxDbi | P10082 |
PeptideAtlasi | P10082 |
PRIDEi | P10082 |
ProteomicsDBi | 52563 [P10082-1] 52564 [P10082-2] |
Protocols and materials databases
Antibodypediai | 3390, 455 antibodies |
Genome annotation databases
Ensembli | ENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1] ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2] |
GeneIDi | 5697 |
KEGGi | hsa:5697 |
UCSCi | uc002ieq.4, human [P10082-1] |
Organism-specific databases
CTDi | 5697 |
DisGeNETi | 5697 |
GeneCardsi | PYY |
HGNCi | HGNC:9748, PYY |
HPAi | ENSG00000131096, Tissue enriched (intestine) |
MIMi | 600781, gene |
neXtProti | NX_P10082 |
OpenTargetsi | ENSG00000131096 |
PharmGKBi | PA34090 |
VEuPathDBi | HostDB:ENSG00000131096.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S267, Eukaryota |
GeneTreei | ENSGT00940000160643 |
HOGENOMi | CLU_162379_1_0_1 |
InParanoidi | P10082 |
OMAi | RDQRSRY |
OrthoDBi | 1542445at2759 |
PhylomeDBi | P10082 |
TreeFami | TF332778 |
Enzyme and pathway databases
PathwayCommonsi | P10082 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P10082 |
Miscellaneous databases
BioGRID-ORCSi | 5697, 4 hits in 979 CRISPR screens |
ChiTaRSi | PYY, human |
EvolutionaryTracei | P10082 |
GeneWikii | Peptide_YY |
GenomeRNAii | 5697 |
Pharosi | P10082, Tbio |
PROi | PR:P10082 |
RNActi | P10082, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000131096, Expressed in mucosa of transverse colon and 78 other tissues |
Genevisiblei | P10082, HS |
Family and domain databases
CDDi | cd00126, PAH, 1 hit |
InterProi | View protein in InterPro IPR001955, Pancreatic_hormone-like IPR020392, Pancreatic_hormone-like_CS |
PANTHERi | PTHR10533, PTHR10533, 1 hit |
Pfami | View protein in Pfam PF00159, Hormone_3, 1 hit |
PRINTSi | PR00278, PANCHORMONE |
SMARTi | View protein in SMART SM00309, PAH, 1 hit |
PROSITEi | View protein in PROSITE PS00265, PANCREATIC_HORMONE_1, 1 hit PS50276, PANCREATIC_HORMONE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PYY_HUMAN | |
Accessioni | P10082Primary (citable) accession number: P10082 Secondary accession number(s): Q5U5Q6, Q6FGH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 11, 2011 | |
Last modified: | April 7, 2021 | |
This is version 187 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families