PYY

Functionⁱ

This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: GO_Central
Inferred from physical interactionⁱ
- 7592911
- 7493937
hormone activity
Source: ProtInc
Traceable author statementⁱ
- 10698177
neuropeptide hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10488139
feeding behavior
Source: ProtInc
Traceable author statementⁱ
- 10698177
G protein-coupled receptor signaling pathway Source: Reactome
neuropeptide signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P10082

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peptide YY1 Publication Short name: PYY1 Publication Alternative name(s): PYY-IBy similarity Peptide tyrosine tyrosine Cleaved into the following chain: Peptide YY(3-36)1 Publication Alternative name(s): PYY-IIBy similarity
Gene namesⁱ	Name:PYY
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000131096.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9748 PYY
MIMⁱ	600781 gene
neXtProtⁱ	NX_P10082

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5697
Open Targets More...OpenTargetsⁱ	ENSG00000131096
PharmGKBⁱ	PA34090

Polymorphism and mutation databases

BioMutaⁱ	PYY
DMDMⁱ	317373516

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 28	2 PublicationsAdd BLAST	28
PeptideⁱPRO_0000025384	29 – 64	Peptide YYAdd BLAST	36
PeptideⁱPRO_0000025385	31 – 64	Peptide YY(3-36)Add BLAST	34
PropeptideⁱPRO_0000025386	68 – 97	Add BLAST	30

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	41	PhosphoserineBy similarity		1
Modified residueⁱ	64	Tyrosine amide2 Publications		1

Post-translational modificationⁱ

The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36).1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	30 – 31	Cleavage; by FAP1 Publication		2

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbⁱ	P10082
PeptideAtlas More...PeptideAtlasⁱ	P10082
PRIDEⁱ	P10082
ProteomicsDBⁱ	52563 52564 [P10082-2]

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000131096 Expressed in 50 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_PYY
Genevisibleⁱ	P10082 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016734 HPA010973

HPAⁱ

CAB016734
HPA010973

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NPY1R	P25929	2	EBI-6655667,EBI-372227
NPY2R	P49146	2	EBI-6655667,EBI-6655721

GO - Molecular functionⁱ

G protein-coupled receptor binding
Source: GO_Central
Inferred from physical interactionⁱ
- 7592911
- 7493937
hormone activity
Source: ProtInc
Traceable author statementⁱ
- 10698177
neuropeptide hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111670, 6 interactors
IntActⁱ	P10082, 4 interactors
Molecular INTeraction database More...MINTⁱ	P10082
STRINGⁱ	9606.ENSP00000353198

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 33	Combined sources	3
Helixⁱ	41 – 59	Combined sources	19
Turnⁱ	60 – 62	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P10082
SMRⁱ	P10082
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10082

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the NPY family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J0E4 Eukaryota ENOG4111U8V LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010775
HOGENOMⁱ	HOG000252942
HOVERGENⁱ	HBG006485
InParanoidⁱ	P10082
KEGG Orthology (KO) More...KOⁱ	K05233
OMAⁱ	YTALRHY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ZRE
PhylomeDBⁱ	P10082
TreeFamⁱ	TF332778

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00126 PAH, 1 hit
InterProⁱ	View protein in InterPro IPR001955 Pancreatic_hormone-like IPR020392 Pancreatic_hormone-like_CS
PANTHERⁱ	PTHR10533 PTHR10533, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00159 Hormone_3, 1 hit
PRINTSⁱ	PR00278 PANCHORMONE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001267 Pancreatic_hormone-like, 1 hit
SMARTⁱ	View protein in SMART SM00309 PAH, 1 hit
PROSITEⁱ	View protein in PROSITE PS00265 PANCREATIC_HORMONE_1, 1 hit PS50276 PANCREATIC_HORMONE_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P10082-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA 
        60         70         80         90 
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR SEGPDLW

Length:97

Mass (Da):11,145

Last modified:January 11, 2011 - v3

Checksum:ⁱC166B73412E356B1

GO

Isoform 2 (identifier: P10082-2) [UniParc]FASTA Add to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
91-97: Missing.

« Hide

        10         20         30         40         50
MVFVRRPWPA LTTVLLALLV CLGALVDAYP IKPEAPREDA SPEELNRYYA 
        60         70         80         90
SLRHYLNLVT RQRYGKRDGP DTLLSKTFFP DGEDRPVRSR

Show »

Length:90

Mass (Da):10,360

Checksum:ⁱA1C48F08021136B4

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047407	37	R → G6 PublicationsCorresponds to variant dbSNP:rs229969Ensembl.	1
Natural variantⁱVAR_006382	72	T → R3 PublicationsCorresponds to variant dbSNP:rs1058046Ensembl.	1
Natural variantⁱVAR_047408	95	D → H. Corresponds to variant dbSNP:rs465407Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005081	91 – 97	Missing in isoform 2. 2 Publications		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13897 Genomic DNA Translation: BAA02997.1 D13897 Genomic DNA Translation: BAA02998.1 D13899 mRNA Translation: BAA03000.1 D13902 mRNA Translation: BAA03002.1 L25648 Genomic DNA Translation: AAA36433.1 CR542129 mRNA Translation: CAG46926.1 AC007993 Genomic DNA No translation available. BC041057 mRNA Translation: AAH41057.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32662.1 [P10082-1]
PIRⁱ	A31358 S33795 S34568 S34569
NCBI Reference Sequences More...RefSeqⁱ	NP_004151.3, NM_004160.5 XP_011523337.1, XM_011525035.1
UniGeneⁱ	Hs.169249

Genome annotation databases

Ensemblⁱ	ENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1] ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2]
GeneIDⁱ	5697
KEGGⁱ	hsa:5697
UCSC genome browser More...UCSCⁱ	uc002ieq.4 human [P10082-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10082	Isoform 2 of Peptide YY		HUMAN		90	UniRef90_P10082
PYY isoform 1		PONAB		97
PYY isoform 2		PANTR		90
Peptide YY		GORGO		97
Uncharacterized protein		PANPA		95
+3

Protein	Similar proteins		Species	Score	Length	Source
P10082	Peptide YY-like		PELRI		36	UniRef50_P10082
Peptide YY-like		CHICK		37
Goannatyrotoxin-Vere1		VARER		99
Peptide YY		RAT		98
Peptide YY		MOUSE		98
+74

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D13897 Genomic DNA Translation: BAA02997.1 D13897 Genomic DNA Translation: BAA02998.1 D13899 mRNA Translation: BAA03000.1 D13902 mRNA Translation: BAA03002.1 L25648 Genomic DNA Translation: AAA36433.1 CR542129 mRNA Translation: CAG46926.1 AC007993 Genomic DNA No translation available. BC041057 mRNA Translation: AAH41057.1
CCDSⁱ	CCDS32662.1 [P10082-1]
PIRⁱ	A31358 S33795 S34568 S34569
RefSeqⁱ	NP_004151.3, NM_004160.5 XP_011523337.1, XM_011525035.1
UniGeneⁱ	Hs.169249

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DEZ	NMR	-	A	29-64	[»]
	2DF0	NMR	-	A	31-64	[»]
	2L60	NMR	-	A	41-64	[»]
	2NA5	NMR	-	A	31-63	[»]
ProteinModelPortalⁱ	P10082
SMRⁱ	P10082
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111670, 6 interactors
IntActⁱ	P10082, 4 interactors
MINTⁱ	P10082
STRINGⁱ	9606.ENSP00000353198

Polymorphism and mutation databases

BioMutaⁱ	PYY
DMDMⁱ	317373516

Proteomic databases

PaxDbⁱ	P10082
PeptideAtlasⁱ	P10082
PRIDEⁱ	P10082
ProteomicsDBⁱ	52563 52564 [P10082-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000360085; ENSP00000353198; ENSG00000131096 [P10082-1] ENST00000592796; ENSP00000467310; ENSG00000131096 [P10082-2]
GeneIDⁱ	5697
KEGGⁱ	hsa:5697
UCSCⁱ	uc002ieq.4 human [P10082-1]

Organism-specific databases

CTDⁱ	5697
DisGeNETⁱ	5697
EuPathDBⁱ	HostDB:ENSG00000131096.10
GeneCardsⁱ	PYY
HGNCⁱ	HGNC:9748 PYY
HPAⁱ	CAB016734 HPA010973
MIMⁱ	600781 gene
neXtProtⁱ	NX_P10082
OpenTargetsⁱ	ENSG00000131096
PharmGKBⁱ	PA34090
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0E4 Eukaryota ENOG4111U8V LUCA
GeneTreeⁱ	ENSGT00390000010775
HOGENOMⁱ	HOG000252942
HOVERGENⁱ	HBG006485
InParanoidⁱ	P10082
KOⁱ	K05233
OMAⁱ	YTALRHY
OrthoDBⁱ	EOG091G0ZRE
PhylomeDBⁱ	P10082
TreeFamⁱ	TF332778

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P10082

Miscellaneous databases

EvolutionaryTraceⁱ	P10082
GeneWikiⁱ	Peptide_YY
GenomeRNAiⁱ	5697
Protein Ontology More...PROⁱ	PR:P10082
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000131096 Expressed in 50 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_PYY
Genevisibleⁱ	P10082 HS

Family and domain databases

CDDⁱ	cd00126 PAH, 1 hit
InterProⁱ	View protein in InterPro IPR001955 Pancreatic_hormone-like IPR020392 Pancreatic_hormone-like_CS
PANTHERⁱ	PTHR10533 PTHR10533, 1 hit
Pfamⁱ	View protein in Pfam PF00159 Hormone_3, 1 hit
PRINTSⁱ	PR00278 PANCHORMONE
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001267 Pancreatic_hormone-like, 1 hit
SMARTⁱ	View protein in SMART SM00309 PAH, 1 hit
PROSITEⁱ	View protein in PROSITE PS00265 PANCREATIC_HORMONE_1, 1 hit PS50276 PANCREATIC_HORMONE_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PYY_HUMAN
Accessionⁱ	P10082Primary (citable) accession number: P10082 Secondary accession number(s): Q5U5Q6, Q6FGH8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10082 (PYY_HUMAN)

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Peptide YY

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Sites

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ