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UniProtKB - P10078 (ZFP28_MOUSE)

Protein

Zinc finger protein 28

Gene

Zfp28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation. May have a role in embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 399C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 456C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri462 – 484C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 680C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 708C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri714 – 736C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 764C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri770 – 792C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 28
Short name:
Zfp-28
Alternative name(s):
Protein mKR5
Gene namesi
Name:Zfp28
Synonyms:Mkr5, Zfp-28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99175 Zfp28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472901 – 825Zinc finger protein 28Add BLAST825

Proteomic databases

MaxQBiP10078
PaxDbiP10078
PRIDEiP10078

PTM databases

iPTMnetiP10078
PhosphoSitePlusiP10078

Expressioni

Tissue specificityi

Expressed predominantly in ovary.

Developmental stagei

Expression decreases in embryo after day 16.

Gene expression databases

BgeeiENSMUSG00000062861 Expressed in 188 organ(s), highest expression level in oocyte
CleanExiMM_ZFP28
ExpressionAtlasiP10078 baseline and differential
GenevisibleiP10078 MM

Interactioni

Protein-protein interaction databases

BioGridi204654, 1 interactor
STRINGi10090.ENSMUSP00000079812

Structurei

3D structure databases

ProteinModelPortaliP10078
SMRiP10078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 174KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri377 – 399C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 456C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri462 – 484C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri490 – 512C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri518 – 540C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri546 – 568C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri574 – 596C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri602 – 624C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri630 – 652C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri658 – 680C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri686 – 708C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri714 – 736C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri742 – 764C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri770 – 792C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOVERGENiHBG018163
InParanoidiP10078
KOiK09228
OMAiTGIYAGK
OrthoDBiEOG091G02KC
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10078-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQGMASVVSC EPWALLGRGA LCTKARPGGG PAAGTVVAPG SPDRGRPRSR 
        60         70         80         90        100
NSLASQDQQG AVTSGTAHKA LFSRDTNFLQ EINRKQEAAP TGTRHKAKSQ 
       110        120        130        140        150
GLVTFGDVAV VFSQEEWEWL NSEQRSLYWK VMLDNYRNLA SLGLCASQPD 
       160        170        180        190        200
MITSLEQGRD PWMMKRKMRK GQHLDLKAMQ ETKEFPPKDL SEETLFLAVL 
       210        220        230        240        250
RKQLLPHRPK CSMVRAAWEG GAVFTTHRGL KTNSGLARDS PAQLVSAQRS 
       260        270        280        290        300
FCKSVTWENC GDRGSVGQQS VQEAQDLLPR QDSHAERVTG RTWSTKLECS 
       310        320        330        340        350
TFRDQDSECT FERNEQETVT PNRAFSEGRD GMCIESGRWF HLNSSDERSH 
       360        370        380        390        400
NCDSGKSFSS NPVVVKETGI CSGKKLFQCN ECKKTFTQSS SLTVHQRIHT 
       410        420        430        440        450
GEKPYKCNQC GKAFSDGSSF ARHQRCHTGK KPYECPECGK AFIQNTSLVR 
       460        470        480        490        500
HWRYYHTGEK PFDCIDCGKA FSDHIGLNQH RRIHTGEKPY TCEVCHKSFR 
       510        520        530        540        550
YGSSLTVHQR IHTGEKPYEC EICRKAFSHH ASLTQHQRVH SGEKPFKCKE 
       560        570        580        590        600
CGKAFRQNIH LASHWRIHTG EKPFECGECG KSFSISSQLA THQRIHTGEK 
       610        620        630        640        650
PYECKVCRKA FTQKAHLAQH QKTHTGEKPY ECKECGKAFS QTTHLIQHQR 
       660        670        680        690        700
VHTGEKPYKC LECGKAFGDN SSCTQHRRLH TGQRPYECVE CGKTFKTKSS 
       710        720        730        740        750
LICHRRCHTG EKPYECSACG KAFSHRQSLS VHQRIHSGKK PYECKECRKT 
       760        770        780        790        800
FIQIGHLNQH KRVHTGERTY NYKKGRRAFR QTAHFAHHQQ IHSGKSPAHH 
       810        820 
SLPSTSNPVD LFSKFVWNPS SLPSS
Length:825
Mass (Da):93,309
Last modified:August 4, 2003 - v3
Checksum:i19BABAC25F2908E6
GO
Isoform 2 (identifier: P10078-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-600: K → KPFECKVCRKAFRQNIHLASHWRIHTGEKPFECGECGKSFSISSQLATHQRIHTGEK

Note: No experimental confirmation available.
Show »
Length:881
Mass (Da):99,745
Checksum:i79243B47C9F89C71
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LJ19A0A140LJ19_MOUSE
Zinc finger protein 28
Zfp28
161Annotation score:
A0A140LIA3A0A140LIA3_MOUSE
Zinc finger protein 28
Zfp28
171Annotation score:
A0A140LIS3A0A140LIS3_MOUSE
Zinc finger protein 28
Zfp28
30Annotation score:
A0A140LJB6A0A140LJB6_MOUSE
Zinc finger protein 28
Zfp28
56Annotation score:
A0A140LIZ0A0A140LIZ0_MOUSE
Zinc finger protein 28
Zfp28
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263R → W in BAC33362 (PubMed:16141072).Curated1
Sequence conflicti426C → Y in CAA31107 (PubMed:3143103).Curated1
Sequence conflicti426C → Y in AAA37120 (PubMed:3143103).Curated1
Sequence conflicti677R → Q (PubMed:3143103).Curated1
Sequence conflicti677R → Q (PubMed:7958967).Curated1
Sequence conflicti683Q → L (PubMed:3143103).Curated1
Sequence conflicti683Q → L (PubMed:7958967).Curated1
Sequence conflicti704 – 705HR → YC (PubMed:3143103).Curated2
Sequence conflicti704 – 705HR → YC (PubMed:7958967).Curated2
Sequence conflicti726R → W (PubMed:3143103).Curated1
Sequence conflicti726R → W (PubMed:7958967).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti658Y → I in strain: 129/Sv; requires 2 nucleotide substitutions. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006882600K → KPFECKVCRKAFRQNIHLAS HWRIHTGEKPFECGECGKSF SISSQLATHQRIHTGEK in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028202 mRNA Translation: BAC25810.1
AK048530 mRNA Translation: BAC33362.1
BC062116 mRNA Translation: AAH62116.1
X12594 mRNA Translation: CAA31107.1
M36516 mRNA Translation: AAA37120.1
L28802 Genomic DNA Translation: AAA64428.1
CCDSiCCDS39752.1 [P10078-1]
PIRiI53859
RefSeqiNP_780456.2, NM_175247.3 [P10078-1]
UniGeneiMm.127014

Genome annotation databases

EnsembliENSMUST00000081022; ENSMUSP00000079812; ENSMUSG00000062861 [P10078-1]
GeneIDi22690
KEGGimmu:22690
UCSCiuc009fbi.1 mouse [P10078-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028202 mRNA Translation: BAC25810.1
AK048530 mRNA Translation: BAC33362.1
BC062116 mRNA Translation: AAH62116.1
X12594 mRNA Translation: CAA31107.1
M36516 mRNA Translation: AAA37120.1
L28802 Genomic DNA Translation: AAA64428.1
CCDSiCCDS39752.1 [P10078-1]
PIRiI53859
RefSeqiNP_780456.2, NM_175247.3 [P10078-1]
UniGeneiMm.127014

3D structure databases

ProteinModelPortaliP10078
SMRiP10078
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204654, 1 interactor
STRINGi10090.ENSMUSP00000079812

PTM databases

iPTMnetiP10078
PhosphoSitePlusiP10078

Proteomic databases

MaxQBiP10078
PaxDbiP10078
PRIDEiP10078

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081022; ENSMUSP00000079812; ENSMUSG00000062861 [P10078-1]
GeneIDi22690
KEGGimmu:22690
UCSCiuc009fbi.1 mouse [P10078-1]

Organism-specific databases

CTDi140612
MGIiMGI:99175 Zfp28

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOVERGENiHBG018163
InParanoidiP10078
KOiK09228
OMAiTGIYAGK
OrthoDBiEOG091G02KC
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:P10078
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062861 Expressed in 188 organ(s), highest expression level in oocyte
CleanExiMM_ZFP28
ExpressionAtlasiP10078 baseline and differential
GenevisibleiP10078 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP28_MOUSE
AccessioniPrimary (citable) accession number: P10078
Secondary accession number(s): Q61776, Q8BT11, Q8C836
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 4, 2003
Last modified: November 7, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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