UniProtKB - P10075 (GLI4_HUMAN)

BLAST

>sp|P10075|GLI4_HUMAN Zinc finger protein GLI4 OS=Homo sapiens OX=9606 GN=GLI4 PE=1 SV=2
MAALGDIQESPSVPSPVSLSSPGTPGTQHHEPQLHLHGHQHGSPGSSPKVLSQPSDLDLQ
DVEEVEIGRDTFWPDSEPKPEQAPRSPGSQAPDEGAGGALRSLLRSLPRRARCSAGFGPE
SSAERPAGQPPGAVPCAQPRGAWRVTLVQQAAAGPEGAPERAAELGVNFGRSRQGSARGA
KPHRCEACGKSFKYNSLLLKHQRIHTGEKPYACHECGKRFRGWSGFIQHHRIHTGEKPYE
CGQCGRAFSHSSHFTQHLRIHNGEKPYKCGECGQAFSQSSNLVRHQRLHTGEKPYACSQC
GKAFIWSSVLIEHQRIHTGEKPYECSDCGKAFRGRSHFFRHLRTHTGEKPFACGACGKAF
GQSSQLIQHQRVHYRE

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History
Entry version 172 (07 Nov 2018)
Sequence version 2 (25 Jul 2003)
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Protein

Zinc finger protein GLI4

Gene

GLI4

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	183 – 205	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	211 – 233	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	239 – 261	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	267 – 289	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	295 – 317	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	323 – 345	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein GLI4 Alternative name(s): Krueppel-related zinc finger protein 4 Protein HKR4
Gene namesⁱ	Name:GLI4 Synonyms:HKR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000250571.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4320 GLI4
MIMⁱ	165280 gene
neXtProtⁱ	NX_P10075

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000250571
PharmGKBⁱ	PA28723

Polymorphism and mutation databases

BioMutaⁱ	GLI4
DMDMⁱ	33302619

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047267	1 – 376	Zinc finger protein GLI4Add BLAST		376

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	86	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P10075
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10075
PaxDbⁱ	P10075
PeptideAtlas More...PeptideAtlasⁱ	P10075
PRIDEⁱ	P10075
ProteomicsDBⁱ	52562

PTM databases

iPTMnetⁱ	P10075
PhosphoSitePlusⁱ	P10075

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000250571 Expressed in 91 organ(s), highest expression level in myometrium
CleanExⁱ	HS_GLI4
ExpressionAtlasⁱ	P10075 baseline and differential
Genevisibleⁱ	P10075 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023131

HPAⁱ

HPA023131

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109000, 3 interactors
IntActⁱ	P10075, 1 interactor
STRINGⁱ	9606.ENSP00000345024

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10075
SMRⁱ	P10075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	183 – 205	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	211 – 233	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	239 – 261	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	267 – 289	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	295 – 317	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	323 – 345	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	351 – 373	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150877
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10075
OMAⁱ	TCWPDSE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10075
TreeFamⁱ	TF337438

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P10075-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV 
        60         70         80         90        100
LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL 
       110        120        130        140        150
RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ 
       160        170        180        190        200
AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK 
       210        220        230        240        250
HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH 
       260        270        280        290        300
SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC 
       310        320        330        340        350
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP 
       360        370 
FACGACGKAF GQSSQLIQHQ RVHYRE

Length:376

Mass (Da):41,145

Last modified:July 25, 2003 - v2

Checksum:ⁱ68B1A638CC0758BC

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RGM1	E5RGM1_HUMAN	Zinc finger protein GLI4 Zinc finger protein GLI4	GLI4	76	Annotation score:
E5RG07	E5RG07_HUMAN	Zinc finger protein GLI4 Zinc finger protein GLI4	GLI4	165	Annotation score:
H0YBH2	H0YBH2_HUMAN	Zinc finger protein GLI4 Zinc finger protein GLI4	GLI4	86	Annotation score:
E5RFY1	E5RFY1_HUMAN	Zinc finger protein GLI4 Zinc finger protein GLI4	GLI4	111	Annotation score:
E5RIX4	E5RIX4_HUMAN	Zinc finger protein GLI4 Zinc finger protein GLI4	GLI4	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	144 – 146	RVT → ARD in AAA35990 (PubMed:2850480).Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052734	180	A → T1 PublicationCorresponds to variant dbSNP:rs1056148Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014165 mRNA Translation: AAH14165.1 M20678 Genomic DNA Translation: AAA35990.1 M20679 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6398.1
PIRⁱ	F31201
NCBI Reference Sequences More...RefSeqⁱ	NP_612474.1, NM_138465.3
UniGeneⁱ	Hs.400533

Genome annotation databases

Ensemblⁱ	ENST00000340042; ENSP00000345024; ENSG00000250571 ENST00000523522; ENSP00000430987; ENSG00000250571
GeneIDⁱ	2738
KEGGⁱ	hsa:2738
UCSC genome browser More...UCSCⁱ	uc003yxx.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10075	GLI family zinc finger 4		PANTR		376	UniRef90_P10075
GLI4 isoform 3		PONAB		376
Uncharacterized protein		CERAT		376
GLI family zinc finger 4		GORGO		376
Uncharacterized protein		MACFA		376
+11

Protein	Similar proteins		Species	Score	Length	Source
P10075	GLI4 isoform 3		PONAB		376	UniRef50_P10075
GLI family zinc finger 4		PANTR		376
Uncharacterized protein		MACNE		376
Uncharacterized protein		MACFA		376
GLI family zinc finger 4		GORGO		376
+15

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC014165 mRNA Translation: AAH14165.1 M20678 Genomic DNA Translation: AAA35990.1 M20679 Genomic DNA No translation available.
CCDSⁱ	CCDS6398.1
PIRⁱ	F31201
RefSeqⁱ	NP_612474.1, NM_138465.3
UniGeneⁱ	Hs.400533

3D structure databases

ProteinModelPortalⁱ	P10075
SMRⁱ	P10075
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109000, 3 interactors
IntActⁱ	P10075, 1 interactor
STRINGⁱ	9606.ENSP00000345024

PTM databases

iPTMnetⁱ	P10075
PhosphoSitePlusⁱ	P10075

Polymorphism and mutation databases

BioMutaⁱ	GLI4
DMDMⁱ	33302619

Proteomic databases

EPDⁱ	P10075
MaxQBⁱ	P10075
PaxDbⁱ	P10075
PeptideAtlasⁱ	P10075
PRIDEⁱ	P10075
ProteomicsDBⁱ	52562

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2738
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340042; ENSP00000345024; ENSG00000250571 ENST00000523522; ENSP00000430987; ENSG00000250571
GeneIDⁱ	2738
KEGGⁱ	hsa:2738
UCSCⁱ	uc003yxx.4 human

Organism-specific databases

CTDⁱ	2738
EuPathDBⁱ	HostDB:ENSG00000250571.6
GeneCardsⁱ	GLI4
HGNCⁱ	HGNC:4320 GLI4
HPAⁱ	HPA023131
MIMⁱ	165280 gene
neXtProtⁱ	NX_P10075
OpenTargetsⁱ	ENSG00000250571
PharmGKBⁱ	PA28723
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150877
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10075
OMAⁱ	TCWPDSE
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10075
TreeFamⁱ	TF337438

Miscellaneous databases

GenomeRNAiⁱ	2738
Protein Ontology More...PROⁱ	PR:P10075
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000250571 Expressed in 91 organ(s), highest expression level in myometrium
CleanExⁱ	HS_GLI4
ExpressionAtlasⁱ	P10075 baseline and differential
Genevisibleⁱ	P10075 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLI4_HUMAN
Accessionⁱ	P10075Primary (citable) accession number: P10075 Secondary accession number(s): Q96CK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 25, 2003
	Last modified:	November 7, 2018
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

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Supporting data

UniProtKB - P10075 (GLI4_HUMAN)

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Zinc finger protein GLI4

GLI4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ