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Protein

Zinc finger protein GLI4

Gene

GLI4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLI4
Alternative name(s):
Krueppel-related zinc finger protein 4
Protein HKR4
Gene namesi
Name:GLI4
Synonyms:HKR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000250571.6
HGNCiHGNC:4320 GLI4
MIMi165280 gene
neXtProtiNX_P10075

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000250571
PharmGKBiPA28723

Polymorphism and mutation databases

BioMutaiGLI4
DMDMi33302619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472671 – 376Zinc finger protein GLI4Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP10075
MaxQBiP10075
PaxDbiP10075
PeptideAtlasiP10075
PRIDEiP10075
ProteomicsDBi52562

PTM databases

iPTMnetiP10075
PhosphoSitePlusiP10075

Expressioni

Gene expression databases

BgeeiENSG00000250571 Expressed in 91 organ(s), highest expression level in myometrium
CleanExiHS_GLI4
ExpressionAtlasiP10075 baseline and differential
GenevisibleiP10075 HS

Organism-specific databases

HPAiHPA023131

Interactioni

Protein-protein interaction databases

BioGridi109000, 3 interactors
IntActiP10075, 1 interactor
STRINGi9606.ENSP00000345024

Structurei

3D structure databases

ProteinModelPortaliP10075
SMRiP10075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri183 – 205C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri211 – 233C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri239 – 261C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10075
OMAiTCWPDSE
OrthoDBiEOG091G02KC
PhylomeDBiP10075
TreeFamiTF337438

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P10075-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV
60 70 80 90 100
LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL
110 120 130 140 150
RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ
160 170 180 190 200
AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK
210 220 230 240 250
HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH
260 270 280 290 300
SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC
310 320 330 340 350
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP
360 370
FACGACGKAF GQSSQLIQHQ RVHYRE
Length:376
Mass (Da):41,145
Last modified:July 25, 2003 - v2
Checksum:i68B1A638CC0758BC
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGM1E5RGM1_HUMAN
Zinc finger protein GLI4
GLI4
76Annotation score:
E5RG07E5RG07_HUMAN
Zinc finger protein GLI4
GLI4
165Annotation score:
H0YBH2H0YBH2_HUMAN
Zinc finger protein GLI4
GLI4
86Annotation score:
E5RFY1E5RFY1_HUMAN
Zinc finger protein GLI4
GLI4
111Annotation score:
E5RIX4E5RIX4_HUMAN
Zinc finger protein GLI4
GLI4
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 146RVT → ARD in AAA35990 (PubMed:2850480).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052734180A → T1 PublicationCorresponds to variant dbSNP:rs1056148Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA Translation: AAH14165.1
M20678 Genomic DNA Translation: AAA35990.1
M20679 Genomic DNA No translation available.
CCDSiCCDS6398.1
PIRiF31201
RefSeqiNP_612474.1, NM_138465.3
UniGeneiHs.400533

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571
ENST00000523522; ENSP00000430987; ENSG00000250571
GeneIDi2738
KEGGihsa:2738
UCSCiuc003yxx.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014165 mRNA Translation: AAH14165.1
M20678 Genomic DNA Translation: AAA35990.1
M20679 Genomic DNA No translation available.
CCDSiCCDS6398.1
PIRiF31201
RefSeqiNP_612474.1, NM_138465.3
UniGeneiHs.400533

3D structure databases

ProteinModelPortaliP10075
SMRiP10075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109000, 3 interactors
IntActiP10075, 1 interactor
STRINGi9606.ENSP00000345024

PTM databases

iPTMnetiP10075
PhosphoSitePlusiP10075

Polymorphism and mutation databases

BioMutaiGLI4
DMDMi33302619

Proteomic databases

EPDiP10075
MaxQBiP10075
PaxDbiP10075
PeptideAtlasiP10075
PRIDEiP10075
ProteomicsDBi52562

Protocols and materials databases

DNASUi2738
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340042; ENSP00000345024; ENSG00000250571
ENST00000523522; ENSP00000430987; ENSG00000250571
GeneIDi2738
KEGGihsa:2738
UCSCiuc003yxx.4 human

Organism-specific databases

CTDi2738
EuPathDBiHostDB:ENSG00000250571.6
GeneCardsiGLI4
HGNCiHGNC:4320 GLI4
HPAiHPA023131
MIMi165280 gene
neXtProtiNX_P10075
OpenTargetsiENSG00000250571
PharmGKBiPA28723
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10075
OMAiTCWPDSE
OrthoDBiEOG091G02KC
PhylomeDBiP10075
TreeFamiTF337438

Miscellaneous databases

GenomeRNAii2738
PROiPR:P10075
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000250571 Expressed in 91 organ(s), highest expression level in myometrium
CleanExiHS_GLI4
ExpressionAtlasiP10075 baseline and differential
GenevisibleiP10075 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGLI4_HUMAN
AccessioniPrimary (citable) accession number: P10075
Secondary accession number(s): Q96CK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 25, 2003
Last modified: November 7, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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