UniProtKB - P10075 (GLI4_HUMAN)
Protein
Zinc finger protein GLI4
Gene
GLI4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 183 – 205 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 211 – 233 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P10075 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein GLI4Alternative name(s): Krueppel-related zinc finger protein 4 Protein HKR4 |
Gene namesi | Name:GLI4 Synonyms:HKR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000250571.6 |
HGNCi | HGNC:4320, GLI4 |
MIMi | 165280, gene |
neXtProti | NX_P10075 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 2738 |
OpenTargetsi | ENSG00000250571 |
PharmGKBi | PA28723 |
Miscellaneous databases
Pharosi | P10075, Tbio |
Polymorphism and mutation databases
BioMutai | GLI4 |
DMDMi | 33302619 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047267 | 1 – 376 | Zinc finger protein GLI4Add BLAST | 376 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P10075 |
jPOSTi | P10075 |
MassIVEi | P10075 |
MaxQBi | P10075 |
PaxDbi | P10075 |
PeptideAtlasi | P10075 |
PRIDEi | P10075 |
ProteomicsDBi | 52562 |
PTM databases
iPTMneti | P10075 |
PhosphoSitePlusi | P10075 |
Expressioni
Gene expression databases
Bgeei | ENSG00000250571, Expressed in stomach and 116 other tissues |
ExpressionAtlasi | P10075, baseline and differential |
Genevisiblei | P10075, HS |
Organism-specific databases
HPAi | ENSG00000250571, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109000, 4 interactors |
IntActi | P10075, 5 interactors |
STRINGi | 9606.ENSP00000345024 |
Miscellaneous databases
RNActi | P10075, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 183 – 205 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 211 – 233 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163360 |
HOGENOMi | CLU_002678_1_0_1 |
InParanoidi | P10075 |
OMAi | HEAQLHL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10075 |
TreeFami | TF337438 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P10075-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV
60 70 80 90 100
LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL
110 120 130 140 150
RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ
160 170 180 190 200
AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK
210 220 230 240 250
HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH
260 270 280 290 300
SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC
310 320 330 340 350
GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP
360 370
FACGACGKAF GQSSQLIQHQ RVHYRE
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFY1 | E5RFY1_HUMAN | Zinc finger protein GLI4 | GLI4 | 111 | Annotation score: | ||
E5RG07 | E5RG07_HUMAN | Zinc finger protein GLI4 | GLI4 | 165 | Annotation score: | ||
E5RGM1 | E5RGM1_HUMAN | Zinc finger protein GLI4 | GLI4 | 76 | Annotation score: | ||
E5RIX4 | E5RIX4_HUMAN | Zinc finger protein GLI4 | GLI4 | 56 | Annotation score: | ||
H0YBH2 | H0YBH2_HUMAN | Zinc finger protein GLI4 | GLI4 | 86 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 – 146 | RVT → ARD in AAA35990 (PubMed:2850480).Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052734 | 180 | A → T1 PublicationCorresponds to variant dbSNP:rs1056148Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014165 mRNA Translation: AAH14165.1 M20678 Genomic DNA Translation: AAA35990.1 M20679 Genomic DNA No translation available. |
CCDSi | CCDS6398.1 |
PIRi | F31201 |
RefSeqi | NP_612474.1, NM_138465.3 |
Genome annotation databases
Ensembli | ENST00000340042; ENSP00000345024; ENSG00000250571 ENST00000523522; ENSP00000430987; ENSG00000250571 |
GeneIDi | 2738 |
KEGGi | hsa:2738 |
UCSCi | uc003yxx.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC014165 mRNA Translation: AAH14165.1 M20678 Genomic DNA Translation: AAA35990.1 M20679 Genomic DNA No translation available. |
CCDSi | CCDS6398.1 |
PIRi | F31201 |
RefSeqi | NP_612474.1, NM_138465.3 |
3D structure databases
SMRi | P10075 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109000, 4 interactors |
IntActi | P10075, 5 interactors |
STRINGi | 9606.ENSP00000345024 |
PTM databases
iPTMneti | P10075 |
PhosphoSitePlusi | P10075 |
Polymorphism and mutation databases
BioMutai | GLI4 |
DMDMi | 33302619 |
Proteomic databases
EPDi | P10075 |
jPOSTi | P10075 |
MassIVEi | P10075 |
MaxQBi | P10075 |
PaxDbi | P10075 |
PeptideAtlasi | P10075 |
PRIDEi | P10075 |
ProteomicsDBi | 52562 |
Protocols and materials databases
Antibodypediai | 43401, 184 antibodies |
DNASUi | 2738 |
Genome annotation databases
Ensembli | ENST00000340042; ENSP00000345024; ENSG00000250571 ENST00000523522; ENSP00000430987; ENSG00000250571 |
GeneIDi | 2738 |
KEGGi | hsa:2738 |
UCSCi | uc003yxx.4, human |
Organism-specific databases
CTDi | 2738 |
DisGeNETi | 2738 |
EuPathDBi | HostDB:ENSG00000250571.6 |
GeneCardsi | GLI4 |
HGNCi | HGNC:4320, GLI4 |
HPAi | ENSG00000250571, Low tissue specificity |
MIMi | 165280, gene |
neXtProti | NX_P10075 |
OpenTargetsi | ENSG00000250571 |
PharmGKBi | PA28723 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163360 |
HOGENOMi | CLU_002678_1_0_1 |
InParanoidi | P10075 |
OMAi | HEAQLHL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10075 |
TreeFami | TF337438 |
Enzyme and pathway databases
PathwayCommonsi | P10075 |
Miscellaneous databases
BioGRID-ORCSi | 2738, 17 hits in 863 CRISPR screens |
ChiTaRSi | GLI4, human |
GenomeRNAii | 2738 |
Pharosi | P10075, Tbio |
PROi | PR:P10075 |
RNActi | P10075, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000250571, Expressed in stomach and 116 other tissues |
ExpressionAtlasi | P10075, baseline and differential |
Genevisiblei | P10075, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLI4_HUMAN | |
Accessioni | P10075Primary (citable) accession number: P10075 Secondary accession number(s): Q96CK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 25, 2003 | |
Last modified: | December 2, 2020 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations