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UniProtKB - P10073 (ZSC22_HUMAN)

Entry version 199 (23 Feb 2022)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
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Protein

Zinc finger and SCAN domain-containing protein 22

Gene

ZSCAN22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri268 – 290C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P10073

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P10073

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 22
Alternative name(s):
Krueppel-related zinc finger protein 2
Protein HKR2
Zinc finger protein 50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSCAN22
Synonyms:HKR2, ZNF50
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4929, ZSCAN22

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		165260, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10073

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182318

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		342945

Open Targets

More...OpenTargetsi		ENSG00000182318

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29307

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10073, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSCAN22

Domain mapping of disease mutations (DMDM)

More...DMDMi		134047986

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472711 – 491Zinc finger and SCAN domain-containing protein 22Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki443Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P10073

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10073

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10073

MaxQB - The MaxQuant DataBase

More...MaxQBi		P10073

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10073

PeptideAtlas

More...PeptideAtlasi		P10073

PRoteomics IDEntifications database

More...PRIDEi		P10073

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52560

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10073

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10073

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182318, Expressed in gastrocnemius and 129 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10073, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182318, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P10073
With#Exp.IntAct
BYSL [Q13895]3EBI-10178224,EBI-358049
CDR2L [Q86X02]3EBI-10178224,EBI-11063830
DMWD [G5E9A7]3EBI-10178224,EBI-10976677
DR1 [Q01658]3EBI-10178224,EBI-750300
DVL3 [Q92997]3EBI-10178224,EBI-739789
GFAP [P14136]3EBI-10178224,EBI-744302
GTF2B [Q00403]3EBI-10178224,EBI-389564
GTF3C3 [Q9Y5Q9]3EBI-10178224,EBI-1054873
KCTD19 [Q17RG1]3EBI-10178224,EBI-10239046
LMNA [P02545]3EBI-10178224,EBI-351935
NDUFV2 [P19404]3EBI-10178224,EBI-713665
NEXN - isoform 4 [Q0ZGT2-4]3EBI-10178224,EBI-10977819
PGBD1 [Q96JS3]9EBI-10178224,EBI-10290053
PRPF31 [Q8WWY3]3EBI-10178224,EBI-1567797
SCAND1 [P57086]6EBI-10178224,EBI-745846
SERTAD2 [Q14140]3EBI-10178224,EBI-2822051
SPRED1 [Q7Z699]3EBI-10178224,EBI-5235340
TLK1 [Q9UKI8]3EBI-10178224,EBI-740492
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-10178224,EBI-10183064
ZKSCAN4 [A0A0S2Z6X0]3EBI-10178224,EBI-16431094
ZKSCAN4 [Q969J2]3EBI-10178224,EBI-2818641
ZKSCAN7 - isoform 2 [Q9P0L1-2]3EBI-10178224,EBI-10698225
ZNF174 - isoform 2 [Q15697-2]3EBI-10178224,EBI-11158827
ZNF24 [P17028]6EBI-10178224,EBI-707773
ZNF263 [O14978]3EBI-10178224,EBI-744493
ZNF397 - isoform 2 [Q8NF99-2]3EBI-10178224,EBI-11524467
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-10178224,EBI-12010736
ZNF446 - isoform 2 [Q9NWS9-2]8EBI-10178224,EBI-740232
ZNF449 [Q6P9G9]3EBI-10178224,EBI-10215956
ZNF483 [Q6P088]3EBI-10178224,EBI-10196963
ZNF496 [Q96IT1]7EBI-10178224,EBI-743906
ZSCAN1 - isoform 2 [Q8NBB4-2]3EBI-10178224,EBI-12021938
ZSCAN16 [Q9H4T2]6EBI-10178224,EBI-723596
ZSCAN18 [Q8TBC5]3EBI-10178224,EBI-3919096
ZSCAN21 [Q9Y5A6]3EBI-10178224,EBI-10281938
ZSCAN23 [Q3MJ62]3EBI-10178224,EBI-5667532
ZSCAN25 - isoform 2 [Q6NSZ9-2]3EBI-10178224,EBI-14650477
ZSCAN32 [Q9NX65]7EBI-10178224,EBI-739949
ZSCAN9 [O15535]3EBI-10178224,EBI-751531

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131214, 32 interactors

Protein interaction database and analysis system

More...IntActi		P10073, 41 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000332433

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10073, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10073

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 131SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 161DisorderedSequence analysisAdd BLAST28
Regioni204 – 249DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi221 – 241Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri268 – 290C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000163014

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10073

Identification of Orthologs from Complete Genome Data

More...OMAi		QQIHFKK

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10073

TreeFam database of animal gene trees

More...TreeFami		TF337913

Family and domain databases

Conserved Domains Database

More...CDDi		cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P10073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL 
        60         70         80         90        100
RFRHFRYEEA SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA 
       110        120        130        140        150
LPPEIQAWVG AQSPKSGEEA AVLVEDLTQV LDKRGWDPGA EPTEASCKQS 
       160        170        180        190        200
DLGESEPSNV TETLMGGVSL GPAFVKACEP EGSSERSGLS GEIWTKSVTQ 
       210        220        230        240        250
QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE KPPSEDKFDL 
       260        270        280        290        300
VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE 
       310        320        330        340        350
CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK 
       360        370        380        390        400
PYKCGECGKT FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR 
       410        420        430        440        450
IHTGEKPYKC DACGRAFSDC SALIRHLRIH SGEKPYQCKV CPKAFAQSSS 
       460        470        480        490 
LIEHQRIHTG EKPYKCSDCG KAFSRSSALM VHLRIHITVL Q
Length:491
Mass (Da):54,561
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FD4BF55E1D00C74
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK128716 mRNA Translation: BAC87588.1
BX537741 mRNA Translation: CAD97822.1
BC101630 mRNA Translation: AAI01631.1
BC112277 mRNA Translation: AAI12278.1
M88360 Genomic DNA Translation: AAA61318.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12975.1

Protein sequence database of the Protein Information Resource

More...PIRi		D31201
D43284

NCBI Reference Sequences

More...RefSeqi		NP_001308045.1, NM_001321116.1
NP_001308046.1, NM_001321117.1
NP_862829.1, NM_181846.2
XP_006723255.1, XM_006723192.3
XP_011525219.1, XM_011526917.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000329665; ENSP00000332433; ENSG00000182318

Database of genes from NCBI RefSeq genomes

More...GeneIDi		342945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:342945

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000329665.5; ENSP00000332433.3; NM_181846.3; NP_862829.1

UCSC genome browser

More...UCSCi		uc002qsc.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128716 mRNA Translation: BAC87588.1
BX537741 mRNA Translation: CAD97822.1
BC101630 mRNA Translation: AAI01631.1
BC112277 mRNA Translation: AAI12278.1
M88360 Genomic DNA Translation: AAA61318.1
CCDSiCCDS12975.1
PIRiD31201
D43284
RefSeqiNP_001308045.1, NM_001321116.1
NP_001308046.1, NM_001321117.1
NP_862829.1, NM_181846.2
XP_006723255.1, XM_006723192.3
XP_011525219.1, XM_011526917.2

3D structure databases

SMRiP10073
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131214, 32 interactors
IntActiP10073, 41 interactors
STRINGi9606.ENSP00000332433

PTM databases

iPTMnetiP10073
PhosphoSitePlusiP10073

Genetic variation databases

BioMutaiZSCAN22
DMDMi134047986

Proteomic databases

EPDiP10073
jPOSTiP10073
MassIVEiP10073
MaxQBiP10073
PaxDbiP10073
PeptideAtlasiP10073
PRIDEiP10073
ProteomicsDBi52560

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P10073, 5 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1829, 172 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		342945

Genome annotation databases

EnsembliENST00000329665; ENSP00000332433; ENSG00000182318
GeneIDi342945
KEGGihsa:342945
MANE-SelectiENST00000329665.5; ENSP00000332433.3; NM_181846.3; NP_862829.1
UCSCiuc002qsc.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		342945
DisGeNETi342945

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSCAN22
HGNCiHGNC:4929, ZSCAN22
HPAiENSG00000182318, Low tissue specificity
MIMi165260, gene
neXtProtiNX_P10073
OpenTargetsiENSG00000182318
PharmGKBiPA29307
VEuPathDBiHostDB:ENSG00000182318

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163014
HOGENOMiCLU_002678_49_8_1
InParanoidiP10073
OMAiQQIHFKK
OrthoDBi1318335at2759
PhylomeDBiP10073
TreeFamiTF337913

Enzyme and pathway databases

PathwayCommonsiP10073
SignaLinkiP10073

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		342945, 6 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSCAN22, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		342945
PharosiP10073, Tdark

Protein Ontology

More...PROi		PR:P10073
RNActiP10073, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182318, Expressed in gastrocnemius and 129 other tissues
GenevisibleiP10073, HS

Family and domain databases

CDDicd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 8 hits
SUPFAMiSSF57667, SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10073
Secondary accession number(s): Q15922, Q7Z3L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 20, 2007
Last modified: February 23, 2022
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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