ZSCAN22

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	268 – 290	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 346	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	352 – 374	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	380 – 402	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	408 – 430	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	436 – 458	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	464 – 486	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger and SCAN domain-containing protein 22 Alternative name(s): Krueppel-related zinc finger protein 2 Protein HKR2 Zinc finger protein 50
Gene namesⁱ	Name:ZSCAN22 Synonyms:HKR2, ZNF50
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000182318.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4929 ZSCAN22
MIMⁱ	165260 gene
neXtProtⁱ	NX_P10073

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	342945
Open Targets More...OpenTargetsⁱ	ENSG00000182318
PharmGKBⁱ	PA29307

Polymorphism and mutation databases

BioMutaⁱ	ZSCAN22
DMDMⁱ	134047986

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047271	1 – 491	Zinc finger and SCAN domain-containing protein 22Add BLAST		491

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	9	PhosphoserineCombined sources		1
Cross-linkⁱ	443	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P10073
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10073
PaxDbⁱ	P10073
PeptideAtlas More...PeptideAtlasⁱ	P10073
PRIDEⁱ	P10073
ProteomicsDBⁱ	52560

PTM databases

iPTMnetⁱ	P10073
PhosphoSitePlusⁱ	P10073

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000182318 Expressed in 105 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_ZSCAN22
Genevisibleⁱ	P10073 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006471

HPAⁱ

HPA006471

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
PGBD1	Q96JS3	7	EBI-10178224,EBI-10290053
ZKSCAN4	A0A0S2Z6X0	3	EBI-10178224,EBI-16431094
ZKSCAN4	Q969J2	3	EBI-10178224,EBI-2818641
ZNF174	Q15697-2	4	EBI-10178224,EBI-11158827
ZNF24	P17028	4	EBI-10178224,EBI-707773
ZNF446	Q9NWS9-2	5	EBI-10178224,EBI-740232
ZNF483	Q6P088	3	EBI-10178224,EBI-10196963
ZNF496	Q96IT1	5	EBI-10178224,EBI-743906
ZSCAN21	Q9Y5A6	4	EBI-10178224,EBI-10281938
ZSCAN32	I3L3J2	5	EBI-10178224,EBI-10178206

Protein-protein interaction databases

BioGridⁱ	131214, 8 interactors
IntActⁱ	P10073, 28 interactors
STRINGⁱ	9606.ENSP00000332433

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10073
SMRⁱ	P10073
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 131	SCAN boxPROSITE-ProRule annotationAdd BLAST		83

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	24 – 28	Poly-Glu		5

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	268 – 290	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	296 – 318	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	324 – 346	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	352 – 374	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	380 – 402	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	408 – 430	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	436 – 458	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	464 – 486	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10073
KEGG Orthology (KO) More...KOⁱ	K09230
OMAⁱ	VPWEEDS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10073
TreeFamⁱ	TF337913

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P10073-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL 
        60         70         80         90        100
RFRHFRYEEA SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA 
       110        120        130        140        150
LPPEIQAWVG AQSPKSGEEA AVLVEDLTQV LDKRGWDPGA EPTEASCKQS 
       160        170        180        190        200
DLGESEPSNV TETLMGGVSL GPAFVKACEP EGSSERSGLS GEIWTKSVTQ 
       210        220        230        240        250
QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE KPPSEDKFDL 
       260        270        280        290        300
VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE 
       310        320        330        340        350
CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK 
       360        370        380        390        400
PYKCGECGKT FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR 
       410        420        430        440        450
IHTGEKPYKC DACGRAFSDC SALIRHLRIH SGEKPYQCKV CPKAFAQSSS 
       460        470        480        490 
LIEHQRIHTG EKPYKCSDCG KAFSRSSALM VHLRIHITVL Q

Length:491

Mass (Da):54,561

Last modified:March 20, 2007 - v2

Checksum:ⁱ4FD4BF55E1D00C74

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK128716 mRNA Translation: BAC87588.1 BX537741 mRNA Translation: CAD97822.1 BC101630 mRNA Translation: AAI01631.1 BC112277 mRNA Translation: AAI12278.1 M88360 Genomic DNA Translation: AAA61318.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12975.1
PIRⁱ	D31201 D43284
NCBI Reference Sequences More...RefSeqⁱ	NP_001308045.1, NM_001321116.1 NP_001308046.1, NM_001321117.1 NP_862829.1, NM_181846.2 XP_006723255.1, XM_006723192.3 XP_011525219.1, XM_011526917.2
UniGeneⁱ	Hs.388162

Genome annotation databases

Ensemblⁱ	ENST00000329665; ENSP00000332433; ENSG00000182318
GeneIDⁱ	342945
KEGGⁱ	hsa:342945
UCSC genome browser More...UCSCⁱ	uc002qsc.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10073	Uncharacterized protein		PAPAN		493	UniRef90_P10073
Uncharacterized protein		COLAP		493
Zinc finger and SCAN domain containing 22		SAIBB		493
Zinc finger and SCAN domain-containing protein 22		CALJA		493
Uncharacterized protein		RHIRO		493
+19

Protein	Similar proteins		Species	Score	Length	Source
P10073	Zinc finger and SCAN domain containing 22		CALJA		493	UniRef50_P10073
Uncharacterized protein		MACFA		493
Uncharacterized protein		CERAT		493
Zinc finger and SCAN domain containing 22		SAIBB		493
Uncharacterized protein		COLAP		493
+33

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK128716 mRNA Translation: BAC87588.1 BX537741 mRNA Translation: CAD97822.1 BC101630 mRNA Translation: AAI01631.1 BC112277 mRNA Translation: AAI12278.1 M88360 Genomic DNA Translation: AAA61318.1
CCDSⁱ	CCDS12975.1
PIRⁱ	D31201 D43284
RefSeqⁱ	NP_001308045.1, NM_001321116.1 NP_001308046.1, NM_001321117.1 NP_862829.1, NM_181846.2 XP_006723255.1, XM_006723192.3 XP_011525219.1, XM_011526917.2
UniGeneⁱ	Hs.388162

3D structure databases

ProteinModelPortalⁱ	P10073
SMRⁱ	P10073
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131214, 8 interactors
IntActⁱ	P10073, 28 interactors
STRINGⁱ	9606.ENSP00000332433

PTM databases

iPTMnetⁱ	P10073
PhosphoSitePlusⁱ	P10073

Polymorphism and mutation databases

BioMutaⁱ	ZSCAN22
DMDMⁱ	134047986

Proteomic databases

EPDⁱ	P10073
MaxQBⁱ	P10073
PaxDbⁱ	P10073
PeptideAtlasⁱ	P10073
PRIDEⁱ	P10073
ProteomicsDBⁱ	52560

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	342945
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000329665; ENSP00000332433; ENSG00000182318
GeneIDⁱ	342945
KEGGⁱ	hsa:342945
UCSCⁱ	uc002qsc.3 human

Organism-specific databases

CTDⁱ	342945
DisGeNETⁱ	342945
EuPathDBⁱ	HostDB:ENSG00000182318.5
GeneCardsⁱ	ZSCAN22
HGNCⁱ	HGNC:4929 ZSCAN22
HPAⁱ	HPA006471
MIMⁱ	165260 gene
neXtProtⁱ	NX_P10073
OpenTargetsⁱ	ENSG00000182318
PharmGKBⁱ	PA29307
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10073
KOⁱ	K09230
OMAⁱ	VPWEEDS
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10073
TreeFamⁱ	TF337913

Miscellaneous databases

GenomeRNAiⁱ	342945
Protein Ontology More...PROⁱ	PR:P10073
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000182318 Expressed in 105 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_ZSCAN22
Genevisibleⁱ	P10073 HS

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZSC22_HUMAN
Accessionⁱ	P10073Primary (citable) accession number: P10073 Secondary accession number(s): Q15922, Q7Z3L8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	March 20, 2007
	Last modified:	October 10, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

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Annotation systems

Supporting data

UniProtKB - P10073 (ZSC22_HUMAN)

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Zinc finger and SCAN domain-containing protein 22

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ