UniProtKB - P10073 (ZSC22_HUMAN)
Protein
Zinc finger and SCAN domain-containing protein 22
Gene
ZSCAN22
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 268 – 290 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P10073 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and SCAN domain-containing protein 22Alternative name(s): Krueppel-related zinc finger protein 2 Protein HKR2 Zinc finger protein 50 |
Gene namesi | Name:ZSCAN22 Synonyms:HKR2, ZNF50 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4929, ZSCAN22 |
MIMi | 165260, gene |
neXtProti | NX_P10073 |
VEuPathDBi | HostDB:ENSG00000182318.5 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 342945 |
OpenTargetsi | ENSG00000182318 |
PharmGKBi | PA29307 |
Miscellaneous databases
Pharosi | P10073, Tdark |
Genetic variation databases
BioMutai | ZSCAN22 |
DMDMi | 134047986 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047271 | 1 – 491 | Zinc finger and SCAN domain-containing protein 22Add BLAST | 491 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | PhosphoserineCombined sources | 1 | |
Cross-linki | 443 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P10073 |
jPOSTi | P10073 |
MassIVEi | P10073 |
MaxQBi | P10073 |
PaxDbi | P10073 |
PeptideAtlasi | P10073 |
PRIDEi | P10073 |
ProteomicsDBi | 52560 |
PTM databases
iPTMneti | P10073 |
PhosphoSitePlusi | P10073 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182318, Expressed in gastrocnemius and 128 other tissues |
Genevisiblei | P10073, HS |
Organism-specific databases
HPAi | ENSG00000182318, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP10073
Protein-protein interaction databases
BioGRIDi | 131214, 32 interactors |
IntActi | P10073, 41 interactors |
STRINGi | 9606.ENSP00000332433 |
Miscellaneous databases
RNActi | P10073, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 131 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 28 | Poly-Glu | 5 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 268 – 290 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 296 – 318 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 324 – 346 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 352 – 374 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 380 – 402 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163014 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P10073 |
OMAi | QQIHFKK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10073 |
TreeFami | TF337913 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
i Sequence
Sequence statusi: Complete.
P10073-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIPKHSLSP VPWEEDSFLQ VKVEEEEEAS LSQGGESSHD HIAHSEAARL
60 70 80 90 100
RFRHFRYEEA SGPHEALAHL RALCCQWLQP EAHSKEQILE LLVLEQFLGA
110 120 130 140 150
LPPEIQAWVG AQSPKSGEEA AVLVEDLTQV LDKRGWDPGA EPTEASCKQS
160 170 180 190 200
DLGESEPSNV TETLMGGVSL GPAFVKACEP EGSSERSGLS GEIWTKSVTQ
210 220 230 240 250
QIHFKKTSGP YKDVPTDQRG RESGASRNSS SAWPNLTSQE KPPSEDKFDL
260 270 280 290 300
VDAYGTEPPY TYSGKRSSKC RECRKMFQSA SALEAHQKTH SRKTPYACSE
310 320 330 340 350
CGKAFSRSTH LAQHQVVHTG AKPHECKECG KAFSRVTHLT QHQRIHTGEK
360 370 380 390 400
PYKCGECGKT FSRSTHLTQH QRVHTGERPY ECDACGKAFS QSTHLTQHQR
410 420 430 440 450
IHTGEKPYKC DACGRAFSDC SALIRHLRIH SGEKPYQCKV CPKAFAQSSS
460 470 480 490
LIEHQRIHTG EKPYKCSDCG KAFSRSSALM VHLRIHITVL Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128716 mRNA Translation: BAC87588.1 BX537741 mRNA Translation: CAD97822.1 BC101630 mRNA Translation: AAI01631.1 BC112277 mRNA Translation: AAI12278.1 M88360 Genomic DNA Translation: AAA61318.1 |
CCDSi | CCDS12975.1 |
PIRi | D31201 D43284 |
RefSeqi | NP_001308045.1, NM_001321116.1 NP_001308046.1, NM_001321117.1 NP_862829.1, NM_181846.2 XP_006723255.1, XM_006723192.3 XP_011525219.1, XM_011526917.2 |
Genome annotation databases
Ensembli | ENST00000329665; ENSP00000332433; ENSG00000182318 |
GeneIDi | 342945 |
KEGGi | hsa:342945 |
UCSCi | uc002qsc.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128716 mRNA Translation: BAC87588.1 BX537741 mRNA Translation: CAD97822.1 BC101630 mRNA Translation: AAI01631.1 BC112277 mRNA Translation: AAI12278.1 M88360 Genomic DNA Translation: AAA61318.1 |
CCDSi | CCDS12975.1 |
PIRi | D31201 D43284 |
RefSeqi | NP_001308045.1, NM_001321116.1 NP_001308046.1, NM_001321117.1 NP_862829.1, NM_181846.2 XP_006723255.1, XM_006723192.3 XP_011525219.1, XM_011526917.2 |
3D structure databases
SMRi | P10073 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131214, 32 interactors |
IntActi | P10073, 41 interactors |
STRINGi | 9606.ENSP00000332433 |
PTM databases
iPTMneti | P10073 |
PhosphoSitePlusi | P10073 |
Genetic variation databases
BioMutai | ZSCAN22 |
DMDMi | 134047986 |
Proteomic databases
EPDi | P10073 |
jPOSTi | P10073 |
MassIVEi | P10073 |
MaxQBi | P10073 |
PaxDbi | P10073 |
PeptideAtlasi | P10073 |
PRIDEi | P10073 |
ProteomicsDBi | 52560 |
Protocols and materials databases
ABCDi | P10073, 5 sequenced antibodies |
Antibodypediai | 1829, 162 antibodies |
DNASUi | 342945 |
Genome annotation databases
Ensembli | ENST00000329665; ENSP00000332433; ENSG00000182318 |
GeneIDi | 342945 |
KEGGi | hsa:342945 |
UCSCi | uc002qsc.3, human |
Organism-specific databases
CTDi | 342945 |
DisGeNETi | 342945 |
GeneCardsi | ZSCAN22 |
HGNCi | HGNC:4929, ZSCAN22 |
HPAi | ENSG00000182318, Low tissue specificity |
MIMi | 165260, gene |
neXtProti | NX_P10073 |
OpenTargetsi | ENSG00000182318 |
PharmGKBi | PA29307 |
VEuPathDBi | HostDB:ENSG00000182318.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163014 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P10073 |
OMAi | QQIHFKK |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10073 |
TreeFami | TF337913 |
Enzyme and pathway databases
PathwayCommonsi | P10073 |
Miscellaneous databases
BioGRID-ORCSi | 342945, 4 hits in 896 CRISPR screens |
ChiTaRSi | ZSCAN22, human |
GenomeRNAii | 342945 |
Pharosi | P10073, Tdark |
PROi | PR:P10073 |
RNActi | P10073, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182318, Expressed in gastrocnemius and 128 other tissues |
Genevisiblei | P10073, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSC22_HUMAN | |
Accessioni | P10073Primary (citable) accession number: P10073 Secondary accession number(s): Q15922, Q7Z3L8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | March 20, 2007 | |
Last modified: | February 10, 2021 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families