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Entry version 190 (12 Aug 2020)
Sequence version 4 (25 Nov 2008)
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Protein

Zinc finger protein 875

Gene

ZNF875

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P10072

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 875Curated
Alternative name(s):
Krueppel-related zinc finger protein 1
Protein HKR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF875Imported
Synonyms:HKR1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000181666.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4928, ZNF875

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
165250, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10072

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284459

Open Targets

More...
OpenTargetsi
ENSG00000181666

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29306

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P10072, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HKR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274257

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000472701 – 659Zinc finger protein 875Add BLAST659

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P10072

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10072

PeptideAtlas

More...
PeptideAtlasi
P10072

PRoteomics IDEntifications database

More...
PRIDEi
P10072

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52558 [P10072-1]
52559 [P10072-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10072

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10072

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181666, Expressed in right lobe of thyroid gland and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P10072, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P10072, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000181666, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129883, 2 interactors

Protein interaction database and analysis system

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IntActi
P10072, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000315505

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P10072, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10072

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 104KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163548

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10072

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
FGAIKYE

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10072

TreeFam database of animal gene trees

More...
TreeFami
TF338096

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10072-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL
60 70 80 90 100
SPAQRTLHRE VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL
110 120 130 140 150
DLCPESKPEI QLSPSCPLIF SSQQALSQHV WLSHLSQLFS SLWAGNPLHL
160 170 180 190 200
GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS RLLFGRVSKN GTSKALSSPP
210 220 230 240 250
EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS GFGEIKYEEF
260 270 280 290 300
GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP
310 320 330 340 350
YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT
360 370 380 390 400
HSGLKPYVCK ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL
410 420 430 440 450
VRHKRTHSGE KPYICRECEQ GFSQKSHLIR HLRTHTGEKP YVCTECGRHF
460 470 480 490 500
SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL KSNLNKHQRS HTGEKPFVCT
510 520 530 540 550
ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL ISHQRTHSGE
560 570 580 590 600
KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA
610 620 630 640 650
HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL

IRHQRTHSG
Length:659
Mass (Da):75,128
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36D48F8EA3A6D80A
GO
Isoform 2 (identifier: P10072-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MRVNHTVSTMLPTCMVHRQTMSCSGAGGIT → MATGLLRAKKE

Show »
Length:640
Mass (Da):73,138
Checksum:i8A3779E239A360B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPW3K7EPW3_HUMAN
Zinc finger protein 875
ZNF875
641Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z6E1Q7Z6E1_HUMAN
HKR1 protein
ZNF875
598Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EME6K7EME6_HUMAN
GLI-Kruppel family member HKR1, iso...
ZNF875 HKR1, hCG_42404
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERA5K7ERA5_HUMAN
Zinc finger protein 875
ZNF875
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL22K7EL22_HUMAN
Zinc finger protein 875
ZNF875
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL05K7EL05_HUMAN
Zinc finger protein 875
ZNF875
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENA5K7ENA5_HUMAN
Zinc finger protein 875
ZNF875
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQG8K7EQG8_HUMAN
Zinc finger protein 875
ZNF875
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL36K7EL36_HUMAN
Zinc finger protein 875
ZNF875
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM51K7EM51_HUMAN
Zinc finger protein 875
ZNF875
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA86058 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047404448R → H. Corresponds to variant dbSNP:rs2921563Ensembl.1
Natural variantiVAR_047405513S → I2 PublicationsCorresponds to variant dbSNP:rs3745765Ensembl.1
Natural variantiVAR_047406628T → I. Corresponds to variant dbSNP:rs3745764Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0357551 – 30MRVNH…AGGIT → MATGLLRAKKE in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB013897 mRNA Translation: BAA86058.1 Different initiation.
AC016590 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56722.1
BC004513 mRNA Translation: AAH04513.2
BC017256 mRNA Translation: AAH17256.1
M20675 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12502.1 [P10072-1]
CCDS82338.1 [P10072-2]

Protein sequence database of the Protein Information Resource

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PIRi
C31201

NCBI Reference Sequences

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RefSeqi
NP_001316692.1, NM_001329763.1 [P10072-2]
NP_001316693.1, NM_001329764.1 [P10072-2]
NP_861451.1, NM_181786.3 [P10072-1]
XP_016882167.1, XM_017026678.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324411; ENSP00000315505; ENSG00000181666 [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666 [P10072-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284459

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284459

UCSC genome browser

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UCSCi
uc002ogb.5, human [P10072-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013897 mRNA Translation: BAA86058.1 Different initiation.
AC016590 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56722.1
BC004513 mRNA Translation: AAH04513.2
BC017256 mRNA Translation: AAH17256.1
M20675 Genomic DNA No translation available.
CCDSiCCDS12502.1 [P10072-1]
CCDS82338.1 [P10072-2]
PIRiC31201
RefSeqiNP_001316692.1, NM_001329763.1 [P10072-2]
NP_001316693.1, NM_001329764.1 [P10072-2]
NP_861451.1, NM_181786.3 [P10072-1]
XP_016882167.1, XM_017026678.1

3D structure databases

SMRiP10072
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129883, 2 interactors
IntActiP10072, 1 interactor
STRINGi9606.ENSP00000315505

PTM databases

iPTMnetiP10072
PhosphoSitePlusiP10072

Polymorphism and mutation databases

BioMutaiHKR1
DMDMi215274257

Proteomic databases

MassIVEiP10072
PaxDbiP10072
PeptideAtlasiP10072
PRIDEiP10072
ProteomicsDBi52558 [P10072-1]
52559 [P10072-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29891, 177 antibodies

Genome annotation databases

EnsembliENST00000324411; ENSP00000315505; ENSG00000181666 [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666 [P10072-2]
GeneIDi284459
KEGGihsa:284459
UCSCiuc002ogb.5, human [P10072-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284459
DisGeNETi284459
EuPathDBiHostDB:ENSG00000181666.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF875
HGNCiHGNC:4928, ZNF875
HPAiENSG00000181666, Low tissue specificity
MIMi165250, gene
neXtProtiNX_P10072
OpenTargetsiENSG00000181666
PharmGKBiPA29306

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000163548
HOGENOMiCLU_002678_44_5_1
InParanoidiP10072
KOiK09228
OMAiFGAIKYE
OrthoDBi1318335at2759
PhylomeDBiP10072
TreeFamiTF338096

Enzyme and pathway databases

PathwayCommonsiP10072
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
284459, 9 hits in 893 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HKR1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HKR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284459
PharosiP10072, Tbio

Protein Ontology

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PROi
PR:P10072
RNActiP10072, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181666, Expressed in right lobe of thyroid gland and 210 other tissues
ExpressionAtlasiP10072, baseline and differential
GenevisibleiP10072, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN875_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10072
Secondary accession number(s): A8MRS7
, Q6PJD0, Q9BSW9, Q9UM09
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: August 12, 2020
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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