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Protein

Krueppel-related zinc finger protein 1

Gene

HKR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-related zinc finger protein 1
Alternative name(s):
Protein HKR1
Zinc finger protein 875
Gene namesi
Name:HKR1
Synonyms:ZNF875
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000181666.17
HGNCiHGNC:4928 HKR1
MIMi165250 gene
neXtProtiNX_P10072

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi284459
OpenTargetsiENSG00000181666
PharmGKBiPA29306

Polymorphism and mutation databases

BioMutaiHKR1
DMDMi215274257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472701 – 659Krueppel-related zinc finger protein 1Add BLAST659

Proteomic databases

PaxDbiP10072
PeptideAtlasiP10072
PRIDEiP10072
ProteomicsDBi52558
52559 [P10072-2]

PTM databases

iPTMnetiP10072
PhosphoSitePlusiP10072

Expressioni

Gene expression databases

BgeeiENSG00000181666 Expressed in 195 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_HKR1
ExpressionAtlasiP10072 baseline and differential
GenevisibleiP10072 HS

Organism-specific databases

HPAiHPA036126
HPA044855

Interactioni

Protein-protein interaction databases

BioGridi129883, 2 interactors
IntActiP10072, 1 interactor
STRINGi9606.ENSP00000315505

Structurei

3D structure databases

ProteinModelPortaliP10072
SMRiP10072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 104KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri301 – 323C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri329 – 351C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 491C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 519C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri525 – 547C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri553 – 575C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063157
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10072
KOiK09228
OMAiGFGAIKY
OrthoDBiEOG091G02KC
PhylomeDBiP10072
TreeFamiTF338096

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10072-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVNHTVSTM LPTCMVHRQT MSCSGAGGIT AFVAFRDVAV YFTQEEWRLL
60 70 80 90 100
SPAQRTLHRE VMLETYNHLV SLEIPSSKPK LIAQLERGEA PWREERKCPL
110 120 130 140 150
DLCPESKPEI QLSPSCPLIF SSQQALSQHV WLSHLSQLFS SLWAGNPLHL
160 170 180 190 200
GKHYPEDQKQ QQDPFCFSGK AEWIQEGEDS RLLFGRVSKN GTSKALSSPP
210 220 230 240 250
EEQQPAQSKE DNTVVDIGSS PERRADLEET DKVLHGLEVS GFGEIKYEEF
260 270 280 290 300
GPGFIKESNL LSLQKTQTGE TPYMYTEWGD SFGSMSVLIK NPRTHSGGKP
310 320 330 340 350
YVCRECGRGF TWKSNLITHQ RTHSGEKPYV CKDCGRGFTW KSNLFTHQRT
360 370 380 390 400
HSGLKPYVCK ECGQSFSLKS NLITHQRAHT GEKPYVCREC GRGFRQHSHL
410 420 430 440 450
VRHKRTHSGE KPYICRECEQ GFSQKSHLIR HLRTHTGEKP YVCTECGRHF
460 470 480 490 500
SWKSNLKTHQ RTHSGVKPYV CLECGQCFSL KSNLNKHQRS HTGEKPFVCT
510 520 530 540 550
ECGRGFTRKS TLSTHQRTHS GEKPFVCAEC GRGFNDKSTL ISHQRTHSGE
560 570 580 590 600
KPFMCRECGR RFRQKPNLFR HKRAHSGAFV CRECGQGFCA KLTLIKHQRA
610 620 630 640 650
HAGGKPHVCR ECGQGFSRQS HLIRHQRTHS GEKPYICRKC GRGFSRKSNL

IRHQRTHSG
Length:659
Mass (Da):75,128
Last modified:November 25, 2008 - v4
Checksum:i36D48F8EA3A6D80A
GO
Isoform 2 (identifier: P10072-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: MRVNHTVSTMLPTCMVHRQTMSCSGAGGIT → MATGLLRAKKE

Show »
Length:640
Mass (Da):73,138
Checksum:i8A3779E239A360B4
GO

Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPW3K7EPW3_HUMAN
Krueppel-related zinc finger protei...
HKR1
641Annotation score:
Q7Z6E1Q7Z6E1_HUMAN
HKR1 protein
HKR1
598Annotation score:
K7EME6K7EME6_HUMAN
GLI-Kruppel family member HKR1, iso...
HKR1 hCG_42404
171Annotation score:
K7ERA5K7ERA5_HUMAN
Krueppel-related zinc finger protei...
HKR1
127Annotation score:
K7EL36K7EL36_HUMAN
Krueppel-related zinc finger protei...
HKR1
91Annotation score:
K7EL22K7EL22_HUMAN
Krueppel-related zinc finger protei...
HKR1
107Annotation score:
K7EL05K7EL05_HUMAN
Krueppel-related zinc finger protei...
HKR1
91Annotation score:
K7EQG8K7EQG8_HUMAN
Krueppel-related zinc finger protei...
HKR1
54Annotation score:
K7EM51K7EM51_HUMAN
Krueppel-related zinc finger protei...
HKR1
77Annotation score:
K7ENA5K7ENA5_HUMAN
Krueppel-related zinc finger protei...
HKR1
46Annotation score:
There are more potential isoformsShow all

Sequence cautioni

The sequence BAA86058 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047404448R → H. Corresponds to variant dbSNP:rs2921563Ensembl.1
Natural variantiVAR_047405513S → I2 PublicationsCorresponds to variant dbSNP:rs3745765Ensembl.1
Natural variantiVAR_047406628T → I. Corresponds to variant dbSNP:rs3745764Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357551 – 30MRVNH…AGGIT → MATGLLRAKKE in isoform 2. CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013897 mRNA Translation: BAA86058.1 Different initiation.
AC016590 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56722.1
BC004513 mRNA Translation: AAH04513.2
BC017256 mRNA Translation: AAH17256.1
M20675 Genomic DNA No translation available.
CCDSiCCDS12502.1 [P10072-1]
CCDS82338.1 [P10072-2]
PIRiC31201
RefSeqiNP_001316692.1, NM_001329763.1 [P10072-2]
NP_001316693.1, NM_001329764.1 [P10072-2]
NP_861451.1, NM_181786.3 [P10072-1]
XP_016882167.1, XM_017026678.1
UniGeneiHs.640243
Hs.657027
Hs.729090

Genome annotation databases

EnsembliENST00000324411; ENSP00000315505; ENSG00000181666 [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666 [P10072-2]
GeneIDi284459
KEGGihsa:284459
UCSCiuc002ogb.5 human [P10072-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013897 mRNA Translation: BAA86058.1 Different initiation.
AC016590 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW56722.1
BC004513 mRNA Translation: AAH04513.2
BC017256 mRNA Translation: AAH17256.1
M20675 Genomic DNA No translation available.
CCDSiCCDS12502.1 [P10072-1]
CCDS82338.1 [P10072-2]
PIRiC31201
RefSeqiNP_001316692.1, NM_001329763.1 [P10072-2]
NP_001316693.1, NM_001329764.1 [P10072-2]
NP_861451.1, NM_181786.3 [P10072-1]
XP_016882167.1, XM_017026678.1
UniGeneiHs.640243
Hs.657027
Hs.729090

3D structure databases

ProteinModelPortaliP10072
SMRiP10072
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129883, 2 interactors
IntActiP10072, 1 interactor
STRINGi9606.ENSP00000315505

PTM databases

iPTMnetiP10072
PhosphoSitePlusiP10072

Polymorphism and mutation databases

BioMutaiHKR1
DMDMi215274257

Proteomic databases

PaxDbiP10072
PeptideAtlasiP10072
PRIDEiP10072
ProteomicsDBi52558
52559 [P10072-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324411; ENSP00000315505; ENSG00000181666 [P10072-1]
ENST00000392153; ENSP00000375994; ENSG00000181666 [P10072-2]
GeneIDi284459
KEGGihsa:284459
UCSCiuc002ogb.5 human [P10072-1]

Organism-specific databases

CTDi284459
DisGeNETi284459
EuPathDBiHostDB:ENSG00000181666.17
GeneCardsiHKR1
HGNCiHGNC:4928 HKR1
HPAiHPA036126
HPA044855
MIMi165250 gene
neXtProtiNX_P10072
OpenTargetsiENSG00000181666
PharmGKBiPA29306
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063157
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10072
KOiK09228
OMAiGFGAIKY
OrthoDBiEOG091G02KC
PhylomeDBiP10072
TreeFamiTF338096

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiHKR1 human
GeneWikiiHKR1
GenomeRNAii284459
PROiPR:P10072
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000181666 Expressed in 195 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_HKR1
ExpressionAtlasiP10072 baseline and differential
GenevisibleiP10072 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 13 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHKR1_HUMAN
AccessioniPrimary (citable) accession number: P10072
Secondary accession number(s): A8MRS7
, Q6PJD0, Q9BSW9, Q9UM09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 177 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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