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Protein

Nucleoprotein

Gene

N

Organism
Measles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, Viral nucleoprotein
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoprotein
Alternative name(s):
Nucleocapsid protein
Short name:
NP
Short name:
Protein N
Gene namesi
Name:N
Synonyms:NP
OrganismiMeasles virus (strain Halle) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11236 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Host cytoplasm, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426561 – 525NucleoproteinAdd BLAST525

Interactioni

Subunit structurei

Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA. In nucleocapsid, binds the P protein and thereby positions the polymerase on the template. Interacts with human FCGR2B protein (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-61650N

Structurei

3D structure databases

SMRiP10050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 400NcoreBy similarityAdd BLAST400
Regioni1 – 375HomomultimerizationBy similarityAdd BLAST375
Regioni401 – 525NtailBy similarityAdd BLAST125
Regioni477 – 505P protein-bindingBy similarityAdd BLAST29

Domaini

Ncore is globular and carries regions required for N self-assembly and RNA-binding. Ntail is an intrinsically disordered monomeric domain (By similarity).By similarity

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit

Sequencei

Sequence statusi: Complete.

P10050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATLLRSLAL FKRNKDKPPI TSGSGGAIRG IKHIIIVPIP GDSSITTRSR
60 70 80 90 100
LLDRLVRLIG NPDVSGPKLT GALIGILSLF VESPGQLIQR ITDDPDVSIR
110 120 130 140 150
LLEVVQSDQS QSGLTFASRG TNMEDEADQY FSHDDPISSD QSRFGWFENK
160 170 180 190 200
EISDIEVQDP EGFNMILGTI LAQIWVLVAK AVTAPDTAAD SELRRWIKYT
210 220 230 240 250
QQRRVVGEFR LERKWLDVVR NRIAEDLSLR RFMVALILDI KRTPGNKPRI
260 270 280 290 300
AEMICNIDTY IVEAGLASFI LTIKFGIETM YPALGLHEFD GELSTLESLM
310 320 330 340 350
NLYQQMGETA PYMVILENSI QNKFSAGSYP LLWSYAMGVG VELENSMGGL
360 370 380 390 400
NFGRSYFDPA YFRLGQEMVR RSAGKVSSTL ASELGITAED ARLVSEIAMH
410 420 430 440 450
TTEDKISRAV GPRQAQVSFL HGDQSENELP RLGGKEDRRV KQSRGEARES
460 470 480 490 500
YRETGPSRAS DARAAHLPTG TPLDIDTASE SSQDPQDSRR SADALLRLQA
510 520
MAGISEEQGS DTDTPIVYND RNLLD
Length:525
Mass (Da):58,160
Last modified:July 1, 1989 - v1
Checksum:i09DE00E733068485
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13480 mRNA Translation: CAA31831.1
PIRiA34040 VHNZMH

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13480 mRNA Translation: CAA31831.1
PIRiA34040 VHNZMH

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UFTelectron microscopy4.30B1-391[»]
SMRiP10050
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61650N

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002021 Paramyx_ncap
PfamiView protein in Pfam
PF00973 Paramyxo_ncap, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNCAP_MEASH
AccessioniPrimary (citable) accession number: P10050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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