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Protein

Pro-opiomelanocortin

Gene

pomc

Organism
Oncorhynchus keta (Chum salmon) (Salmo keta)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin: Endogenous orexigenic opiate.
Met-enkephalin: Endogenous opiate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndorphin, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 8 chains:
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Melanotropin beta
Gene namesi
Name:pomc
OrganismiOncorhynchus keta (Chum salmon) (Salmo keta)
Taxonomic identifieri8018 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000002508323 – 97Sequence analysisAdd BLAST75
PeptideiPRO_000002508498 – 138CorticotropinAdd BLAST41
PeptideiPRO_000002508598 – 112Melanocyte-stimulating hormone alpha1 PublicationAdd BLAST15
PeptideiPRO_0000025086116 – 138Corticotropin-like intermediary peptideAdd BLAST23
PeptideiPRO_0000025087141 – 226Lipotropin betaAdd BLAST86
PeptideiPRO_0000025088141 – 195Lipotropin gammaAdd BLAST55
PeptideiPRO_0000025089179 – 195Melanocyte-stimulating hormone betaAdd BLAST17
PeptideiPRO_0000025090198 – 226Beta-endorphin1 PublicationAdd BLAST29
PeptideiPRO_0000025091198 – 202Met-enkephalin1 Publication5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N-acetylserine; in Corticotropin1 Publication1
Modified residuei198N-acetyltyrosine; in Beta-endorphin and Met-enkephalin1 Publication1

Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.

Keywords - PTMi

Acetylation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiP10000

PTM databases

iPTMnetiP10000

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004341

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR013593 Melanocortin_N
IPR013532 Opioid_neuropept
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 2 hits
PF08384 NPP, 1 hit
PF08035 Op_neuropeptide, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 2 hits
SM01364 NPP, 1 hit
SM01365 Op_neuropeptide, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCAPWLLAV VVVCVCNPGV GGQCWDSSHC KDLPSEDKIL ECTHLFRSGL
60 70 80 90 100
QDESPEPRSA AQQSTEESLS LGILLAALTS GERALDADPE PHSDKRHSYS
110 120 130 140 150
MEHFRWGKPI GHKRRPIKVY ASSLEGGDSS EGTFPLQARR QLGSWEDEMV
160 170 180 190 200
GALGNQGAKA QTKVVPRTLT VTGLQDKKDG SYRMGHFRWG SPTAIKRYGG
210 220
FMKPYTKQSH KPLITLLKHI TLKNEQ
Length:226
Mass (Da):24,982
Last modified:February 1, 1991 - v2
Checksum:i327CA785F69B1B24
GO

Sequence cautioni

The sequence AAA49426 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27692 mRNA Translation: AAA49426.1 Different initiation.
K02613 mRNA Translation: AAA49424.1
K02614 mRNA Translation: AAA49425.1
X01122 mRNA Translation: CAA25591.1
PIRiI51080 CTONPK

Similar proteinsi

Entry informationi

Entry nameiCOLI_ONCKE
AccessioniPrimary (citable) accession number: P10000
Secondary accession number(s): P01199
, P01204, P87470, P87471, P87472, P87473, P87474, P87475, P87476, P87477, P87478, Q90521, Q92024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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