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Entry version 2 (12 Aug 2020)
Sequence version 1 (17 Jun 2020)
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Protein

Coproporphyrin-dependent heme b biosynthesis bifunctional protein

Gene

PPA0308

Organism
Cutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:25646457). Catalyzes the insertion of ferrous iron into coproporphyrin III to form coproheme III (By similarity). Also catalyzes the decarboxylation of coproheme III to heme b (protoheme IX), the last step of the pathway (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe-coproporphyrin IIIBy similarityNote: Fe-coproporphyrin III acts as both substrate and redox cofactor.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protoheme biosynthesis

This protein is involved in the pathway protoheme biosynthesis, which is part of Porphyrin-containing compound metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi193IronBy similarity1
Metal bindingi285IronBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei583For coproheme decarboxylase activityBy similarity1
Metal bindingi606Iron (Fe-coproporphyrin III axial ligand)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Oxidoreductase
Biological processHeme biosynthesis, Porphyrin biosynthesis
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
PACN267747:G1G0Y-343-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00252

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coproporphyrin-dependent heme b biosynthesis bifunctional proteinCurated
Including the following 2 domains:
Coproporphyrin III ferrochelataseBy similarity (EC:4.99.1.9By similarity)
Coproheme decarboxylaseBy similarity (EC:1.3.98.5By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:PPA0308
ORF Names:cbac_01720Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCutibacterium acnes (strain DSM 16379 / KPA171202) (Propionibacterium acnes)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267747 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaPropionibacterialesPropionibacteriaceaeCutibacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000603 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004503261 – 683Coproporphyrin-dependent heme b biosynthesis bifunctional proteinAdd BLAST683

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
267747.PPA0308

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 330Coproporphyrin III ferrochelataseCuratedAdd BLAST330
Regioni460 – 683Coproheme decarboxylaseCuratedAdd BLAST224

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the ferrochelatase family.Curated
In the C-terminal section; belongs to the ChdC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0276, Bacteria
COG3253, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024568_0_0_11

KEGG Orthology (KO)

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KOi
K01772

Identification of Orthologs from Complete Genome Data

More...
OMAi
MKDLRYV

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00419, Ferrochelatase_C, 1 hit
cd03411, Ferrochelatase_N, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00323, Ferrochelatase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011008, Dimeric_a/b-barrel
IPR001015, Ferrochelatase
IPR033644, Ferrochelatase_C
IPR033659, Ferrochelatase_N
IPR010644, Put_peroxidase/dismutase

The PANTHER Classification System

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PANTHERi
PTHR11108, PTHR11108, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF06778, Chlor_dismutase, 1 hit
PF00762, Ferrochelatase, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54909, SSF54909, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00109, hemH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0DTW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTANPYAAPT DPLAPYSAVL VVSFGGPRSP EEVMPFLRRV SHGRIPEERL
60 70 80 90 100
ADVARHYDRF GGVSPINDAT DVFVNAIGNE LRRHGVRVPV LLGNRNGTPF
110 120 130 140 150
LEEALTDMHA HGVRRVLAVV TSAYASYSGC RQYREEIATA LAHAGITDMQ
160 170 180 190 200
VDKVPPFNEA PGFIRANAEA LMQAFMRIPP TPLEATRVVF VTHSIPDSMQ
210 220 230 240 250
DASGAGQPGT DYISQHKAVC ERVAGQVRQV FGNMPQWDLA YCSRSGRPSD
260 270 280 290 300
PWLEPDIIDH LRSLPEQGVQ SVVVAPIGFV ADHMEVVNDL DYEAAEAAKE
310 320 330 340 350
SGLAFTRAAT AGTHSAFIAD LAGLILSQAA AARGEGGNLT SWPAPCVAGC
360 370 380 390 400
CRRYPDAQDI PAVSGGDVES VAAGADVVDA EPGGVDFVPS GSASAVDRPG
410 420 430 440 450
PEAVELETPP SPYNPLTKET PMSDHSSADS VIEGPRDDEV PAGSYTAPTD
460 470 480 490 500
PRDTPVIPEE VNASSKWAMY SVFRVATALP AEDDERRRLV EGSDEWAGQS
510 520 530 540 550
GVDTRGWYDL SGLRANADLL VWWVSDDPAV LQDAYHRFRA SGLGRHLEPV
560 570 580 590 600
WSNVGVHRPA EFNKSHLPSC FAGIAPRRWA AFYPFIRSKE WYLLPAADRS
610 620 630 640 650
RMLREHGIVG AASSDVKAST LAAFALGDYE WILALEGDDL ARIVDVMKDL
660 670 680
RYVEARRYVD VDTPFFTGER VSPVVWADRQ MRA
Length:683
Mass (Da):74,065
Last modified:June 17, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E27CFA6BA620B00
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82065.1
CP025935 Genomic DNA Translation: QAZ50313.1

NCBI Reference Sequences

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RefSeqi
WP_002517081.1, NC_006085.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAT82065; AAT82065; PPA0308

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2932271

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pac:PPA0308

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|267747.3.peg.319

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017283 Genomic DNA Translation: AAT82065.1
CP025935 Genomic DNA Translation: QAZ50313.1
RefSeqiWP_002517081.1, NC_006085.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi267747.PPA0308

Genome annotation databases

EnsemblBacteriaiAAT82065; AAT82065; PPA0308
GeneIDi2932271
KEGGipac:PPA0308
PATRICifig|267747.3.peg.319

Phylogenomic databases

eggNOGiCOG0276, Bacteria
COG3253, Bacteria
HOGENOMiCLU_024568_0_0_11
KOiK01772
OMAiMKDLRYV

Enzyme and pathway databases

UniPathwayiUPA00252
BioCyciPACN267747:G1G0Y-343-MONOMER

Family and domain databases

CDDicd00419, Ferrochelatase_C, 1 hit
cd03411, Ferrochelatase_N, 1 hit
HAMAPiMF_00323, Ferrochelatase, 1 hit
InterProiView protein in InterPro
IPR011008, Dimeric_a/b-barrel
IPR001015, Ferrochelatase
IPR033644, Ferrochelatase_C
IPR033659, Ferrochelatase_N
IPR010644, Put_peroxidase/dismutase
PANTHERiPTHR11108, PTHR11108, 1 hit
PfamiView protein in Pfam
PF06778, Chlor_dismutase, 1 hit
PF00762, Ferrochelatase, 1 hit
SUPFAMiSSF54909, SSF54909, 1 hit
TIGRFAMsiTIGR00109, hemH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPFCB_CUTAK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DTW0
Secondary accession number(s): Q6AB01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 17, 2020
Last sequence update: June 17, 2020
Last modified: August 12, 2020
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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