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Entry version 2 (11 Dec 2019)
Sequence version 1 (13 Nov 2019)
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Protein

A type blood alpha-D-galactosamine galactosaminidase

Gene
N/A
Organism
Flavonifractor plautii (Fusobacterium plautii)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

One of an enzyme pair that work together to convert the A antigen to the H antigen of the O blood type, which together release galactosamine. Catalyzes the second step in the conversion, acts on the product of the first reaction (FpGalNAcDeAc, AC P0DTR4). Is specific for galactosamine containing sugars, does not cleave GalNAc residues.1 Publication

Miscellaneous

DNA was isolated from a male human fecal sample of AB+ blood type, the sequence was given to UniProtKB by the submitters.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=64.5 µM for GalN antigen type 1 penta-MU1 Publication

    pH dependencei

    Optimum pH is 6.5.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei463Nucleophile1 Publication1
    Active sitei5321 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionGlycosidase, Hydrolase

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    A type blood alpha-D-galactosamine galactosaminidase1 Publication (EC:3.2.1.-1 Publication)
    Alternative name(s):
    FpGalactosaminidase1 Publication
    Short name:
    FpGalNase1 Publication
    GH361 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFlavonifractor plautii (Fusobacterium plautii)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri292800 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesRuminococcaceaeFlavonifractor

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

    5 µg/ml of this enzyme pair converts A blood type to O blood type in an hour, and can be removed by centrifugation, showing the pair can be used for production of universal type donor blood.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi463D → A, G or S: Loss of activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000044857227 – 1078A type blood alpha-D-galactosamine galactosaminidaseAdd BLAST1052

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni306 – 570Glycoside hydrolase 36 domain1 PublicationAdd BLAST265
    Regioni699 – 1078Not required for activity on soluble substrates1 PublicationAdd BLAST380

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Has an N-terminal glycoside hydrolase 36 domain with a probable carbohydrate-binding domain in the C-terminus. The C-terminus is not required for activity on soluble substrates but increases efficiency of cleavage in red blood cells.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the glycosyl hydrolase 36 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.120.260, 3 hits
    3.20.20.70, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013785 Aldolase_TIM
    IPR008979 Galactose-bd-like_sf
    IPR002252 Glyco_hydro_36
    IPR017853 Glycoside_hydrolase_SF

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02065 Melibiase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51445 SSF51445, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P0DTR5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRGKKFISLT LSTMLCLQLL PTASFAAAPA TDTGNAGLIA EGDYAIAGNG
    60 70 80 90 100
    VRVTYDADGQ TITLYRTEGS GLIQMSKPSP LGGPVIGGQE VQDFSHISCD
    110 120 130 140 150
    VEQSTSGVMG SGQRMTITSQ SMSTGLIRTY VLETSDIEEG VVYTATSYEA
    160 170 180 190 200
    GASDVEVSWF IGSVYELYGA EDRIWSYNGG GEGPMHYYDT LQKIDLTDSG
    210 220 230 240 250
    KFSRENKQDD TAASIPVSDI YIADGGITVG DASATRREVH TPVQETSDSA
    260 270 280 290 300
    QVSIGWPGKV IAAGSVIEIG ESFAVVHPGD YYNGLRGYKN AMDHLGVIMP
    310 320 330 340 350
    APGDIPDSSY DLRWESWGWG FNWTIDLIIG KLDELQAAGV KQITLDDGWY
    360 370 380 390 400
    TNAGDWALNP EKFPNGASDA LRLTDAIHEH GMTALLWWRP CDGGIDSILY
    410 420 430 440 450
    QQHPEYFVMD ADGRPARLPT PGGGTNPSLG YALCPMADGA IASQVDFVNR
    460 470 480 490 500
    AMNDWGFDGF KGDYVWSMPE CYNPAHNHAS PEESTEKQSE IYRVSYEAMV
    510 520 530 540 550
    ANDPNVFNLL CNCGTPQDYY SLPYMTQIAT ADPTSVDQTR RRVKAYKALM
    560 570 580 590 600
    GDYFPVTADH NNIWYPSAVG TGSVLIEKRD LSGTAKEEYE KWLGIADTVQ
    610 620 630 640 650
    LQKGRFIGDL YSYGFDPYET YVVEKDGVMY YAFYKDGSKY SPTGYPDIEL
    660 670 680 690 700
    KGLDPNKMYR IVDYVNDRVV ATNLMGDNAV FNTRFSDYLL VKAVEISEPD
    710 720 730 740 750
    PEPVDPDYGF TSVDDRDEAL IYTGTWHDDN NASFSEGTAR YTNSTDASVV
    760 770 780 790 800
    FSFTGTSIRW YGQRDTNFGT AEVYLDDELK TTVDANGAAE AGVCLFEALD
    810 820 830 840 850
    LPAAEHTIKI VCKSGVIDID RFAYEAATLE PIYEKVDALS DRITYVGNWE
    860 870 880 890 900
    EYHNSEFYMG NAMRTDEAGA YAELTFRGTA VRLYAEMSFN FGTADVYLDG
    910 920 930 940 950
    ELVENIILYG QEATGQLMFE RTGLEEGEHT IRLVQNAWNI NLDYISYLPE
    960 970 980 990 1000
    QDQPTPPETT VTVDAMDAQL VYTGVWNDDY HDVFQEGTAR YASSAGASVE
    1010 1020 1030 1040 1050
    FEFTGSEIRW YGQNDSNFGV ASVYIDNEFV QQVNVNGAAA VGKLLFQKAD
    1060 1070
    LPAGSHTIRI VCDTPVIDLD YLTYTTNA
    Length:1,078
    Mass (Da):118,707
    Last modified:November 13, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86348685D13811B8
    GO

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    Gene3Di2.60.120.260, 3 hits
    3.20.20.70, 1 hit
    InterProiView protein in InterPro
    IPR013785 Aldolase_TIM
    IPR008979 Galactose-bd-like_sf
    IPR002252 Glyco_hydro_36
    IPR017853 Glycoside_hydrolase_SF
    PfamiView protein in Pfam
    PF02065 Melibiase, 1 hit
    SUPFAMiSSF51445 SSF51445, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGAL_FLAPL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DTR5
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2019
    Last sequence update: November 13, 2019
    Last modified: December 11, 2019
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
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