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UniProtKB - P0DSW6 (PROF_VARV)
Protein
Profilin
Gene
A42R
Organism
Variola virus
Status
Functioni
Participates in either intracellular transport of viral proteins or intercellular spread of the virus. Cellular profilins modulate actin filament dynamics (polymerization and depolymerization) via direct binding to actin through an actin-binding domain as well as by modulation of other actin-binding proteins. In contrast to cellular homologs, the poxvirus profilins seem to bind actin only weakly (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin-dependent intracellular transport of virus towards nucleus Source: UniProtKB-KW
- viral entry into host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-binding |
Biological process | Actin-dependent inwards viral transport, Cytoplasmic inwards viral transport, Host-virus interaction, Virus entry into host cell |
Names & Taxonomyi
Protein namesi | Recommended name: Profilin |
Gene namesi | ORF Names:A42R, A45R, A47R, A50R |
Organismi | Variola virus |
Taxonomic identifieri | 10255 [NCBI] |
Taxonomic lineagei | Viruses › Varidnaviria › Bamfordvirae › Nucleocytoviricota › Pokkesviricetes › Chitovirales › Poxviridae › Chordopoxvirinae › Orthopoxvirus |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm Note: Localizes to inclusion bodies formed by viral A25/ATI protein in the cytoplasm of the host cell.
Keywords - Cellular componenti
Host cytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000448117 | 1 – 133 | ProfilinAdd BLAST | 133 |
Interactioni
Subunit structurei
Interacts with host TPM1.
Interacts with protein A25 (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Belongs to the profilin family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DSW6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEWHKIIED ISKNNNFEDA AIVDYKTTKN VLAAIPNRTF AKINPGEVIP
60 70 80 90 100
LITNHNILKP LIGQKFCIVY TNSLMDENTY AMELLTGYAP VSPIVIARTH
110 120 130
TALIFLMGKP TTSRRDVYRT CRDHATRVRA TGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22579 Genomic DNA Translation: AAA60897.1 Y16780 Genomic DNA Translation: CAB54753.1 |
PIRi | C36853 |
RefSeqi | NP_042197.1, NC_001611.1 |
Genome annotation databases
GeneIDi | 1486528 |
KEGGi | vg:1486528 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22579 Genomic DNA Translation: AAA60897.1 Y16780 Genomic DNA Translation: CAB54753.1 |
PIRi | C36853 |
RefSeqi | NP_042197.1, NC_001611.1 |
3D structure databases
SMRi | P0DSW6 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 1486528 |
KEGGi | vg:1486528 |
Family and domain databases
InterProi | View protein in InterPro IPR005455, PFN IPR036140, PFN_sf IPR027310, Profilin_CS |
Pfami | View protein in Pfam PF00235, Profilin, 1 hit |
SMARTi | View protein in SMART SM00392, PROF, 1 hit |
SUPFAMi | SSF55770, SSF55770, 1 hit |
PROSITEi | View protein in PROSITE PS00414, PROFILIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROF_VARV | |
Accessioni | P0DSW6Primary (citable) accession number: P0DSW6 Secondary accession number(s): P33828, Q76PV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2019 |
Last sequence update: | October 16, 2019 | |
Last modified: | September 29, 2021 | |
This is version 10 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |