UniProtKB - P0DQJ5 (VSTX1_ACAGO)
Protein
U1-theraphotoxin-Agm3a
Gene
N/A
Organism
Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
Status
Functioni
Inhibits sodium channels Nav1.7/SCN9A and potassium channels Kv11.1/KCNH2. Also binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) with very slow apparent binding kinetics and affects channel gating. Reaches its target by dynamically partitioning into anionic or zwitterionic headgroup lipid membranes. May bind to the open state of KvAP.By similarity
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: U1-theraphotoxin-Agm3a1 PublicationShort name: U1-TRTX-Agm3a1 Publication |
Organismi | Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus) |
Taxonomic identifieri | 115339 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Mygalomorphae › Theraphosidae › Acanthoscurria |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
PropeptideiPRO_0000448549 | 22 – 29 | By similarity | 8 | |
ChainiPRO_0000448550 | 30 – 60 | U1-theraphotoxin-Agm3a1 PublicationAdd BLAST | 31 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 45 | By similarity | ||
Disulfide bondi | 38 ↔ 50 | By similarity | ||
Disulfide bondi | 44 ↔ 57 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Domaini
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Sequence similaritiesi
Keywords - Domaini
Knottin, SignalFamily and domain databases
InterProi | View protein in InterPro IPR011696, Huwentoxin-1 IPR013140, Huwentoxin_CS1 |
Pfami | View protein in Pfam PF07740, Toxin_12, 1 hit |
PROSITEi | View protein in PROSITE PS60021, HWTX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0DQJ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFSVLVFIL GLVLLLALSS ATEMEENARA CGSFMWKCSE RLPCCQEYVC
60
SPQWKWCQNP
Mass spectrometryi
Molecular mass is 3690.5 Da. Determined by ESI. Monoisotopic mass.1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0DQJ5 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR011696, Huwentoxin-1 IPR013140, Huwentoxin_CS1 |
Pfami | View protein in Pfam PF07740, Toxin_12, 1 hit |
PROSITEi | View protein in PROSITE PS60021, HWTX_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VSTX1_ACAGO | |
Accessioni | P0DQJ5Primary (citable) accession number: P0DQJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2019 |
Last sequence update: | November 13, 2019 | |
Last modified: | December 2, 2020 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |