UniProtKB - P0DQJ3 (TXA1_ACAGO)
Protein
U1-theraphotoxin-Agm1a
Gene
N/A
Organism
Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus)
Status
Functioni
Is toxic to both insects and mammals. Induces reversible paralysis when injected into S.frugiperda larvae. Reduces both the amplitude and frequency of responses from muscle (GF-TTM and GF-DLM) pathways in the D.melanogaster giant fiber circuit, suggesting an action at the neuromuscular junction, which is mediated by glutamatergic receptors. In mice, intracranial injection of 30 µg causes increased urination, myoclonus, hypermotility with circular movements followed by respiratory and generalized seizures resulting in death within 25-35 minutes of injection.By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: U1-theraphotoxin-Agm1a1 PublicationShort name: U1-TRTX-Agm1a1 Publication |
Organismi | Acanthoscurria gomesiana (Tarantula spider) (Phormictopus pheopygus) |
Taxonomic identifieri | 115339 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Mygalomorphae › Theraphosidae › Acanthoscurria |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000448546 | 1 – 48 | U1-theraphotoxin-Agm1a1 PublicationAdd BLAST | 48 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 4 ↔ 34 | By similarity | ||
Disulfide bondi | 8 ↔ 40 | By similarity | ||
Disulfide bondi | 22 ↔ 45 | By similarity | ||
Modified residuei | 44 | Methionine sulfoxide; partial1 Publication | 1 |
Keywords - PTMi
Disulfide bond, OxidationExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR012625, Toxin_20 |
Pfami | View protein in Pfam PF08089, Toxin_20, 1 hit |
i Sequence
Sequence statusi: Complete.
P0DQJ3-1 [UniParc]FASTAAdd to basket
10 20 30 40
IIECFFSCEI EKDGKSKEGK PCKPKGDKDK DKKCSGGWRC KIKMCLKI
Mass spectrometryi
Molecular mass is 5457.7 Da. Determined by ESI. Monoisotopic mass.1 Publication
Molecular mass is 5473.7 Da. Determined by ESI. Oxidized form, monoisotopic mass.1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | P0DQJ3 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR012625, Toxin_20 |
Pfami | View protein in Pfam PF08089, Toxin_20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TXA1_ACAGO | |
Accessioni | P0DQJ3Primary (citable) accession number: P0DQJ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2019 |
Last sequence update: | November 13, 2019 | |
Last modified: | December 2, 2020 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |