UniProtKB - P0DQJ2 (ACR1_ACTTE)
Protein
U-actitoxin-Ate1
Gene
N/A
Organism
Actinia tenebrosa (Australian red waratah sea anemone)
Status
Functioni
Probable toxin expected to be employed in prey capture and/or defense against predators (based on its abundance in tentacles). Does not show activity on mammalian voltage-gated potassium and sodium channels, and does not induce change in behavior and mortality rates in crustacea (redclaw crayfish) (PubMed:31302115). Shows moderate cytotoxic activity against MCF-7 and MDA-MB-231 breast cancer cell lines (PubMed:31302115). Has only a weak affinity for lipid membranes (PubMed:31302115).1 Publication
Miscellaneous
The 26-Cys-Pro-27 bond exists only in the trans-isomerization.1 Publication
Does not show activity on voltage-gated potassium channels (Kv1.1-Kv1.6, Kv2.1, Kv4.2, and Shaker IR), voltage-gated sodium channels (Nav1.2, Nav1.4, Nav1.5, and Nav1.6), and the insect channel BgNav1.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: U-actitoxin-Ate11 PublicationShort name: U-AITX-Ate11 Publication |
Organismi | Actinia tenebrosa (Australian red waratah sea anemone) |
Taxonomic identifieri | 6105 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Actiniidae › Actinia |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Nematocyst 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- nematocyst Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nematocyst, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | 1 PublicationAdd BLAST | 15 | |
PeptideiPRO_0000448542 | 16 – 28 | U-actitoxin-Ate11 PublicationAdd BLAST | 13 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 20 ↔ 26 | Combined sources1 Publication |
Post-translational modificationi
May be N-glycosylated at Asn-22. Activity with this modification has not be tested.1 Publication
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Interactioni
Subunit structurei
Monomer in solution.
1 PublicationStructurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Cross-referencesi
Web resourcesi
Biological Magnetic Resonance Data Bank |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OQP | NMR | - | A | 16-28 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACR1_ACTTE | |
Accessioni | P0DQJ2Primary (citable) accession number: P0DQJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2019 |
Last sequence update: | November 13, 2019 | |
Last modified: | February 26, 2020 | |
This is version 3 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references