UniProtKB - P0DPQ2 (COW2_CONFG)
Protein
Contryphan-Fr2
Gene
N/A
Organism
Conus frigidus (Frigid cone)
Status
Functioni
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa).By similarity
Miscellaneous
Exists in two forms, due to cis-trans isomerization at 2-Cys-hydroxyPro-3. The cis conformation is the major form.By similarity
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Contryphan-Fr2CuratedAlternative name(s): Fr9651 Publication |
Organismi | Conus frigidus (Frigid cone) |
Taxonomic identifieri | 101755 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Virgiconus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000445269 | 1 – 8 | Contryphan-Fr21 Publication | 8 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 2 ↔ 8 | 1 Publication | ||
Modified residuei | 3 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 4 | D-tryptophan1 Publication | 1 | |
Modified residuei | 8 | Cysteine amide1 Publication | 1 |
Keywords - PTMi
Amidation, D-amino acid, Disulfide bond, HydroxylationExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Domaini
The cysteine framework is C-C.Curated
Sequence similaritiesi
Family and domain databases
PROSITEi | View protein in PROSITE PS60027 CONTRYPHAN, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 965.43 Da from positions 1 - 8. Determined by MALDI. Monoisotopic mass.1 Publication
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
PROSITEi | View protein in PROSITE PS60027 CONTRYPHAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COW2_CONFG | |
Accessioni | P0DPQ2Primary (citable) accession number: P0DPQ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2018 |
Last sequence update: | October 10, 2018 | |
Last modified: | November 7, 2018 | |
This is version 2 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families