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Protein

Neuroblastoma breakpoint family member 9

Gene

NBPF9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroblastoma breakpoint family member 9
Gene namesi
Name:NBPF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31991 NBPF9
MIMi613999 gene
neXtProtiNX_Q3BBW0

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000269713

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880441 – 1111Neuroblastoma breakpoint family member 9Add BLAST1111

Expressioni

Tissue specificityi

Expressed in a neuroblastoma cell line.1 Publication

Organism-specific databases

HPAiHPA038748
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 259NBPF 1PROSITE-ProRule annotationAdd BLAST95
Domaini436 – 528NBPF 2PROSITE-ProRule annotationAdd BLAST93
Domaini529 – 600NBPF 3PROSITE-ProRule annotationAdd BLAST72
Domaini601 – 692NBPF 4PROSITE-ProRule annotationAdd BLAST92
Domaini695 – 750NBPF 5PROSITE-ProRule annotationAdd BLAST56
Domaini751 – 843NBPF 6PROSITE-ProRule annotationAdd BLAST93
Domaini844 – 919NBPF 7PROSITE-ProRule annotationAdd BLAST76
Domaini920 – 1012NBPF 8PROSITE-ProRule annotationAdd BLAST93
Domaini1013 – 1111NBPF 9PROSITE-ProRule annotationAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili70 – 130Sequence analysisAdd BLAST61
Coiled coili341 – 401Sequence analysisAdd BLAST61

Sequence similaritiesi

Belongs to the NBPF family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00420000029746
OrthoDBiEOG091G03WI

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 9 hits
SMARTiView protein in SMART
SM01148 DUF1220, 9 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P0DPF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVVSAGPWSS EKAEMNILEI NEKLRPQLAE NKQQFGNLKE RCFLTQLAGF
60 70 80 90 100
LANRQKKYKY EECKDLIKFM LRNERQFKEE KLAEQLKQAE ELRQYKVLVH
110 120 130 140 150
SQERELTQLK EKLREGRDAS RSLNEHLQAL LTPDEPDKSQ GQDLQEQLAE
160 170 180 190 200
GCRLAQHLVQ KLSPENDEDE DEDVQVEEDE KVLESSAPRE VQKAEESKVA
210 220 230 240 250
EDSLEECAIT CSNSHGPCDS NQPHKNIKIT FEEDEVNSTL VVDRESSHDE
260 270 280 290 300
CQDALNILPV PGPTSSATNV SMVVSAGPLS SEKAEMNILE INEKLRPQLA
310 320 330 340 350
EKKQQFRNLK EKCFLTQLAG FLANQQNKYK YEECKDLIKF MLRNERQFKE
360 370 380 390 400
EKLAEQLKQA EELRQYKVLV HAQERELTQL REKLREGRDA SRSLNEHLQA
410 420 430 440 450
LLTPDEPDKS QGQDLQEQLA EGCRLAQHLV QKLSPENDND DDEDVQIEVA
460 470 480 490 500
EKVQKSSAPR EMQKAEEKEV PEDSLEECAI TYSNSHGPYD SNQPHRKTKI
510 520 530 540 550
TFEEDKVDST LIGSSSHVER EDAVHIIPEN ESDDEEEEEK GPVSPRNLQE
560 570 580 590 600
SEEEEVPQES WDEGYSTPSI PPEMLASYKS YSSTFHSLEE QQVCMAVDIG
610 620 630 640 650
RHRWDQVKKE DQEATGPRLS RELLDEKGPE VLQDSLDRCY STPSGCLELT
660 670 680 690 700
DSCQPYRSAF YVLEQQRVGL AVDMDEIEKY QEVEEDQDPS CPRLSRELLD
710 720 730 740 750
EKEPEVLQDS LGRWYSTPSG YLELPDLGQP YSSAVYSLEE QYLGLALDLD
760 770 780 790 800
RIKKDQEEEE DQGPPCPRLS RELLEVVEPE VLQDSLDRCY STPSSCLEQP
810 820 830 840 850
DSCQPYGSSF YALEEKHVGF SLDVGEIEKK GKGKKRRGRR SKKKRRRGRK
860 870 880 890 900
EGEENQNPPC PRLSRELLDE KEPEVLQDSL DRCYSTPSGY LELPDLGQPY
910 920 930 940 950
SSAVYSLEEQ YLGLALDVDR IKKDQEEEED QGPPCPRLSR ELLEVVEPEV
960 970 980 990 1000
LQDSLDRCYS TPSSCLEQPD SCQPYGSSFY ALEEKHVGFS LDVGEIEKKG
1010 1020 1030 1040 1050
KGKKRRGRRS KKERRRGRKE GEEDQNPPCP RLNGVLMEVE EPEVLQDSLD
1060 1070 1080 1090 1100
GCYSTPSMYF ELPDSFQHYR SVFYSFEEQH ISFALYVDNR FFTLTVTSLH
1110
LVFQMEVIFP Q
Note: No experimental confirmation available. Derived from EST data.
Length:1,111
Mass (Da):127,756
Last modified:March 28, 2018 - v1
Checksum:i45ECF606F97DB02E
GO
Isoform 2 (identifier: P0DPF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     765-933: Missing.

Show »
Length:942
Mass (Da):108,436
Checksum:i36F219C4C792FAC4
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0Y3A0A087X0Y3_HUMAN
Neuroblastoma breakpoint family mem...
NBPF9
299Annotation score:
A0A087WVG0A0A087WVG0_HUMAN
Neuroblastoma breakpoint family mem...
NBPF9
867Annotation score:
A0A087WYQ9A0A087WYQ9_HUMAN
Neuroblastoma breakpoint family mem...
NBPF9
942Annotation score:
A0A087WZE1A0A087WZE1_HUMAN
Neuroblastoma breakpoint family mem...
NBPF9
981Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186S → P in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti200A → T in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti442D → N in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti447I → V in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti637D → Y in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti722L → P in AAX85113 (PubMed:16079250).Curated1
Sequence conflicti972C → W in AAX85113 (PubMed:16079250).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059364765 – 933Missing in isoform 2. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894574 mRNA Translation: AAX85113.1
AC239804 Genomic DNA No translation available.
CCDSiCCDS72895.1 [P0DPF3-2]
CCDS72896.1 [P0DPF3-1]
RefSeqiNP_001032764.2, NM_001037675.3 [P0DPF3-2]
NP_001264373.1, NM_001277444.1 [P0DPF3-1]
XP_006711380.1, XM_006711317.2
UniGeneiHs.445080
Hs.714127

Genome annotation databases

EnsembliENST00000584027; ENSP00000463665; ENSG00000269713 [P0DPF3-1]
ENST00000610300; ENSP00000481471; ENSG00000269713 [P0DPF3-2]
ENST00000613595; ENSP00000483900; ENSG00000269713 [P0DPF3-2]
ENST00000615421; ENSP00000477979; ENSG00000269713 [P0DPF3-1]
GeneIDi400818
KEGGihsa:400818

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY894574 mRNA Translation: AAX85113.1
AC239804 Genomic DNA No translation available.
CCDSiCCDS72895.1 [P0DPF3-2]
CCDS72896.1 [P0DPF3-1]
RefSeqiNP_001032764.2, NM_001037675.3 [P0DPF3-2]
NP_001264373.1, NM_001277444.1 [P0DPF3-1]
XP_006711380.1, XM_006711317.2
UniGeneiHs.445080
Hs.714127

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000584027; ENSP00000463665; ENSG00000269713 [P0DPF3-1]
ENST00000610300; ENSP00000481471; ENSG00000269713 [P0DPF3-2]
ENST00000613595; ENSP00000483900; ENSG00000269713 [P0DPF3-2]
ENST00000615421; ENSP00000477979; ENSG00000269713 [P0DPF3-1]
GeneIDi400818
KEGGihsa:400818

Organism-specific databases

CTDi400818
HGNCiHGNC:31991 NBPF9
HPAiHPA038748
HPA042595
HPA043105
HPA043692
HPA044023
HPA046971
HPA058050
MIMi613999 gene
neXtProtiNX_Q3BBW0
OpenTargetsiENSG00000269713
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00420000029746
OrthoDBiEOG091G03WI

Miscellaneous databases

PROiPR:P0DPF3
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR010630 NBPF_dom
PfamiView protein in Pfam
PF06758 DUF1220, 9 hits
SMARTiView protein in SMART
SM01148 DUF1220, 9 hits
PROSITEiView protein in PROSITE
PS51316 NBPF, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNBPF9_HUMAN
AccessioniPrimary (citable) accession number: P0DPF3
Secondary accession number(s): A0A075B761
, A0A087WVA0, A0A087WY26, Q3BBV1, Q3BBW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2018
Last sequence update: March 28, 2018
Last modified: October 10, 2018
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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