UniProtKB - P0DPE5 (CJ1C1_EPIJA)
Protein
Toxin AnmTx Cj 1c-1
Gene
N/A
Organism
Epiactis japonica (Sea anemone) (Cnidopus japonicus)
Status
Functioni
In vivo, induces marked paralysis on shrimps (C.multidentata) at 10-20 seconds after injection and a weak toxicity when injected into fly larvae (M.domestica).1 Publication
Caution
Toxicity tests have been done on recombinant non-amidated toxin.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of signal transduction Source: InterPro
Keywordsi
Molecular function | Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Toxin AnmTx Cj 1c-11 Publication |
Organismi | Epiactis japonica (Sea anemone) (Cnidopus japonicus) |
Taxonomic identifieri | 58804 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Actiniidae › Epiactis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Other locations
- Nematocyst Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- nematocyst Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nematocyst, SecretedPathology & Biotechi
Toxic dosei
LD(100) is 30 µg/g on the shrimp C.multidentata.1 Publication
LD50 is 30 µg/g when injected into fly larvae (M.domestica).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 – 7 | Curated | ›7 | |
ChainiPRO_0000443394 | 8 – 53 | Toxin AnmTx Cj 1c-11 PublicationAdd BLAST | 46 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 9 ↔ 50 | By similarity | ||
Disulfide bondi | 11 ↔ 41 | By similarity | ||
Disulfide bondi | 33 ↔ 51 | By similarity | ||
Modified residuei | 53 | Glutamic acid 1-amideCurated | 1 |
Post-translational modificationi
Contains 3 disulfide bonds.Curated
Keywords - PTMi
Amidation, Disulfide bondFamily & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P0DPE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNKRGVPCR CESDGPPRQN NALSGTTFYV VGCNKAGWNK CRYINAISTC
CKEG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Curated | 1 |
Cross-referencesi
3D structure databases
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
Gene3Di | 2.20.20.10, 1 hit |
InterProi | View protein in InterPro IPR000693 Anenome_toxin IPR023355 Myo_ane_neurotoxin_sf |
Pfami | View protein in Pfam PF00706 Toxin_4, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | CJ1C1_EPIJA | |
Accessioni | P0DPE5Primary (citable) accession number: P0DPE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 28, 2018 |
Last sequence update: | February 28, 2018 | |
Last modified: | April 25, 2018 | |
This is version 3 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |