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Entry version 14 (08 May 2019)
Sequence version 1 (28 Feb 2018)
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Protein

Endothelin-converting enzyme 2

Gene

ECE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.4 µM for big ET-11 Publication
  2. KM=1.4 µM for peptide E1 Publication
  3. KM=27.4 µM for bradykinin1 Publication
  4. KM=48.4 µM for dynorphin B1 Publication

    pH dependencei

    Optimum pH is 5.0-5.5. Inactive at neutral pH.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi648Zinc; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei649PROSITE-ProRule annotation1
    Metal bindingi652Zinc; catalyticPROSITE-ProRule annotation1
    Metal bindingi708Zinc; catalyticPROSITE-ProRule annotation1
    Active sitei712Proton donorPROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Metalloprotease, Methyltransferase, Multifunctional enzyme, Protease, Transferase
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-375276 Peptide ligand-binding receptors

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M13.003

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Endothelin-converting enzyme 21 Publication (EC:3.4.24.711 Publication)
    Short name:
    ECE-2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ECE2Imported
    Synonyms:KIAA06041 Publication
    ORF Names:UNQ403/PRO7401 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:13275 ECE2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610145 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P0DPD6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 106CytoplasmicCuratedAdd BLAST106
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127Helical; Signal-anchor for type II membrane proteinCuratedAdd BLAST21
    Topological domaini128 – 811LumenalCuratedAdd BLAST684

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000145194

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5890

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004432931 – 811Endothelin-converting enzyme 2Add BLAST811

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi140 ↔ 145PROSITE-ProRule annotation
    Disulfide bondi163 ↔ 796PROSITE-ProRule annotation
    Disulfide bondi171 ↔ 756PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi227 ↔ 476PROSITE-ProRule annotation
    Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi357N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi580N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
    Disulfide bondi685 ↔ 808PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PeptideAtlas

    More...
    PeptideAtlasi
    P0DPD6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P0DPD6 baseline and differential

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA043346

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    Protein interaction database and analysis system

    More...
    IntActi
    P0DPD6, 1 interactor

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P0DPD6

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P0DPD6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini139 – 811Peptidase M13PROSITE-ProRule annotationAdd BLAST673

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M13 family.PROSITE-ProRule annotationCurated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156921

    KEGG Orthology (KO)

    More...
    KOi
    K01415
    K22857

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DESYYRE

    Database of Orthologous Groups

    More...
    OrthoDBi
    282463at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd08662 M13, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1380.10, 1 hit
    3.40.390.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR024079 MetalloPept_cat_dom_sf
    IPR000718 Peptidase_M13
    IPR018497 Peptidase_M13_C
    IPR042089 Peptidase_M13_dom_2
    IPR008753 Peptidase_M13_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11733 PTHR11733, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01431 Peptidase_M13, 1 hit
    PF05649 Peptidase_M13_N, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00786 NEPRILYSIN

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51885 NEPRILYSIN, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform ECE2-1 (identifier: P0DPD6-4) [UniParc]FASTAAdd to basket
    Also known as: ECE2-2C1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNVALQELGA GSNMVEYKRA TLRDEDAPET PVEGGASPDA MEVGKGASPF
    60 70 80 90 100
    SPGPSPGMTP GTPRSSGLFW RVTCPHLRSI SGLCSRTMVG FQKGTRQLLG
    110 120 130 140 150
    SRTQLELVLA GASLLLAALL LGCLVALGVQ YHRDPSHSTC LTEACIRVAG
    160 170 180 190 200
    KILESLDRGV SPCEDFYQFS CGGWIRRNPL PDGRSRWNTF NSLWDQNQAI
    210 220 230 240 250
    LKHLLENTTF NSSSEAEQKT QRFYLSCLQV ERIEELGAQP LRDLIEKIGG
    260 270 280 290 300
    WNITGPWDQD NFMEVLKAVA GTYRATPFFT VYISADSKSS NSNVIQVDQS
    310 320 330 340 350
    GLFLPSRDYY LNRTANEKVL TAYLDYMEEL GMLLGGRPTS TREQMQQVLE
    360 370 380 390 400
    LEIQLANITV PQDQRRDEEK IYHKMSISEL QALAPSMDWL EFLSFLLSPL
    410 420 430 440 450
    ELSDSEPVVV YGMDYLQQVS ELINRTEPSI LNNYLIWNLV QKTTSSLDRR
    460 470 480 490 500
    FESAQEKLLE TLYGTKKSCV PRWQTCISNT DDALGFALGS LFVKATFDRQ
    510 520 530 540 550
    SKEIAEGMIS EIRTAFEEAL GQLVWMDEKT RQAAKEKADA IYDMIGFPDF
    560 570 580 590 600
    ILEPKELDDV YDGYEISEDS FFQNMLNLYN FSAKVMADQL RKPPSRDQWS
    610 620 630 640 650
    MTPQTVNAYY LPTKNEIVFP AGILQAPFYA RNHPKALNFG GIGVVMGHEL
    660 670 680 690 700
    THAFDDQGRE YDKEGNLRPW WQNESLAAFR NHTACMEEQY NQYQVNGERL
    710 720 730 740 750
    NGRQTLGENI ADNGGLKAAY NAYKAWLRKH GEEQQLPAVG LTNHQLFFVG
    760 770 780 790 800
    FAQVWCSVRT PESSHEGLVT DPHSPARFRV LGTLSNSRDF LRHFGCPVGS
    810
    PMNPGQLCEV W
    Length:811
    Mass (Da):91,211
    Last modified:February 28, 2018 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7379F7AFEA937FCE
    GO
    Isoform ECE2-2 (identifier: P0DPD6-2) [UniParc] [UniParc]FASTAAdd to basket
    Also known as: ECE-2B1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         43-88: Missing.

    Show »
    Length:765
    Mass (Da):86,470
    Checksum:i89D1B831B5628694
    GO
    Isoform ECE2-3 (identifier: P0DPD6-3) [UniParc] [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-88: Missing.

    Show »
    Length:736
    Mass (Da):83,322
    Checksum:i77F14FE5AC80E187
    GO
    Isoform EEF1AKMT4-ECE2-1 (identifier: P0DPD8-1) [UniParc] [UniParc]FASTAAdd to basket
    Also known as: ECE-2A1 Publication
    The sequence of this isoform can be found in the external entry P0DPD8.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Note: Based on a naturally occurring readthrough transcript which produces an EEF1AKMT4-ECE2 fusion protein.1 Publication
    Length:883
    Mass (Da):99,773
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0Y5G8H0Y5G8_HUMAN
    Endothelin-converting enzyme 2
    ECE2
    716Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WCL9F8WCL9_HUMAN
    Endothelin-converting enzyme 2
    ECE2
    67Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA25530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395F → S in AAI42951 (PubMed:15489334).Curated1
    Sequence conflicti711A → T in AAQ89362 (PubMed:12975309).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037085499R → Q. Corresponds to variant dbSNP:rs35875049Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05932414 – 88Missing in isoform ECE2-3. Add BLAST75
    Alternative sequenceiVSP_05932543 – 88Missing in isoform ECE2-2. Add BLAST46

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF428264 mRNA Translation: AAL30387.1
    AF192531 mRNA Translation: AAG28399.1
    AF521189 mRNA Translation: AAM77664.1
    AB011176 mRNA Translation: BAA25530.2 Different initiation.
    AY359003 mRNA Translation: AAQ89362.1
    AC061705 Genomic DNA No translation available.
    AC078797 Genomic DNA No translation available.
    BC142950 mRNA Translation: AAI42951.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS33899.1 [P0DPD6-3]
    CCDS43179.1
    CCDS46969.1 [P0DPD6-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001032401.1, NM_001037324.2 [P0DPD6-3]
    NP_001093590.1, NM_001100120.1 [P0DPD6-4]
    NP_001093591.1, NM_001100121.1 [P0DPD6-2]
    NP_055508.3, NM_014693.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000357474; ENSP00000350066; ENSG00000145194 [P0DPD6-4]
    ENST00000359140; ENSP00000352052; ENSG00000145194 [P0DPD6-3]
    ENST00000404464; ENSP00000385846; ENSG00000145194 [P0DPD6-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    110599583
    9718

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:110599583
    hsa:9718

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF428264 mRNA Translation: AAL30387.1
    AF192531 mRNA Translation: AAG28399.1
    AF521189 mRNA Translation: AAM77664.1
    AB011176 mRNA Translation: BAA25530.2 Different initiation.
    AY359003 mRNA Translation: AAQ89362.1
    AC061705 Genomic DNA No translation available.
    AC078797 Genomic DNA No translation available.
    BC142950 mRNA Translation: AAI42951.1
    CCDSiCCDS33899.1 [P0DPD6-3]
    CCDS43179.1
    CCDS46969.1 [P0DPD6-2]
    RefSeqiNP_001032401.1, NM_001037324.2 [P0DPD6-3]
    NP_001093590.1, NM_001100120.1 [P0DPD6-4]
    NP_001093591.1, NM_001100121.1 [P0DPD6-2]
    NP_055508.3, NM_014693.3

    3D structure databases

    SMRiP0DPD6
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiP0DPD6, 1 interactor

    Chemistry databases

    BindingDBiP0DPD6
    ChEMBLiCHEMBL5890

    Protein family/group databases

    MEROPSiM13.003

    Proteomic databases

    PeptideAtlasiP0DPD6

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000357474; ENSP00000350066; ENSG00000145194 [P0DPD6-4]
    ENST00000359140; ENSP00000352052; ENSG00000145194 [P0DPD6-3]
    ENST00000404464; ENSP00000385846; ENSG00000145194 [P0DPD6-2]
    GeneIDi110599583
    9718
    KEGGihsa:110599583
    hsa:9718

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    110599583
    9718

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ECE2
    HGNCiHGNC:13275 ECE2
    HPAiHPA043346
    MIMi610145 gene
    neXtProtiNX_P0DPD6
    OpenTargetsiENSG00000145194

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    GeneTreeiENSGT00940000156921
    KOiK01415
    K22857
    OMAiDESYYRE
    OrthoDBi282463at2759

    Enzyme and pathway databases

    ReactomeiR-HSA-375276 Peptide ligand-binding receptors

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P0DPD6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    ExpressionAtlasiP0DPD6 baseline and differential

    Family and domain databases

    CDDicd08662 M13, 1 hit
    Gene3Di1.10.1380.10, 1 hit
    3.40.390.10, 1 hit
    InterProiView protein in InterPro
    IPR024079 MetalloPept_cat_dom_sf
    IPR000718 Peptidase_M13
    IPR018497 Peptidase_M13_C
    IPR042089 Peptidase_M13_dom_2
    IPR008753 Peptidase_M13_N
    PANTHERiPTHR11733 PTHR11733, 1 hit
    PfamiView protein in Pfam
    PF01431 Peptidase_M13, 1 hit
    PF05649 Peptidase_M13_N, 1 hit
    PRINTSiPR00786 NEPRILYSIN
    PROSITEiView protein in PROSITE
    PS51885 NEPRILYSIN, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECE2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DPD6
    Secondary accession number(s): A5PLK8
    , O60344, Q6NTG7, Q6UW36, Q8NFD7, Q96NX3, Q96NX4, Q9BRZ8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
    Last sequence update: February 28, 2018
    Last modified: May 8, 2019
    This is version 14 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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