UniProtKB - P0DPB4 (SCHI1_MOUSE)
Schwannomin-interacting protein 1
Schip1
Functioni
GO - Molecular functioni
- identical protein binding Source: MGI
- protein homodimerization activity Source: MGI
GO - Biological processi
- estrogen metabolic process Source: MGI
- face morphogenesis Source: MGI
- female gonad development Source: MGI
- fibroblast migration Source: MGI
- kidney development Source: MGI
- luteinization Source: MGI
- nitrogen compound metabolic process Source: MGI
- platelet-derived growth factor receptor signaling pathway Source: MGI
- post-embryonic development Source: MGI
- roof of mouth development Source: MGI
- skeletal system morphogenesis Source: MGI
- smooth muscle tissue development Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Schwannomin-interacting protein 11 PublicationShort name: SCHIP-11 Publication |
Gene namesi | Name:Schip1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353557 Schip1 |
Subcellular locationi
Other locations
- cytoplasm Source: MGI
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288928 | 1 – 484 | Schwannomin-interacting protein 1Add BLAST | 484 |
PTM databases
iPTMneti | P0DPB4 |
Expressioni
Gene expression databases
ExpressionAtlasi | P0DPB4 baseline and differential |
Genevisiblei | Q3TI53 MM |
Interactioni
Subunit structurei
Homooligomer (via coiled coil domain) (By similarity).
Interacts with NF2; the interaction is direct (By similarity).
Interacts with ANK3 (By similarity).
By similarityBinary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P35240 | 2 | EBI-1397475,EBI-1014472 | From Homo sapiens. |
GO - Molecular functioni
- identical protein binding Source: MGI
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
IntActi | P0DPB4, 1 interactor |
STRINGi | 10090.ENSMUSP00000029346 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 421 – 455 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 67 | Ser-richAdd BLAST | 35 | |
Compositional biasi | 99 – 104 | Poly-Glu | 6 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00390000011127 |
OMAi | XLQSGMN |
OrthoDBi | 1290403at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR039045 SCHIP_1 IPR015649 SCHIP_1_C |
PANTHERi | PTHR13103 PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148 SCHIP-1, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERSEQRVRA AWDCDPGKQA DRDYREDGMD LGSDAGSSSS SRASSQSNST
60 70 80 90 100
KVTPCSECKS SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE
110 120 130 140 150
EEEEDDRGYR DDGCPAREPG DVSARIGSSG SGSRSAATTM PSPMPNGNLH
160 170 180 190 200
PHDPQDLRHN GNVVVAGRPN ASRVPRRPIQ KTQPPGSRRG GRNRASGGLC
210 220 230 240 250
LQPPDGGTRV PEEPPAPPMD WEALEKHLAG LQFREQEVRN QGQARTNSTS
260 270 280 290 300
AQKNERESIR QKLALGSFFD DGPGIYTSCS KSGKPSLSAR LQSGMNLQIC
310 320 330 340 350
FVNDSGSDKD SDADDSKTET SLDTPLSPMS KQSSSYSDRD TTEEESESLD
360 370 380 390 400
DMDFLTRQKK LQAEAKMALA MAKPMAKMQV EVEKQNRKKS PVADLLPHMP
410 420 430 440 450
HISECLMKRS LKPTDLRDMT IGQLQVIVND LHSQIESLNE ELVQLLLIRD
460 470 480
ELHTEQDAML VDIEDLTRHA ESQQKHMAEK MPAK
The sequence of this isoform differs from the canonical sequence as follows:
1-28: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-240: Missing.
241-250: QGQARTNSTS → MVHQENCSYQ
The sequence of this isoform differs from the canonical sequence as follows:
23-250: Missing.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R1J0 | S4R1J0_MOUSE | Schwannomin interacting protein 1 i... | Schip1 | 261 | Annotation score: | ||
A0A0A6YXQ5 | A0A0A6YXQ5_MOUSE | Schwannomin-interacting protein 1 | Schip1 | 388 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 166 | A → V in AAF34244 (PubMed:10669747).Curated | 1 | |
Sequence conflicti | 384 | K → R in BAB32387 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025831 | 1 – 240 | Missing in isoform Schip1-3. 2 PublicationsAdd BLAST | 240 | |
Alternative sequenceiVSP_046119 | 1 – 28 | Missing in isoform Schip1-2. 2 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_046121 | 23 – 250 | Missing in isoform Schip1-4. 1 PublicationAdd BLAST | 228 | |
Alternative sequenceiVSP_025834 | 241 – 250 | QGQARTNSTS → MVHQENCSYQ in isoform Schip1-3. 2 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU163407 mRNA Translation: ABW06760.1 EU163408 mRNA Translation: ABW06761.1 AK021361 mRNA Translation: BAB32387.1 Sequence problems. AK168005 mRNA Translation: BAE39993.1 AK146930 mRNA Translation: BAE27541.1 AC093360 Genomic DNA No translation available. AC114675 Genomic DNA No translation available. AC121306 Genomic DNA No translation available. AC122913 Genomic DNA No translation available. AC164401 Genomic DNA No translation available. BC060529 mRNA Translation: AAH60529.1 BC094348 mRNA Translation: AAH94348.1 Sequence problems. AF145716 mRNA Translation: AAF34244.1 |
CCDSi | CCDS50926.1 CCDS50927.1 [P0DPB4-4] CCDS50929.1 [P0DPB4-3] CCDS71249.1 [P0DPB4-2] |
RefSeqi | NP_001106891.1, NM_001113420.1 [P0DPB4-4] NP_001106892.1, NM_001113421.1 [P0DPB4-1] NP_001268973.1, NM_001282044.1 [P0DPB4-2] NP_001268974.1, NM_001282045.1 [P0DPB4-2] NP_038956.2, NM_013928.5 [P0DPB4-3] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU163407 mRNA Translation: ABW06760.1 EU163408 mRNA Translation: ABW06761.1 AK021361 mRNA Translation: BAB32387.1 Sequence problems. AK168005 mRNA Translation: BAE39993.1 AK146930 mRNA Translation: BAE27541.1 AC093360 Genomic DNA No translation available. AC114675 Genomic DNA No translation available. AC121306 Genomic DNA No translation available. AC122913 Genomic DNA No translation available. AC164401 Genomic DNA No translation available. BC060529 mRNA Translation: AAH60529.1 BC094348 mRNA Translation: AAH94348.1 Sequence problems. AF145716 mRNA Translation: AAF34244.1 |
CCDSi | CCDS50926.1 CCDS50927.1 [P0DPB4-4] CCDS50929.1 [P0DPB4-3] CCDS71249.1 [P0DPB4-2] |
RefSeqi | NP_001106891.1, NM_001113420.1 [P0DPB4-4] NP_001106892.1, NM_001113421.1 [P0DPB4-1] NP_001268973.1, NM_001282044.1 [P0DPB4-2] NP_001268974.1, NM_001282045.1 [P0DPB4-2] NP_038956.2, NM_013928.5 [P0DPB4-3] |
3D structure databases
SMRi | P0DPB4 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P0DPB4, 1 interactor |
STRINGi | 10090.ENSMUSP00000029346 |
PTM databases
iPTMneti | P0DPB4 |
Genome annotation databases
Organism-specific databases
CTDi | 29970 |
MGIi | MGI:1353557 Schip1 |
Phylogenomic databases
GeneTreei | ENSGT00390000011127 |
OMAi | XLQSGMN |
OrthoDBi | 1290403at2759 |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P0DPB4 baseline and differential |
Genevisiblei | Q3TI53 MM |
Family and domain databases
InterProi | View protein in InterPro IPR039045 SCHIP_1 IPR015649 SCHIP_1_C |
PANTHERi | PTHR13103 PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148 SCHIP-1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCHI1_MOUSE | |
Accessioni | P0DPB4Primary (citable) accession number: P0DPB4 Secondary accession number(s): A8IJC6 Q9JLR0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2017 |
Last sequence update: | November 22, 2017 | |
Last modified: | October 16, 2019 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot