UniProtKB - P0DPB3 (SCHI1_HUMAN)
Schwannomin-interacting protein 1
SCHIP1
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- positive regulation of hippo signaling Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P0DPB3 |
Names & Taxonomyi
Protein namesi | Recommended name: Schwannomin-interacting protein 1ImportedShort name: SCHIP-11 Publication |
Gene namesi | Name:SCHIP1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15678, SCHIP1 |
neXtProti | NX_P0DPB3 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 29970 |
OpenTargetsi | ENSG00000151967 ENSG00000283154 |
Miscellaneous databases
Pharosi | P0DPB3, Tbio |
Genetic variation databases
BioMutai | SCHIP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288927 | 1 – 487 | Schwannomin-interacting protein 1Add BLAST | 487 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P0DPB3 |
jPOSTi | P0DPB3 |
MassIVEi | P0DPB3 |
PeptideAtlasi | P0DPB3 |
PRIDEi | P0DPB3 |
PTM databases
iPTMneti | P0DPB3 |
Expressioni
Tissue specificityi
Gene expression databases
ExpressionAtlasi | P0DPB3, baseline and differential |
Genevisiblei | Q9P0W5, HS |
Organism-specific databases
HPAi | ENSG00000151967, Group enriched (brain, heart muscle, skeletal muscle) |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP0DPB3
With | #Exp. | IntAct |
---|---|---|
PSMD4 [P55036] | 2 | EBI-1397509,EBI-359318 |
itself | 2 | EBI-1397509,EBI-1397509 |
SCOC [Q9UIL1] | 4 | EBI-1397509,EBI-2686537 |
ZC3H13 [Q5T200] | 2 | EBI-1397509,EBI-2679720 |
Isoform SCHIP1-4 [P0DPB3-4]
With | #Exp. | IntAct |
---|---|---|
PRPF18 [Q99633] | 3 | EBI-11962426,EBI-2798416 |
SCOC - isoform 3 [Q9UIL1-3] | 5 | EBI-11962426,EBI-10692913 |
SMARCD1 [Q96GM5] | 3 | EBI-11962426,EBI-358489 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
IntActi | P0DPB3, 50 interactors |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 424 – 458 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 32 – 67 | Ser-richAdd BLAST | 36 | |
Compositional biasi | 99 – 106 | Poly-Glu | 8 | |
Compositional biasi | 132 – 136 | Poly-Gly | 5 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00390000011127 |
OrthoDBi | 1290403at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR039045, SCHIP_1 IPR015649, SCHIP_1_C |
PANTHERi | PTHR13103, PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148, SCHIP-1, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERSGQRVTT WDCDQGKHSD SDYREDGMDL GSDAGSSSSS SRASSQSNST
60 70 80 90 100
KVTPCSECKS SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE
110 120 130 140 150
EEEEDERDQR GYRDDRSPAR EPGDVSARTR SGGGGGRSAT TAMPPPVPNG
160 170 180 190 200
NLHQHDPQDL RHNGNVVVAG RPSCSRGPRR AIQKPQPAGG RRSGRGPAAG
210 220 230 240 250
GLCLQPPDGG TCVPEEPPVP PMDWEALEKH LAGLQFREQE VRNQGQARTN
260 270 280 290 300
STSAQKNERE SIRQKLALGS FFDDGPGIYT SCSKSGKPSL SSRLQSGMNL
310 320 330 340 350
QICFVNDSGS DKDSDADDSK TETSLDTPLS PMSKQSSSYS DRDTTEEESE
360 370 380 390 400
SLDDMDFLTR QKKLQAEAKM ALAMAKPMAK MQVEVEKQNR KKSPVADLLP
410 420 430 440 450
HMPHISECLM KRSLKPTDLR DMTIGQLQVI VNDLHSQIES LNEELVQLLL
460 470 480
IRDELHTEQD AMLVDIEDLT RHAESQQKHM AEKMPAK
The sequence of this isoform differs from the canonical sequence as follows:
241-253: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
22-253: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-243: Missing.
244-253: QGQARTNSTS → MVHQDNCSYQ
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JWG6 | C9JWG6_HUMAN | Schwannomin interacting protein 1, ... | SCHIP1 hCG_2022069 | 260 | Annotation score: | ||
F8WDG0 | F8WDG0_HUMAN | Schwannomin-interacting protein 1 | SCHIP1 | 52 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | Missing in AAH36535 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051332 | 101 | E → K. Corresponds to variant dbSNP:rs3732851Ensembl. | 1 | |
Natural variantiVAR_032534 | 481 | A → V1 PublicationCorresponds to variant dbSNP:rs17850021Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025827 | 1 – 243 | Missing in isoform SCHIP1-4. 2 PublicationsAdd BLAST | 243 | |
Alternative sequenceiVSP_025828 | 22 – 253 | Missing in isoform SCHIP1-3. 1 PublicationAdd BLAST | 232 | |
Alternative sequenceiVSP_025829 | 241 – 253 | Missing in isoform SCHIP1-2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_025830 | 244 – 253 | QGQARTNSTS → MVHQDNCSYQ in isoform SCHIP1-4. 2 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145713 mRNA Translation: AAF34241.1 AF145714 mRNA Translation: AAF34242.1 AF145715 mRNA Translation: AAF34243.1 AK091871 mRNA Translation: BAG52432.1 CH471052 Genomic DNA Translation: EAW78662.1 BC005947 mRNA Translation: AAH05947.1 BC036535 mRNA Translation: AAH36535.1 AF070614 mRNA Translation: AAC25386.1 |
CCDSi | CCDS3186.1 CCDS56292.1 [P0DPB3-2] CCDS56293.1 [P0DPB3-3] CCDS56294.1 [P0DPB3-4] |
RefSeqi | NP_001184036.1, NM_001197107.1 [P0DPB3-2] NP_001184037.1, NM_001197108.1 [P0DPB3-3] NP_001184038.1, NM_001197109.1 [P0DPB3-4] NP_055390.1, NM_014575.3 [P0DPB3-1] |
Genome annotation databases
Ensembli | ENST00000445224; ENSP00000404860; ENSG00000151967 [P0DPB3-4] |
GeneIDi | 29970 |
KEGGi | hsa:29970 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145713 mRNA Translation: AAF34241.1 AF145714 mRNA Translation: AAF34242.1 AF145715 mRNA Translation: AAF34243.1 AK091871 mRNA Translation: BAG52432.1 CH471052 Genomic DNA Translation: EAW78662.1 BC005947 mRNA Translation: AAH05947.1 BC036535 mRNA Translation: AAH36535.1 AF070614 mRNA Translation: AAC25386.1 |
CCDSi | CCDS3186.1 CCDS56292.1 [P0DPB3-2] CCDS56293.1 [P0DPB3-3] CCDS56294.1 [P0DPB3-4] |
RefSeqi | NP_001184036.1, NM_001197107.1 [P0DPB3-2] NP_001184037.1, NM_001197108.1 [P0DPB3-3] NP_001184038.1, NM_001197109.1 [P0DPB3-4] NP_055390.1, NM_014575.3 [P0DPB3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P0DPB3, 50 interactors |
PTM databases
iPTMneti | P0DPB3 |
Genetic variation databases
BioMutai | SCHIP1 |
Proteomic databases
EPDi | P0DPB3 |
jPOSTi | P0DPB3 |
MassIVEi | P0DPB3 |
PeptideAtlasi | P0DPB3 |
PRIDEi | P0DPB3 |
Protocols and materials databases
Antibodypediai | 1013, 109 antibodies |
Genome annotation databases
Ensembli | ENST00000445224; ENSP00000404860; ENSG00000151967 [P0DPB3-4] |
GeneIDi | 29970 |
KEGGi | hsa:29970 |
Organism-specific databases
CTDi | 29970 |
DisGeNETi | 29970 |
GeneCardsi | SCHIP1 |
HGNCi | HGNC:15678, SCHIP1 |
HPAi | ENSG00000151967, Group enriched (brain, heart muscle, skeletal muscle) |
neXtProti | NX_P0DPB3 |
OpenTargetsi | ENSG00000151967 ENSG00000283154 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000011127 |
OrthoDBi | 1290403at2759 |
Enzyme and pathway databases
PathwayCommonsi | P0DPB3 |
Miscellaneous databases
Pharosi | P0DPB3, Tbio |
PROi | PR:P0DPB3 |
Gene expression databases
ExpressionAtlasi | P0DPB3, baseline and differential |
Genevisiblei | Q9P0W5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039045, SCHIP_1 IPR015649, SCHIP_1_C |
PANTHERi | PTHR13103, PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148, SCHIP-1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCHI1_HUMAN | |
Accessioni | P0DPB3Primary (citable) accession number: P0DPB3 Secondary accession number(s): B3KRM0 Q9P0W5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2017 |
Last sequence update: | November 22, 2017 | |
Last modified: | February 10, 2021 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM