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UniProtKB - P0DPB3 (SCHI1_HUMAN)
Protein
Schwannomin-interacting protein 1
Gene
SCHIP1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- positive regulation of hippo signaling Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P0DPB3 |
SignaLinki | P0DPB3 |
Names & Taxonomyi
Protein namesi | Recommended name: Schwannomin-interacting protein 1ImportedShort name: SCHIP-11 Publication |
Gene namesi | Name:SCHIP1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15678, SCHIP1 |
MIMi | 619206, gene |
neXtProti | NX_P0DPB3 |
VEuPathDBi | HostDB:ENSG00000151967 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 29970 |
OpenTargetsi | ENSG00000151967 ENSG00000283154 |
Miscellaneous databases
Pharosi | P0DPB3, Tbio |
Genetic variation databases
BioMutai | SCHIP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288927 | 1 – 487 | Schwannomin-interacting protein 1Add BLAST | 487 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P0DPB3 |
jPOSTi | P0DPB3 |
MassIVEi | P0DPB3 |
PeptideAtlasi | P0DPB3 |
PTM databases
iPTMneti | P0DPB3 |
PhosphoSitePlusi | P0DPB3 |
Expressioni
Tissue specificityi
Preferentially expressed in brain, skeletal muscles and heart. Also expressed in detected in pancreas, kidney, liver, lung, and placenta.1 Publication
Gene expression databases
ExpressionAtlasi | P0DPB3, baseline and differential |
Genevisiblei | Q9P0W5, HS |
Organism-specific databases
HPAi | ENSG00000151967, Tissue enhanced (brain, heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Binary interactionsi
P0DPB3
With | #Exp. | IntAct |
---|---|---|
PSMD4 [P55036] | 2 | EBI-1397509,EBI-359318 |
itself | 2 | EBI-1397509,EBI-1397509 |
SCOC [Q9UIL1] | 4 | EBI-1397509,EBI-2686537 |
ZC3H13 [Q5T200] | 2 | EBI-1397509,EBI-2679720 |
Isoform SCHIP1-4 [P0DPB3-4]
With | #Exp. | IntAct |
---|---|---|
PRPF18 [Q99633] | 3 | EBI-11962426,EBI-2798416 |
SCOC - isoform 3 [Q9UIL1-3] | 5 | EBI-11962426,EBI-10692913 |
SMARCD1 [Q96GM5] | 3 | EBI-11962426,EBI-358489 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
IntActi | P0DPB3, 50 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 74 | DisorderedSequence analysisAdd BLAST | 74 | |
Regioni | 88 – 221 | DisorderedSequence analysisAdd BLAST | 134 | |
Regioni | 236 – 260 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 308 – 354 | DisorderedSequence analysisAdd BLAST | 47 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 424 – 458 | Sequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 29 | Basic and acidic residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 32 – 68 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 94 – 108 | Acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 109 – 123 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 239 – 257 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 323 – 339 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the SCHIP1 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00390000011127 |
OrthoDBi | 1290403at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR039045, SCHIP_1 IPR015649, SCHIP_1_C |
PANTHERi | PTHR13103, PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148, SCHIP-1, 1 hit |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketIsoform SCHIP1-1 (identifier: P0DPB3-1) [UniParc]FASTAAdd to basket
Also known as: SCHIP-11 Publication, SCHIP-1a1 Publication
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERSGQRVTT WDCDQGKHSD SDYREDGMDL GSDAGSSSSS SRASSQSNST
60 70 80 90 100
KVTPCSECKS SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE
110 120 130 140 150
EEEEDERDQR GYRDDRSPAR EPGDVSARTR SGGGGGRSAT TAMPPPVPNG
160 170 180 190 200
NLHQHDPQDL RHNGNVVVAG RPSCSRGPRR AIQKPQPAGG RRSGRGPAAG
210 220 230 240 250
GLCLQPPDGG TCVPEEPPVP PMDWEALEKH LAGLQFREQE VRNQGQARTN
260 270 280 290 300
STSAQKNERE SIRQKLALGS FFDDGPGIYT SCSKSGKPSL SSRLQSGMNL
310 320 330 340 350
QICFVNDSGS DKDSDADDSK TETSLDTPLS PMSKQSSSYS DRDTTEEESE
360 370 380 390 400
SLDDMDFLTR QKKLQAEAKM ALAMAKPMAK MQVEVEKQNR KKSPVADLLP
410 420 430 440 450
HMPHISECLM KRSLKPTDLR DMTIGQLQVI VNDLHSQIES LNEELVQLLL
460 470 480
IRDELHTEQD AMLVDIEDLT RHAESQQKHM AEKMPAK
Isoform SCHIP1-2 (identifier: P0DPB3-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D241/2531 Publication
The sequence of this isoform differs from the canonical sequence as follows:
241-253: Missing.
Isoform SCHIP1-3 (identifier: P0DPB3-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D22/2531 Publication
The sequence of this isoform differs from the canonical sequence as follows:
22-253: Missing.
Isoform SCHIP1-4 (identifier: P0DPB3-4) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-243: Missing.
244-253: QGQARTNSTS → MVHQDNCSYQ
Isoform IQCJ-SCHIP1-1 (identifier: B3KU38-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry B3KU38.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoform IQCJ-SCHIP1-2 (identifier: B3KU38-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry B3KU38.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | Missing in AAH36535 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051332 | 101 | E → K. Corresponds to variant dbSNP:rs3732851Ensembl. | 1 | |
Natural variantiVAR_032534 | 481 | A → V1 PublicationCorresponds to variant dbSNP:rs17850021Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025827 | 1 – 243 | Missing in isoform SCHIP1-4. 2 PublicationsAdd BLAST | 243 | |
Alternative sequenceiVSP_025828 | 22 – 253 | Missing in isoform SCHIP1-3. 1 PublicationAdd BLAST | 232 | |
Alternative sequenceiVSP_025829 | 241 – 253 | Missing in isoform SCHIP1-2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_025830 | 244 – 253 | QGQARTNSTS → MVHQDNCSYQ in isoform SCHIP1-4. 2 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145713 mRNA Translation: AAF34241.1 AF145714 mRNA Translation: AAF34242.1 AF145715 mRNA Translation: AAF34243.1 AK091871 mRNA Translation: BAG52432.1 CH471052 Genomic DNA Translation: EAW78662.1 BC005947 mRNA Translation: AAH05947.1 BC036535 mRNA Translation: AAH36535.1 AF070614 mRNA Translation: AAC25386.1 |
CCDSi | CCDS3186.1 CCDS56292.1 [P0DPB3-2] CCDS56293.1 [P0DPB3-3] CCDS56294.1 [P0DPB3-4] |
RefSeqi | NP_001184036.1, NM_001197107.1 [P0DPB3-2] NP_001184037.1, NM_001197108.1 [P0DPB3-3] NP_001184038.1, NM_001197109.1 [P0DPB3-4] NP_055390.1, NM_014575.3 [P0DPB3-1] |
Genome annotation databases
Ensembli | ENST00000445224.6; ENSP00000404860.2; ENSG00000151967.18 [P0DPB3-4] |
GeneIDi | 29970 |
KEGGi | hsa:29970 |
MANE-Selecti | ENST00000638749.2; ENSP00000491030.1; NM_014575.4; NP_055390.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF145713 mRNA Translation: AAF34241.1 AF145714 mRNA Translation: AAF34242.1 AF145715 mRNA Translation: AAF34243.1 AK091871 mRNA Translation: BAG52432.1 CH471052 Genomic DNA Translation: EAW78662.1 BC005947 mRNA Translation: AAH05947.1 BC036535 mRNA Translation: AAH36535.1 AF070614 mRNA Translation: AAC25386.1 |
CCDSi | CCDS3186.1 CCDS56292.1 [P0DPB3-2] CCDS56293.1 [P0DPB3-3] CCDS56294.1 [P0DPB3-4] |
RefSeqi | NP_001184036.1, NM_001197107.1 [P0DPB3-2] NP_001184037.1, NM_001197108.1 [P0DPB3-3] NP_001184038.1, NM_001197109.1 [P0DPB3-4] NP_055390.1, NM_014575.3 [P0DPB3-1] |
3D structure databases
AlphaFoldDBi | P0DPB3 |
SMRi | P0DPB3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P0DPB3, 50 interactors |
PTM databases
iPTMneti | P0DPB3 |
PhosphoSitePlusi | P0DPB3 |
Genetic variation databases
BioMutai | SCHIP1 |
Proteomic databases
EPDi | P0DPB3 |
jPOSTi | P0DPB3 |
MassIVEi | P0DPB3 |
PeptideAtlasi | P0DPB3 |
Protocols and materials databases
Antibodypediai | 1013, 113 antibodies from 16 providers |
DNASUi | 29970 |
Genome annotation databases
Ensembli | ENST00000445224.6; ENSP00000404860.2; ENSG00000151967.18 [P0DPB3-4] |
GeneIDi | 29970 |
KEGGi | hsa:29970 |
MANE-Selecti | ENST00000638749.2; ENSP00000491030.1; NM_014575.4; NP_055390.1 |
Organism-specific databases
CTDi | 29970 |
DisGeNETi | 29970 |
GeneCardsi | SCHIP1 |
HGNCi | HGNC:15678, SCHIP1 |
HPAi | ENSG00000151967, Tissue enhanced (brain, heart muscle, skeletal muscle, tongue) |
MIMi | 619206, gene |
neXtProti | NX_P0DPB3 |
OpenTargetsi | ENSG00000151967 ENSG00000283154 |
VEuPathDBi | HostDB:ENSG00000151967 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000011127 |
OrthoDBi | 1290403at2759 |
Enzyme and pathway databases
PathwayCommonsi | P0DPB3 |
SignaLinki | P0DPB3 |
Miscellaneous databases
Pharosi | P0DPB3, Tbio |
PROi | PR:P0DPB3 |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P0DPB3, baseline and differential |
Genevisiblei | Q9P0W5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039045, SCHIP_1 IPR015649, SCHIP_1_C |
PANTHERi | PTHR13103, PTHR13103, 1 hit |
Pfami | View protein in Pfam PF10148, SCHIP-1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCHI1_HUMAN | |
Accessioni | P0DPB3Primary (citable) accession number: P0DPB3 Secondary accession number(s): B3KRM0 Q9P0W5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2017 |
Last sequence update: | November 22, 2017 | |
Last modified: | May 25, 2022 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families