LYNX1

Functionⁱ

Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs. Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4₂:beta-2₃ to low sensitivity alpha-4₃:beta-2₂ nAChR (By similarity). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)₂:beta-4 and (alpha-3:beta-4)₂:alpha-5 nAChRs suggesting an interaction with nAChR alpha-3^-:⁺beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)₂:alpha-3 when compared to (alpha-3:beta-2)₂:alpha-5 nAChRs (PubMed:28100642). Prevents plasticity in the primary visual cortex late in life (By similarity).By similarity2 Publications

Miscellaneous

Isoform 1 is considered to be an endogenous "prototoxin", that shares a N-terminal three-finger structure with snake alpha-neurotoxins.1 Publication

GO - Molecular functionⁱ

acetylcholine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21252236
acetylcholine receptor inhibitor activity Source: Ensembl
acetylcholine receptor regulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21252236
ion channel inhibitor activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of neurotransmitter receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21252236
synaptic transmission, cholinergic Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ly-6/neurotoxin-like protein 1Curated Alternative name(s): Endogenous prototoxin LYNX11 Publication Testicular tissue protein Li 112Imported
Gene namesⁱ	Name:LYNX1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29604 LYNX1
MIMⁱ	606110 gene
neXtProtⁱ	NX_P0DP58

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180155

OpenTargetsⁱ

ENSG00000180155

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST	20
ChainⁱPRO_0000036154	21 – 91	Ly-6/neurotoxin-like protein 1Sequence analysisAdd BLAST	71
PropeptideⁱPRO_0000440641	92 – 116	Removed in mature formSequence analysisAdd BLAST	25

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	23 ↔ 46	Combined sources1 Publication
Disulfide bondⁱ	26 ↔ 33	Combined sources1 Publication
Disulfide bondⁱ	39 ↔ 64	Combined sources1 Publication
Disulfide bondⁱ	68 ↔ 85	Combined sources1 Publication
Disulfide bondⁱ	86 ↔ 91	Combined sources1 Publication
Lipidationⁱ	91	GPI-anchor amidated cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0DP58

PeptideAtlasⁱ

P0DP58

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_LYNX1
ExpressionAtlasⁱ	P0DP58 baseline and differential
Genevisibleⁱ	Q9BZG9 HS

Interactionⁱ

Subunit structureⁱ

Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits. Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly (By similarity).By similarity

GO - Molecular functionⁱ

acetylcholine receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21252236

View the complete GO annotation on QuickGO ...

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	26 – 31	Combined sources	6
Beta strandⁱ	36 – 38	Combined sources	3
Beta strandⁱ	45 – 54	Combined sources	10
Beta strandⁱ	57 – 66	Combined sources	10
Beta strandⁱ	75 – 77	Combined sources	3
Beta strandⁱ	80 – 86	Combined sources	7
Turnⁱ	89 – 92	Combined sources	4

Show more details

3D structure databases

SMRⁱ	P0DP58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – 107	UPAR/Ly6Sequence analysisAdd BLAST		87

Keywords - Domainⁱ

Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00720000108940 ENSGT00730000111571
OMAⁱ	RTYYTPY

Family and domain databases

InterProⁱ	View protein in InterPro IPR016054 LY6_UPA_recep-like IPR035076 Toxin/TOLIP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00087 Toxin_TOLIP, 1 hit
SMARTⁱ	View protein in SMART SM00134 LU, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P0DP58-1) [UniParc]FASTA Add to basket

Also known as: LYNX11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPLLTLILV VLMGLPLAQA LDCHVCAYNG DNCFNPMRCP AMVAYCMTTR 
        60         70         80         90        100
TYYTPTRMKV SKSCVPRCFE TVYDGYSKHA STTSCCQYDL CNGTGLATPA 
       110 
TLALAPILLA TLWGLL

Length:116

Mass (Da):12,641

Last modified:July 5, 2017 - v1

Checksum:ⁱBF5827EB64BFE6F6

GO

Isoform 2 (identifier: P0DP58-2) [UniParc] [UniParc]FASTA Add to basket

Also known as: LYNX1-SLURP21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
52-116: YYTPTRMKVS...ILLATLWGLL → SAAEAIWCHQ...CCQTSLCNHD

« Hide

        10         20         30         40         50
MTPLLTLILV VLMGLPLAQA LDCHVCAYNG DNCFNPMRCP AMVAYCMTTR 
        60         70         80         90        100
TSAAEAIWCH QCTGFGGCSH GSRCLRDSTH CVTTATRVLS NTEDLPLVTK 
       110        120        130 
MCHIGCPDIP SLGLGPYVSI ACCQTSLCNH D

Note: Based on a naturally occurring readthrough transcript which produces a LYNX1-SLURP2 fusion protein.1 Publication

Show »

Length:131

Mass (Da):14,026

Checksum:ⁱFAD1259D48A036D7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A087WYG6	A0A087WYG6_HUMAN	Ly-6/neurotoxin-like protein 1 Ly-6/neurotoxin-like protein 1	LYNX1	84	Annotation score:
A0A087WZS0	A0A087WZS0_HUMAN	Ly-6/neurotoxin-like protein 1 Ly-6/neurotoxin-like protein 1	LYNX1	82	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058978	52 – 116	YYTPT…LWGLL → SAAEAIWCHQCTGFGGCSHG SRCLRDSTHCVTTATRVLSN TEDLPLVTKMCHIGCPDIPS LGLGPYVSIACCQTSLCNHD in isoform 2. Add BLAST		65

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005425 mRNA Translation: AEE61023.1 AC083841 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82299.1 CH471162 Genomic DNA Translation: EAW82301.1 CH471162 Genomic DNA Translation: EAW82302.1 CH471162 Genomic DNA Translation: EAW82303.1 CH471162 Genomic DNA Translation: EAW82304.1 AF321824 mRNA Translation: AAK01642.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6389.1
NCBI Reference Sequences More...RefSeqⁱ	NP_076435.1, NM_023946.3 [P0DP58-2] NP_803252.1, NM_177457.4 [P0DP58-1] NP_803429.1, NM_177476.3 [P0DP58-1] NP_803430.1, NM_177477.3 [P0DP58-1]
UniGeneⁱ	Hs.158665 Hs.604828

Genome annotation databases

Ensemblⁱ	ENST00000614491; ENSP00000477648; ENSG00000180155 [P0DP58-1] ENST00000620006; ENSP00000478402; ENSG00000180155 [P0DP58-1] ENST00000621401; ENSP00000478390; ENSG00000180155 [P0DP58-1]
GeneIDⁱ	111188157 66004
KEGGⁱ	hsa:111188157 hsa:66004

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DP58	Ly-6/neurotoxin-like protein 1 (Fragment)		HUMAN		82	UniRef100_P0DP58
Ly-6/neurotoxin-like protein 1 (Fragment)		HUMAN		84
P0DP58-2	LYNX1 isoform 2		PANTR		131	UniRef100_A0A2J8LFK9

Protein	Similar proteins		Species	Score	Length	Source
P0DP58	Ly-6/neurotoxin-like protein 1		BOVIN		116	UniRef90_P0DP58
Ly-6/neurotoxin-like protein 1		PANTR		116
Ly-6/neurotoxin-like protein 1		SAIBB		116
Ly-6/neurotoxin-like protein 1 (Fragment)		HUMAN		82
Uncharacterized protein		SHEEP		119
+35
P0DP58-2	LYNX1-SLURP2 readthrough		PONAB		131	UniRef90_H2PRB7
Uncharacterized protein		CHLSB		133
LYNX1 isoform 2		PANTR		131
Uncharacterized protein		MACFA		131
UPI0005F5380B		CERAT		133
+3

Protein	Similar proteins		Species	Score	Length	Source
P0DP58	Ly-6/neurotoxin-like protein 1		SAIBB		116	UniRef50_P0DP58
Ly-6/neurotoxin-like protein 1		BOVIN		116
Ly-6/neurotoxin-like protein 1		PANTR		116
Ly-6/neurotoxin-like protein 1		MACMU		118
Ly-6/neurotoxin-like protein 1 (Fragment)		HUMAN		82
+57
P0DP58-2	LYNX1-SLURP2 readthrough		PONAB		131	UniRef50_H2PRB7
Uncharacterized protein		CHLSB		133
Uncharacterized protein		MACFA		131
LYNX1 isoform 2		PANTR		131
Uncharacterized protein (Fragment)		AILME		129
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005425 mRNA Translation: AEE61023.1 AC083841 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82299.1 CH471162 Genomic DNA Translation: EAW82301.1 CH471162 Genomic DNA Translation: EAW82302.1 CH471162 Genomic DNA Translation: EAW82303.1 CH471162 Genomic DNA Translation: EAW82304.1 AF321824 mRNA Translation: AAK01642.1
CCDSⁱ	CCDS6389.1
RefSeqⁱ	NP_076435.1, NM_023946.3 [P0DP58-2] NP_803252.1, NM_177457.4 [P0DP58-1] NP_803429.1, NM_177476.3 [P0DP58-1] NP_803430.1, NM_177477.3 [P0DP58-1]
UniGeneⁱ	Hs.158665 Hs.604828

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1VYE	model	-	A	1-80	[»]
	2L03	NMR	-	A	21-93	[»]
SMRⁱ	P0DP58
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	P0DP58

PeptideAtlasⁱ

P0DP58

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000614491; ENSP00000477648; ENSG00000180155 [P0DP58-1] ENST00000620006; ENSP00000478402; ENSG00000180155 [P0DP58-1] ENST00000621401; ENSP00000478390; ENSG00000180155 [P0DP58-1]
GeneIDⁱ	111188157 66004
KEGGⁱ	hsa:111188157 hsa:66004

Organism-specific databases

CTDⁱ	111188157 66004
GeneCardsⁱ	LYNX1
HGNCⁱ	HGNC:29604 LYNX1
MIMⁱ	606110 gene
neXtProtⁱ	NX_P0DP58
OpenTargetsⁱ	ENSG00000180155
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00720000108940 ENSGT00730000111571
OMAⁱ	RTYYTPY

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0DP58
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_LYNX1
ExpressionAtlasⁱ	P0DP58 baseline and differential
Genevisibleⁱ	Q9BZG9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR016054 LY6_UPA_recep-like IPR035076 Toxin/TOLIP
Pfamⁱ	View protein in Pfam PF00087 Toxin_TOLIP, 1 hit
SMARTⁱ	View protein in SMART SM00134 LU, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LYNX1_HUMAN
Accessionⁱ	P0DP58Primary (citable) accession number: P0DP58 Secondary accession number(s): A0A140VJN6 , D3DWI7, G3XAC2, Q86SR0, Q9BZG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 5, 2017
	Last sequence update:	July 5, 2017
	Last modified:	October 10, 2018
	This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DP58 (LYNX1_HUMAN)

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Ly-6/neurotoxin-like protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ