UniProtKB - P0DP58 (LYNX1_HUMAN)
Ly-6/neurotoxin-like protein 1
LYNX1
Functioni
Miscellaneous
GO - Molecular functioni
- acetylcholine receptor binding Source: UniProtKB
- acetylcholine receptor inhibitor activity Source: GO_Central
- acetylcholine receptor regulator activity Source: UniProtKB
- ion channel inhibitor activity Source: Ensembl
GO - Biological processi
- regulation of neurotransmitter receptor activity Source: UniProtKB
- synaptic transmission, cholinergic Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P0DP58 |
Names & Taxonomyi
Protein namesi | Recommended name: Ly-6/neurotoxin-like protein 1CuratedAlternative name(s): Endogenous prototoxin LYNX11 Publication Testicular tissue protein Li 112Imported |
Gene namesi | Name:LYNX1Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29604, LYNX1 |
MIMi | 606110, gene |
neXtProti | NX_P0DP58 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysis; GPI-anchor Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- dendrite By similarity
Note: Detected in Purkinje cells soma and proximal dendrites.By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- anchored component of membrane Source: GO_Central
- dendrite Source: UniProtKB-SubCell
- synapse Source: GOC
Keywords - Cellular componenti
Cell membrane, Cell projection, Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 111188157 66004 |
OpenTargetsi | ENSG00000180155 |
Miscellaneous databases
Pharosi | P0DP58, Tbio |
Genetic variation databases
BioMutai | LYNX1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000036154 | 21 – 91 | Ly-6/neurotoxin-like protein 1Sequence analysisAdd BLAST | 71 | |
PropeptideiPRO_0000440641 | 92 – 116 | Removed in mature formSequence analysisAdd BLAST | 25 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 23 ↔ 46 | Combined sources1 Publication | ||
Disulfide bondi | 26 ↔ 33 | Combined sources1 Publication | ||
Disulfide bondi | 39 ↔ 64 | Combined sources1 Publication | ||
Disulfide bondi | 68 ↔ 85 | Combined sources1 Publication | ||
Disulfide bondi | 86 ↔ 91 | Combined sources1 Publication | ||
Lipidationi | 91 | GPI-anchor amidated cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P0DP58 |
MassIVEi | P0DP58 |
PeptideAtlasi | P0DP58 |
PRIDEi | P0DP58 |
PTM databases
iPTMneti | P0DP58 |
Expressioni
Gene expression databases
ExpressionAtlasi | P0DP58, baseline and differential |
Genevisiblei | Q9BZG9, HS |
Organism-specific databases
HPAi | ENSG00000180155, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Interacts with nAChRs containing alpha-4:beta-2 (CHRNA4:CHRNB2) and alpha-7 (CHRNA7) subunits.
Interacts with CHRNA4 probably in the endoplasmic reticulum prior to nAChR pentameric assembly (By similarity).
By similarityBinary interactionsi
Hide detailsIsoform 2 [P0DP58-2]
GO - Molecular functioni
- acetylcholine receptor binding Source: UniProtKB
Protein-protein interaction databases
IntActi | P0DP58, 24 interactors |
STRINGi | 9606.ENSP00000479586 |
Miscellaneous databases
RNActi | P0DP58, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P0DP58 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 107 | UPAR/Ly6Sequence analysisAdd BLAST | 87 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502T3MP, Eukaryota |
GeneTreei | ENSGT00730000111571 ENSGT00940000153378 |
OMAi | YTPYRMK |
OrthoDBi | 1544318at2759 |
PhylomeDBi | P0DP58 |
Family and domain databases
CDDi | cd00117, LU, 1 hit |
InterProi | View protein in InterPro IPR016054, LY6_UPA_recep-like IPR035076, Toxin/TOLIP |
Pfami | View protein in Pfam PF00087, Toxin_TOLIP, 1 hit |
SMARTi | View protein in SMART SM00134, LU, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTPLLTLILV VLMGLPLAQA LDCHVCAYNG DNCFNPMRCP AMVAYCMTTR
60 70 80 90 100
TYYTPTRMKV SKSCVPRCFE TVYDGYSKHA STTSCCQYDL CNGTGLATPA
110
TLALAPILLA TLWGLL
The sequence of this isoform differs from the canonical sequence as follows:
52-116: YYTPTRMKVS...ILLATLWGLL → SAAEAIWCHQ...CCQTSLCNHD
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZS0 | A0A087WZS0_HUMAN | Ly-6/neurotoxin-like protein 1 | LYNX1 | 82 | Annotation score: | ||
A0A087WYG6 | A0A087WYG6_HUMAN | Ly-6/neurotoxin-like protein 1 | LYNX1 | 84 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058978 | 52 – 116 | YYTPT…LWGLL → SAAEAIWCHQCTGFGGCSHG SRCLRDSTHCVTTATRVLSN TEDLPLVTKMCHIGCPDIPS LGLGPYVSIACCQTSLCNHD in isoform 2. Add BLAST | 65 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005425 mRNA Translation: AEE61023.1 AC083841 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82299.1 CH471162 Genomic DNA Translation: EAW82301.1 CH471162 Genomic DNA Translation: EAW82302.1 CH471162 Genomic DNA Translation: EAW82303.1 CH471162 Genomic DNA Translation: EAW82304.1 AF321824 mRNA Translation: AAK01642.1 |
CCDSi | CCDS6389.1 |
RefSeqi | NP_076435.1, NM_023946.3 [P0DP58-2] NP_803252.1, NM_177457.4 [P0DP58-1] NP_803429.1, NM_177476.3 [P0DP58-1] NP_803430.1, NM_177477.3 [P0DP58-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005425 mRNA Translation: AEE61023.1 AC083841 Genomic DNA No translation available. CH471162 Genomic DNA Translation: EAW82299.1 CH471162 Genomic DNA Translation: EAW82301.1 CH471162 Genomic DNA Translation: EAW82302.1 CH471162 Genomic DNA Translation: EAW82303.1 CH471162 Genomic DNA Translation: EAW82304.1 AF321824 mRNA Translation: AAK01642.1 |
CCDSi | CCDS6389.1 |
RefSeqi | NP_076435.1, NM_023946.3 [P0DP58-2] NP_803252.1, NM_177457.4 [P0DP58-1] NP_803429.1, NM_177476.3 [P0DP58-1] NP_803430.1, NM_177477.3 [P0DP58-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1VYE | model | - | A | 1-80 | [»] | |
2L03 | NMR | - | A | 21-93 | [»] | |
SMRi | P0DP58 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P0DP58, 24 interactors |
STRINGi | 9606.ENSP00000479586 |
PTM databases
iPTMneti | P0DP58 |
Genetic variation databases
BioMutai | LYNX1 |
Proteomic databases
jPOSTi | P0DP58 |
MassIVEi | P0DP58 |
PeptideAtlasi | P0DP58 |
PRIDEi | P0DP58 |
Protocols and materials databases
Antibodypediai | 21624, 30 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 111188157 66004 |
DisGeNETi | 111188157 66004 |
GeneCardsi | LYNX1 |
HGNCi | HGNC:29604, LYNX1 |
HPAi | ENSG00000180155, Tissue enhanced (brain) |
MIMi | 606110, gene |
neXtProti | NX_P0DP58 |
OpenTargetsi | ENSG00000180155 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T3MP, Eukaryota |
GeneTreei | ENSGT00730000111571 ENSGT00940000153378 |
OMAi | YTPYRMK |
OrthoDBi | 1544318at2759 |
PhylomeDBi | P0DP58 |
Enzyme and pathway databases
PathwayCommonsi | P0DP58 |
Miscellaneous databases
BioGRID-ORCSi | 66004, 4 hits in 985 CRISPR screens |
GenomeRNAii | 66004 |
Pharosi | P0DP58, Tbio |
PROi | PR:P0DP58 |
RNActi | P0DP58, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P0DP58, baseline and differential |
Genevisiblei | Q9BZG9, HS |
Family and domain databases
CDDi | cd00117, LU, 1 hit |
InterProi | View protein in InterPro IPR016054, LY6_UPA_recep-like IPR035076, Toxin/TOLIP |
Pfami | View protein in Pfam PF00087, Toxin_TOLIP, 1 hit |
SMARTi | View protein in SMART SM00134, LU, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYNX1_HUMAN | |
Accessioni | P0DP58Primary (citable) accession number: P0DP58 Secondary accession number(s): A0A140VJN6 Q9BZG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2017 |
Last sequence update: | July 5, 2017 | |
Last modified: | April 7, 2021 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references