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Protein

Cation channel sperm-associated protein subunit epsilon

Gene

Catspere

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation (PubMed:28226241). Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (PubMed:28226241).1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit epsilon1 Publication
Short name:
CatSper-epsilon1 Publication
Short name:
CatSperepsilon1 Publication
Alternative name(s):
C1orf101-like protein1 Publication
Gene namesi
Name:Catspere1 PublicationImported
Synonyms:Gm7068Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3647531 Catspere

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 937ExtracellularCuratedAdd BLAST902
Transmembranei938 – 958HelicalSequence analysisAdd BLAST21
Topological domaini959 – 985CytoplasmicCuratedAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000044063536 – 985Cation channel sperm-associated protein subunit epsilonSequence analysisAdd BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

PTM databases

PhosphoSitePlusiP0DP43

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Interactioni

Subunit structurei

Component of the CatSper complex.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR028751 CATSPERD/E
PANTHERiPTHR33722 PTHR33722, 1 hit
PfamiView protein in Pfam
PF15020 CATSPERD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0DP43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSAGQRKPG SLLALQALQK WLLRGGVGAM LARQVVAALL LWLSCCVSAL
60 70 80 90 100
WRYYINSQDY SIFSTRSSIK LEYEGNSFVS WKIPESCKVE NTTSPKTTLH
110 120 130 140 150
CKRAGIHTIK PIAGNQEVER HLTVDNSYIC YLWYFTVVDV YYNLSQIVTI
160 170 180 190 200
WVYDPESAST EELIWTAKKP SLSSRVLTKQ MNTLGQRPFI FTVEKRLTYH
210 220 230 240 250
PGPLTSEGTW VIHLPMSSDD IAKVIRGNKV AFQDCFIANL YFMLTYPMTI
260 270 280 290 300
ISEPPGYEPL TVPPGSPLML SWDTCISTFA LLATDQETFQ TNDSFQTWTR
310 320 330 340 350
VRAPPGILSD AQRHSLRDVI IFDQGTLFLV DGTVYLRTED EFTKLDESRG
360 370 380 390 400
ISETGILGFS KRRWCQIRYL YKLASKKSIL IAWSKTTVYA GYATFRFVTL
410 420 430 440 450
TDTAKLKDFL KLPQTDTLEV MSVEYLWHPL EAAVLLSHCS VCTTNTRNIR
460 470 480 490 500
IVIYSAIFQT WTLQDFELQL PKEAILEFRF LYSAMPDIIM WDQHHVYYSY
510 520 530 540 550
KNFTVVGTIS TPSGETNLSS LSQGSKIHQV LTDRIGNVVV KMENNVMFYI
560 570 580 590 600
KADITEAVIL HTWVNTTAKT VVLFDKSFEV CILYYNENLD EKYQLQTQPY
610 620 630 640 650
PLILELQSIN KDLGDWCPYL AFQHNIHSQF YHMDKGESLT IWSQIVYPEN
660 670 680 690 700
RGLYIVVEHY GSSVMTWTQN LEYEIASGFC TKTMITRFFQ TTNYELVDNY
710 720 730 740 750
YQLQKENTGL MLLQFRPSEF SRTCLTAKPV FEIDVGCDSS KYIMVRGFNK
760 770 780 790 800
SRCQRRDFSY VIDKELLRES LSDNLKVRYD VAKYGCPLTL ELGQMFQPIV
810 820 830 840 850
ELYDENGFIK IVDANFILWE IHGRNDYTFN STMEQNGCIN EAQTWDSMIE
860 870 880 890 900
ENPDIPLDDV WGPQNYRPCF SYAIGKPGDL GQPYEILNYS NKNHIKWPMT
910 920 930 940 950
YAGMYVYRLK ILDPNYSFCN LTTIFAIESL GMIPRSSVYL VAALIFVLML
960 970 980
TFISILVLSY FWYLKIYRQF IIEPLHKRPA KQKKN
Length:985
Mass (Da):113,803
Last modified:June 7, 2017 - v1
Checksum:i2752FB5563DBD80B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157787 Genomic DNA No translation available.
AC163217 Genomic DNA No translation available.
RefSeqiXP_006497146.1, XM_006497083.2

Genome annotation databases

GeneIDi631584
KEGGimmu:631584

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157787 Genomic DNA No translation available.
AC163217 Genomic DNA No translation available.
RefSeqiXP_006497146.1, XM_006497083.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiP0DP43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi631584
KEGGimmu:631584

Organism-specific databases

CTDi631584
MGIiMGI:3647531 Catspere

Miscellaneous databases

ChiTaRSiGm7068 mouse
PROiPR:P0DP43
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR028751 CATSPERD/E
PANTHERiPTHR33722 PTHR33722, 1 hit
PfamiView protein in Pfam
PF15020 CATSPERD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTSRE_MOUSE
AccessioniPrimary (citable) accession number: P0DP43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2017
Last sequence update: June 7, 2017
Last modified: April 25, 2018
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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