UniProtKB - P0DP26 (CALM1_MOUSE)
Calmodulin-1
Calm1
Functioni
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity).
By similarityMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 21 – 32 | 1Combined sourcesAdd BLAST | 12 | |
Calcium bindingi | 57 – 68 | 2Combined sourcesAdd BLAST | 12 | |
Calcium bindingi | 94 – 105 | 3Combined sourcesAdd BLAST | 12 | |
Calcium bindingi | 130 – 141 | 4Combined sourcesAdd BLAST | 12 |
GO - Molecular functioni
- adenylate cyclase activator activity Source: MGI
- adenylate cyclase binding Source: MGI
- calcium channel inhibitor activity Source: UniProtKB
- calcium-dependent protein binding Source: MGI
- calcium ion binding Source: UniProtKB
- disordered domain specific binding Source: MGI
- enzyme regulator activity Source: GO_Central
- nitric-oxide synthase binding Source: MGI
- nitric-oxide synthase regulator activity Source: MGI
- N-terminal myristoylation domain binding Source: MGI
- phosphatidylinositol 3-kinase binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
- protein N-terminus binding Source: MGI
- protein phosphatase activator activity Source: MGI
- titin binding Source: MGI
- transmembrane transporter binding Source: MGI
- type 3 metabotropic glutamate receptor binding Source: MGI
GO - Biological processi
- activation of adenylate cyclase activity Source: MGI
- autophagosome membrane docking Source: UniProtKB
- calcium-mediated signaling Source: MGI
- detection of calcium ion Source: MGI
- establishment of protein localization to membrane Source: MGI
- establishment of protein localization to mitochondrial membrane Source: MGI
- G2/M transition of mitotic cell cycle Source: MGI
- mitochondrion-endoplasmic reticulum membrane tethering Source: UniProtKB
- negative regulation of high voltage-gated calcium channel activity Source: Ensembl
- negative regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- organelle localization by membrane tethering Source: UniProtKB
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of autophagic cell death Source: Ensembl
- positive regulation of cyclic-nucleotide phosphodiesterase activity Source: MGI
- positive regulation of DNA binding Source: MGI
- positive regulation of nitric-oxide synthase activity Source: MGI
- positive regulation of phosphoprotein phosphatase activity Source: MGI
- positive regulation of protein dephosphorylation Source: MGI
- positive regulation of ryanodine-sensitive calcium-release channel activity Source: MGI
- potassium ion transmembrane transport Source: Ensembl
- protein autophosphorylation Source: Ensembl
- regulation of cardiac muscle cell action potential Source: Ensembl
- regulation of cardiac muscle contraction Source: MGI
- regulation of cytokinesis Source: MGI
- regulation of heart rate Source: MGI
- regulation of high voltage-gated calcium channel activity Source: MGI
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: MGI
- regulation of response to tumor cell Source: Ensembl
- regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- regulation of synaptic vesicle endocytosis Source: MGI
- regulation of synaptic vesicle exocytosis Source: MGI
- response to amphetamine Source: Ensembl
- response to calcium ion Source: MGI
- response to corticosterone Source: Ensembl
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-111932, CaMK IV-mediated phosphorylation of CREB R-MMU-111933, Calmodulin induced events R-MMU-111957, Cam-PDE 1 activation R-MMU-114608, Platelet degranulation R-MMU-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-MMU-163615, PKA activation R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-2025928, Calcineurin activates NFAT R-MMU-203615, eNOS activation R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-2672351, Stimuli-sensing channels R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-4086398, Ca2+ pathway R-MMU-418359, Reduction of cytosolic Ca++ levels R-MMU-425561, Sodium/Calcium exchangers R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-MMU-445355, Smooth Muscle Contraction R-MMU-451308, Activation of Ca-permeable Kainate Receptor R-MMU-5218920, VEGFR2 mediated vascular permeability R-MMU-5576892, Phase 0 - rapid depolarisation R-MMU-5578775, Ion homeostasis R-MMU-5607763, CLEC7A (Dectin-1) induces NFAT activation R-MMU-5626467, RHO GTPases activate IQGAPs R-MMU-5627123, RHO GTPases activate PAKs R-MMU-5673000, RAF activation R-MMU-5673001, RAF/MAP kinase cascade R-MMU-70221, Glycogen breakdown (glycogenolysis) R-MMU-8876725, Protein methylation R-MMU-9009391, Extra-nuclear estrogen signaling R-MMU-936837, Ion transport by P-type ATPases R-MMU-9619229, Activation of RAC1 downstream of NMDARs R-MMU-9648002, RAS processing |
Names & Taxonomyi
Protein namesi | Recommended name: Calmodulin-1By similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:88251, Calm1 |
VEuPathDBi | HostDB:ENSMUSG00000001175 HostDB:ENSMUSG00000019370 HostDB:ENSMUSG00000036438 |
Subcellular locationi
Cytoskeleton
- spindle By similarity
- spindle pole By similarity
- centrosome By similarity
Note: Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.By similarity
Cytoskeleton
- centrosome Source: MGI
- spindle microtubule Source: MGI
- spindle pole Source: MGI
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial membrane Source: Ensembl
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
- voltage-gated potassium channel complex Source: MGI
Other locations
- calcium channel complex Source: MGI
- catalytic complex Source: MGI
- cytoplasm Source: UniProtKB
- DAPK1-calmodulin complex Source: Ensembl
- growth cone Source: MGI
- myelin sheath Source: CAFA
- neuron projection Source: MGI
- protein-containing complex Source: MGI
- sarcomere Source: MGI
- synaptic vesicle membrane Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 115 | E → A: Decreases interaction with SCN8A in the absence of calcium. 1 Publication | 1 | |
Mutagenesisi | 121 | E → A: Decreases interaction with SCN8A in the absence of calcium. 1 Publication | 1 | |
Mutagenesisi | 124 | E → A: Decreases interaction with SCN8A in the absence of calcium. 1 Publication | 1 | |
Mutagenesisi | 128 | E → A: Decreases interaction with SCN8A in the absence of calcium. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL3562176 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000439935 | 2 – 149 | Calmodulin-1Add BLAST | 148 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 22 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 45 | Phosphothreonine; by CaMK4By similarity | 1 | |
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 95 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 100 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 116 | N6,N6,N6-trimethyllysine; alternateBy similarity | 1 | |
Modified residuei | 116 | N6-methyllysine; alternateBy similarity | 1 | |
Modified residuei | 139 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P0DP26 |
PTM databases
iPTMneti | P0DP26 |
MetOSitei | P0DP26 |
PhosphoSitePlusi | P0DP26 |
Interactioni
Subunit structurei
Interacts with CEP97, CCP110, MYO1C, TTN/titin and SRY.
Interacts with MYO10.
Interacts with RRAD (By similarity).
Interacts with USP6; the interaction is calcium dependent (By similarity).
Interacts with CDK5RAP2.
Interacts with SCN5A (By similarity).
Interacts with FCHO1.
Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure.
Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity).
Interacts with RYR1 (PubMed:18650434).
Interacts with MYO5A (PubMed:17151196).
Interacts with IQCF1 (PubMed:25380116).
Interacts with SYT7 (PubMed:24569478).
Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity).
Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:18650434).
Interacts with PCP4; regulates calmodulin calcium-binding (By similarity).
Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (By similarity).
Interacts with alpha-synuclein/SNCA (By similarity).
Interacts with SLC9A1 in a calcium-dependent manner (By similarity). In the absence of Ca(+2), interacts with GIMAP4 (via IQ domain) (PubMed:16569770).
Interacts with SCN8A; the interaction modulates the inactivation rate of SCN8A (PubMed:23942337). Interaction with KIF1A; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility (By similarity).
Interacts with KCNN3 (By similarity).
Interacts with KCNQ1 (via C-terminus); forms a heterooctameric structure (with 4:4 KCNQ1:CALM stoichiometry) in a calcium-independent manner (By similarity).
Interacts with PIK3C3; the interaction modulates PIK3C3 kinase activity (By similarity).
Interacts with HINT1; interaction increases in the presence of calcium ions (PubMed:31088288).
Interacts with HINT3 (PubMed:31088288).
By similarity7 PublicationsBinary interactionsi
P0DP26
GO - Molecular functioni
- adenylate cyclase binding Source: MGI
- calcium-dependent protein binding Source: MGI
- disordered domain specific binding Source: MGI
- nitric-oxide synthase binding Source: MGI
- N-terminal myristoylation domain binding Source: MGI
- phosphatidylinositol 3-kinase binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
- protein N-terminus binding Source: MGI
- titin binding Source: MGI
- transmembrane transporter binding Source: MGI
- type 3 metabotropic glutamate receptor binding Source: MGI
Protein-protein interaction databases
ComplexPortali | CPX-1006, Calcineurin-Calmodulin-AKAP5 complex, beta-R1 variant CPX-1007, Calcineurin-Calmodulin complex, gamma-R1 variant CPX-1008, Calcineurin-Calmodulin complex, beta-R2 variant CPX-1010, Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1011, Calcineurin-Calmodulin complex, beta-R1 variant CPX-1049, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1051, Calcineurin-Calmodulin complex, gamma-R2 variant CPX-106, DAPK1 - calmodulin complex CPX-1113, Calcineurin-Calmodulin-AKAP5 complex, gamma-R1 variant CPX-1115, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-1117, Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant CPX-1119, Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant CPX-5826, Kv7.1 channel complex CPX-881, Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
IntActi | P0DP26, 24 interactors |
MINTi | P0DP26 |
STRINGi | 10090.ENSMUSP00000019514 |
Miscellaneous databases
RNActi | P0DP26, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P0DP26 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 43 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 44 – 79 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 81 – 116 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 117 – 149 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 149 | Necessary and sufficient for interaction with PCP4By similarityAdd BLAST | 73 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
OMAi | DEMIREP |
OrthoDBi | 1386217at2759 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q4EHJ0 | A0A3Q4EHJ0_MOUSE | Calmodulin-1 | Calm1 Calm2 | 113 | Annotation score: | ||
G3UX57 | G3UX57_MOUSE | Calmodulin-3 | Calm3 | 39 | Annotation score: | ||
G3UZ90 | G3UZ90_MOUSE | Calmodulin-3 | Calm3 | 65 | Annotation score: | ||
A0A571BE58 | A0A571BE58_MOUSE | Calmodulin-2 | Calm2 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | G → N in AAA66182 (PubMed:3384819).Curated | 1 | |
Sequence conflicti | 55 | E → V in BAE41271 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 69 | F → L in BAE40191 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 82 | S → G in BAE31439 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 82 | S → G in BAE31644 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 82 | S → G in BAE31442 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 126 | I → T in BAE31579 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 143 | V → L in BAB28959 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19381 mRNA Translation: AAA66182.1 X61432 mRNA Translation: CAA43674.1 AK004673 mRNA Translation: BAB23462.1 AK013695 mRNA Translation: BAB28959.1 AK088141 mRNA Translation: BAC40168.1 AK150288 mRNA Translation: BAE29443.1 AK150978 mRNA Translation: BAE30007.1 AK151001 mRNA Translation: BAE30025.1 AK151552 mRNA Translation: BAE30497.1 AK151784 mRNA Translation: BAE30686.1 AK151923 mRNA Translation: BAE30801.1 AK151992 mRNA Translation: BAE30856.1 AK152148 mRNA Translation: BAE30984.1 AK152715 mRNA Translation: BAE31439.1 AK152719 mRNA Translation: BAE31442.1 AK152850 mRNA Translation: BAE31543.1 AK152897 mRNA Translation: BAE31579.1 AK153004 mRNA Translation: BAE31644.1 AK153348 mRNA Translation: BAE31924.1 AK153426 mRNA Translation: BAE31985.1 AK153546 mRNA Translation: BAE32083.1 AK159762 mRNA Translation: BAE35353.1 AK160057 mRNA Translation: BAE35595.1 AK160508 mRNA Translation: BAE35832.1 AK161302 mRNA Translation: BAE36309.1 AK162314 mRNA Translation: BAE36849.1 AK166308 mRNA Translation: BAE38695.1 AK167353 mRNA Translation: BAE39452.1 AK168002 mRNA Translation: BAE39990.1 AK168241 mRNA Translation: BAE40191.1 AK168663 mRNA Translation: BAE40516.1 AK168803 mRNA Translation: BAE40633.1 AK169027 mRNA Translation: BAE40819.1 AK169055 mRNA Translation: BAE40843.1 AK169640 mRNA Translation: BAE41271.1 BC054805 mRNA Translation: AAH54805.1 |
CCDSi | CCDS36523.1 |
PIRi | I49567 |
RefSeqi | NP_001300863.1, NM_001313934.1 NP_031615.1, NM_007589.5 NP_031616.1, NM_007590.3 NP_033920.1, NM_009790.5 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19381 mRNA Translation: AAA66182.1 X61432 mRNA Translation: CAA43674.1 AK004673 mRNA Translation: BAB23462.1 AK013695 mRNA Translation: BAB28959.1 AK088141 mRNA Translation: BAC40168.1 AK150288 mRNA Translation: BAE29443.1 AK150978 mRNA Translation: BAE30007.1 AK151001 mRNA Translation: BAE30025.1 AK151552 mRNA Translation: BAE30497.1 AK151784 mRNA Translation: BAE30686.1 AK151923 mRNA Translation: BAE30801.1 AK151992 mRNA Translation: BAE30856.1 AK152148 mRNA Translation: BAE30984.1 AK152715 mRNA Translation: BAE31439.1 AK152719 mRNA Translation: BAE31442.1 AK152850 mRNA Translation: BAE31543.1 AK152897 mRNA Translation: BAE31579.1 AK153004 mRNA Translation: BAE31644.1 AK153348 mRNA Translation: BAE31924.1 AK153426 mRNA Translation: BAE31985.1 AK153546 mRNA Translation: BAE32083.1 AK159762 mRNA Translation: BAE35353.1 AK160057 mRNA Translation: BAE35595.1 AK160508 mRNA Translation: BAE35832.1 AK161302 mRNA Translation: BAE36309.1 AK162314 mRNA Translation: BAE36849.1 AK166308 mRNA Translation: BAE38695.1 AK167353 mRNA Translation: BAE39452.1 AK168002 mRNA Translation: BAE39990.1 AK168241 mRNA Translation: BAE40191.1 AK168663 mRNA Translation: BAE40516.1 AK168803 mRNA Translation: BAE40633.1 AK169027 mRNA Translation: BAE40819.1 AK169055 mRNA Translation: BAE40843.1 AK169640 mRNA Translation: BAE41271.1 BC054805 mRNA Translation: AAH54805.1 |
CCDSi | CCDS36523.1 |
PIRi | I49567 |
RefSeqi | NP_001300863.1, NM_001313934.1 NP_031615.1, NM_007589.5 NP_031616.1, NM_007590.3 NP_033920.1, NM_009790.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UP5 | X-ray | 1.90 | A/B | 2-149 | [»] | |
2DFS | electron microscopy | 24.00 | B/C/D/E/F/G/N/O/P/Q/R/S | 2-149 | [»] | |
2IX7 | X-ray | 2.50 | A/B | 3-147 | [»] | |
3WFN | X-ray | 1.95 | B/C/D/E | 1-149 | [»] | |
4E50 | X-ray | 2.70 | A | 1-149 | [»] | |
4E53 | X-ray | 2.69 | A/B | 1-149 | [»] | |
4HEX | X-ray | 2.00 | A/B | 1-149 | [»] | |
4ZLK | X-ray | 2.50 | B | 1-149 | [»] | |
7B1G | electron microscopy | 3.60 | E | 1-149 | [»] | |
7CQP | X-ray | 1.90 | B | 1-78 | [»] | |
SMRi | P0DP26 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-1006, Calcineurin-Calmodulin-AKAP5 complex, beta-R1 variant CPX-1007, Calcineurin-Calmodulin complex, gamma-R1 variant CPX-1008, Calcineurin-Calmodulin complex, beta-R2 variant CPX-1010, Calcineurin-Calmodulin complex, alpha-R1 variant CPX-1011, Calcineurin-Calmodulin complex, beta-R1 variant CPX-1049, Calcineurin-Calmodulin complex, alpha-R2 variant CPX-1051, Calcineurin-Calmodulin complex, gamma-R2 variant CPX-106, DAPK1 - calmodulin complex CPX-1113, Calcineurin-Calmodulin-AKAP5 complex, gamma-R1 variant CPX-1115, Calcineurin-Calmodulin-AKAP5 complex, alpha-R2 variant CPX-1117, Calcineurin-Calmodulin-AKAP5 complex, beta-R2 variant CPX-1119, Calcineurin-Calmodulin-AKAP5 complex, gamma-R2 variant CPX-5826, Kv7.1 channel complex CPX-881, Calcineurin-Calmodulin-AKAP5 complex, alpha-R1 variant |
IntActi | P0DP26, 24 interactors |
MINTi | P0DP26 |
STRINGi | 10090.ENSMUSP00000019514 |
Chemistry databases
ChEMBLi | CHEMBL3562176 |
PTM databases
iPTMneti | P0DP26 |
MetOSitei | P0DP26 |
PhosphoSitePlusi | P0DP26 |
Proteomic databases
jPOSTi | P0DP26 |
Protocols and materials databases
Antibodypediai | 39411, 181 antibodies from 17 providers 4344, 534 antibodies from 33 providers 53945, 70 antibodies from 14 providers |
DNASUi | 12313 |
Genome annotation databases
Organism-specific databases
CTDi | 801 805 808 |
MGIi | MGI:88251, Calm1 |
VEuPathDBi | HostDB:ENSMUSG00000001175 HostDB:ENSMUSG00000019370 HostDB:ENSMUSG00000036438 |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
OMAi | DEMIREP |
OrthoDBi | 1386217at2759 |
Enzyme and pathway databases
Reactomei | R-MMU-111932, CaMK IV-mediated phosphorylation of CREB R-MMU-111933, Calmodulin induced events R-MMU-111957, Cam-PDE 1 activation R-MMU-114608, Platelet degranulation R-MMU-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-MMU-163615, PKA activation R-MMU-1855204, Synthesis of IP3 and IP4 in the cytosol R-MMU-2025928, Calcineurin activates NFAT R-MMU-203615, eNOS activation R-MMU-2514859, Inactivation, recovery and regulation of the phototransduction cascade R-MMU-2672351, Stimuli-sensing channels R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-4086398, Ca2+ pathway R-MMU-418359, Reduction of cytosolic Ca++ levels R-MMU-425561, Sodium/Calcium exchangers R-MMU-438066, Unblocking of NMDA receptors, glutamate binding and activation R-MMU-442729, CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde R-MMU-445355, Smooth Muscle Contraction R-MMU-451308, Activation of Ca-permeable Kainate Receptor R-MMU-5218920, VEGFR2 mediated vascular permeability R-MMU-5576892, Phase 0 - rapid depolarisation R-MMU-5578775, Ion homeostasis R-MMU-5607763, CLEC7A (Dectin-1) induces NFAT activation R-MMU-5626467, RHO GTPases activate IQGAPs R-MMU-5627123, RHO GTPases activate PAKs R-MMU-5673000, RAF activation R-MMU-5673001, RAF/MAP kinase cascade R-MMU-70221, Glycogen breakdown (glycogenolysis) R-MMU-8876725, Protein methylation R-MMU-9009391, Extra-nuclear estrogen signaling R-MMU-936837, Ion transport by P-type ATPases R-MMU-9619229, Activation of RAC1 downstream of NMDARs R-MMU-9648002, RAS processing |
Miscellaneous databases
BioGRID-ORCSi | 12313, 4 hits in 67 CRISPR screens 12314, 1 hit in 62 CRISPR screens 12315, 1 hit in 64 CRISPR screens |
ChiTaRSi | Calm1, mouse |
PROi | PR:P0DP26 |
RNActi | P0DP26, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P0DP26, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CALM1_MOUSE | |
Accessioni | P0DP26Primary (citable) accession number: P0DP26 Secondary accession number(s): P02593 Q9D6G4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2017 |
Last sequence update: | May 10, 2017 | |
Last modified: | February 23, 2022 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families