CALM3

Functionⁱ

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.By similarity1 Publication

Miscellaneous

This protein has four functional calcium-binding sites.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	21 – 32	11 PublicationAdd BLAST	12
Calcium bindingⁱ	57 – 68	21 PublicationAdd BLAST	12
Calcium bindingⁱ	94 – 105	31 PublicationAdd BLAST	12
Calcium bindingⁱ	130 – 141	41 PublicationAdd BLAST	12

GO - Molecular functionⁱ

adenylate cyclase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11807546
adenylate cyclase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11807546
calcium-dependent protein binding Source: Ensembl
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 27516456
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19855925
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 21167176
- 23040497
nitric-oxide synthase binding Source: Ensembl
nitric-oxide synthase regulator activity Source: Ensembl
N-terminal myristoylation domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15632291
phosphatidylinositol 3-kinase binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20668654
protein phosphatase activator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
protein serine/threonine kinase activator activity
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
titin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7607248
type 3 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity Source: Ensembl
detection of calcium ion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
establishment of protein localization to mitochondrial membrane Source: Ensembl
G2/M transition of mitotic cell cycle Source: Ensembl
G protein-coupled receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 10899953
negative regulation of peptidyl-threonine phosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
positive regulation by host of symbiont cAMP-mediated signal transduction
Source: CAFA
Inferred from direct assayⁱ
- 11807546
positive regulation of cyclic-nucleotide phosphodiesterase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of DNA binding Source: Ensembl
positive regulation of nitric-oxide synthase activity Source: Ensembl
positive regulation of peptidyl-threonine phosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of phosphoprotein phosphatase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of protein autophosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of protein dephosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of protein serine/threonine kinase activity
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of ryanodine-sensitive calcium-release channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226167
regulation of cardiac muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16760425
regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
regulation of high voltage-gated calcium channel activity Source: Ensembl
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226167
regulation of synaptic vesicle endocytosis Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl
response to amphetamine Source: Ensembl
response to calcium ion
Source: BHF-UCL
Inferred from direct assayⁱ
- 7607248
response to corticosterone Source: Ensembl
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calmodulin-3Imported
Gene namesⁱ	Name:CALM3Imported Synonyms:CALML2, CAM3, CAMC, CAMIII
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1449 CALM3
MIMⁱ	114183 gene
neXtProtⁱ	NX_P0DP25

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare condition caused by mutation in CALM3 that lead to an arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress.1 Publication

Keywords - Diseaseⁱ

Disease mutation, Long QT syndrome

Organism-specific databases

MalaCards human disease database More...MalaCardsⁱ	CALM3
Open Targets More...OpenTargetsⁱ	ENSG00000143933 ENSG00000160014 ENSG00000198668
Orphanetⁱ	3286 Catecholaminergic polymorphic ventricular tachycardia

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000439934	2 – 149	Calmodulin-3Add BLAST		148

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources2 Publications	1
Modified residueⁱ	22	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residueⁱ	45	Phosphothreonine; by CaMK4By similarity	1
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	95	N6-acetyllysineCombined sources	1
Modified residueⁱ	100	PhosphotyrosineCombined sources	1
Modified residueⁱ	102	PhosphoserineCombined sources	1
Modified residueⁱ	111	PhosphothreonineCombined sources	1
Modified residueⁱ	116	N6,N6,N6-trimethyllysine; alternateCombined sources1 Publication	1
Modified residueⁱ	116	N6-methyllysine; alternateCombined sources	1
Modified residueⁱ	139	PhosphotyrosineCombined sources	1

Post-translational modificationⁱ

Ubiquitination results in a strongly decreased activity.By similarity

Phosphorylation results in a decreased activity.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEⁱ	P0DP25

PRIDEⁱ

P0DP25

PTM databases

iPTMnetⁱ	P0DP25

iPTMnetⁱ

P0DP25

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	P0DP25 baseline and differential

ExpressionAtlasⁱ

P0DP25 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044999

HPAⁱ

HPA044999

Interactionⁱ

Subunit structureⁱ

Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (By similarity). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).By similarity13 Publications

GO - Molecular functionⁱ

adenylate cyclase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11807546
calcium-dependent protein binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19855925
ion channel binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 21167176
- 23040497
nitric-oxide synthase binding Source: Ensembl
N-terminal myristoylation domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15632291
phosphatidylinositol 3-kinase binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20668654
titin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7607248
type 3 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	P0DP25

BindingDBⁱ

P0DP25

Structureⁱ

3D structure databases

SMRⁱ	P0DP25
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 43	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	44 – 79	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	81 – 116	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	117 – 149	EF-hand 4PROSITE-ProRule annotationAdd BLAST	33

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	77 – 149	Necessary and sufficient for interaction with PCP41 PublicationAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the calmodulin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118901
KEGG Orthology (KO) More...KOⁱ	K02183

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR039030 Calmodulin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR23050:SF311 PTHR23050:SF311, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P0DP25-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ 
        60         70         80         90        100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY 
       110        120        130        140 
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Length:149

Mass (Da):16,838

Last modified:May 10, 2017 - v1

Checksum:ⁱ6B4BC3FCDE10727B

GO

Sequence cautionⁱ

The sequence CAA36839 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_078261	103	A → V Probable disease-associated mutation found in a patient with CPVT; decreased calcium-binding affinity; not changed binding to RYR2; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed action potential duration. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04046 mRNA Translation: AAA51918.1 X52606, X52607, X52608 Genomic DNA Translation: CAA36839.1 Sequence problems. BT006855 mRNA Translation: AAP35501.1 AC093503 Genomic DNA No translation available. BC005137 mRNA Translation: AAH05137.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33061.1 CCDS86782.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001316851.1, NM_001329922.1 NP_001316852.1, NM_001329923.1 NP_001316853.1, NM_001329924.1 NP_001316854.1, NM_001329925.1 NP_001316855.1, NM_001329926.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4
UniGeneⁱ	Hs.282410 Hs.468442 Hs.515487

Genome annotation databases

Ensemblⁱ	ENST00000291295; ENSP00000291295; ENSG00000160014 ENST00000596362; ENSP00000472141; ENSG00000160014
GeneIDⁱ	801 805 808
KEGGⁱ	hsa:801 hsa:805 hsa:808

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DP25	Calmodulin-1	)	HUMAN		149	UniRef100_P0DP23
Calmodulin-A (Fragment)	)	ORYLA		136
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
+288

Protein	Similar proteins		Species	Score	Length	Source
P0DP25	Calmodulin-1	)	HUMAN		149	UniRef90_P0DP23
Calmodulin-A (Fragment)	)	ORYLA		136
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
+288

Protein	Similar proteins		Species	Score	Length	Source
P0DP25	Calmodulin-1	)	HUMAN		149	UniRef50_P0DP23
Calmodulin-A (Fragment)	)	ORYLA		136
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
+289

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04046 mRNA Translation: AAA51918.1 X52606, X52607, X52608 Genomic DNA Translation: CAA36839.1 Sequence problems. BT006855 mRNA Translation: AAP35501.1 AC093503 Genomic DNA No translation available. BC005137 mRNA Translation: AAH05137.1
CCDSⁱ	CCDS33061.1 CCDS86782.1
RefSeqⁱ	NP_001316851.1, NM_001329922.1 NP_001316852.1, NM_001329923.1 NP_001316853.1, NM_001329924.1 NP_001316854.1, NM_001329925.1 NP_001316855.1, NM_001329926.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4
UniGeneⁱ	Hs.282410 Hs.468442 Hs.515487

3D structure databases

SMRⁱ	P0DP25
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

BindingDBⁱ	P0DP25

BindingDBⁱ

P0DP25

PTM databases

iPTMnetⁱ	P0DP25

iPTMnetⁱ

P0DP25

Proteomic databases

PRIDEⁱ	P0DP25

PRIDEⁱ

P0DP25

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000291295; ENSP00000291295; ENSG00000160014 ENST00000596362; ENSP00000472141; ENSG00000160014
GeneIDⁱ	801 805 808
KEGGⁱ	hsa:801 hsa:805 hsa:808

Organism-specific databases

CTDⁱ	801 805 808
GeneCardsⁱ	CALM3
HGNCⁱ	HGNC:1449 CALM3
HPAⁱ	HPA044999
MalaCardsⁱ	CALM3
MIMⁱ	114183 gene
neXtProtⁱ	NX_P0DP25
OpenTargetsⁱ	ENSG00000143933 ENSG00000160014 ENSG00000198668
Orphanetⁱ	3286 Catecholaminergic polymorphic ventricular tachycardia
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00760000118901
KOⁱ	K02183

Miscellaneous databases

ChiTaRSⁱ	CALM3 human
Protein Ontology More...PROⁱ	PR:P0DP25
SOURCEⁱ	Search...

Gene expression databases

ExpressionAtlasⁱ	P0DP25 baseline and differential

ExpressionAtlasⁱ

P0DP25 baseline and differential

Family and domain databases

CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR039030 Calmodulin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR23050:SF311 PTHR23050:SF311, 1 hit
Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CALM3_HUMAN
Accessionⁱ	P0DP25Primary (citable) accession number: P0DP25 Secondary accession number(s): P02593 Q96HK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2017
	Last sequence update:	May 10, 2017
	Last modified:	November 7, 2018
	This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DP25 (CALM3_HUMAN)

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Calmodulin-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ