UniProtKB - P0DP24 (CALM2_HUMAN)
Calmodulin-2
CALM2
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 21 – 32 | 11 PublicationAdd BLAST | 12 | |
Calcium bindingi | 57 – 68 | 21 PublicationAdd BLAST | 12 | |
Calcium bindingi | 94 – 105 | 31 PublicationAdd BLAST | 12 | |
Calcium bindingi | 130 – 141 | 41 PublicationAdd BLAST | 12 |
GO - Molecular functioni
- adenylate cyclase activator activity Source: UniProtKB
- adenylate cyclase binding Source: CAFA
- calcium channel inhibitor activity Source: UniProtKB
- calcium ion binding Source: UniProtKB
- disordered domain specific binding Source: CAFA
- enzyme regulator activity Source: GO_Central
- ion channel binding Source: BHF-UCL
- N-terminal myristoylation domain binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- protein kinase binding Source: BHF-UCL
- protein phosphatase activator activity Source: BHF-UCL
- protein serine/threonine kinase activator activity Source: BHF-UCL
- titin binding Source: BHF-UCL
GO - Biological processi
- calcium-mediated signaling Source: GO_Central
- detection of calcium ion Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: UniProtKB
- microtubule cytoskeleton organization Source: GO_Central
- negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
- negative regulation of ryanodine-sensitive calcium-release channel activity Source: UniProtKB
- positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
- positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
- positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
- positive regulation of protein autophosphorylation Source: BHF-UCL
- positive regulation of protein dephosphorylation Source: BHF-UCL
- positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
- positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
- regulation of cardiac muscle contraction Source: BHF-UCL
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
- regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
- regulation of cytokinesis Source: UniProtKB
- regulation of heart rate Source: BHF-UCL
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
- response to calcium ion Source: BHF-UCL
- substantia nigra development Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P0DP24 |
Names & Taxonomyi
Protein namesi | Recommended name: Calmodulin-2Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1445, CALM2 |
MIMi | 114182, gene |
neXtProti | NX_P0DP24 |
Subcellular locationi
Cytoskeleton
- spindle 1 Publication
- spindle pole 1 Publication
- centrosome 1 Publication
Note: Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Cytoskeleton
- centrosome Source: UniProtKB
- spindle microtubule Source: UniProtKB
- spindle pole Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- calcium channel complex Source: BHF-UCL
- catalytic complex Source: CAFA
- cytoplasm Source: UniProtKB
- protein-containing complex Source: CAFA
- sarcomere Source: BHF-UCL
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Long QT syndrome 15 (LQT15)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073276 | 96 | D → V in LQT15; reduction in calcium affinity; highly decreased calcium-dependent inactivation of L-type calcium channel; increased action potential duration; not changed protein abundance; not changed structure; increased thermal stability in absence of calcium; decreased thermal stability in presence of calcium; significantly increased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882254EnsemblClinVar. | 1 | |
Natural variantiVAR_073277 | 98 | N → I in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124647EnsemblClinVar. | 1 | |
Natural variantiVAR_078543 | 98 | N → S in LQT15; the mutant has significantly reduced calcium affinity compared to wild-type; calmodulin-RYR2 interaction is defective at low intracellular Ca(2+) concentrations and restored at moderate to high Ca(2+) concentrations; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; significantly reduced ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs398124647EnsemblClinVar. | 1 | |
Natural variantiVAR_078544 | 130 | D → G in LQT15; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar. | 1 | |
Natural variantiVAR_078262 | 130 | D → V in LQT15. 1 Publication | 1 | |
Natural variantiVAR_073279 | 132 | D → E in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124648EnsemblClinVar. | 1 | |
Natural variantiVAR_073280 | 134 | D → H in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124650EnsemblClinVar. | 1 | |
Natural variantiVAR_073281 | 136 | Q → P in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124649EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Long QT syndromeOrganism-specific databases
DisGeNETi | 801 805 808 |
GeneReviewsi | CALM2 |
MalaCardsi | CALM2 |
MIMi | 616249, phenotype |
OpenTargetsi | ENSG00000143933 ENSG00000160014 ENSG00000198668 |
Orphaneti | 3286, Catecholaminergic polymorphic ventricular tachycardia 101016, Romano-Ward syndrome |
Miscellaneous databases
Pharosi | P0DP24, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4296043 |
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
DrugCentrali | P0DP24 |
Genetic variation databases
BioMutai | CALM2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000439933 | 2 – 149 | Calmodulin-2Add BLAST | 148 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources2 Publications | 1 | |
Modified residuei | 22 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity | ||
Modified residuei | 45 | Phosphothreonine; by CaMK4By similarity | 1 | |
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 100 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 116 | N6,N6,N6-trimethyllysine; alternateCombined sources1 Publication | 1 | |
Modified residuei | 116 | N6-methyllysine; alternateCombined sources | 1 | |
Modified residuei | 139 | PhosphotyrosineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P0DP24 |
MassIVEi | P0DP24 |
PTM databases
iPTMneti | P0DP24 |
Expressioni
Gene expression databases
ExpressionAtlasi | P0DP24, baseline and differential |
Organism-specific databases
HPAi | ENSG00000143933, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MYO1C, MYO5A and RRAD.
Interacts with MYO10 (By similarity).
Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545).
Interacts with USP6; the interaction is calcium dependent (PubMed:16127172).
Interacts with CDK5RAP2 (PubMed:20466722).
Interacts with SCN5A (By similarity).
Interacts with RYR1 (PubMed:18650434).
Interacts with FCHO1 (PubMed:22484487).
Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (By similarity).
Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity).
Interacts with IQCF1 (By similarity).
Interacts with SYT7 (By similarity).
Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity).
Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367).
Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793).
Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates in the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).
By similarity14 PublicationsGO - Molecular functioni
- adenylate cyclase binding Source: CAFA
- disordered domain specific binding Source: CAFA
- ion channel binding Source: BHF-UCL
- N-terminal myristoylation domain binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- protein kinase binding Source: BHF-UCL
- titin binding Source: BHF-UCL
Chemistry databases
BindingDBi | P0DP24 |
Miscellaneous databases
RNActi | P0DP24, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P0DP24 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 43 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 44 – 79 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 81 – 116 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 117 – 149 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 149 | Necessary and sufficient for interaction with PCP41 PublicationAdd BLAST | 73 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
OMAi | SPHESSN |
OrthoDBi | 1386217at2759 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | E → Q in AAH08437 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073276 | 96 | D → V in LQT15; reduction in calcium affinity; highly decreased calcium-dependent inactivation of L-type calcium channel; increased action potential duration; not changed protein abundance; not changed structure; increased thermal stability in absence of calcium; decreased thermal stability in presence of calcium; significantly increased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882254EnsemblClinVar. | 1 | |
Natural variantiVAR_073277 | 98 | N → I in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124647EnsemblClinVar. | 1 | |
Natural variantiVAR_078543 | 98 | N → S in LQT15; the mutant has significantly reduced calcium affinity compared to wild-type; calmodulin-RYR2 interaction is defective at low intracellular Ca(2+) concentrations and restored at moderate to high Ca(2+) concentrations; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; significantly reduced ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs398124647EnsemblClinVar. | 1 | |
Natural variantiVAR_078544 | 130 | D → G in LQT15; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar. | 1 | |
Natural variantiVAR_078262 | 130 | D → V in LQT15. 1 Publication | 1 | |
Natural variantiVAR_073279 | 132 | D → E in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124648EnsemblClinVar. | 1 | |
Natural variantiVAR_073280 | 134 | D → H in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124650EnsemblClinVar. | 1 | |
Natural variantiVAR_073281 | 136 | Q → P in LQT15; reduction in calcium affinity. 1 PublicationCorresponds to variant dbSNP:rs398124649EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19311 mRNA Translation: AAA35641.1 D45887 mRNA Translation: BAA08302.1 U94728, U94725, U94726 Genomic DNA Translation: AAC83174.1 BT009916 mRNA Translation: AAP88918.1 CR541990 mRNA Translation: CAG46787.1 CR542021 mRNA Translation: CAG46818.1 AC073283 Genomic DNA Translation: AAY24085.1 BC003354 mRNA Translation: AAH03354.1 BC006464 mRNA Translation: AAH06464.1 BC008437 mRNA Translation: AAH08437.1 BC017385 mRNA Translation: AAH17385.1 BC018677 mRNA Translation: AAH18677.1 BC026065 mRNA Translation: AAH26065.1 |
CCDSi | CCDS1832.1 |
RefSeqi | NP_001292553.1, NM_001305624.1 NP_001292554.1, NM_001305625.1 NP_001292555.1, NM_001305626.1 NP_001316851.1, NM_001329922.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4 |
Genome annotation databases
Ensembli | ENST00000272298; ENSP00000272298; ENSG00000143933 |
GeneIDi | 801 805 808 |
KEGGi | hsa:801 hsa:805 hsa:808 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19311 mRNA Translation: AAA35641.1 D45887 mRNA Translation: BAA08302.1 U94728, U94725, U94726 Genomic DNA Translation: AAC83174.1 BT009916 mRNA Translation: AAP88918.1 CR541990 mRNA Translation: CAG46787.1 CR542021 mRNA Translation: CAG46818.1 AC073283 Genomic DNA Translation: AAY24085.1 BC003354 mRNA Translation: AAH03354.1 BC006464 mRNA Translation: AAH06464.1 BC008437 mRNA Translation: AAH08437.1 BC017385 mRNA Translation: AAH17385.1 BC018677 mRNA Translation: AAH18677.1 BC026065 mRNA Translation: AAH26065.1 |
CCDSi | CCDS1832.1 |
RefSeqi | NP_001292553.1, NM_001305624.1 NP_001292554.1, NM_001305625.1 NP_001292555.1, NM_001305626.1 NP_001316851.1, NM_001329922.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3O77 | X-ray | 2.35 | A | 45-149 | [»] | |
3O78 | X-ray | 2.60 | A/B | 45-149 | [»] | |
5COC | X-ray | 2.67 | A | 10-78 | [»] | |
5J03 | X-ray | 2.00 | B | 1-149 | [»] | |
5NIN | X-ray | 1.70 | A/B | 1-149 | [»] | |
5VMS | electron microscopy | 3.70 | B | 1-149 | [»] | |
5WSU | X-ray | 3.00 | A/B | 2-149 | [»] | |
5WSV | X-ray | 2.33 | A/C | 1-147 | [»] | |
6PLM | X-ray | 2.59 | C/D | 2-148 | [»] | |
6S5T | electron microscopy | 4.15 | B | 1-149 | [»] | |
6SZ5 | X-ray | 2.23 | A | 1-149 | [»] | |
6Y4O | X-ray | 1.84 | A | 1-149 | [»] | |
SMRi | P0DP24 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | P0DP24 |
ChEMBLi | CHEMBL4296043 |
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
DrugCentrali | P0DP24 |
PTM databases
iPTMneti | P0DP24 |
Genetic variation databases
BioMutai | CALM2 |
Proteomic databases
jPOSTi | P0DP24 |
MassIVEi | P0DP24 |
Protocols and materials databases
Antibodypediai | 53945, 68 antibodies |
Genome annotation databases
Ensembli | ENST00000272298; ENSP00000272298; ENSG00000143933 |
GeneIDi | 801 805 808 |
KEGGi | hsa:801 hsa:805 hsa:808 |
Organism-specific databases
CTDi | 801 805 808 |
DisGeNETi | 801 805 808 |
GeneCardsi | CALM2 |
GeneReviewsi | CALM2 |
HGNCi | HGNC:1445, CALM2 |
HPAi | ENSG00000143933, Low tissue specificity |
MalaCardsi | CALM2 |
MIMi | 114182, gene 616249, phenotype |
neXtProti | NX_P0DP24 |
OpenTargetsi | ENSG00000143933 ENSG00000160014 ENSG00000198668 |
Orphaneti | 3286, Catecholaminergic polymorphic ventricular tachycardia 101016, Romano-Ward syndrome |
GenAtlasi | Search... |
Phylogenomic databases
OMAi | SPHESSN |
OrthoDBi | 1386217at2759 |
Enzyme and pathway databases
PathwayCommonsi | P0DP24 |
Miscellaneous databases
BioGRID-ORCSi | 801, 3 hits in 877 CRISPR screens 805, 28 hits in 836 CRISPR screens 808, 34 hits in 872 CRISPR screens |
ChiTaRSi | CALM2, human |
Pharosi | P0DP24, Tclin |
PROi | PR:P0DP24 |
RNActi | P0DP24, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P0DP24, baseline and differential |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CALM2_HUMAN | |
Accessioni | P0DP24Primary (citable) accession number: P0DP24 Secondary accession number(s): P02593 Q96HK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2017 |
Last sequence update: | May 10, 2017 | |
Last modified: | February 10, 2021 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families