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Protein

Calmodulin-1

Gene

CALM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).4 Publications

Miscellaneous

This protein has four functional calcium-binding sites.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Combined sources2 PublicationsAdd BLAST12
Calcium bindingi57 – 682Combined sources2 PublicationsAdd BLAST12
Calcium bindingi94 – 1053Combined sources2 PublicationsAdd BLAST12
Calcium bindingi130 – 1414Combined sources2 PublicationsAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111997 CaM pathway
R-HSA-114608 Platelet degranulation
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-163615 PKA activation
R-HSA-180024 DARPP-32 events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-203615 eNOS activation
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2672351 Stimuli-sensing channels
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-4086398 Ca2+ pathway
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-442717 CREB phosphorylation through the activation of CaMKK
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442745 Activation of CaMK IV
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-445355 Smooth Muscle Contraction
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-8876725 Protein methylation
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

MoonDBiP0DP23 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-1Imported
Gene namesi
Name:CALM11 PublicationImported
Synonyms:CALM, CAM, CAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:1442 CALM1
MIMi114180 gene
neXtProtiNX_P0DP23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4)4 Publications
The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.
Disease descriptionAn arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant.
See also OMIM:614916
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06922254N → I in CPVT4; increased RYR2 calcium-release channel activity; not changed calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; not changed thermal stability both in the absence and presence of calcium; no effect on the calcium binding affinity; significantly increased binding of RYR2; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs267607276EnsemblClinVar.1
Natural variantiVAR_07854198N → S in CPVT4; the mutant has significantly reduced calcium affinity compared to wild-type; calmodulin-RYR2 interaction is defective at low intracellular Ca(2+) concentrations and restored at moderate to high Ca(2+) concentrations; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; significantly reduced ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs398124647EnsemblClinVar.1
Long QT syndrome 14 (LQT14)5 Publications
The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
Disease descriptionA form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
See also OMIM:616247
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07327590F → L in LQT14; significantly decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 2 PublicationsCorresponds to variant dbSNP:rs730882253EnsemblClinVar.1
Natural variantiVAR_078542130D → G in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of clacium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar.1
Natural variantiVAR_078263141E → G in LQT14; decreased calcium affinity; loss of CACNA1C calcium-dependent-inactivation; no effect on intracellular RYR2-mediated calcium release. 1 Publication1
Natural variantiVAR_073282142F → L in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; no effect on RYR2 interaction; significantly reduced ryanodine-sensitive calcium-release channel activity. 3 PublicationsCorresponds to variant dbSNP:rs11551462Ensembl.1

Keywords - Diseasei

Disease mutation, Long QT syndrome

Organism-specific databases

MalaCardsiCALM1
MIMi614916 phenotype
616247 phenotype
OpenTargetsiENSG00000143933
ENSG00000160014
ENSG00000198668

Chemistry databases

ChEMBLiCHEMBL6093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00004399322 – 149Calmodulin-1Add BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei22N6-acetyllysine; alternateCombined sources1
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei45Phosphothreonine; by CaMK4By similarity1
Modified residuei82PhosphoserineCombined sources1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei100PhosphotyrosineCombined sources1
Modified residuei102PhosphoserineCombined sources1
Modified residuei111PhosphothreonineCombined sources1
Modified residuei116N6,N6,N6-trimethyllysine; alternateCombined sources1 Publication1
Modified residuei116N6-methyllysine; alternateCombined sources1
Modified residuei139PhosphotyrosineCombined sources1

Post-translational modificationi

Ubiquitination results in a strongly decreased activity.By similarity
Phosphorylation results in a decreased activity.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlasiP0DP23
PRIDEiP0DP23

PTM databases

iPTMnetiP0DP23
PhosphoSitePlusiP0DP23

Expressioni

Gene expression databases

ExpressionAtlasiP0DP23 baseline and differential

Organism-specific databases

HPAiHPA044999

Interactioni

Subunit structurei

Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (PubMed:21167176). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed:23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).By similarity20 Publications
(Microbial infection) Interacts with Rubella virus protease/methyltransferase p150.1 Publication

GO - Molecular functioni

Chemistry databases

BindingDBiP0DP23

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP0DP23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni77 – 149Necessary and sufficient for interaction with PCP41 PublicationAdd BLAST73

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK02183
OMAiPHESSNQ

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR039030 Calmodulin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR23050:SF311 PTHR23050:SF311, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P0DP23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:May 10, 2017 - v1
Checksum:i6B4BC3FCDE10727B
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96HY3Q96HY3_HUMAN
CALM1 protein
CALM1 CALM2, CALM3, hCG_17033, hCG_20313
113Annotation score:
M0QZ52M0QZ52_HUMAN
Calmodulin 3 (Phosphorylase kinase,...
CALM1 CALM2, CALM3, hCG_20313
83Annotation score:
G3V361G3V361_HUMAN
Calmodulin-1
CALM1
98Annotation score:
E7ETZ0E7ETZ0_HUMAN
Calmodulin-1
CALM1
150Annotation score:
H0Y7A7H0Y7A7_HUMAN
Calmodulin-2
CALM2
187Annotation score:
E7EMB3E7EMB3_HUMAN
Calmodulin-2
CALM2
196Annotation score:
G3V226G3V226_HUMAN
Calmodulin-1
CALM1
76Annotation score:
G3V479G3V479_HUMAN
Calmodulin-1
CALM1
83Annotation score:
F8WBR5F8WBR5_HUMAN
Calmodulin-2
CALM2
65Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06922254N → I in CPVT4; increased RYR2 calcium-release channel activity; not changed calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; not changed thermal stability both in the absence and presence of calcium; no effect on the calcium binding affinity; significantly increased binding of RYR2; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs267607276EnsemblClinVar.1
Natural variantiVAR_07327590F → L in LQT14; significantly decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 2 PublicationsCorresponds to variant dbSNP:rs730882253EnsemblClinVar.1
Natural variantiVAR_07854198N → S in CPVT4; the mutant has significantly reduced calcium affinity compared to wild-type; calmodulin-RYR2 interaction is defective at low intracellular Ca(2+) concentrations and restored at moderate to high Ca(2+) concentrations; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; significantly reduced ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs398124647EnsemblClinVar.1
Natural variantiVAR_078542130D → G in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of clacium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar.1
Natural variantiVAR_078263141E → G in LQT14; decreased calcium affinity; loss of CACNA1C calcium-dependent-inactivation; no effect on intracellular RYR2-mediated calcium release. 1 Publication1
Natural variantiVAR_073282142F → L in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; no effect on RYR2 interaction; significantly reduced ryanodine-sensitive calcium-release channel activity. 3 PublicationsCorresponds to variant dbSNP:rs11551462Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27319 mRNA Translation: AAA35635.1
U12022, U11886 Genomic DNA Translation: AAB60644.1
BT006818 mRNA Translation: AAP35464.1
AC006536 Genomic DNA Translation: AAD45181.1
AL512791 Genomic DNA No translation available.
BC000454 mRNA Translation: AAH00454.1
BC008597 mRNA Translation: AAH08597.1
BC011834 mRNA Translation: AAH11834.1
BC047523 mRNA No translation available.
CCDSiCCDS9892.1
PIRiS48728 MCHU
RefSeqiNP_001316851.1, NM_001329922.1
NP_001734.1, NM_001743.5
NP_005175.2, NM_005184.3
NP_008819.1, NM_006888.4
UniGeneiHs.282410
Hs.468442
Hs.515487

Genome annotation databases

EnsembliENST00000356978; ENSP00000349467; ENSG00000198668
GeneIDi801
805
808
KEGGihsa:801
hsa:805
hsa:808

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

A question of length - Issue 105 of May 2009

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27319 mRNA Translation: AAA35635.1
U12022, U11886 Genomic DNA Translation: AAB60644.1
BT006818 mRNA Translation: AAP35464.1
AC006536 Genomic DNA Translation: AAD45181.1
AL512791 Genomic DNA No translation available.
BC000454 mRNA Translation: AAH00454.1
BC008597 mRNA Translation: AAH08597.1
BC011834 mRNA Translation: AAH11834.1
BC047523 mRNA No translation available.
CCDSiCCDS9892.1
PIRiS48728 MCHU
RefSeqiNP_001316851.1, NM_001329922.1
NP_001734.1, NM_001743.5
NP_005175.2, NM_005184.3
NP_008819.1, NM_006888.4
UniGeneiHs.282410
Hs.468442
Hs.515487

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJImodel-A5-148[»]
1CDLX-ray2.00A/B/C/D2-148[»]
1CLLX-ray1.70A2-149[»]
1CTRX-ray2.45A2-149[»]
1IWQX-ray2.00A2-149[»]
1J7ONMR-A2-77[»]
1J7PNMR-A83-149[»]
1K90X-ray2.75D/E/F2-149[»]
1K93X-ray2.95D/E/F6-149[»]
1L7ZX-ray2.30A2-149[»]
1LVCX-ray3.60D/E/F1-149[»]
1NKFNMR-A94-105[»]
1PK0X-ray3.30D/E/F2-148[»]
1S26X-ray3.00D/E/F2-149[»]
1SK6X-ray3.20D/E/F2-149[»]
1SW8NMR-A2-80[»]
1UP5X-ray1.90A/B2-149[»]
1WRZX-ray2.00A1-149[»]
1XFUX-ray3.35O/P/Q/R/S/T1-149[»]
1XFVX-ray3.35O/P/Q/R/S/T1-149[»]
1XFWX-ray3.40O/P/Q/R/S/T1-149[»]
1XFXX-ray3.20O/P/Q/R/S/T1-149[»]
1XFYX-ray3.30O/P/Q/R/S/T1-149[»]
1XFZX-ray3.25O/P/Q/R/S/T1-149[»]
1Y6WX-ray2.40A2-149[»]
1YR5X-ray1.70A2-149[»]
1YRTX-ray2.10B76-149[»]
1YRUX-ray2.50B76-149[»]
1ZOTX-ray2.20B80-148[»]
1ZUZX-ray1.91A1-149[»]
2BE6X-ray2.00A/B/C1-149[»]
2F3YX-ray1.45A2-149[»]
2F3ZX-ray1.60A2-149[»]
2HF5NMR-A47-114[»]
2I08X-ray2.00A3-79[»]
2JZINMR-A2-149[»]
2K0ENMR-A2-149[»]
2K0FNMR-A2-149[»]
2K0JNMR-A3-149[»]
2K61NMR-A2-149[»]
2KNENMR-A2-149[»]
2KUGNMR-A2-77[»]
2KUHNMR-A83-149[»]
2L53NMR-A2-149[»]
2L7LNMR-A2-149[»]
2LGFNMR-A3-149[»]
2LL6NMR-A2-149[»]
2LL7NMR-A2-149[»]
2LQCNMR-A2-78[»]
2LQPNMR-A79-149[»]
2LV6Other-A2-149[»]
2M0JNMR-A2-149[»]
2M0KNMR-A2-149[»]
2M55NMR-A2-149[»]
2MG5NMR-A2-149[»]
2N27NMR-A2-149[»]
2N6ANMR-A6-147[»]
2N77NMR-A77-149[»]
2N8JNMR-A2-149[»]
2R28X-ray1.86A/B1-149[»]
2V01X-ray2.15A2-149[»]
2V02X-ray2.20A2-149[»]
2VAYX-ray1.94A4-149[»]
2W73X-ray1.45A/B/E/F1-149[»]
2WELX-ray1.90D1-149[»]
2X0GX-ray2.20B2-149[»]
2Y4VX-ray1.80A1-149[»]
3BYAX-ray1.85A2-149[»]
3DVEX-ray2.35A2-149[»]
3DVJX-ray2.80A2-149[»]
3DVKX-ray2.30A2-149[»]
3DVMX-ray2.60A2-149[»]
3EWTX-ray2.40A2-149[»]
3EWVX-ray2.60A2-149[»]
3G43X-ray2.10A/B/C/D2-149[»]
3HR4X-ray2.50B/D/F/H1-149[»]
3J41electron microscopy25.0E/F1-149[»]
3O77X-ray2.35A1-149[»]
3O78X-ray2.60A/B1-149[»]
3OXQX-ray2.55A/B/C/D1-149[»]
3SUIX-ray1.95A1-149[»]
3UCTX-ray1.90A/B2-80[»]
3UCWX-ray1.76A/B/C/D2-80[»]
3UCYX-ray1.80A2-80[»]
4BW7X-ray1.81A/C1-149[»]
4BW8X-ray1.80A/B1-149[»]
4BYFX-ray2.74B/D1-149[»]
4DCKX-ray2.20B1-149[»]
4DJCX-ray1.35A1-149[»]
4GOWX-ray2.60D4-147[»]
4JPZX-ray3.02C/I1-149[»]
4JQ0X-ray3.84C1-149[»]
4L79X-ray2.30B1-149[»]
4LZXX-ray1.50A2-149[»]
4M1LX-ray2.10A2-149[»]
4OVNX-ray2.80A/B/C/D/E1-149[»]
4Q57X-ray1.80A10-74[»]
4Q5UX-ray1.95A1-149[»]
4UMOX-ray3.00C/D1-149[»]
4UPUX-ray2.34A2-149[»]
4V0CX-ray2.86C/D1-149[»]
5COCX-ray2.67A5-78[»]
5DBRX-ray2.25A5-149[»]
5DOWX-ray1.70A/C/E/G2-149[»]
5DSUX-ray1.93A3-78[»]
5GGMNMR-A2-149[»]
5I0IX-ray3.15C/E3-147[»]
G84-126[»]
I84-147[»]
5J03X-ray2.00B1-149[»]
5J8HNMR-A2-149[»]
5JQAX-ray1.80A1-149[»]
5JTHX-ray1.84A1-149[»]
5K7Lelectron microscopy3.78B1-149[»]
5K8QX-ray1.74A1-149[»]
5OEONMR-A1-149[»]
5TP5NMR-A2-149[»]
5TP6NMR-A2-149[»]
5V02X-ray1.78R1-149[»]
5V03X-ray1.58R1-149[»]
5V7XX-ray3.14B1-149[»]
5WBXX-ray1.90R5-148[»]
5WC5X-ray2.30R5-148[»]
6B8LX-ray2.30B/D/F/H1-149[»]
6B8MX-ray2.30B/D/F/H1-149[»]
6B8NX-ray2.20B/D/F/H1-149[»]
6B8PX-ray2.20B/D/F/H1-149[»]
6B8QX-ray2.60B/D/F/H1-149[»]
6C1Delectron microscopy3.20R2-149[»]
6C1Gelectron microscopy3.80R2-149[»]
6C1Helectron microscopy3.90R2-149[»]
6CNMelectron microscopy3.40E/F/G/H1-149[»]
6CNNelectron microscopy3.50E/F/G/H1-149[»]
6CNOelectron microscopy4.70E/F/G/H1-149[»]
6E2Felectron microscopy3.90E1-149[»]
6E2Gelectron microscopy3.60E1-149[»]
6FEGNMR-B1-149[»]
6FEHNMR-B1-149[»]
SMRiP0DP23
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP0DP23
ChEMBLiCHEMBL6093

Protein family/group databases

MoonDBiP0DP23 Predicted

PTM databases

iPTMnetiP0DP23
PhosphoSitePlusiP0DP23

Proteomic databases

PeptideAtlasiP0DP23
PRIDEiP0DP23

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356978; ENSP00000349467; ENSG00000198668
GeneIDi801
805
808
KEGGihsa:801
hsa:805
hsa:808

Organism-specific databases

CTDi801
805
808
GeneCardsiCALM1
HGNCiHGNC:1442 CALM1
HPAiHPA044999
MalaCardsiCALM1
MIMi114180 gene
614916 phenotype
616247 phenotype
neXtProtiNX_P0DP23
OpenTargetsiENSG00000143933
ENSG00000160014
ENSG00000198668
GenAtlasiSearch...

Phylogenomic databases

KOiK02183
OMAiPHESSNQ

Enzyme and pathway databases

ReactomeiR-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111997 CaM pathway
R-HSA-114608 Platelet degranulation
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-163615 PKA activation
R-HSA-180024 DARPP-32 events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-203615 eNOS activation
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2672351 Stimuli-sensing channels
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-4086398 Ca2+ pathway
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-442717 CREB phosphorylation through the activation of CaMKK
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442745 Activation of CaMK IV
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-445355 Smooth Muscle Contraction
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-8876725 Protein methylation
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSiCALM1 human
PROiPR:P0DP23
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP0DP23 baseline and differential

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR039030 Calmodulin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR23050:SF311 PTHR23050:SF311, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCALM1_HUMAN
AccessioniPrimary (citable) accession number: P0DP23
Secondary accession number(s): P02593
, P62158, P70667, P99014, Q13942, Q53S29, Q61379, Q61380, Q96HK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: May 10, 2017
Last modified: November 7, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  7. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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