CALM1

Functionⁱ

Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).4 Publications

Miscellaneous

This protein has four functional calcium-binding sites.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	21 – 32	1Combined sources2 PublicationsAdd BLAST	12
Calcium bindingⁱ	57 – 68	2Combined sources2 PublicationsAdd BLAST	12
Calcium bindingⁱ	94 – 105	3Combined sources2 PublicationsAdd BLAST	12
Calcium bindingⁱ	130 – 141	4Combined sources2 PublicationsAdd BLAST	12

GO - Molecular functionⁱ

adenylate cyclase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11807546
adenylate cyclase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11807546
calcium channel inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26969752
calcium-dependent protein binding Source: Ensembl
calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19855925
inositol-1,4,5-trisphosphate 3-kinase activity Source: Reactome
ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 27564677
ligand-gated ion channel activity Source: Reactome
nitric-oxide synthase binding Source: Ensembl
nitric-oxide synthase regulator activity Source: Ensembl
N-terminal myristoylation domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15632291
phosphatidylinositol 3-kinase binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20668654
protein phosphatase activator activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
protein serine/threonine kinase activator activity
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
Ras guanyl-nucleotide exchange factor activity Source: Reactome
titin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7607248
type 3 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity Source: Ensembl
cofactor metabolic process Source: Reactome
detection of calcium ion
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
establishment of protein localization to mitochondrial membrane Source: Ensembl
Fc-epsilon receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 10899953
inositol phosphate metabolic process Source: Reactome
MAPK cascade Source: Reactome
muscle contraction Source: Reactome
negative regulation of peptidyl-threonine phosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
negative regulation of ryanodine-sensitive calcium-release channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26164367
platelet degranulation Source: Reactome
positive regulation by host of symbiont cAMP-mediated signal transduction
Source: CAFA
Inferred from direct assayⁱ
- 11807546
positive regulation of cyclic-nucleotide phosphodiesterase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of nitric-oxide synthase activity Source: Ensembl
positive regulation of peptidyl-threonine phosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of phosphoprotein phosphatase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of protein autophosphorylation
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of protein dephosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8631777
positive regulation of protein serine/threonine kinase activity
Source: BHF-UCL
Traceable author statementⁱ
- 20668654
positive regulation of ryanodine-sensitive calcium-release channel activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226167
regulation of cardiac muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16760425
regulation of heart rate
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23040497
regulation of high voltage-gated calcium channel activity Source: Ensembl
regulation of nitric-oxide synthase activity Source: Reactome
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Source: BHF-UCL
Inferred from direct assayⁱ
- 20226167
regulation of rhodopsin mediated signaling pathway Source: Reactome
regulation of ryanodine-sensitive calcium-release channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22067155
regulation of synaptic vesicle endocytosis Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl
response to amphetamine Source: Ensembl
response to calcium ion
Source: BHF-UCL
Inferred from direct assayⁱ
- 7607248
response to corticosterone Source: Ensembl
substantia nigra development
Source: UniProtKB
Inferred from high throughput expression patternⁱ
- 22926577
Wnt signaling pathway, calcium modulating pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111932 CaMK IV-mediated phosphorylation of CREB R-HSA-111933 Calmodulin induced events R-HSA-111957 Cam-PDE 1 activation R-HSA-111997 CaM pathway R-HSA-114608 Platelet degranulation R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-163615 PKA activation R-HSA-180024 DARPP-32 events R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol R-HSA-2025928 Calcineurin activates NFAT R-HSA-203615 eNOS activation R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2672351 Stimuli-sensing channels R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-4086398 Ca2+ pathway R-HSA-418359 Reduction of cytosolic Ca++ levels R-HSA-425561 Sodium/Calcium exchangers R-HSA-442717 CREB phosphorylation through the activation of CaMKK R-HSA-442729 CREB phosphorylation through the activation of CaMKII R-HSA-442745 Activation of CaMK IV R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-445355 Smooth Muscle Contraction R-HSA-451308 Activation of Ca-permeable Kainate Receptor R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5576892 Phase 0 - rapid depolarisation R-HSA-5578775 Ion homeostasis R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5627123 RHO GTPases activate PAKs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-70221 Glycogen breakdown (glycogenolysis) R-HSA-8876725 Protein methylation R-HSA-936837 Ion transport by P-type ATPases R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111997 CaM pathway
R-HSA-114608 Platelet degranulation
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-163615 PKA activation
R-HSA-180024 DARPP-32 events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-203615 eNOS activation
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2672351 Stimuli-sensing channels
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-4086398 Ca2+ pathway
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-442717 CREB phosphorylation through the activation of CaMKK
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442745 Activation of CaMK IV
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-445355 Smooth Muscle Contraction
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-8876725 Protein methylation
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

MoonDBⁱ	P0DP23 Predicted

MoonDBⁱ

P0DP23 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calmodulin-1Imported
Gene namesⁱ	Name:CALM11 PublicationImported Synonyms:CALM, CAM, CAM1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1442 CALM1
MIMⁱ	114180 gene
neXtProtⁱ	NX_P0DP23

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ventricular tachycardia, catecholaminergic polymorphic, 4 (CPVT4)4 Publications

The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.

Disease descriptionAn arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT4 inheritance is autosomal dominant.

Long QT syndrome 14 (LQT14)5 Publications

The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.

Disease descriptionA form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_073275	90	F → L in LQT14; significantly decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 2 PublicationsCorresponds to variant dbSNP:rs730882253EnsemblClinVar.	1
Natural variantⁱVAR_078542	130	D → G in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of clacium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar.	1
Natural variantⁱVAR_078263	141	E → G in LQT14; decreased calcium affinity; loss of CACNA1C calcium-dependent-inactivation; no effect on intracellular RYR2-mediated calcium release. 1 Publication	1
Natural variantⁱVAR_073282	142	F → L in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; no effect on RYR2 interaction; significantly reduced ryanodine-sensitive calcium-release channel activity. 3 PublicationsCorresponds to variant dbSNP:rs11551462Ensembl.	1

Keywords - Diseaseⁱ

Disease mutation, Long QT syndrome

Organism-specific databases

MalaCards human disease database More...MalaCardsⁱ	CALM1
MIMⁱ	614916 phenotype 616247 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143933 ENSG00000160014 ENSG00000198668

Chemistry databases

ChEMBLⁱ	CHEMBL6093

ChEMBLⁱ

CHEMBL6093

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources2 Publications
ChainⁱPRO_0000439932	2 – 149	Calmodulin-1Add BLAST		148

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources2 Publications	1
Modified residueⁱ	22	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residueⁱ	45	Phosphothreonine; by CaMK4By similarity	1
Modified residueⁱ	82	PhosphoserineCombined sources	1
Modified residueⁱ	95	N6-acetyllysineCombined sources	1
Modified residueⁱ	100	PhosphotyrosineCombined sources	1
Modified residueⁱ	102	PhosphoserineCombined sources	1
Modified residueⁱ	111	PhosphothreonineCombined sources	1
Modified residueⁱ	116	N6,N6,N6-trimethyllysine; alternateCombined sources1 Publication	1
Modified residueⁱ	116	N6-methyllysine; alternateCombined sources	1
Modified residueⁱ	139	PhosphotyrosineCombined sources	1

Post-translational modificationⁱ

Ubiquitination results in a strongly decreased activity.By similarity

Phosphorylation results in a decreased activity.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P0DP23
PRIDEⁱ	P0DP23

PTM databases

iPTMnetⁱ	P0DP23
PhosphoSitePlusⁱ	P0DP23

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	P0DP23 baseline and differential

ExpressionAtlasⁱ

P0DP23 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044999

HPAⁱ

HPA044999

Interactionⁱ

Subunit structureⁱ

Interacts with MYO1C, MYO5A and RRAD. Interacts with MYO10 (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY (PubMed:9804419, PubMed:12871148, PubMed:15746192, PubMed:16760425, PubMed:17719545). Interacts with USP6; the interaction is calcium dependent (PubMed:16127172). Interacts with CDK5RAP2 (PubMed:20466722). Interacts with SCN5A (PubMed:21167176). Interacts with RYR1 (PubMed:18650434). Interacts with FCHO1 (PubMed:22484487). Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic domains from two MIP subunits promotes MIP water channel closure (PubMed:23893133). Interacts with ORAI1; this may play a role in the regulation of ORAI1-mediated calcium transport (By similarity). Interacts with IQCF1 (By similarity). Interacts with SYT7 (By similarity). Interacts with CEACAM1 (via cytoplasmic domain); this interaction is in a calcium dependent manner and reduces homophilic cell adhesion through dissociation of dimer (By similarity). Interacts with RYR2; regulates RYR2 calcium-release channel activity (PubMed:27516456, PubMed:18650434, PubMed:26164367). Interacts with PCP4; regulates calmodulin calcium-binding (PubMed:27876793). Interacts with the heterotetrameric KCNQ2 and KCNQ3 channel; the interaction is calcium-independent, constitutive and participates to the proper assembly of a functional heterotetrameric M channel (PubMed:27564677).By similarity20 Publications

(Microbial infection) Interacts with Rubella virus protease/methyltransferase p150.1 Publication

GO - Molecular functionⁱ

adenylate cyclase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11807546
calcium-dependent protein binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 19855925
ion channel binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 27564677
nitric-oxide synthase binding Source: Ensembl
N-terminal myristoylation domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15632291
phosphatidylinositol 3-kinase binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
protein kinase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 20668654
Ras guanyl-nucleotide exchange factor activity Source: Reactome
titin binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7607248
type 3 metabotropic glutamate receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ

P0DP23

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	2 – 4	Combined sources	3
Helixⁱ	7 – 20	Combined sources	14
Beta strandⁱ	21 – 23	Combined sources	3
Beta strandⁱ	25 – 28	Combined sources	4
Helixⁱ	30 – 39	Combined sources	10
Helixⁱ	46 – 56	Combined sources	11
Helixⁱ	57 – 59	Combined sources	3
Beta strandⁱ	61 – 65	Combined sources	5
Helixⁱ	66 – 93	Combined sources	28
Beta strandⁱ	94 – 96	Combined sources	3
Beta strandⁱ	97 – 101	Combined sources	5
Helixⁱ	103 – 112	Combined sources	10
Beta strandⁱ	113 – 115	Combined sources	3
Helixⁱ	119 – 129	Combined sources	11
Turnⁱ	130 – 132	Combined sources	3
Beta strandⁱ	133 – 138	Combined sources	6
Helixⁱ	139 – 146	Combined sources	8

Show more details

3D structure databases

SMRⁱ	P0DP23
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 43	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	44 – 79	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	81 – 116	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	117 – 149	EF-hand 4PROSITE-ProRule annotationAdd BLAST	33

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	77 – 149	Necessary and sufficient for interaction with PCP41 PublicationAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the calmodulin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K02183
OMAⁱ	PHESSNQ

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR039030 Calmodulin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR23050:SF311 PTHR23050:SF311, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 4 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show all Align All

P0DP23-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ 
        60         70         80         90        100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY 
       110        120        130        140 
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK

Length:149

Mass (Da):16,838

Last modified:May 10, 2017 - v1

Checksum:ⁱ6B4BC3FCDE10727B

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q96HY3	Q96HY3_HUMAN	CALM1 protein CALM1 protein (Calmodulin 2 (Phosphorylase kinase, delta), isoform CRA_a) (Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_a) (Calmodulin-1) (Calmodulin-3) (LP7057 protein)	CALM1 CALM2, CALM3, hCG_17033, hCG_20313	113	Annotation score:
M0QZ52	M0QZ52_HUMAN	Calmodulin 3 (Phosphorylase kinase,... Calmodulin 3 (Phosphorylase kinase, delta), isoform CRA_d (Calmodulin-1) (Calmodulin-2) (Calmodulin-3)	CALM1 CALM2, CALM3, hCG_20313	83	Annotation score:
G3V361	G3V361_HUMAN	Calmodulin-1 Calmodulin-1	CALM1	98	Annotation score:
E7ETZ0	E7ETZ0_HUMAN	Calmodulin-1 Calmodulin-1	CALM1	150	Annotation score:
H0Y7A7	H0Y7A7_HUMAN	Calmodulin-2 Calmodulin-2	CALM2	187	Annotation score:
E7EMB3	E7EMB3_HUMAN	Calmodulin-2 Calmodulin-2	CALM2	196	Annotation score:
G3V226	G3V226_HUMAN	Calmodulin-1 Calmodulin-1	CALM1	76	Annotation score:
G3V479	G3V479_HUMAN	Calmodulin-1 Calmodulin-1	CALM1	83	Annotation score:
F8WBR5	F8WBR5_HUMAN	Calmodulin-2 Calmodulin-2	CALM2	65	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069222	54	N → I in CPVT4; increased RYR2 calcium-release channel activity; not changed calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; not changed thermal stability both in the absence and presence of calcium; no effect on the calcium binding affinity; significantly increased binding of RYR2; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs267607276EnsemblClinVar.	1
Natural variantⁱVAR_073275	90	F → L in LQT14; significantly decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 2 PublicationsCorresponds to variant dbSNP:rs730882253EnsemblClinVar.	1
Natural variantⁱVAR_078541	98	N → S in CPVT4; the mutant has significantly reduced calcium affinity compared to wild-type; calmodulin-RYR2 interaction is defective at low intracellular Ca(2+) concentrations and restored at moderate to high Ca(2+) concentrations; increased RYR2 calcium-release channel activity; decreased calcium-dependent inactivation of L-type calcium channel; not changed protein abundance; not changed structure; significantly reduced ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs398124647EnsemblClinVar.	1
Natural variantⁱVAR_078542	130	D → G in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of clacium; significantly decreased RYR2 interaction; increased ryanodine-sensitive calcium-release channel activity; decreased of KCNN2 calcium-activated potassium channel activity; not changed KCNN2 expression; not changed KCNN2 location at membrane. 4 PublicationsCorresponds to variant dbSNP:rs730882252EnsemblClinVar.	1
Natural variantⁱVAR_078263	141	E → G in LQT14; decreased calcium affinity; loss of CACNA1C calcium-dependent-inactivation; no effect on intracellular RYR2-mediated calcium release. 1 Publication	1
Natural variantⁱVAR_073282	142	F → L in LQT14; reduction in calcium affinity; not changed protein abundance; not changed structure; significantly decreased thermal stability in presence of calcium; no effect on RYR2 interaction; significantly reduced ryanodine-sensitive calcium-release channel activity. 3 PublicationsCorresponds to variant dbSNP:rs11551462Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27319 mRNA Translation: AAA35635.1 U12022, U11886 Genomic DNA Translation: AAB60644.1 BT006818 mRNA Translation: AAP35464.1 AC006536 Genomic DNA Translation: AAD45181.1 AL512791 Genomic DNA No translation available. BC000454 mRNA Translation: AAH00454.1 BC008597 mRNA Translation: AAH08597.1 BC011834 mRNA Translation: AAH11834.1 BC047523 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9892.1
PIRⁱ	S48728 MCHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001316851.1, NM_001329922.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4
UniGeneⁱ	Hs.282410 Hs.468442 Hs.515487

Genome annotation databases

Ensemblⁱ	ENST00000356978; ENSP00000349467; ENSG00000198668
GeneIDⁱ	801 805 808
KEGGⁱ	hsa:801 hsa:805 hsa:808

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P0DP23	Calmodulin-A (Fragment)	)	ORYLA		136	UniRef100_P0DP23
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
Calmodulin-1	)	XENLA		149
+288

Protein	Similar proteins		Species	Score	Length	Source
P0DP23	Calmodulin-A (Fragment)	)	ORYLA		136	UniRef90_P0DP23
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
Calmodulin-1	)	XENLA		149
+288

Protein	Similar proteins		Species	Score	Length	Source
P0DP23	Calmodulin-A (Fragment)	)	ORYLA		136	UniRef50_P0DP23
Calmodulin-alpha (Fragment)	)	ARBPU		142
Calmodulin-1	)	MOUSE		149
Calmodulin-1	)	RAT		149
Calmodulin-1	)	XENLA		149
+289

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

A question of length - Issue 105 of May 2009

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27319 mRNA Translation: AAA35635.1 U12022, U11886 Genomic DNA Translation: AAB60644.1 BT006818 mRNA Translation: AAP35464.1 AC006536 Genomic DNA Translation: AAD45181.1 AL512791 Genomic DNA No translation available. BC000454 mRNA Translation: AAH00454.1 BC008597 mRNA Translation: AAH08597.1 BC011834 mRNA Translation: AAH11834.1 BC047523 mRNA No translation available.
CCDSⁱ	CCDS9892.1
PIRⁱ	S48728 MCHU
RefSeqⁱ	NP_001316851.1, NM_001329922.1 NP_001734.1, NM_001743.5 NP_005175.2, NM_005184.3 NP_008819.1, NM_006888.4
UniGeneⁱ	Hs.282410 Hs.468442 Hs.515487

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1AJI	model	-	A	5-148	[»]
	1CDL	X-ray	2.00	A/B/C/D	2-148	[»]
	1CLL	X-ray	1.70	A	2-149	[»]
	1CTR	X-ray	2.45	A	2-149	[»]
	1IWQ	X-ray	2.00	A	2-149	[»]
	1J7O	NMR	-	A	2-77	[»]
	1J7P	NMR	-	A	83-149	[»]
	1K90	X-ray	2.75	D/E/F	2-149	[»]
	1K93	X-ray	2.95	D/E/F	6-149	[»]
	1L7Z	X-ray	2.30	A	2-149	[»]
	1LVC	X-ray	3.60	D/E/F	1-149	[»]
	1NKF	NMR	-	A	94-105	[»]
	1PK0	X-ray	3.30	D/E/F	2-148	[»]
	1S26	X-ray	3.00	D/E/F	2-149	[»]
	1SK6	X-ray	3.20	D/E/F	2-149	[»]
	1SW8	NMR	-	A	2-80	[»]
	1UP5	X-ray	1.90	A/B	2-149	[»]
	1WRZ	X-ray	2.00	A	1-149	[»]
	1XFU	X-ray	3.35	O/P/Q/R/S/T	1-149	[»]
	1XFV	X-ray	3.35	O/P/Q/R/S/T	1-149	[»]
	1XFW	X-ray	3.40	O/P/Q/R/S/T	1-149	[»]
	1XFX	X-ray	3.20	O/P/Q/R/S/T	1-149	[»]
	1XFY	X-ray	3.30	O/P/Q/R/S/T	1-149	[»]
	1XFZ	X-ray	3.25	O/P/Q/R/S/T	1-149	[»]
	1Y6W	X-ray	2.40	A	2-149	[»]
	1YR5	X-ray	1.70	A	2-149	[»]
	1YRT	X-ray	2.10	B	76-149	[»]
	1YRU	X-ray	2.50	B	76-149	[»]
	1ZOT	X-ray	2.20	B	80-148	[»]
	1ZUZ	X-ray	1.91	A	1-149	[»]
	2BE6	X-ray	2.00	A/B/C	1-149	[»]
	2F3Y	X-ray	1.45	A	2-149	[»]
	2F3Z	X-ray	1.60	A	2-149	[»]
	2HF5	NMR	-	A	47-114	[»]
	2I08	X-ray	2.00	A	3-79	[»]
	2JZI	NMR	-	A	2-149	[»]
	2K0E	NMR	-	A	2-149	[»]
	2K0F	NMR	-	A	2-149	[»]
	2K0J	NMR	-	A	3-149	[»]
	2K61	NMR	-	A	2-149	[»]
	2KNE	NMR	-	A	2-149	[»]
	2KUG	NMR	-	A	2-77	[»]
	2KUH	NMR	-	A	83-149	[»]
	2L53	NMR	-	A	2-149	[»]
	2L7L	NMR	-	A	2-149	[»]
	2LGF	NMR	-	A	3-149	[»]
	2LL6	NMR	-	A	2-149	[»]
	2LL7	NMR	-	A	2-149	[»]
	2LQC	NMR	-	A	2-78	[»]
	2LQP	NMR	-	A	79-149	[»]
	2LV6	Other	-	A	2-149	[»]
	2M0J	NMR	-	A	2-149	[»]
	2M0K	NMR	-	A	2-149	[»]
	2M55	NMR	-	A	2-149	[»]
	2MG5	NMR	-	A	2-149	[»]
	2N27	NMR	-	A	2-149	[»]
	2N6A	NMR	-	A	6-147	[»]
	2N77	NMR	-	A	77-149	[»]
	2N8J	NMR	-	A	2-149	[»]
	2R28	X-ray	1.86	A/B	1-149	[»]
	2V01	X-ray	2.15	A	2-149	[»]
	2V02	X-ray	2.20	A	2-149	[»]
	2VAY	X-ray	1.94	A	4-149	[»]
2W73	X-ray	1.45	A/B/E/F	1-149	[»]
2WEL	X-ray	1.90	D	1-149	[»]
2X0G	X-ray	2.20	B	2-149	[»]
2Y4V	X-ray	1.80	A	1-149	[»]
3BYA	X-ray	1.85	A	2-149	[»]
3DVE	X-ray	2.35	A	2-149	[»]
3DVJ	X-ray	2.80	A	2-149	[»]
3DVK	X-ray	2.30	A	2-149	[»]
3DVM	X-ray	2.60	A	2-149	[»]
3EWT	X-ray	2.40	A	2-149	[»]
3EWV	X-ray	2.60	A	2-149	[»]
3G43	X-ray	2.10	A/B/C/D	2-149	[»]
3HR4	X-ray	2.50	B/D/F/H	1-149	[»]
3J41	electron microscopy	25.0	E/F	1-149	[»]
3O77	X-ray	2.35	A	1-149	[»]
3O78	X-ray	2.60	A/B	1-149	[»]
3OXQ	X-ray	2.55	A/B/C/D	1-149	[»]
3SUI	X-ray	1.95	A	1-149	[»]
3UCT	X-ray	1.90	A/B	2-80	[»]
3UCW	X-ray	1.76	A/B/C/D	2-80	[»]
3UCY	X-ray	1.80	A	2-80	[»]
4BW7	X-ray	1.81	A/C	1-149	[»]
4BW8	X-ray	1.80	A/B	1-149	[»]
4BYF	X-ray	2.74	B/D	1-149	[»]
4DCK	X-ray	2.20	B	1-149	[»]
4DJC	X-ray	1.35	A	1-149	[»]
4GOW	X-ray	2.60	D	4-147	[»]
4JPZ	X-ray	3.02	C/I	1-149	[»]
4JQ0	X-ray	3.84	C	1-149	[»]
4L79	X-ray	2.30	B	1-149	[»]
4LZX	X-ray	1.50	A	2-149	[»]
4M1L	X-ray	2.10	A	2-149	[»]
4OVN	X-ray	2.80	A/B/C/D/E	1-149	[»]
4Q57	X-ray	1.80	A	10-74	[»]
4Q5U	X-ray	1.95	A	1-149	[»]
4UMO	X-ray	3.00	C/D	1-149	[»]
4UPU	X-ray	2.34	A	2-149	[»]
4V0C	X-ray	2.86	C/D	1-149	[»]
5COC	X-ray	2.67	A	5-78	[»]
5DBR	X-ray	2.25	A	5-149	[»]
5DOW	X-ray	1.70	A/C/E/G	2-149	[»]
5DSU	X-ray	1.93	A	3-78	[»]
5GGM	NMR	-	A	2-149	[»]
5I0I	X-ray	3.15	C/E	3-147	[»]
			G	84-126	[»]
			I	84-147	[»]
5J03	X-ray	2.00	B	1-149	[»]
5J8H	NMR	-	A	2-149	[»]
5JQA	X-ray	1.80	A	1-149	[»]
5JTH	X-ray	1.84	A	1-149	[»]
5K7L	electron microscopy	3.78	B	1-149	[»]
5K8Q	X-ray	1.74	A	1-149	[»]
5OEO	NMR	-	A	1-149	[»]
5TP5	NMR	-	A	2-149	[»]
5TP6	NMR	-	A	2-149	[»]
5V02	X-ray	1.78	R	1-149	[»]
5V03	X-ray	1.58	R	1-149	[»]
5V7X	X-ray	3.14	B	1-149	[»]
5WBX	X-ray	1.90	R	5-148	[»]
5WC5	X-ray	2.30	R	5-148	[»]
6B8L	X-ray	2.30	B/D/F/H	1-149	[»]
6B8M	X-ray	2.30	B/D/F/H	1-149	[»]
6B8N	X-ray	2.20	B/D/F/H	1-149	[»]
6B8P	X-ray	2.20	B/D/F/H	1-149	[»]
6B8Q	X-ray	2.60	B/D/F/H	1-149	[»]
6C1D	electron microscopy	3.20	R	2-149	[»]
6C1G	electron microscopy	3.80	R	2-149	[»]
6C1H	electron microscopy	3.90	R	2-149	[»]
6CNM	electron microscopy	3.40	E/F/G/H	1-149	[»]
6CNN	electron microscopy	3.50	E/F/G/H	1-149	[»]
6CNO	electron microscopy	4.70	E/F/G/H	1-149	[»]
6E2F	electron microscopy	3.90	E	1-149	[»]
6E2G	electron microscopy	3.60	E	1-149	[»]
6FEG	NMR	-	B	1-149	[»]
6FEH	NMR	-	B	1-149	[»]
SMRⁱ	P0DP23
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

BindingDBⁱ	P0DP23
ChEMBLⁱ	CHEMBL6093

Protein family/group databases

MoonDBⁱ	P0DP23 Predicted

MoonDBⁱ

P0DP23 Predicted

PTM databases

iPTMnetⁱ	P0DP23
PhosphoSitePlusⁱ	P0DP23

Proteomic databases

PeptideAtlasⁱ	P0DP23
PRIDEⁱ	P0DP23

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356978; ENSP00000349467; ENSG00000198668
GeneIDⁱ	801 805 808
KEGGⁱ	hsa:801 hsa:805 hsa:808

Organism-specific databases

CTDⁱ	801 805 808
GeneCardsⁱ	CALM1
HGNCⁱ	HGNC:1442 CALM1
HPAⁱ	HPA044999
MalaCardsⁱ	CALM1
MIMⁱ	114180 gene 614916 phenotype 616247 phenotype
neXtProtⁱ	NX_P0DP23
OpenTargetsⁱ	ENSG00000143933 ENSG00000160014 ENSG00000198668
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

KOⁱ	K02183
OMAⁱ	PHESSNQ

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111932 CaMK IV-mediated phosphorylation of CREB R-HSA-111933 Calmodulin induced events R-HSA-111957 Cam-PDE 1 activation R-HSA-111997 CaM pathway R-HSA-114608 Platelet degranulation R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-163615 PKA activation R-HSA-180024 DARPP-32 events R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol R-HSA-2025928 Calcineurin activates NFAT R-HSA-203615 eNOS activation R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-2672351 Stimuli-sensing channels R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-4086398 Ca2+ pathway R-HSA-418359 Reduction of cytosolic Ca++ levels R-HSA-425561 Sodium/Calcium exchangers R-HSA-442717 CREB phosphorylation through the activation of CaMKK R-HSA-442729 CREB phosphorylation through the activation of CaMKII R-HSA-442745 Activation of CaMK IV R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor R-HSA-445355 Smooth Muscle Contraction R-HSA-451308 Activation of Ca-permeable Kainate Receptor R-HSA-5210891 Uptake and function of anthrax toxins R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5576892 Phase 0 - rapid depolarisation R-HSA-5578775 Ion homeostasis R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation R-HSA-5626467 RHO GTPases activate IQGAPs R-HSA-5627123 RHO GTPases activate PAKs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-70221 Glycogen breakdown (glycogenolysis) R-HSA-8876725 Protein methylation R-HSA-936837 Ion transport by P-type ATPases R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-111933 Calmodulin induced events
R-HSA-111957 Cam-PDE 1 activation
R-HSA-111997 CaM pathway
R-HSA-114608 Platelet degranulation
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-163615 PKA activation
R-HSA-180024 DARPP-32 events
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-203615 eNOS activation
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-HSA-2672351 Stimuli-sensing channels
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-4086398 Ca2+ pathway
R-HSA-418359 Reduction of cytosolic Ca++ levels
R-HSA-425561 Sodium/Calcium exchangers
R-HSA-442717 CREB phosphorylation through the activation of CaMKK
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442745 Activation of CaMK IV
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-445355 Smooth Muscle Contraction
R-HSA-451308 Activation of Ca-permeable Kainate Receptor
R-HSA-5210891 Uptake and function of anthrax toxins
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-5576892 Phase 0 - rapid depolarisation
R-HSA-5578775 Ion homeostasis
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-5626467 RHO GTPases activate IQGAPs
R-HSA-5627123 RHO GTPases activate PAKs
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-8876725 Protein methylation
R-HSA-936837 Ion transport by P-type ATPases
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSⁱ	CALM1 human
Protein Ontology More...PROⁱ	PR:P0DP23
SOURCEⁱ	Search...

Gene expression databases

ExpressionAtlasⁱ	P0DP23 baseline and differential

ExpressionAtlasⁱ

P0DP23 baseline and differential

Family and domain databases

CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR039030 Calmodulin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR23050:SF311 PTHR23050:SF311, 1 hit
Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 2 hits
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CALM1_HUMAN
Accessionⁱ	P0DP23Primary (citable) accession number: P0DP23 Secondary accession number(s): P02593 Q96HK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2017
	Last sequence update:	May 10, 2017
	Last modified:	November 7, 2018
	This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0DP23 (CALM1_HUMAN)

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Calmodulin-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Cytosol

Extracellular region or secreted

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ